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Determination of functional fitness age in women aged 50 and older

Journal of sport and Health science 2019年第3期8卷 267-272页

作者： Edgar Johani Latorre-Rojas Joan Antoni Prat-subirana Xavier Peirau-Terés sebastià mas-Alòs José Vicente Beltrán-Garrido Antoni Planas-Anzano National institute of Physical Education of Catalonia University of Lleida Physical Fitness Sport and Recreation Department Floridablanca Campus University Santo Tomas Aquino Department of Nursery and Physiotherapy University of Lleida EUsEs TE Health and Sport Science School Rovira i Virgili University

Background: The construction of useful and attainable indicators of fitness assessment deserves special attention in clinical practice. We aimed to construct an indicator of the functional fitness age(FFA) of women aged 50 and older by an equation using fitness outcomes and its correlation with chronological age(CA) and to analyze the external validity of our results by comparing our sample to ***: Participants(n=459, age: 70.3 ± 7.9 years, mean ± sD) were evaluated using the senior Fitness Test battery. We applied a multiple regression and a subsequent Holt's exponential smoothing to analyze the ***: We obtained a statistically significant expression of F(6, 452) = 328.384; p in which the coefficients of the equation explain81% of variability(R_(corrected)~2 = 0.813). The equation correlates fitness assessment in women aged 50 and over with regards to CA:FFA = 40.146 + 0.350 X Cs(stand)-0.714 X AC(rep)-0.110 X sT(step)-0.177 X CsR(cm)-0.101 X Bs(cm) + 8.835 X FUG(s) where Cs means chair stand test, AC. means arm curl test, sT means 2-min step test, CsR means chair sit-and-reach test, Bs means back scratch test, FUG means 8-foot up-and-go test. We compared this index with percentiles distribution from our sample and from other ***: We suggest the use of FFA as a valid indicator of fitness in adult and senior women as well as a useful motivational tool to undertake exercise programs.

关键词： Disability Elderly Exercise Fitness assessment Health outcomes senior Fitness Test

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Plant-herbivore assemblages under natural conditions are driven by plant size,not chemical defenses

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Journal of Plant Ecology 2017年第6期10卷 1012-1021页

作者： Eva Castells Maria Morante sandra saura-mas Anabel Blasco-Moreno Departament de Farmacologia Terapèutica i ToxicologiaUniversitat Autònoma de BarcelonaCerdanyola del Vallès 08193Spain CREAF Cerdanyola del Vallès 08193Spain Department de Biologia Animal Vegetal i EcologiaUniversitat Autònoma de BarcelonaCerdanyola del Vallès 08193Spain servei d’Estadística Aplicada Universitat Autònoma de BarcelonaCerdanyola del Vallès 08193Spain

Aims Plant secondary metabolites have been traditionally recognized as key traits regulating plant-herbivore ***,the ecological relevance of secondary metabolites as resistance mecha-nisms in comparison to other plant attributes,including physical,morphological or ecological traits,has been recently *** aim to evaluate the role of chemical defenses,plant size and the presence of insect competitors on driving the differences in her-bivory damage under natural *** We performed a replicated field study on the herbivore commu-nity associated with four senecio species(***,***,*** and ***)during a full-reproductive season in Montseny Natural Park(catalonia,NE spain).Pyrrolizidine alka-loids(PAs),the most characteristic chemical defenses of senecio due to their toxic effects on herbivores,were analyzed by gas *** plant size was estimated by the number of flower heads produced over the entire reproductive *** used linear mixed models to explore the relationships between total PA concentrations,plant size and herbivory *** Findings PA concentrations were not related to the natural guild of herbivores within any plant species or insect ***,no significant interactions were found between insect species sharing the same host *** contrast,herbivore abundance was positively related to plant size in ***,*** and *** found no evidence that PAs confer an increased plant resistance against herbivores in *** study supports the hypothesis that plant chemical defenses have a secondary role in determining plant-her-bivore assemblages in comparison to other plant traits under the complexity of natural conditions.

