Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice

作     者：Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi 

作者机构：Department of Gastroenterology and Hepatology Osaka UniversityGraduate School of Medicine2-2K1Yamada-okaSuitaOsaka 565-0871Japan Department of Metabolic Medicine Osaka UniversityGraduate School of Medicine2-2B5Yamada-okaSuitaOsaka 565-0871Japan Sumitomo Hospital 5-3-20Kita-Ku nakanoshimaOsaka530-0005Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第21期

页      面：3352-3358页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Adiponectin Lipopolysaccharide Kupffer cell TNF-alpha IL10 

摘      要：AIM： To examine the effects of adiponectin on the functions of Kupffer cells, key modulators of lipopolysaccharide （LPS） -induced liver ***： D-galactosamine （GAIN） and LPS were injected intraperitoneally into adiponectin-/- mice and wild type mice. Kupffer cells, isolated from Sprague-Dawley rats, were preincubated with or without adiponectin, and then treated with ***： In knockout mice, GalN/LPS injection significantly lowered the survival rate, significantly raised the plasma levels of alanine transaminase and tumor necrosis factor-α （TNF-α） and significantly reduced IL-10 levels compared with wild type mice. TNF-α gene expression in the liver was which higher and those of IL-10 were lower in knockout mice than in wild type mice. In cultured adiponectin-pre-treated Kupffer cells, LPS significantly lowered TNF-α levels and raised IL-10 levels in the culture media and their respective gene expression levels, compared with Kupffer cells without ***： Adiponectin supresses TNF-α production and induces IL-10 production by Kupffer cells in response to LPS stimulation, and a lack of adiponectin enhances LPS-induced liver injury.