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Catalyst-free growth of ZnO nanowires on various-oriented sapphire substrates by pulsed-laser deposition

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Journal of Semiconductors 2016年第2期37卷 20-24页

作者： Tetsuya Shimogaki masahiro takahashi Masaaki Yamasaki Taichi Fukuda Mitsuhiro Higashihata Hiroshi Ikenoue Daisuke Nakamura Tatsuo Okada Department of Information Science and Electrical Engineering Kyushu University

Catalyst-free growth of one-dimensional zinc oxide （ZnO） nanowires is reported. ZnO nanowires were synthesized on ZnO buffer layers deposited on various-oriented sapphire substrates. Syntheses of ZnO buffer layers and nanowires were performed by ultraviolet pulsed-laser deposition. ZnO nanowire＇s number density was the lowest in the case of using m-cut sapphire substrates. ZnO nanowires grown on a-cut sapphire substrates had vertical alignment with distances of tens to hundreds of nanometers. On the other hand, ZnO nanowires grown on c-cut sapphire substrates had the biggest nucleation rate. The dependence of crystalline orientation of ZnO buffer layers on the orientation of sapphire substrates were investigated by electron back scatter diffraction measurement. From their results, the growth models of ZnO buffer layers were suggested and the variations in morphological properties ofZnO nanowires were discussed.

关键词： zinc oxide nanowire catalyst free growth pulsed laser deposition

Greywater Treatment by High Rate Algal Pond under Sahelian Conditions for Reuse in Irrigation

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Journal of Water Resource and Protection 2015年第14期7卷 1143-1155页

作者： Ynoussa Maiga masahiro takahashi Thimotée Yirbour Kpangnane Somda Amadou Hama Maiga Laboratory of Microbiology and Microbial Biotechnology University of Ouagadougou Ouagadougou Burkina Faso Environmental Engineering and Science Hokkaido University Sapporo-shi Japan Laboratory of Water Decontamination Ecosystems and Health International Institute for Water and Environmental Engineering Ouagadougou Burkina Faso

High Rate Algal Pond (HRAP) was constructed and operated using a mixer device to investigate its capability in treating greywater for reuse in gardening. Physico-chemical and microbiological parameters were monitored. With a hydraulic retention time of 7.5 days and a solid retention time of 20 days, the average removal efficiencies (ARE) were 69% and 62% for BOD5 and COD respectively. The ARE for , and were 23%, 52% and 43% respectively. The removal of suspended solids (SS) was unsatisfactory, which could be attributed to the low average algal settling efficiencies of 9.3% and 16.0% achieved after 30 and 60 minutes respectively. The ARE of fecal coliforms, Escherichia coli and enterococci were 2.65, 3.14 and 3.17 log units respectively. In view of the results, the HRAP technology could be adapted for greywater treatment in sahelian regions. However, further studies on the diversity of the algal species growing in the HRAP unit are necessary in order to increase the removal of SS. Hazards of a reuse of the effluents are discussed on the basis of the various qualitative parameters. The residual content of E. coli was varying from 4 CFU per 100 mL. Based on WHO guidelines for greywater reuse in irrigation, the effluents could be used for restricted irrigation (E. coli < 105 CFU per 100 mL). Furthermore, the reuse potential is discussed on the basis of FAO guidelines using SAR (3.03 to 4.11), electrical conductivity (482 to 4500 μS/cm) and pH values (6.45 to 8.6).

关键词： Greywater Treatment High Rate Algal Pond Irrigation Reuse Sahelian Region

Cochlear Implantation in Patients with Eosinophilic Otitis Media

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第1期4卷 32-37页

作者： masahiro takahashi Yasuhiro Arai Naoko Sakuma Daisuke Sano Goshi Nishimura Takahide Taguchi Nobuhiko Oridate Satoshi Iwasaki Shin-Ichi Usami Department of Otorhinolaryngology Head and Neck Surgery Yokohama City University School of Medicine Yokohama Japan Department of Otorhinolaryngology International University of Health and Welfare Mita Hospital Tokyo Japan Department of Otorhinolaryngology Shinshu University School of Medicine Nagano Japan

It is known that cochlear implantation for deaf patients with eosinophilic otitis media (EOM) is safe and can provide good speech perception. However, the best timing of implant surgery in patients with EOM is not yet known. The aim of this case report is to suggest the appropriate timing of the surgery in EOM patients with deaf. Cochlear implantation was indicated in two patients with EOM. One underwent cochlear implantation in the absence of any ear discharge. In the other case, implant surgery was delayed for three years due to persistent ear discharge. No complications related to implant device or skin flap were observed in either case. The speech recognition score after implantation was good in the first case and poor in the second case. Perioperative complications were manageable even in the patient with persistent ear discharge. However, the delay in implant surgery due to the persistent ear discharge resulted in a poor speech recognition score. Early implantation should be considered even in EOM patients with ear discharge, although the presence of active middle ear inflammation is regarded as one of the contraindications for implantation according to the current Japanese guidelines.

