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Omeprazole-based triple therapy with low-versus high-dose of clarithromycin plus amoxicillin for H pylori eradication in Iranian population

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World Journal of Gastroenterology 2007年第6期13卷 930-933页

作者： Ali Asghar Keshavarz homayoon Bashiri Mahtab Rahbar Department of Gastroenterology and Hepatology Emam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran Department of Internal Medicine Emam Reza Hospital Kermanshah Iran Department of Pathology Emam Reza Hospital Kermanshah Iran

AIM： To investigate the efficacy and tolerability of H pylori eradication in an omeprazole-based triple therapy with high and low dose of clarithromycin and amoxicillin. METHODS： One hundred and sixty H pylori positive patients were randomly assigned to two groups based on the following 2 wk investigation; （1） group A or low-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 250 mg b.i.d and amoxicillin 500 mg b.i.d; and （2） group B or high-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 500 mg b.i.d and amoxicillin 1000 mg b.i.d. During the study Hpylori status was assessed by histology and rapid urease test prior and by 13C-urea breath test 6 wk after the therapy. Standard questionnaires were administered to determine the compliance to treatment and possible adverse events of therapy. Data were subject to x^2 to compare the eradication rates in the two groups. The significant level of 95% （P ≤ 0.05） was considered statistically different. RESULTS： We found that the per-protocol eradication rate was 88% （68/77） in group A, and 89% （67/75） in group B. The intension-to-treat eradication rate was 85% （68/80） in group A and 83.75% （67180） in group B. Overall adverse events were 26% in group A and 31% in group B. The adverse events were generally mild in nature and tolerated well in both groups with a compliance of 98% in group A vs 96% in group B. CONCLUSION： The omeprazole-based low dose regimen of darithromycin and amoxicillin for two weeks in Hpylori eradication is as effective as high dose regimen in Iranian population.

关键词： Triple therapy Hpy/ori Amoxicillin Clarithromycin Low-dose regimen

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Crowdsourcing-Based Framework for Teaching Quality Evaluation and Feedback Using Linguistic 2-Tuple

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Computers, Materials & Continua 2018年第10期57卷 81-96页

作者： Tiejun Wang Tao Wu Amir homayoon Ashrafzadeh Jia He Department of Computer Science Chengdu University of Information and TechnologyChengdu610025China. CSIT Department School of ScienceRMIT UniversityMelbourne3058Australia.

Crowdsourcing is widely used in various fields to collect goods and services from large *** teaching quality by collecting feedback from experts or students after class is not only delayed but also not *** this paper,we present a crowdsourcing-based framework to evaluate teaching quality in the classroom using a weighted average operator to aggregate information from students’questionnaires described by linguistic 2-tuple *** we define crowd grade based on similarity degree to distinguish contribution from different students and minimize the abnormal students’impact on the *** crowd grade would be updated at the end of each feedback so it can guarantee the evaluation ***,a simulated case is shown to illustrate how to apply this framework to assess teaching quality in the ***,we developed a prototype and carried out some experiments on a series of real questionnaires and two sets of modified *** results show that teachers can locate the weak points of teaching and furthermore to identify the abnormal students to improve the teaching ***,our approach provides a strong tolerance for the abnormal student to make the evaluation more accurate.

关键词： Teaching quality evaluation crowdsourcing linguistic 2-tuple group decision making

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Dedifferentiated liposarcoma arising from the sigmoid mesocolon: A case report

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World Journal of Gastroenterology 2007年第30期13卷 4147-4148页

作者： Brody Winn John Gao homayoon Akbari Baishali Bhattacharya Department of Pathology and Surgery Rhode Island Hospital Warren Alpert Medical School of Brown University Providence Rhode Island United States Department of Surgery Rhode Island Hospital Warren Alpert Medical School of Brown University Providence Rhode Island United States

Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. It occurs most commonly in the retroperitoneum and rarely in other anatomic locations. In the present report, we describe a case of dedifferentiated liposarcoma that occurred in an unusual location, sigmoid mesocolon, which has not yet been documented.

