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Evaluation Method of the Gait Motion Based on Self-organizing Map Using the Gravity Center Fluctuation on the Sole

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International Journal of Automation and computing 2017年第5期14卷 603-614页

作者： Koji Makino masahiro nakamura Hidenori Omori Yoshinobu Hanagata Shohei Ueda Kyosuke Nakagawa Kazuyoshi Ishida Hidetsugu Terada Graduate School of Engineering University of YamanashiKofuYamanashi 400-8511Japan Kofu Municipal Hospital KofuYamanashi 400-0832Japan

This paper describes the evaluation method of the gait motion in walk rehabilitation. We assume that the evaluation consists of the classification of the measured data and the prediction of the feature of the gait motion. The method may enable a doctor and a physical therapist to recognize the condition of the patients more easily, and increase the motivation of patient further for rehabilitation. However, it is difficult to divide the gait motion into discrete categories, since the gait motion continuously changes and does not have the clear boundaries. Therefore, the self-organizing map （SOM） that is able to arrange the continuous data on the almost continuous map is employed in order to classify them. And, the feature of the gait motion is predicted by the classification. In this study, we adopt the gravity-center fluctuation （GCF） on the sole as the measured data. First, it is shown that the pattern of the CCF that is obtained by our developed measurement system includes the feature of the gait motion. Secondly, the relation between the pattern of the GCF and the feature of the gait motion that the doctor and the physical therapist evaluate by visual inspection is considered using the SOM. Next, we describe the prediction of following features measured by numerical values： the length of stride, the velocity of walk and the difference of steps that are important for the doctor and the physical therapist to make a diagnosis of the condition of the gait motion in walk rehabilitation. Finally, it is investigated that the position of a new test data that is arranged on the map accords with the prediction. As a consequence, we confirm that the method using the SOM is often useful to classify and predict the condition of the patient.

关键词： Gait motion self-organizing map (SOM) rehabilitation evaluation method gravity center fluctuation (GCF).

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利用声学管通过体积速度测量法预测车外发动机噪声

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汽车与新动力 2005年第6期37卷 50-54页

作者： masahiro nakamura Mitsuo Nakano 台卫华

为了预测车辆稳态运行时车外噪声中的发动机噪声,研制了一种声学管,用以测量发动机的辐射噪声。采用加速度计测量发动机表面振动,特别是像排气歧管等处的振动是一项困难的工作。建议采用如下测量方法:将一根内置传声器的声学管安放在距... 详细信息

为了预测车辆稳态运行时车外噪声中的发动机噪声,研制了一种声学管,用以测量发动机的辐射噪声。采用加速度计测量发动机表面振动,特别是像排气歧管等处的振动是一项困难的工作。建议采用如下测量方法:将一根内置传声器的声学管安放在距发动机指定距离处,使测量能够覆盖发动机的整个表面。通过采用测得的体积速度和传播特性预测了距车辆指定距离处车外噪声中的发动机噪声。预测结果与以前的试验值相当吻合。

关键词：噪声声学管体积速度测量

Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors

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World Journal of Gastroenterology 2013年第30期19卷 4887-4896页

作者： Hiroshi Matsumura Kazushige Nirei Hitomi nakamura Teruhisa Higuchi Yasuo Arakawa masahiro Ogawa Naohide Tanaka Mitsuhiko Moriyama Division of Gastroenterology and Hepatology Department of MedicineNihon University School of MedicineTokyo173-8610Japan

AIM:To evaluate the histopathological findings of type C liver disease to determine risk factors for development of hepatocellular carcinoma(HCC).METHODS:We studied 232 patients,who underwent liver biopsy for type C chronic liver disease between 1992 and 2009,with sustained virological response(SVR)after interferon *** patients were divided into two groups according to the F stage 0+1+2 group(n = 182)and F3+4 group(n = 50).We prospectively observed and compared the incidence of HCC of the patients with SVR in the F0+1+2 and F3+4 ***,the background factors and liver histopathological findings,including the degree of fibrosis,F stage,inflammation,necrosis,bile duct obstruction,fat deposition,and degree of irregular regeneration(IR)of hepatocytes,were correlated with the risk of developing ***:HCC developed in three of 182(1.6%)patients in the F0+1+2 group,and four of 50(8.0%)in the F3+4 *** cumulative incidence of HCC in the former group was found to be significantly lower than in the F3+4 group(log rank test P = 0.0224).The presence of atypical hepatocytes among IR of hepatocytes in the F3+4 group resulted in a higher cumulative incidence of HCC,and was significantly correlated with risk of HCC development(RR = 20.748,95%CI:1.335-322.5,P = 0.0303).CONCLUSION:Atypical hepatocytes among the histopathological findings of type C liver disease may be an important risk factor for HCC development along with progression of liver fibrosis.