关键词： senecio herbivory chemical defenses pyrrolizidine alkaloids plant traits

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Extracorporeal liver support in severe alcoholic hepatitis

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World Journal of Gastroenterology 2014年第25期20卷 8011-8017页

作者： Albert Parés Antoni mas Liver Unit Hospital ClínicUniversity of BarcelonaIDIBAPSCIBERehd08036 BarcelonaSpain

The severity of alcoholic hepatitis(AH) which may coexist with cirrhosis varies greatly, from asymptomatic forms which are detected in alcoholic patients without any sign of liver disease, except laboratory abnormalities, to severe forms characterised by deep jaundice, ascites, hepatic encephalopathy and low prothrombin index. in hospitalized patients the mortality could be as high as 75%. The elevated number of therapeutic proposals reported for more than forty years reveals the lack of efficacy of a particular modality. Even in the most favorable trials, the survival is already very poor and in some cases related to the development of renal failure or hepatorenal syndrome. There are some motivating reports concerning albumin dialysis as a support treatment in patients with severe AH, either alone or in combination with other pharmacological therapies. The favorable effects of albumin dialysis in patients with severe AH suggest that the procedure used alone or in combination with other therapies may have a role in this clinical condition. This will be particularly relevant to offer an alternative therapy in these patients, thus being a potential bridge to recovery or to be listed for liver transplantation.

关键词： Acute alcoholic hepatitis Alcoholic liver disease

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inflammation-induced PiNCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons

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Translational Neurodegeneration 2020年第3期9卷 393-408页

作者： Kalimuthusamy Natarajaseenivasan santhanam shanmughapriya Prema Velusamy Matthew sayre Alvaro Garcia Nestor mas Gomez Dianne Langford Department of Neurosciences and Center for Neurovirology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPA 19140USA Department of Microbiology Bharathidasan UniversityTiruchirappalli 620024India Heart and Vascular institute Department of MedicineDepartment of Cellular and Molecular PhysiologyPenn State College of MedicineHersheyPA 17033USA

Background:Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain *** neurodegenerative disorders,people living with human immunodeficiency virus(HiM)and Alzheimer's disease(AD)are particularly vulnerable to metabolic disturbances,but the mechanistic connections of inflammation,neurodegeneration and bioenergetic deficits in the central nervous system(CNs)are poorly *** particularly interesting new cysteine histidine-rich-protein(PiNCH)is nearly undetectable in healthy mature neurons,but is robustly expressed in tauopathy-associated neurodegenerative diseases including HiV infection and *** robust PiNCH expression has been reported in neurons in the brains of patients with HiV and AD,the molecular mechanisms and cellular consequences of increased PiNCH expression in CNs disease remain largely ***:We investigated the regulatory mechanisms responsible for PiNCH protein-mediated changes in bioenergetics,mitochondrial subcellular localization and bioenergetic deficits in neurons exposed to physialogical levels of TNFa or the HiV protein *** in the PiNCH-iLK-Parvin(PiP)complex association with cofilin and TEsK1 were assessed to identify factors responsible for actin depolymerization and mitochondrial *** and pharmacological inhibition experiments were conducted to confirm PiNCH specificity and to reinstate proper protein-protein complex ***:We identified MEF2A as the PiNCH transcription factor in neuroinflammation and determined the biological consequences of increased PiNCH in ***-mediated activation of MEF2A via increased cellular calcium induced PiNCH,leading to disruption of the PiP ternary complex,cofilin activation by TEsK1 inactivation,and actin *** disruption of actin led to perinuclear mislocalization of mitochondria by destabilizing the kinesin-dependent mitochondrial transport machinery,resulting i

关键词： Neuron Mitochondria Actin PiNCH Neuroinflammation

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Heterogeneous catalysts with programmable topologies generated by reticulation of organocatalysts into metal-organic frameworks:The case of squaramide

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Nano Research 2021年第2期14卷 458-465页