关键词： Dedifferentiated liposarcoma Sigmoid mesocolon

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Design of a heterosubtypic epitope-based peptide vaccine fused with hemokinin-1 against influenza viruses

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Virologica Sinica 2015年第3期30卷 200-207页

作者： Shahla Shahsavandi Mohammad Majid Ebrahimi Kaveh Sadeghi homayoon Mahravani Razi Vaccine & Serum Research Institute Karaj 31975 Iran

Influenza viruses continue to emerge and re-emerge, posing new threats for public health. Control and treatment of influenza depends mainly on vaccination and chemoprophylaxis with approved antiviral drugs. Identification of specific epitopes derived from influenza viruses has significantly advanced the development of epitope-based vaccines. Here, we explore the idea of using HLA binding data to design an epitope-based vaccine that can elicit heterosubtypic T-cell responses against circulating H7N9, H5N1, and H9N2 subtypes. The hemokinin-1(HK-1) peptide sequence was used to induce immune responses against the influenza viruses. Five conserved high score cytotoxic T lymphocyte(CTL) epitopes restricted to HLA-A*0201-binding peptides within the hemagglutinin(HA) protein of the viruses were chosen, and two HA CTL/HK-1 chimera protein models designed. Using in silico analysis, which involves interferon epitope scanning, protein structure prediction, antigenic epitope determination, and model quality evaluation, chimeric proteins were designed. The applicability of one of these proteins as a heterosubtypic epitopebased vaccine candidate was analyzed.

关键词： epitope-based vaccine hemokinin-1 heterosubtypic immunity influenza virus

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A Novel Metaheuristic Algorithm: The Team Competition and Cooperation Optimization Algorithm

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Computers, Materials & Continua 2022年第11期73卷 2879-2896页

作者： Tao Wu Xinyu Wu Jingjue Chen Xi Chen Amir homayoon Ashrafzadeh School of Computer Science Chengdu University of Information TechnologyChengdu610225China School of Computer Science and Engineering Southwest Minzu UniversityChengdu610041China CSIT Department School of ScienceRMIT UniversityMelbourne3058Australia

Metaheuristic algorithm is a generalization of heuristic algorithm that can be applied to almost all optimization *** optimization problems,metaheuristic algorithm is one of the methods to find its optimal solution or approximate solution under limited *** of the existing metaheuristic algorithms are designed for serial ***,existing algorithms still have a lot of room for improvement in convergence speed,robustness,and *** address these issues,this paper proposes an easily parallelizable metaheuristic optimization algorithm called team competition and cooperation optimization(TCCO)inspired by the process of human team cooperation and *** proposed algorithm attempts to mathematically model human team cooperation and competition to promote the optimization process and find an approximate solution as close as possible to the optimal solution under limited *** order to evaluate the performance of the proposed algorithm,this paper compares the solution accuracy and convergence speed of the TCCO algorithm with the Grasshopper Optimization Algorithm(GOA),Seagull Optimization Algorithm(SOA),Whale Optimization Algorithm(WOA)and Sparrow Search Algorithm(SSA).Experiment results of 30 test functions commonly used in the optimization field indicate that,compared with these current advanced metaheuristic algorithms,TCCO has strong competitiveness in both solution accuracy and convergence speed.

关键词： Optimization metaheuristic algorithm

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A Novel Quantum-Behaved Particle Swarm Optimization Algorithm

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Computers, Materials & Continua 2020年第5期63卷 873-890页

作者： Tao Wu Lei Xie Xi Chen Amir homayoon Ashrafzadeh Shu Zhang School of Computer Science Chengdu University of Information TechnologyChengdu610225China School of Computer Science and Technology Southwest Minzu UniversityChengdu610041China CSIT Department School of ScienceRMIT UniversityMelbourne3058Australia Department of Emergency Medicine West China HospitalSichuan UniversityChengdu610041China

The efficient management of ambulance routing for emergency requests is vital to save lives when a disaster ***-behaved Particle Swarm Optimization(QPSO)algorithm is a kind of metaheuristic algorithms applied to deal with the problem of *** paper analyzed the motion pattern of particles in a square potential well,given the position equation of the particles by solving the Schrödinger equation and proposed the Binary Correlation QPSO Algorithm Based on Square Potential Well(BC-QSPSO).In this novel algorithm,the intrinsic cognitive link between particles’experience information and group sharing information was created by using normal Copula *** that,the control parameters chosen strategy gives through ***,the simulation results of the test functions show that the improved algorithms outperform the original QPSO algorithm and due to the error gradient information will not be over utilized in square potential well,the particles are easy to jump out of the local optimum,the BC-QSPSO is more suitable to solve the functions with correlative variables.