关键词： Hepatocellular carcinoma Irregular regeneration of hepatocytes Liver fibrosis Type C chronic liver disease Histopathology of liver biopsy

Movement pattern of red seabream Pagrus major and yellowtail Seriola quinqueradiata around Offshore Wind Turbine and the neighboring habitats in the waters near Goto Islands, Japan

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Aquaculture and Fisheries 2021年第3期6卷 300-308页

作者： Khyria Swaleh Karama Yoshiki Matsushita masahiro Inoue Kenta Kojima Kazuki Tone Itsumi nakamura Ryo Kawabe Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasaki852-8521Japan Kenya Marine and Fisheries Research Institute P.O.Box81651-80100Mombasa20100Kenya Organization for Marine Science and Technology Nagasaki UniversityNagasaki852-8521Japan Nagasaki Branch Fisheries Infrastructure Development CenterNagasaki850-0035Japan Faculty of Fisheries Nagasaki UniversityNagasaki852-8521Japan Institute for East China Sea Research Organization for Marine Science and TechnologyNagasaki UniversityNagasaki851-2213Japan

We investigated movement pattern of commercial important fish around Offshore Wind Turbine(OWT)and neighboring habitats in Goto *** tagged 55 individuals of 2 fish species and released around the OWT in 2017.(27 Pagrus major from 1st Feb 2017 to 16th Mar 2017(winter),8 *** and 20 Seriola quinqueradiata from 13th July 2017 to 13th Oct 2017(summer)).Acoustic receivers were deployed at OWT,south artificial reef(AS),trapnet(TN),north FAD(F1)and south FAD(F2)in winter and two more receivers were deployed at north artificial reef(AN)and natural reef(NR)in *** observed 12 *** at OWT for a day after released in winter,majority of fish(13 individuals)were detected at *** summer,7 *** were observed at OWT,1 visited TN within the day,but others *** *** stayed at OWT longer than *** after released and disappeared within 2 *** mostly moved around AS,AN,*** time from K-M curve was 10 days for *** in winter,a day in summer and 3 days for *** species showed low affinity for OWT as recorded low residency index despite the season.

关键词： Biotelemetry Habitat usage Offshore wind turbine Red seabream Pagrus major Yellowtail Seriola quinqueradiata

Catalyst-free growth of ZnO nanowires on various-oriented sapphire substrates by pulsed-laser deposition

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Journal of Semiconductors 2016年第2期37卷 20-24页

作者： Tetsuya Shimogaki masahiro Takahashi Masaaki Yamasaki Taichi Fukuda Mitsuhiro Higashihata Hiroshi Ikenoue Daisuke nakamura Tatsuo Okada Department of Information Science and Electrical Engineering Kyushu University

Catalyst-free growth of one-dimensional zinc oxide （ZnO） nanowires is reported. ZnO nanowires were synthesized on ZnO buffer layers deposited on various-oriented sapphire substrates. Syntheses of ZnO buffer layers and nanowires were performed by ultraviolet pulsed-laser deposition. ZnO nanowire＇s number density was the lowest in the case of using m-cut sapphire substrates. ZnO nanowires grown on a-cut sapphire substrates had vertical alignment with distances of tens to hundreds of nanometers. On the other hand, ZnO nanowires grown on c-cut sapphire substrates had the biggest nucleation rate. The dependence of crystalline orientation of ZnO buffer layers on the orientation of sapphire substrates were investigated by electron back scatter diffraction measurement. From their results, the growth models of ZnO buffer layers were suggested and the variations in morphological properties ofZnO nanowires were discussed.

关键词： zinc oxide nanowire catalyst free growth pulsed laser deposition

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Globoside accelerates the differentiation of dental epithelial cells into ameloblasts

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International Journal of Oral Science 2016年第4期8卷 205-212页

作者： Takashi nakamura Yuta Chiba masahiro Naruse Kan Saito Hidemitsu Harada Satoshi Fukumoto Division of Molecular Pharmacology and Cell Biophysics Department of Oral Biology Tohoku University Graduate School of Dentistry Division of Pediatric Dentistry Department of Oral Health and Development Sciences Tohoku University Graduate School of Dentistry Division of Developmental Biology and Regenerative Medicine Department of Anatomy Iwate Medical University

