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possible role of soluble fibrin monomer complex after gastroenterological surgery

World Journal of Gastroenterology 2017年第12期23卷 2209-2216页

作者： Masatoshi Kochi Manabu shimomura Takao Hinoi Hiroyuki Egi Kazuaki Tanabe Yasuyo Ishizaki Tomohiro Adachi Hirotaka Tashiro Hideki Ohdan Department of Gastroenterological and Transplant Surgery Applied Life SciencesInstitute of Biomedical and Health SciencesHiroshima University Department of Surgery National Hospital Organization Higashihiroshima Medical Center Department of Surgery Institute for Clinical ResearchNational Hospital Organization Kure Medical Center and Chu-goku Cancer Center Department of Surgery National Hospital Organization Hiroshima-nishi Medical Center

AIM To examine the role of soluble fibrin monomer complex(SFMC) in the prediction of hypercoagulable state after gastroenterological *** We collected data on the clinical risk factors and fibrin-related makers from patients who underwent gastroenterological surgery at Hiroshima University Hospital between April 1, 2014 and March 31, 2015. We investigated the clinical significance of SFMC, which is known to reflect the early plasmatic activation of coagulation, in the view of these fibrin related *** A total of 123 patients were included in the present study. There were no patients with symptomatic VTE. Thirty-five(28%) patients received postoperative anticoagulant therapy. In the multivariate analysis, a high SFMC level on POD 1 was independently associated with D-dimer elevation on POD 7(OR = 4.31, 95%CI: 1.10-18.30, P = 0.03). The cutoff SFMC level was 3.8 μg/ml(AUC = 0.78, sensitivity, 63%, specificity, 89%). The D-dimer level on POD 7 was significantly reduced in high-SFMC patients who received anticoagulant therapy in comparison to highSFMC patients who did *** The SFMC on POD 1 strongly predicted the hypercoagulable state after gastroenterological surgery than the clinical risk factors and the other fibrin related markers.

关键词： Hypercoagulable state Gastroenterological surgery Soluble fibrin monomer complex Venous thromboembolism Anticoagulant therapy

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Friction reduction of glycocalyx of human endothelial cells cultured on anionic hydrogel scaffolds

Friction reduction of glycocalyx of human endothelial cells ...

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2007年全国高分子学术论文报告会

作者：陈咏梅龚建萍 Takayuki Kurokawa masaru Tanaka Yasuda Kazunori Sadaaki Yamamoto Masatsugu shimomura Yoshihito Osada Graduate School of Science Hokkaido University Sapporo 060-0810Japan Creative Research Initiative’SOUSEI’Hokkaido UniversitySapporo 001-0021 Graduate School of Science Hokkaido University Sapporo 060-0810Japan Graduate School of Science Hokkaido University Sapporo 060-0810Japan Nanotechnology Research Center Research Institute for Electronic Science Hokkaido UniversitySapporo001-0021Japan Creative Research Initiative’SOUSEI’ Hokkaido University Sapporo 001-0021 School of MedicineHokkaido UniversitySapporo 060-0810Japan Creative Research Initiative’SOUSEI’ Hokkaido University Sapporo 001-0021 Nanotechnology Research Center Research Institute for Electronic Science Hokkaido UniversitySapporo001-0021Japan Graduate School of Science Hokkaido University Sapporo 060-0810Japan

＜正＞In the in vivo vascular system,the inner surface of blood vessel is covered by a monolayer of endothelial cell（EC）that exposes to the blood *** great interesting, the red blood cells can deform and smoothly squeeze though the capillary of a diameter much *** this process,the friction should occur between soft ECs and deformable blood red ***,only when the surface friction between the inner surface wall of

关键词： hydrogel cell culture glycocalyx friction platelet adhesion

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Interaction of <i>Helicobacter pylori</i>Cell Membrane with Non-Esterified Cholesterol and Other Steroids

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Open Journal of Medical Microbiology 2013年第1期3卷 70-79页

作者： Hirofumi shimomura Kouichi Hosoda Yoshikazu Hirai Division aof Bacteriology Department of Infection and Immunity Jichi Medical University Tochigi Japan Division of Bacteriology Department of Infection and Immunity Jichi Medical University Tochigi Japan

Helicobacter pylori performs the unique action of assimilating exogenous non-esterified cholesterol into its cell membrane. This bacterium aggressively incorporates non-esterified cholesterol into the membrane, induces its glucosylation, and uses both non-esterified cholesterol and glucosylated cholesterols as membrane lipid compositions. The reason for this assimilation of non-esterified cholesterol into the cell membrane of H. pylori has eluded investigators for many years. Recent hypotheses posit that the sterol-uptake and sterol-glucosylation contribute to the survival of H. pylori cells in different ways. The incorporation of the non-esterified cholesterol into the cell membrane fortifies the resistance of H. pylori against the antibacterial actions of phosphatidylcholines, antibiotics, and bile salts. In parallel, the glucosylation of the non-esterified cholesterol incorporated into the cell membrane serves H. pylori in two ways. First, it helps the bacterium evade host immune responses, such as phagocytosis by macrophages and activation of antigen-specific T cells. Second, it detoxifies sterols fatal to the bacterium via a novel action of sterol glucosylation recently described in another report from our group. The reluctance of H. pylori to absorb esterified cholesterol remains unexplained. A recent study by our group has demonstrated that the phosphatidylethanolamine (PE) in the outer membrane of H. pylori serves as a steroid-binding lipid the incorporation of non-esterified cholesterol into the membrane. We have also discovered that the myristic acid (C14:0) molecule attached to the PE of this bacterium plays an important role in the selective binding of non-esterified cholesterol but not esterified cholesterol.