作者： Anna Broto-Ribas Claudia Vignatti Alicia Jimenez-Almarza Javier Luis-Barrera Zahra Dolatkhah Felipe Gandara inhar imaz Ruben mas-Balleste Jose Aleman Daniel maspoch Catalan institute of Nanoscience and Nanotechnology(iCN2) CSIC and The Barcelona Institute of Science and Technology08193 BarcelonaSpain inorganic Chemistry Department Modulo 7Universidad Autonoma de Madrid28049 MadridSpain Organic Chemistry Department Modulo 1Universidad Autonoma de Madrid28049 MadridSpain Materials science Factory Instituto de Ciencia de Materiales de Madrid(ICMM)Consejo Superior de Investigaciones Cientificas(CSIC)Calle Sor Juana Ines de la Cruz328049 MadridSpain institute for Advanced Research in Chemical sciences(iAdChem) Campus Universidad Autonoma de Madrid28049 MadridSpain institucio Catalana de Recerca i Estudis Avangats(iCREA) 08100 BarcelonaSpain

A well-established strategy to synthesize heterogeneous,metal-organic framework(MOF)catalysts that exhibit nanoconfinement effects,and specific pores with highly-localized catalytic sites,is to use organic linkers containing organocatalytic ***,we report that by combining this linker approach with reticular chemistry,and exploiting three-dimensioanl(3D)MOF-structural data from the Cambridge structural Database,we have designed four heterogeneous MOF-based catalysts for standard organic *** programmable MOFs are isoreticular versions of pcu iRMOF-16,feu UiO-68 and pillared-pcu sNU-8X,the three most common topologies of MOFs built from the organic linker p.p'-terphenyldicarboxylic acid(tpdc).To synthesize the four squaramide-based MOFs,we designed and synthesized a linker,4,4’-((3,4-dioxocyclobut-1-ene-1,2-diyl)bis(azanedyil))dibenzoic acid(sq_tpdc),which is identical in directionality and length to tpdc but which contains organocatalytic squaramide *** were chosen because their immobilization into a framework enhances its reactivity and stability while avoiding any self-quenching ***,the four MOFs share the same organocatalytic squaramide moiety,but confine it within distinct pore *** then evaluated these MOFs as heterogeneous H-bonding catalysts in organic transformations:a Friedel-Crafts alkylation and an epoxide *** of them exhibited good performance in both reactions but all showed distinct catalytic profiles that reflect their structural differences.

关键词： reticular chemistry metal-organic frameworks H-bond catalysis squaramide Friedel-Cratts epoxide ring-opening

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The importance of functional diversity in the stability of Mediterranean shrubland communities after the impact of extreme climatic events

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Journal of Plant Ecology 2017年第2期10卷 281-293页

作者： Enrique Gde la Riva Francisco Lloret ignacio MPérez-Ramos Teodoro Marañón sandra saura-mas Ricardo Díaz-Delgado Rafael Villar Area de Ecología Facultad de CienciasUniversidad de Cordoba.14071 CordobaSpain CREAF Cerdanyola del Vallés08193 BarcelonaSpain Unitat d’Ecologia Dept.Biologia AnimalBiologia Vegetal i EcologiaUniversitat Autònoma BarcelonaEdifici CCampus UAB08193Cerdanyola del VallèsBarcelonaSpain iRNAs CSICAv.Reina Mercedes 10PO Box 1052.41080 SevillaSpain Estación Biológica de Doñana CSIC.c/Americo Vespucios/nIsla de la Cartuja.41092 SevillaSpain

Aims Extreme climatic events may have important consequences for plant community structure and *** 2005,a severe drought together with a cold winter promoted extensive damage and mortal-ity in shrubland communities of southwest spain(Doñana National Park).Here,we aim to identify the mechanisms underlying commu-nity stability(resistance and resilience)in response to this extreme climatic event,considering changes in the functional structure of these *** We used a trait-based approach,quantifying variations in 10 func-tional traits at the community level(community weighted means,CWM)and the functional diversity(functional richness,evenness and divergence)in 18 plots at three different times:predating the climatic event(estimated from the sum of the live and dead volume of each species in 2007),and 2 and 8 years after the 2005 *** also quantified the differences in functional traits and functional diversity between adult and recruit stages,which allowed us to bet-ter understand the contribution of the recruitment to the mainte-nance of the functional structure and diversity of the *** Findings Communities with higher functional divergence before the cli-matic event maintained nearly constant their levels of functional divergence 8 years after,but they were more prone to changes in species *** resistance in terms of vegeta-tion cover was positively correlated with root dry matter content,whereas community resilience was positively correlated with leaf chlorophyll(LChl).We also found that some values(weighted means)of functional community traits(such as root dry matter con-tent and LChl)had increased 2 years after the event,returning to the pre-event conditions after 8 *** addition,there was hardly any establishment of new species in the community and the recruits did not make substantial differences to the community functional *** seed mass differed significantly between the adult and se