Tooth crown morphogenesis is tightly regulated by the proliferation and differentiation of dental epithelial cells. Globoside （Gb4）, a globo-series glycosphingolipid, is highly expressed during embryogenesis as well as organogenesis, including tooth development. We previously reported that Gb4 is dominantly expressed in the neutral lipid fraction of dental epithelial cells. However, because its functional role in tooth development remains unknown, we investigated the involvement of Gb4 in dental epithelial cell differentiation. The expression of Gb4 was detected in ameloblasts of postnatal mouse molars and incisors. A cell culture analysis using HAT-7 cells, a rat-derived dental epithelial cell line, revealed that Gb4 did not promote dental epithelial cell proliferation. Interestingly, exogenous administration of Gb4 enhanced the gene expression of enamel extracellular matrix proteins such as ameloblastin, amelogenin, and enamelin in dental epithelial cells as well as in developing tooth germs. Gb4 also induced the expression of TrkB, one of the key receptors required for ameloblast induction in dental epithelial cells. In contrast, Gb4 downregulated the expression of p75, a receptor for neurotrophins （including neurotrophin-4） and a marker of undifferentiated dental epithelial cells. In addition, we found that exogenous administration of Gb4 to dental epithelial cells stimulated the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase signalling pathways. Furthermore, Gb4 induced the expression of epiprofin and Runx2, the positive regulators for ameloblastin gene transcription. Thus, our results suggest that Gb4 contributes to promoting the differentiation of dental epithelial cells into ameloblasts.

关键词： ameloblast differentiation enamel matrix epiprofin glycosphingolipids tooth development

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Picosecond burst pulse machining with temporal energy modulation

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Chinese Optics Letters 2020年第12期18卷 87-91页

作者： Akinao nakamura Tomoki Mizuta Yasuhiko Shimotsuma Masaaki Sakakura Tomohito Otobe masahiro Shimizu Kiyotaka Miura Department of Material Chemistry Graduate School of Engineering Kyoto University National Institutes for Quantum and Radiological Science and Technology Kansai Photon Science Institute

Suppression of stress and crack generation during picosecond laser processing in transparent brittle materials such as glass was successfully demonstrated by a picosecond laser pulse with temporal energy modulation. The origin of deterioration in processing accuracy could be interpreted in terms of the discontinuous movement of plasma in the vicinity of the focus. To reveal the effectiveness of the temporal energy modulation for smooth machining, such plasma motion was simulated by the finite-difference time-domain method. Furthermore, photoinduced birefringence was observed using a high-speed polarization camera.

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Picosecond burst pulse machining with temporal energy modulation [Invited]

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Chinese Optics Letters 2020年第12期18卷 83-87页

作者： Akinao nakamura Tomoki Mizuta Yasuhiko Shimotsuma Masaaki Sakakura Tomohito Otobe masahiro Shimizu Kiyotaka Miura Department of Material Chemistry Graduate School of EngineeringKyoto UniversityKyoto 615-8510Japan National Institutes for Quantum and Radiological Science and Technology Kansai Photon Science InstituteKyoto 619-0215Japan

Suppression of stress and crack generation during picosecond laser processing in transparent brittle materials such as glass was successfully demonstrated by a picosecond laser pulse with temporal energy *** origin of deterioration in processing accuracy could be interpreted in terms of the discontinuous movement of plasma in the vicinity of the *** reveal the effectiveness of the temporal energy modulation for smootli machining,such plasma motion was simulated by the fiidtc-d ifference time-domain method.F urt her more,photoinduced birefringence was observed using a high-speed polarization camera.

关键词： picosecond laser energy modulation burst pulse material processing stress distribution

Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric anastomosis

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World Journal of Gastroenterology 2015年第28期21卷 8723-8729页

作者： Taro Oshikiri Yoshinobu Yamamoto Ikuya Miki masahiro Tsuda Tetsu nakamura Yasuhiro Fujino masahiro Tominaga Yoshihiro Kakeji Department of Gastroenterological Surgery Hyogo Cancer Center Department of Gastroenterological Oncology Hyogo Cancer Center Division of Gastrointestinal Surgery Department of Surgery Graduate School of MedicineKobe University

Esophagectomy with extended lymphadenectomy and gastric conduit reconstruction is a radical procedure for the treatment of esophageal cancer that is associated with a high morbidity *** conduit necrosis is a fatal complication that occurs in 2%of ***,two-stage salvage surgery consisting of removal of the necrotic gastric conduit followed by reconstruction has been performed;however,this procedure has a high morbidity *** describe a61-year-old man who underwent minimally invasive esophagectomy complicated by slowly progressive gastric conduit necrosis associated with complete neck drainage and a stable overall *** was a 2 cm gap in the *** there was no evidence of residual gastric conduit necrosis,a removable,covered self-expanding metal stent(SEMS)was inserted to bridge the *** stent was fixed to the patient's ear with silk thread through the lasso on its proximal end to prevent *** weeks after insertion,the stent was removed easily without any associated *** anastomotic defect was completely bridged with granulation tissue,showing progressive epithelialization without leakage or *** patient was discharged home in good general *** is the first report of the successful conservative management of esophago-gastric conduit anastomosis disruption with SEMS placement.

关键词： Esophagectomy Gastric conduit necrosis Disruption of anastomosis Self-expanding metal stent Hanarostent Conservative management