关键词： Ambulance routing problem quantum-behaved particle swarm optimization square potential well convergence

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Detailed seismic risk analysis of electrical substation equipment using a reliability based approach

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 495-511页

作者： Amir Ghahremani Baghmisheh Milad Khodaei Ali Zare Feiz Abadi homayoon E.Estekanchi Department of Civil Engineering University of British ColumbiaVancouver V6T 2B8Canada Department of Civil Engineering University of TabrizTabriz 51666Iran Department of Civil Engineering Sharif University of TechnologyTehran 11155-9313Iran

This paper proposes a risk analysis framework for substation structures based on reliability *** though several risk assessment approaches have been developed for buildings,detailed risk analysis procedures for infrastructure components have been lacking in prior *** proposed framework is showcased by its application to a system of interconnected structures at a power substation in *** element models of structures are developed and validated in accordance with previous *** uncertainties in the material,mass,and geometric properties of structures are described by random variables that are input to the finite element *** artificial ground motion model is employed to comprehensively consider uncertainty in ground *** Carlo sampling is subsequently conducted on the library of probabilistic *** analysis resulted in the loss distribution in the life cycle of ***,the loss associated with six earthquake scenarios having specific magnitudes and return periods is *** application provides insight into the most vulnerable equipment in the considered ***,introduced risk measures can guide stakeholders to make risk-based decisions to optimize design or prioritize a retrofit of infrastructure components under conditions of uncertainty.

关键词： seismic risk reliability analysis infrastructure components loss estimation uncertainty

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Halothane hepatitis in Iran:A review of 59 cases

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World Journal of Gastroenterology 2008年第34期14卷 5322-5326页

作者： Payam Eghtesadi-Araghi Amir-Ali Sohrabpour homayoon Vahedi Mehdi Saberi-Firoozi Digestive Disease Research Center Shariati HospitalMedical Sciences/University of Tehran Gastroenterology Research Center Shiraz University of Medical Sciences Digestive Disease Research Center Shariati Hospital Medical Sciences/University of Tehran

AIM:To study halothane hepatitis (HH) in Iran and its associated risk factors. METHODS: We retrospectively studied files of all cases diagnosed with HH referred to three referral hospitals and four private centers in Iran from April 1994 to September 2006. Information on age at surgery, gender, medications history, obesity, history of previous exposure, previous reaction to halothane, familial history, type of surgery, perioperative hypoxia or sepsis, morbidity and mortality were recorded and analyzed. RESULTS: A total of 59 cases were identifi ed. Forty- eight (81%) were women. The median age at the time of surgery was 44 years (range, 18 to 80 years). Sixty percent of patients were above 40-year-old. Obesity was observed in 22.2%. Previous history of exposures to halothane was noted in 61% of which 50% had history of post-exposure reaction. Coronary artery bypass graft (CABG), cholecystectomy, and cosmetic surgeries (mainly weight reduction) were the most frequent surgeries. The mortality rate was 12.2%. In patients developing encephalopathy, it was as high as 50%. CONCLUSION: HH remains an important cause of morbidity and mortality in centers still using this anesthetic. However, a large percentage of these casescould have been avoided. To lessen occurrence of further cases of HH, the authors suggest that in female patients having a history of surgery (or delivery) with general anesthesia, the use of halothane should be absolutely avoided. Utilization of proper substitutes in adults’ anesthesia is advocated.