关键词： Helicobacter pylori Cholesterol-α-Glucosyltransferase Phosphatidylethanolamine

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Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice

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World Journal of Gastroenterology 2006年第21期12卷 3352-3358页

作者： Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro shimomura Norio Hayashi Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine2-2K1Yamada-okaSuitaOsaka 565-0871Japan Department of Metabolic Medicine Osaka University Graduate School of Medicine2-2B5Yamada-okaSuitaOsaka 565-0871Japan Sumitomo Hospital 5-3-20 Kita-Ku nakanoshimaOsaka530-0005Japan

AIM： To examine the effects of adiponectin on the functions of Kupffer cells, key modulators of lipopolysaccharide （LPS） -induced liver ***： D-galactosamine （GAIN） and LPS were injected intraperitoneally into adiponectin-/- mice and wild type mice. Kupffer cells, isolated from Sprague-Dawley rats, were preincubated with or without adiponectin, and then treated with ***： In knockout mice, GalN/LPS injection significantly lowered the survival rate, significantly raised the plasma levels of alanine transaminase and tumor necrosis factor-α （TNF-α） and significantly reduced IL-10 levels compared with wild type mice. TNF-α gene expression in the liver was which higher and those of IL-10 were lower in knockout mice than in wild type mice. In cultured adiponectin-pre-treated Kupffer cells, LPS significantly lowered TNF-α levels and raised IL-10 levels in the culture media and their respective gene expression levels, compared with Kupffer cells without ***： Adiponectin supresses TNF-α production and induces IL-10 production by Kupffer cells in response to LPS stimulation, and a lack of adiponectin enhances LPS-induced liver injury.

关键词： Adiponectin Lipopolysaccharide Kupffer cell TNF-alpha IL10

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Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice

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World Journal of Gastroenterology 2008年第42期14卷 6473-6480页

作者： Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro shimomura Department of Gastroenterology and Hepatology Graduate School of Medicine Osaka University 2-2 Yamada-oka Suita Osaka 565-0871 Japan Department of Pathology Osaka Medical Center for Cancer and Cardiovascular Diseases Research Institute 1-3-2 Nakamichi Higashinari-ku Osaka 537-8511 Japan Department of Metabolic Medicine Graduate School of Medicine Osaka University 2-2 Yamada-oka Suita Osaka 565-0871 Japan Department of Biochemistry Osaka MedicaCenter for Cancer and Cardiovascular Diseases ResearchInstitute 1-3-2 Nakamichi Higashinari-ku Osaka 537-8511Japan Department of Gastrointestinal Oncology Osaka Medical Center for Cancer and Cardiovascular Diseases 1-3-3 Nakamichi Higashinari-ku Osaka 537-8511 Japan

AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and ***:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) ***:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO *** mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal *** addition,KO mice showed higher incidence and frequency of liver tumors after AOM *** percent of WT mice developed liver tumors,and these WT mice had only a single *** contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple ***:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in *** study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects.

关键词： Adiponectin Colorectal carcinogenesis Azoxymethane Cell proliferation Cyclooxygenase-2 Liver tumor formation

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A Method for Structuring Service Failure Factors to Realize Highly Reliable Services

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Journal of Mechanics Engineering and Automation 2013年第12期3卷 747-755页

作者： Junpei Saito Yusuke Kurita Koji Kimita Yoshiki shimomura Department of System Design Tokyo Metropolitan University Tokyo 19-0065 Japan Department of Management Science Tokyo University of Science Tokyo 162-8601 Japan

As the society matures, customer requirements have become more varied. Services have been attracting increasing attention from industry and academic field as an effective mean to satisfy such varied customer requirements. In order to make a profit, it is important for companies to build and maintain long-term relationships with customers. Therefore, service providers should maintain their service quality and always satisfy their customers. To realize highly reliable product or services, in general, it is an effective approach to prevent failures from occurring in the use phase. Therefore, it is necessary that analysts identify the factors that could cause service failure and take appropriate measures against the target failure factor in advance. However, service failure factors are varied compared to physical products because service failures occur due to uncertainty elements such as human factors. In this study, we aim to enable service analysts to identify the critical failure factor from a number of failure factors. To achieve this, we identify complex failure factors and relationships among them from the viewpoint of the field where the service provided. This paper proposes a method for structuring the causal sequence between service failure factors by using a method of system modeling.

关键词： Service failure factors service reliability service engineering.