关键词： Eosinophilic Otitis Media Cochlear Implantation Speech Recognition

The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability

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Protein & Cell 2011年第9期2卷 755-763页

作者： Kentaro Ito Akinori takahashi masahiro Morita Toru Suzuki Tadashi Yamamoto Division of Oncology Department of Cancer BiologyInstitute of Medical ScienceUniversity of TokyoTokyo 108-8639Japan Cell Signal Unit Okinawa Institute of Science and Technology1919-1Okinawa 904-0412Japan

The human CCR4-NOT deadenylase complex consists of at least nine enzymatic and non-enzymatic *** evidence suggests that the non-enzymatic subunits are involved in the regulation of mRNA deadenylation,although their precise roles remain to be *** this study,we addressed the function of the CNOT1 subunit by depleting its expression in HeLa *** cytometric analysis revealed that the sub G1 fraction was increased in CNOT1-depleted ***,the same level of the sub G1 fraction was seen when cells were treated with a mixture of siRNAs targeted against all enzymatic subunits,suggesting that CNOT1 depletion induces apoptosis by destroying the CCR4-NOT-associated deadenylase *** analysis revealed that CNOT1 depletion leads to a reduction in the amount of other CCR4-NOT ***,the specific activity of the CNOT6L immunoprecipitates-associated deadenylase from CNOT1-depleted cells was less than that from control *** formation of P-bodies,where mRNA decay is reported to take place,was largely suppressed in CNOT1-depleted ***,CNOT1 has an important role in exhibiting enzymatic activity of the CCR4-NOT complex,and thus is critical in control of mRNA deadenylation and mRNA *** further showed that CNOT1 depletion enhanced CHOP mRNA levels and activated caspase-4,which is associated with endoplasmic reticulum ER stress-induced *** together,CNOT1 depletion structurally and functionally deteriorates the CCR4-NOTcomplex and induces stabilization of mRNAs,which results in the increment of translation causing ER stress-mediated *** conclude that CNOT1 contributes to cell viability by securing the activity of the CCR4-NOT deadenylase.

关键词： deadenylation CCR4-NOT small interfering RNA P-bodies apoptosis

Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press

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Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 412-417页

作者： Takashi Osamura Yoshiko Takeuchi Risako Onodera masahiro Kitamura Yoshiteru takahashi Kohei Tahara Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University1-25-4Daigaku-NishiGifu501-1196Japan Pharmaceutical Technology Department Sawai Pharmaceutical Co.Ltd12-34HiroshibachoSuita-ShiOsaka564-0052Japan

We previously determined 'Tableting properties' by using a multi-functional single-punch tablet press(GTP-1). We proposed plotting 'Compactability' on the x-axis against'Manufacturability' on the y-axis to allow visual evaluation of 'Tableting properties'. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure'Tableting properties' with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad 'Manufacturability', leading to sticking of powder on *** also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine.

关键词： Tableting Formulation design Lubricant Punch shape Single-punch tablet press Losartan potassium

Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 113-119页

作者： Takashi Osamura Yoshiko Takeuchi Risako Onodera masahiro Kitamura Yoshiteru takahashi Kohei Tahara Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University Pharmaceutical Technology Department Sawai Pharmaceutical Co.Ltd

We previously determined "Tableting properties" by using a multi-functional single-punch tablet press(GTP-1). We plotted "Compactability" on the x-axis against "Manufacturability"on the y-axis to allow visual evaluation of "Tableting properties". Here, we examined whether this evaluation method can be used in the formulation design of tablets prepared by wet granulation. We used the GTP-1 to measure "Tableting properties" with different amounts of binder, disintegrant, and lubricant, and compared the results with those of tableting on a commercial rotary tableting machine. Tableting failures(capping and binding in particular) occurred when samples that had been evaluated as having poor "Compactability" or"Manufacturability" on the GTP-1 were compressed on the rotary tableting machine. Thus,our evaluation method predicted tableting failure at the commercial scale. The method will prove useful for scaling up production.

