检索结果-南通市图书馆

Serum cystatin C can be used as a marker of renal function even in patients with intestinal urinary diversion

Asian Journal of Urology 2015年第3期2卷 167-169页

作者： masahiro Matsuki Toshiaki Tanaka Takeshi Maehana Koji Ichihara masahiro yanase Masanori Matsukawa Hideki Adachi Satoshi Takahashi Naoya Masumori Department of Urology Sapporo Medical UniversitySchool of MedicineSapporoJapan Sapporo Kidney Disease Treatment Forum SapporoJapan Department of Urology Sunagawa City Medical CenterSunagawaJapan Department of Urology Takikawa Municipal HospitalTakikawaJapan Department of Urology SaiseikaiOtaru HospitalOtaruJapan

Objective:Recently,serum cystatin C(CysC)has been used as a novel marker of renal ***,there is a lack of data on CysC levels in patients with intestinal urinary diversion(UD).Here we report CysC levels in such ***:We prospectively observed 38 patients who were diagnosed with bladder cancer and subsequently treated with radical cystectomy and UD at our institution in 2012 and *** creatinine(sCr)and CysC were obtained optionally at the same time at least 1 month after radical cystectomy and ***:The median CysC and sCr concentrations were 1.12 mg/L(range 0.75-2.47 mg/L)and 0.99 mg/dL(range 0.61-2.22 mg/dL),*** median estimated concentrations of glomerular filtration rate(GFR)based on CysC(eGFRcys)and GFR based on creatinine(eGFRcreat)were 61.08 mL/min/1.73 m^2(range 22.64e99.89 mL/min/1.73 m^2)and 58.01 mL/min/1.73 m^2(range 23.48e91.82 mL/min/1.73 m2),*** had a significant correlation with sCr(r=0.8607,p<0.0001)and eGFRcreat(r=-0.8993,p<0.0001).eGFRcys also had a significant correlation with eGFRcreat(r=0.8104,p<0.0001).Conclusion:The correlation between CysC and sCr was strong and the correlation coefficient was equivalent to that in patients without *** results suggest that CysC is not affected by UD and can be used as a marker of renal function similarly to sCr in patients with UD.

关键词： Renal function Cystatin C Urinary diversion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinicopathological Analysis of Patients with Nonmuscle-Invasive Bladder Cancer Who Underwent Radical Cystectomy

引用

Surgical Science 2012年第7期3卷 347-352页

作者： Naotaka Nishiyama Hiroshi Kitamura Masatoshi Mutoh masahiro yanase Hiroyuki Iwaki Tadashi Hasegawa Taiji Tsukamoto Departments of Surgical Pathology Sapporo Medical University School of Medicine Sapporo Japan Departments of Urology Sapporo Medical University School of Medicine Sapporo Japan Divisions of Pathology Sunagawa City Medical Center Sunagawa Japan Divisions of Urology Sunagawa City Medical Center Sunagawa Japan

Objectives: Surgical specimens obtained at the time of the last transurethral resection of bladder tumor (TURBT) for patients with nonmuscle-invasive bladder cancer (NMIBC) who underwent radical cystectomy were retrospectively evaluated in order to investigate the relationship between pathological variation and upstaging of NMIBC. Methods and Materials: Twenty patients (19 men, 1 woman;aged 69.4 ± 12.1 (mean ± SD) years) diagnosed with NMIBC underwent radical cystectomy during follow-up. Results: Five of the 20 patients (25%) had pathological upstaging in the radical cystectomy specimens. There was a statistical association between pathological upstaging and cancer death (p = 0.002). There were three patterns of pathological variation in the upstaged specimens: 1) in patients with BCG-resistant NMIBC, urothelial carcinoma invaded through the lamina propria;2) urothelial carcinoma showed diffuse invasion beyond the deep lamina propria, and the cancer cells had infiltrated as single cells and formed nodules;3) TURBT specimens showed a micropapillary variant. Conclusions: Since these pathological variations correlated with pathological upstaging, they may provide an indication for cystectomy in NMIBC patients.

关键词： Clinicopathological Examination Nonmuscle-Invasive Bladder Cancer Radical Cystectomy Pathological Upstaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells

引用

World Journal of Gastroenterology 2007年第38期13卷 5071-5078页

作者： Kazuaki Tejima masahiro Arai Hitoshi Ikeda Tomoaki Tomiya Mikio yanase Yukiko Inoue Takako Nishikawa Naoko Watanabe Natsuko Ohtomo Masao Omata Kenji Fujiwara Department of Gastroenterology University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan Department of Gastroenterology Toshiba General Hospital 6-3-22 Higashiooi Shinagawa-ku Tokyo 140-8522 Japan Yokohama Rosai Hospital 3211 Kozukue-cho Kouhoku-ku Yokohama-shi Kanagawa 222-0036 Japan

AIM: To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. METHODS: The in vitro effect of H2O2 pretreatment was investigated in rat isolated hepatocytes subjected to anoxia/reoxygenation. Cell viability was assessed with propidium iodide fluorometry. In other experiments, rat livers were excised and subjected to warm ischemia/ reperfusion in an isolated perfused liver system to determine leakage of liver enzymes. Preconditioning was performed by H2O2 perfusion, or by stopping the perfusion for 10 min followed by 10 min of reperfusion. To inhibit Kupffer cell function or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gadolinium chloride was injected prior to liver excision, or diphenyleneiodonium, an inhibitor of NADPH oxidase, was added to the perfusate, respectively. Histological detection of oxygen radical formation in Kupffer cells was performed by perfusion with nitro blue tetrazolium. RESULTS: Anoxia/reoxygenation decreased hepatocyte viability compared to the controls. Pretreatment with H2O2 did not improve such hepatocyte injury. In liver perfusion experiments, however, H2O2 preconditioning reduced warm ischemia/reperfusion injury, which wasreversed by inhibition of Kupffer cell function or NADPH oxidase. Histological examination revealed that H2O2 preconditioning induced oxygen radical formation in Kupffer cells. NADPH oxidase inhibition also reversed hepatoprotection by ischemic preconditioning. CONCLUSION: H2O2 preconditioning protects hepato- cytes against warm ischemia/reperfusion injury via NADPH oxidase in Kupffer cells, and not directly. NADPH oxidase also mediates hepatoprotection by ischemic preconditioning.

关键词： Diphenyieneiodonium chioride Ischemia/ reperfusion injury Ischemic preconditioning Liver transplantation Oxygen radicals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：