关键词： Anesthesia Inhalation Halothane Hepatitis Drug-Induced

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Suppository naproxen reduces incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis: Randomized controlled trial

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World Journal of Gastroenterology 2016年第21期22卷 5114-5121页

作者： Fariborz Mansour-Ghanaei Farahnaz Joukar Zahra Taherzadeh homayoon Sokhanvar Tolou Hasandokht Gastrointestinal and Liver Diseases Research Center Guilan University of Medical Sciences Razi Hospital Department of Community Medicine Guilan University of Medical Sciences

AIM: To determine the efficacy of rectally administered naproxen for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).METHODS: This double-blind randomized control trial conducted from January 2013 to April 2014 at the Gastrointestinal and Liver Diseases Research Center in Rasht, Iran. A total of 324 patients were selected from candidates for diagnostic or therapeutic ERCP by using the simple sampling method. Patients received a single dose of Naproxen (500 mg; n = 162) or a placebo (n = 162) per rectum immediately before ERCP. The overall incidence of PEP, incidence of mild to severe PEP, serum amylase levels and adverse effects were measured. The primary outcome measure was the development of pancreatitis onset of pain in the upper abdomen and elevation of the serum amylase level to > 3 × the upper normal limit (60-100 IU/L) within 24 h after ERCP. The severity of PEP was classified according to the duration of therapeutic intervention for PEP: mild, 2-3 d; moderate 4-10 d; and severe, > 10 d and/or necessitated surgical or intensive treatment, or contributed to ***: PEP occurred in 12% (40/324) of participants, and was significantly more frequent in the placebo group compared to the naproxen group (P < 0.01). Of the participants, 25.9% (84/324) developed hyperamylasemia within 2 h of procedure completion, among whom only 35 cases belonged to the naproxen group (P < 0.01). The incidence of PEP was significantly higher in female sex, in patients receiving pancreatic duct injection, more than 3 times pancreatic duct cannulations, and ERCP duration more than 40 min (Ps < 0.01). There were no statistically significant differences between the groups regarding the procedures or factors that might increase the risk of PEP, sphincterotomy, precut requirement, biliary duct injection and number of pancreatic duct cannulations. In the subgroup of patients with pancreatic

关键词： Naproxen Nonsteroidal anti-inflammatory drugs Pancreatic duct injection Post-endoscopic retrograde cholangiopancreatography Pancreatitis Serum amylase

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Comparison of Immune Responses against FMD by a DNA Vaccine Encoding the FMDV/O/IRN/2007 VP1 Gene and the Conventional Inactivated Vaccine in an Animal Model

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Virologica Sinica 2012年第5期27卷 286-291页

作者： Farahnaz Motamedi Sedeh Hoorieh Soleimanjahi AmirReza Jalilian homayoon Mahravani Agricultural Medical and Industrial Research School Virology Department Faculty of Medical ScienceTarbiat Modares University RaziVaccine and Serum Research Institute

Foot-and-mouth disease virus （FMDV） is highly contagious and responsible for huge outbreaks among cloven hoofed animals. The aim of the present study is to evaluate a plasmid DNA immunization system that expresses the FMDV/OflRN/2007 VP1 gene and compare it with the conventional inactivated vaccine in an animal model. The VP1 gene was sub-cloned into the unique Kpn I and BamH I cloning sites of the peDNA3.1＋ and pEGFP-N1 vectors to construct the VPI gene cassettes. The transfected BHKT7 cells with sub-cloned pEGFP-N1-VP1 vector expressed GFP-VP1 fusion protein and displayed more green fluorescence spots than the transfected BHKT7 cells with pEGFP-N1 vector, which solely expressed the GFP protein. Six mice groups were respectively immunized by the sub-cloned pcDNA3.1＋-VP1 gene cassette as the DNA vaccine, DNA vaccine and PCMV-SPORT-GMCSF vector （as molecular adjuvant） together, conventional vaccine, PBS （as negative control）, pcDNA3.1＋ vector （as control group） and PCMV-SPORT vector that contained the GMCSF gene （as control group）. Significant neutralizing antibody responses were induced in the mice which were immunized using plasmid vectors expressing the VP1 and GMCSF genes together, the DNA vaccine alone and the conventional inactivated vaccine （P〈0.05）. Co-administration of DNA vaccine and GMCSF gene improved neutralizing antibody response in comparison with administration of the DNA vaccine alone, but this response was the most for the conventional vaccine group. However, induction of humeral immunity response in the conventional vaccine group was more protective than for the DNA vaccine, but T-cell proliferation and IFN-？ concentration were the most in DNA vaccine with the GMCSF gene. Therefore the group that was vaccinated by DNA vaccine with the GMCSF gene, showed protective neutralizing antibody response and the most Thl cellular immunity.

关键词： DNA vaccine Foot-and-mouth disease virus Immune Response VP 1 gene

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