关键词： tableting formulation design wet granulation capping binding single-punch tablet press

Serum cystatin C can be used as a marker of renal function even in patients with intestinal urinary diversion

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Asian Journal of Urology 2015年第3期2卷 167-169页

作者： masahiro Matsuki Toshiaki Tanaka Takeshi Maehana Koji Ichihara masahiro Yanase Masanori Matsukawa Hideki Adachi Satoshi takahashi Naoya Masumori Department of Urology Sapporo Medical UniversitySchool of MedicineSapporoJapan Sapporo Kidney Disease Treatment Forum SapporoJapan Department of Urology Sunagawa City Medical CenterSunagawaJapan Department of Urology Takikawa Municipal HospitalTakikawaJapan Department of Urology SaiseikaiOtaru HospitalOtaruJapan

Objective:Recently,serum cystatin C(CysC)has been used as a novel marker of renal ***,there is a lack of data on CysC levels in patients with intestinal urinary diversion(UD).Here we report CysC levels in such ***:We prospectively observed 38 patients who were diagnosed with bladder cancer and subsequently treated with radical cystectomy and UD at our institution in 2012 and *** creatinine(sCr)and CysC were obtained optionally at the same time at least 1 month after radical cystectomy and ***:The median CysC and sCr concentrations were 1.12 mg/L(range 0.75-2.47 mg/L)and 0.99 mg/dL(range 0.61-2.22 mg/dL),*** median estimated concentrations of glomerular filtration rate(GFR)based on CysC(eGFRcys)and GFR based on creatinine(eGFRcreat)were 61.08 mL/min/1.73 m^2(range 22.64e99.89 mL/min/1.73 m^2)and 58.01 mL/min/1.73 m^2(range 23.48e91.82 mL/min/1.73 m2),*** had a significant correlation with sCr(r=0.8607,p<0.0001)and eGFRcreat(r=-0.8993,p<0.0001).eGFRcys also had a significant correlation with eGFRcreat(r=0.8104,p<0.0001).Conclusion:The correlation between CysC and sCr was strong and the correlation coefficient was equivalent to that in patients without *** results suggest that CysC is not affected by UD and can be used as a marker of renal function similarly to sCr in patients with UD.

关键词： Renal function Cystatin C Urinary diversion

Fabrication of MoSi_2-SiC Composites by a Spark Plasma Sintering Method

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International Journal of Minerals,Metallurgy and Materials 1999年第2期13卷 116-118页

作者： Kurokawa, Kazuya Ube, Makoto takahashi, Hideaki takahashi, Heishichiro Division of Molecular Chemistry Graduate School of Engineering Hokkaido University Kita-ku Sapporo 060-8628 Kita-13 Nishi-8 Japan Center for Advanced Research of Energy Technology Hokkaido University Japan

MolybdenUmdisilicidepeoSi,)hashighmeltingpoint（2293K）,relativelylowdensity（6.249/cm3）,abrittle-to-ductiletemper;tabout1173K[l]andoutstandingoxidationresistance[2M].Forthisreason,thedisilicidematrixcompositesarebei... 详细信息

关键词： MoSi2-SiC composite spark plasma sintering in-siam Synthesis sintering behavior

Successful hepatic resection for recurrent hepatocellular carcinoma after lenvatinib treatment:A case report

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World Journal of Hepatology 2020年第12期12卷 1349-1357页

作者： Hideki Yokoo Hiroyuki takahashi masahiro Hagiwara Hiroyoshi Iwata Koji Imai Yoshinori Saito NaotoMatsuno Hiroyuki Furukawa Division of Hepato-Biliary-Pancreatic Surgery and Transplant Surgery Department of SurgeryAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Department of Gastroenterology Asahikawa-Kosei General HospitalAsahikawa 078-8211HokkaidoJapan

BACKGROUND Lenvatinib has been shown to be noninferior to sorafenib regarding prognosis and recurrence rate in patients with unresectable hepatocellular carcinoma(HCC)who have not received prior systemic *** patients treated with lenvatinib,40%of cases achieved sufficient tumor reduction to make potential surgery ***,the outcomes of such surgery are *** report a successful case of hepatic resection for recurrent HCC after lenvatinib *** SUMMARY A 69-year-old man underwent right anterior sectionectomy for HCC in segment 8 of the *** months later,he was found to have an intrahepatic HCC recurrence that grew rapidly to 10 cm in diameter with sternal bone *** confirming partial response to lenvatinib administration for 2 mo,a second hepatectomy was *** examination showed that 80%of the tumor was *** patient did not develop any adverse effects under lenvatinib *** was discharged at 25 d after *** therapy for bone metastases continued to be given under lenvatinib,and the patient has remained alive for 1 year after the second *** The prognosis of patients with recurrent HCC may be improved by liver resection combined with prior lenvatinib therapy.

关键词： Conversion to surgery Lenvatinib Recurrent hepatocellular carcinoma Case report Neoadjuvant therapy Molecular targeted therapy