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移动荷载作用下建筑垃圾再生路面响应分析

公路 2024年第1期69卷 58-65页

作者：杨振宇杨三强褚嘉怡候月军刘杰河北大学建筑工程学院保定市071000 北京市政建设集团有限责任公司北京市100000 保定市绿生环境科技有限公司保定市071000

为研究砖混类建筑垃圾用于道路基层填筑的再生路面在移动荷载下的力学响应问题,通过室内试验对不同再生骨料掺量的再生混合料进行抗压回弹模量试验,分析再生混合料力学性能特点;利用ABAQUS有限元分析软件建立再生路面三维道路模型,分析... 详细信息

为研究砖混类建筑垃圾用于道路基层填筑的再生路面在移动荷载下的力学响应问题,通过室内试验对不同再生骨料掺量的再生混合料进行抗压回弹模量试验,分析再生混合料力学性能特点;利用ABAQUS有限元分析软件建立再生路面三维道路模型,分析了移动荷载下再生路面力学响应规律;并基于正交试验,就再生下基层厚度、底基层厚度及再生骨料掺量对结构力学响应影响进行敏感性分析。研究结果表明:(1)建筑垃圾再生骨料具有压碎值大、密度小、吸水率大的特点,再生混合料最佳含水率与最大干密度随再生料掺量的增多分别增大与减小,再生混合料抗压回弹模量随再生料掺量的增多呈现先增大后减小的趋势,因此将砖混类再生骨料用于基层铺筑时建议掺量在40%以下,并应严格控制再生骨料中砖混比例;(2)在移动荷载作用下,建筑垃圾再生路面动力响应具有“应变集中”与“应变交替”的现象,最大竖向应变达到381.94με;(3)建筑垃圾再生路面下基层厚度、底基层厚度对道路性能的影响大于再生骨料掺量的影响。研究结果可为建筑垃圾再生路面结构设计提供理论依据和技术参考。

关键词：道路工程路面基层建筑垃圾移动荷载力学响应正交试验

Tuning the electrochemical Property of the Ultrafine metal-oxide Nanoclusters by Iron Phthalocyanine as efficient Catalysts for energy Storage and Conversion

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energy & environmental materials 2019年第1期2卷 5-17页

作者： Yi Cheng Xing Wu Jean-Pierre Veder Lars Thomsen san Ping Jiang Shuangyin Wang Department of environmental engineering School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China John de Laeter Centre Curtin UniversityPerth WA 6102Australia Australian Synchrotron Clayton Vic.3168Australia Western Australian School of mines:minerals Energy and Chemical Engineering and Fuels and Energy Technology InstituteCurtin UniversityPerth WA 6102Australia State Key Laboratory of Chem/Bio-Sensing and Chemometrics College of Chemistry and Chemical engineering Hunan UniversityChangsha 410082HunanChina

Nanoclusters(NCs)have been demonstrated of outstanding performance in electrochemical energy storage and conversion technologies due to their strong quantum confinement effects and strong interaction with ***,we developed a class of ultrafine metal-oxide(mOx,m=Fe,Co and Ni)NCs incorporated with iron phthalocyanine(FePc),mOx/FePc-G,supported on graphene as high-performance catalysts for oxygen reduction reaction(ORR),oxygen evolution reaction(OeR),and carbon dioxide reduction(CO2RR).The high activities for ORR and OeR are attributed to the electron donation and accepting ability of the highly redox active of FePc-G that could tune the properties of *** FeOx/FePc-G exhibits an extremely positive half-wave potential(e1/2)of 0.888 and 0.610 V for ORR in alkaline and neutral conditions,respectively,which is around 60 mV more positive than that of Pt/*** NiOx/FePc-G shows similar OeR activity with the state-of-the-art catalysts,Ir/C,and better performance than NiFeO NCs supported on ***,the CoOx/FePc-G and NiOx/FePc-G show high activity and selectivity to reduce CO2 into CO with a low onset potential of-0.22 V(overpotential is 0.11 V).