关键词： climate change Doñana drought functional trait recruitment resilience resistance

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Genetic dissection of climacteric fruit ripening in a melon population segregating for ripening behavior

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Horticulture Research 2020年第1期7卷 459-476页

作者： Lara Pereira Miguel santo Domingo Valentino Ruggieri Jason Argyris Michael A.Phillips Guangwei Zhao Qun Lian Yongyang Xu Yuhua He sanwen Huang Marta Pujol Jordi Garcia-mas Centre for Research in Agricultural Genomics(CRAG)CsiC-iRTA-UAB-UB Edifici CRAGCampus UAB08193 CerdanyolaBarcelonaSpain iRTA(institut de Recerca i Tecnologia Agroalimentàries) Edifici CRAGCampus UAB08193 CerdanyolaBarcelonaSpain Department of Biology University of Toronto–MississaugaMississaugaON L5L 1C6Canada Zhengzhou Fruit Research institute Chinese Academy of Agricultural SciencesZhengzhouChina shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina

Melon is as an alternative model to understand fruit ripening due to the coexistence of climacteric and non-climacteric varieties within the same species,allowing the study of the processes that regulate this complex trait with genetic *** phenotyped a population of recombinant inbred lines(RiLs),obtained by crossing a climacteric(Védrantais,cantalupensis type)and a non-climcteric variety(Piel de sapo T111,inodorus type),for traits related to climacteric maturation and ethylene *** in the RiL population exhibited various combinations of phenotypes that differed in the amount of ethylene produced,the early onset of ethylene production,and other phenotypes associated with *** characterized a major QTL on chromosome 8,ETHQV8.1,which is sufficient to activate climacteric ripening,and other minor QTLs that may modulate the climacteric *** ETHQV8.1 allele was validated by using two reciprocal introgression line populations generated by crossing Védrantais and Piel de sapo and analyzing the ETHQV8.1 region in each of the genetic backgrounds.A Genome-wide association study(GWAs)using 211 accessions of the *** further identified two regions on chromosome 8 associated with the production of aromas,one of these regions overlapping with the 154.1 kb interval containing *** ETHQV8.1 region contains several candidate genes that may be related to fruit *** work sheds light into the regulation mechanisms of a complex trait such as fruit ripening.

关键词： behavior fruit reciprocal

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identifying sex-specific differences in the carotid revascularisation literature:findings from a scoping review

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stroke & Vascular Neurology 2021年第3期6卷 496-499,I0085-I0096页

作者： Vignan Yogendrakumar Michel shamy Brian Dewar Dean A Fergusson Dar Dowlatshahi Candyce Hamel sophia Gocan Mark Fedyk Jean-Louis mas Peter Rothwell Virginia Howard Olena Bereznyakova On behalf of the WoW-CAD investigators Department of Medicine Division of Neurology and Ottawa Hospital Research InstituteUniversity of OttawaOttawaOntarioCanada Epidemiology Program Ottawa Hospital Research InstituteOttawaOntarioCanada stroke Prevention Clinic Ottawa HospitalOttawaOntarioCanada Bioethics Program UC Davis Department of MedicineSacramentoCaliforniaUSA Universite Paris Descartes Faculte de Medecine site Cochin Parislle-de-FranceFrance service de Neurologie Hôital Sainte-AnneParisFrance The University of Alabama at Birmingham school of Medicine BirminghamAlabamaUSA school of Public Health University of Alabama at BirminghamBirminghamAlabamaUSA 不详