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Abscess in the inguinal hernial sac after peritonitis surgery: A case report

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World Journal of Gastroenterology 2009年第8期15卷 1007-1009页

作者： Satoshi Ikeda Haruka Takeda Masanori Yoshimitsu Takao Hinoi Makoto Yoshida Daisuke Sumitani Yuji Takakura Yasuo Kawaguchi Manabu shimomura Masakazu Tokunaga Katsufumi Kawahori Hideki Ohdan Masazumi Okajima Department of Endoscopic Surgery and Surgical Science Graduate School of Biomedical Science Hiroshima University Hiroshima 734-8551 Japan Department of Surgery Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Science Hiroshima University Hiroshima 734-8551 Japan

In this paper, we report an extremely rare case of an abscess that developed in the inguinal hernial sac after surgery for peritonitis. A 60-year-old man underwent laparoscopic low anterior resection for rectal cancer. One day after this operation, peritoneal drainage and ileostomy were performed for rectal anastomotic leakage. Five days after the second operation, computed tomography revealed an abscess in the left inguinal hernial sac. Subsequently, hernioplasty and resection of the inflamed sac were performed.

关键词： Inguinal hernia Hernial sac abscess Peritonitis Anastomotic leakage, Rectal cancer

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Synthesis and Characterization of Triarylamine-Based Block Copolymers by Combination of C-N Coupling and ATRP for Photorefractive Applications

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Open Journal of Organic Polymer Materials 2012年第4期2卷 53-62页

作者： Zhenbo Cao Kousuke Kousuke Tsuchiy Takeshi shimomura Kenji Ogino Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Tokyo Japan

Poly(4-butyltriarylamine)s with t-butyldimethylsilyl terminal protecting group (PBTPA-TBS) with various molecular weights were prepared by C-N coupling polymerization. The resulting precursors were postfunctionalized and subse- quently used as macroinitiators for atom transfer radial polymerization (ATRP) of n-butyl acrylate (n-BA) and ethyl acrylate (EA). Both the polymerization processes were controlled and the polymers were characterized by 1H NMR, gel permeation chromatography (GPC) and thermal properties, which confirmed the successful synthesis of all the poly-mers. The microphase separated behaviors of the poly (4-butyltriarylamine)-block-poly (butyl acrylate) (PBTPA-b-PBA) were examined by AFM in the film showing phase separation structures for all the polymers. The photorefractive property of the composite based on PBTPA-b-PBA block copolymer was evaluated by two-beam coupling experiment. A relative high gain coefficient of 42.7 cm?1 was obtained at the electric field of 31 V/?m.

关键词： C-N Coupling Atrp Triarylamine Acrylate Ester Photorefractivity

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Implementation of soft microfingers for a hMSC aggregate manipulation system

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Microsystems & Nanoengineering 2016年第1期2卷 311-317页

作者： Satoshi Konishi Shuhei shimomura Shuhei Tajima Yasuhiko Tabata Department of Mechanical Engineering Ritsumeikan University1-1-1 Noji-higashKusatsuShiga 525-8577Japan Graduate School of Science and Engineering Ritsumeikan University1-1-1 Noji-higashKusatsuShiga 525-8577Japan Institute for Frontier Medical Sciences Kyoto UniversityYoshida-shimoadachiSakyo-kuKyoto 606-8501Japan

This paper describes a pneumatic balloon actuator(PBA)composed of polydimethylsiloxane(PDMS)for cellular aggregate *** evaluated the ability of the microdevice to manipulate a tiny and sensitive cellular aggregate without causing serious *** used human mesenchymal stem cells(hMSCs)for the cellular *** describe the design,fabrication,characterization and operation of the soft microfingers to pinch and release a spherical hMSC aggregate(φ200μm),and we employed a PBA to serve as an artificial muscle to drive the microfingers.A design of the microfingers in terms of dimensions,generated force and contact conditions was *** designed dimensions of a single finger were 560μm×900μ*** summary,we demonstrate the utility of the surface modification of a fingertip for pinching and releasing a cellular aggregate and describe a manipulation system that was constructed to drive and control the *** implemented manipulation system,which is composed of microfingers and a positioning mechanism,was tested and verified in a series of operations.

关键词： cellular aggregate manipulation pinching releasing positioning pneumatic balloon actuator soft MEMS surface modification

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Studies to Decrease Cogging Force and Pulsating Thrust in the Prototype Linear Permanent Magnet Vernier Motor

Studies to Decrease Cogging Force and Pulsating Thrust in th...

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第11届国际电机与系统学术会议

作者： Shoji shimomura Masayasu Fujieda Katsuhiro Hoshino Department of Electrical Engineering Shibaura Institute of TechnologyTokyo 135-8548 Japan

＜正＞Vernier motors are known as a large torque machine. Its feature is most suitable for linear direct drive ***, in general,linear machines have a large cogging force and pulsating force,due to the ***,the authors have studied an improvement of the force characteristics in a linear permanent magnet vernier motor,which is the type that has small magnets on both the stator and the *** paper,first,shows an investigation for reducing the cogging force and its ***, the cause of the pulsation force that arises in load running and its improvement are *** the result of the improvements,the good force characteristics that include only slight cogging and pulsation force have been obtained.

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