关键词： CO2 reduction reaction iron phthalocyanine metal-oxide nanoclusters oxygen evolution reaction oxygen reduction reaction

基于炎性因子、卵巢功能、安全性评价宫腔镜子宫内膜电切术治疗子宫异常出血的临床疗效

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四川生理科学杂志 2024年第8期46卷 1813-1815页

作者：张三丽李爱丽李亚紧上蔡县人民医院妇科河南驻马店463800

目的:探究宫腔镜子宫内膜电切术(Hysteroscopic transcervical resection of endometrial,TCRe)治疗子宫异常出血(Abnormal uterine bleeding,AUB)的效果。方法:选取2020年1月至2023年4月本院收治的92例AUB患者作为研究对象。随机将患者分为对照组和观察组,每组各46例。对照组接受宫腔镜刮除术治疗;观察组接受TCRe治疗。对比两组的围术期指标,于术后3m对比两组手术效果、并发症,对比两组术前、术后1m、术后3 m卵巢功能[雌二醇(estradiol,e2)、促黄体生成激素(Luteinizing hormone,LH)、促卵泡生成激素(Follicle stimulating hormone,FSH)],对比两组术前、术后1 d、术后3 d的炎性因子水平。结果:观察组的手术优良率高于对照组(Pm、3 m血清LH、FSH水平均低于对照组,e2水平均高于对照组(Pe治疗AUB患者,能减少并发症,提升手术效果,优化围术期指标,改善卵巢功能。

关键词：炎性因子卵巢功能子宫异常出血

Small-signal multi-frequency model for Grid-connected Inverter System with PWm effect

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CSee Journal of Power and energy Systems 2020年第2期6卷 307-317页

作者： Guocheng san Wenlin Zhang Ran Luo Xiaoqiang Guo Huanhai Xin elisabetta Tedeschi mariusz malinowski Yanshan University QinhuangdaoChina Zhejiang University HangzhouChina Department of electric Power engineering Norwegian University of Science and Technology7491 TrondheimNorway Institute of Control and Industrial electronics Warsaw University of Technology00-662 WarsawPoland

It is a well known fact that pulse width modulation(PWm)produces sideband *** this point into account,the accuracy of the grid-connected inverter model can be *** this paper,considering the aliasing effect of the PWm sideband components on the closed-loop control,a complete representation for the transfer function of the PWm is ***,a multi-frequency model of grid-connected inverter system is *** is convenient for obtaining a PWm gain for grid-connected inverter system,which is *** order to have an easy physical expression of the effects caused by the sideband components,an approximation is applied to simplify the PWm *** stability analysis is used to prove that PWm gain considering PWm effect is more precise than the conventional *** results verify the effectiveness of our proposal.

关键词： Grid-connected inverter multi-frequency model pulse width modulation stability analysis

Tiaoxin Recipe, a Chinese herbal formula, inhibits microRNA-34a expression in the APPswe/PS1Δe9 mouse model of Alzheimer’s disease

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Journal of Integrative medicine 2019年第6期17卷 404-409页

作者： Yi-ran Hu san-li Xing Chuan Chen Ding-zhu Shen Jiu-lin Chen Shanghai Geriatric Institute of Chinese medicine Shanghai University of Traditional Chinese Medicine

Objective: To investigate the effect and underlying mechanisms of Tiaoxin Recipe(a Chinese herbal formula) treatment on Alzheimer's disease(AD).methods: Twelve-week-old APPswe/PS1 De9(APP/PS1) double transgenic mice were used as a model of AD-afflicted mice. One group of mice was treated with Tiaoxin Recipe by gastrogavage for 12 weeks,while two other groups were given intraperitoneal injections of nicotinamide adenine dinucleotide or FK866 for 4 weeks. morris water maze and thioflavin S staining tests were performed to evaluate cognitive impairment and amyloid plaque deposition, respectively. Serum amyloid-β1-42(Aβ1-42) content was detected using an enzyme-linked immunosorbent assay, and quantitative reverse transcriptionpolymerase chain reaction was performed to examine the expression levels of microRNA-34 a(miR-34 a) in cortex and hippocampus samples of the study ***: Compared with the normal control group, the memory and learning abilities of the APP/PS1 model group were found to be impaired(P e increased levels of senile plaque deposition in cortex and hippocampus(P miR-34 a expression(P erum Aβ1-42 content(P eatment with Tiaoxin Recipe significantly reduced memory impairment(P educing amyloid plaque accumulation in cortex and hippocampus(P miR-34 a expression(P erum Aβ1-42 content(P ecipe is a viable complementary or alternative therapeutic treatment that is capable of delaying the development of early-stage AD by inhibiting the expression of miR-34 a.