Objective No systematic review of the literature has dedicated itself to looking at the management of symptomatic carotid stenosis in female *** this scoping review,we aimed to identify all randomised controlled trials(RCTs)that reported sex-specific outcomes for patients who underwent carotid revascularisation,and determine whether sufficient information is reported within these studies to assess short-term and long-term outcomes in female ***,setting and participants We systematically searched Medline,Embase,Pubmed and Cochrane libraries for RCTs published between 1991 and 2020 that included female patients and compared either endarterectomy with stenting,or any revascularisation(endarterectomy or stenting)with medical therapy in patients with symptomatic high-grade(>50%)carotid *** From 1537 references examined,27 eligible studies were ***-specific outcomes were reported in 13 *** patient characteristics of enrolled female patients were reported in 2 of those 13 *** outcomes reported included stroke and death,however,there was significant heterogeneity in the reporting of both periprocedural and long-term ***-specific differences relating to the degree of stenosis and time from index event to treatment are largely limited to studies comparing endarterectomy to medical *** events were not reported by *** Only half of the previously published RCTs and systematic reviews report sex-specific *** analyses on the results of carotid artery intervention for female patients with symptomatic stenosis are limited.

关键词： carotid stenosis finding

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Latest Crystallographic Results on the structure Antibacterial Activity Relationships in New Quinolones

Latest Crystallographic Results on the Structure Antibacteri...

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sixteenth Congress of the international Union of Crystallography

作者： s.Garcia-Granda J.Frigola J.Corbera J.mas Departamento de Quimica Fisica y Analftica Universidad de Oviedo Departamento de Quimica Medica Laboratorios Dr.Esteve S.A.BarcelonaSpain

＜正＞A family of novel antibacterial quinolones and naphthyridines was prepared （***,***.,1993,36,000）.Within this series the usual piperazine or aminopyrrolidine groups were replaced by 7- azetidinyl *** with outstandingly broad-spectrum activity,particularly against Gram-positive organisms,improved in vitro efficacy in high blood levels were identified among thesg new *** order to detect the structural trends responsible for the antibacterial activity of these compounds aQs AR study was performed（***,Pharmacochemistry Library,1991,16,397- 400）.

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sUMOylation inhibition Mediated by Disruption of sUMO El-E2 interactions Confers Plant susceptibility to Necrotrophic Fungal Pathogens

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Molecular Plant 2017年第5期10卷 709-720页

作者： Laura Castano-Miquel Abraham mas ines Teixeira Josep segui Anna Perearnau Bhagyasree N. Thampi Arnaldo L. schapire Natalia Rodrigo Gaelle La Verde silvia Manrique Maria Coca L. Maria Lois Center for Research in Agricultural Genomics - CRAG Edifici CRAG-Campus UAB Bellaterra (Cerdanyola del Vall~s) 08193 Barcelona Spain

Protein modification by sUMO modulates essential biological processes in eukaryotes. sUMOylation is facilitated by sequential action of the El-activating, E2-conjugating, and E3-1igase enzymes. in plants, sUMO regulates plant development and stress responses, which are key determinants in agricultural productivity. To generate additional tools for advancing our knowledge about the sUMO biology, we have developed a strategy for inhibiting in vivo sUMO conjugation based on disruption of sUMO El-E2 interactions through expression of E1 sAE2uFDct domain. Targeted mutagenesis and phylogenetic analyses revealed that this inhibition involves a short motif in sAE2uFDct highly divergent across kingdoms. Transgenic plants expressing the sAE2UFDCt domain displayed dose-dependent inhibition of sUMO conjugation, and have revealed the existence of a post-transcriptional mechanism that regulates sUMO E2 conjugating enzyme levels. interestingly, these transgenic plants displayed increased suscep- tibility to necrotrophic fungal infections by Botrytis cinerea and Plectosphaerella cucumerina. Early after fungal inoculation, host sUMO conjugation was post-transcriptionally downregulated, suggesting that targeting sUMOylation machinery could constitute a novel mechanism for fungal pathogenicity. These findings support the role of sUMOylation as a mechanism involved in plant protection from environmental stresses. in addition, the strategy for inhibiting sUMO conjugation in vivo described in this study might be applicable in important crop plants and other non-plant organisms regardless of their genetic complexity.

关键词： sUMQ inhibition development flowering necrotrophic fungi El-activating enzyme El-E2interaction disruption

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