关键词： Alzheimer's disease Tiaoxin Recipe microRNA-34a Transgenic mice Amyloid-β Herb

An electromagnetic view of relay time in propagation of neural signals

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Chinese Physics B 2021年第2期30卷 589-594页

作者： Jing-Jing Xu san-Jin Xu Fan Wang Sheng-Yong Xu School of microelectronics Shandong UniversityJi'nan 250100China Department of electronics School of Electronics Engineering and Computer SciencePeking UniversityBeijing 100871China

We review the experimental and computational data about the propagation of neural signals in myelinated axons in mice,cats,rabbits,and frogs published in the past five *** contrast to the natural assumption that neural signals occur one by one in time and in space,we figure out that neural signals are highly overlapped in time between neighboring *** phenomenon was occasionally illustrated in some early reports,but seemed to have been overlooked for some *** shift in time between two successive neural signals from neighboring nodes,defined as relay timeτ,was calculated to be only 16.3μs-87.0μs,i.e.,0.8%-4.4%of the average duration of an action potential peak(roughly 2 ms).We present a clearer picture of the exact physical process about how the information transmits along a myelinated axon,rather than a whole action potential peak,what is transmitted is only a rising electric field caused by transmembrane ion *** in the paper,τrepresents the waiting time until the neighboring node senses an attenuated electric field reaching the threshold to trigger the open *** mechanisms addressed in this work have the potential to be universal,and may hold clues to revealing the exact triggering processes of voltage-gated ion channels and various brain functions.

关键词： neural signal relay propagation velocity electromagnetic field model ion channels

extraterrestrial Life in the Thermosphere: Plasmas, UAP, Pre-Life, Fourth State of matter

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Journal of modern Physics 2024年第3期15卷 322-376页

作者： R. Joseph C. Impey O. Planchon R. del Gaudio m. Abu Safa A. R. Sumanarathna e. Ansbro D. Duvall G. Bianciardi C. H. Gibson R. Schild Astrobiology Research Center California USA Department of Astronomy University of Arizona Tucson USA Biogéosciences Laboratory University of Burgundy Dijon France Department of Biology University of Naples Federico II Naples Italy Department of Applied Physics Palestine Polytechnic University Hebron Palestine Department of Research and Innovation Eco Astronomy International Research Center Tetouan Morocco Space exploration Ltd. Boyle County Roscommon Ireland Department of Zoology Oklahoma State University (Emeritus) Stillwater USA Department of Science and medicine Università Degli Studi di Siena Tuscany Italy Center for Astrophysics and Space Sciences University of California (Emeritus) San Diego USA Center for Astrophysics Harvard-Smithsonian (Emeritus) Cambridge USA

“Plasmas” up to a kilometer in size and behaving similarly to multicellular organisms have been filmed on 10 separate NASA space shuttle missions, over 200 miles above earth within the thermosphere. These self-illuminated “plasmas” are attracted to and may “feed on” electromagnetic radiation. They have different morphologies: 1) cone, 2) cloud, 3) donut, 4) spherical-cylindrical;and have been filmed flying towards and descending from the thermosphere into thunderstorms;congregating by the hundreds and interacting with satellites generating electromagnetic activity;approaching the Space Shuttles. Computerized analysis of flight path trajectories documents these plasmas travel at different velocities from different directions and change their angle of trajectory making 45°, 90°, and 180° shifts and follow each other. They’ve been filmed accelerating, slowing down, stopping, congregating, engaging in “hunter-predatory” behavior and intersecting plasmas leaving a plasma dust trail in their wake. Similar life-like behaviors have been demonstrated by plasmas created experimentally. “Plasmas” may have been photographed in the 1940s by WWII pilots (identified as “Foo fighters”);repeatedly observed and filmed by astronauts and military pilots and classified as Unidentified Aerial—Anomalous Phenomenon. Plasmas are not biological but may represent a form of pre-life that via the incorporation of elements common in space, could result in the synthesis of RNA. Plasmas constitute a fourth state of matter, are attracted to electromagnetic activity, and when observed in the lower atmosphere likely account for many of the UFO-UAP sightings over the centuries.

关键词： extraterrestrials Plasmas Dusty Plasmas extremophiles Life in Space Abiogenesis Origins of Life RNA World

F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit

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World Journal of Gastroenterology 2023年第28期29卷 4433-4450页

作者： Zhi Liu Ning-Yuan Chen Zhao Zhang Sai Zhou san-Yuan Hu Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Shandong Provincial Qian Foshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina Department of General Surgery Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117Shandong ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a major health burden with an increasing global ***,the unavailability of knowledge underlying NAFLD pathogenesis inhibits effective preventive and therapeutic *** To explore the molecular mechanism of *** Whole genome sequencing(WGS)analysis was performed on liver tissues from patients with NAFLD(n=6)and patients with normal metabolic conditions(n=6)to identify the target genes.A NAFLD C57BL6/J mouse model induced by 16 wk of high-fat diet feeding and a hepatocyte-specific F-box only protein 2(FBXO2)overexpression mouse model were used for in vivo *** transfection,co-immunoprecipitation-based mass spectrometry assays,and ubiquitination in HepG2 cells and HeK293T cells were used for in vitro *** A total of 30982 genes were detected in WGS analysis,with 649 up-regulated and 178 *** of FBXO2,an e3 ligase,was upregulated in the liver tissues of patients with ***-specific FBXO2 overexpression facilitated NAFLD-associated phenotypes in *** of FBXO2 aggravated odium oleate(OA)-induced lipid accumulation in HepG2 cells,resulting in an abnormal expression of genes related to lipid metabolism,such as fatty acid synthase,peroxisome proliferator-activated receptor alpha,and so *** contrast,knocking down FBXO2 in HepG2 cells significantly alleviated the OA-induced lipid accumulation and aberrant expression of lipid metabolism *** hydroxyl CoA dehydrogenase alpha subunit(HADHA),a protein involved in oxidative stress,was a target of FBXO2-mediated ***2 directly bound to HADHA and facilitated its proteasomal degradation in HepG2 and HeK293T *** with HADHA alleviated lipid accumulation caused by FBXO2 overexpression in HepG2 *** FBXO2 exacerbates lipid accumulation by targeting HADHA and is a potential therapeutic target for NAFLD。

关键词： F-box only protein 2 Nonalcoholic fatty liver disease The hydroxyl CoA dehydrogenase alpha subunit Liver steatosis Ubiquitination Lipid accumulation

HVOF-sprayed HAp/S53P4 BG composite coatings on an AZ31 alloy for potential applications in temporary implants

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Journal of magnesium and Alloys 2024年第1期12卷 345-360页

作者： Carlos A.Poblano-Salas John Henao Astrid L.Giraldo-Betancur Paola Forero-Sossa Diego German espinosa-Arbelaez Jorge A.González-Sánchez Luis R.Dzib-Pérez Susana T.estrada-moo Idelfonso e.Pech-Pech CIATeQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATeQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad Tecnológica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDeSI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center for Corrosion Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive thermal spray coatings produced via high-velocity oxygen fuel spray(HVOF)from hydroxyapatite(HAp)and bioactive glasses(BG)have the potential to be employed on temporary implants due to the ability of both HAp and BG to dissolve and promote osseointegration,considering that both phases have different reaction and dissolution rates under in-vitro *** the present work,75%***-25%wt.S53P4 bioactive glass powders were HVOF-sprayed to obtain HAp/S53P4 BG composite coatings on a bioresorbable AZ31 *** study is focused on exploring the effect of the stand-off distance and fuel/oxygen ratio variation as HVOF parameters to obtain stable structural coatings and to establish their effect on the phases and microstructure produced in those *** characterization techniques,such as scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy,were employed to characterize relevant structural and microstructural properties of the composite *** results showed that thermal gradients during coating deposition must be managed to avoid delamination due to the high temperature achieved(max 550℃)and the differences in coefficients of thermal *** was also found that both spraying distance and oxygen/fuel ratio allowed to keep the hydroxyapatite as the main phase in the *** addition,in-vitro electrochemical studies were performed on the obtained HAp/S53P4 BG composite coatings and compared against the uncoated AZ31 *** results showed a significant decrease in hydrogen evolution(at least 98%)when the bioactive coating was applied on the mg alloy during evaluation in simulated body fluid(SBF).

关键词： Coatings Composites Thermal spray Temporary implants Hydrogen evolution