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Recycling of solid-state batteries—challenge and opportunity for a circular economy?

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Materials Futures 2024年第1期3卷 10-30页

作者： martine Jacob Kerstin Wissel Oliver Clemens 1 Department of Chemical Materials Synthesis University of StuttgartInstitute of Materials ScienceHeisenbergstraße 370569 StuttgartGermany Technical University of Darmstadt Institute of Materials ScienceAlarich-Weiss-Straße 264287 DarmstadtGermany

The tremendous efforts made in the research field of solid-state Li-ion batteries have led to considerable advancement of this technology and the first market-ready systems can be expected in the near *** research community is currently investigating different solid-state electrolyte classes(***,sulfides,halides and polymers)with a focus on further optimizing the synthesis and electrochemical ***,so far,the development of sustainable recycling strategies allowing for an efficient backflow of critical elements contained in these batteries into the economic cycle and thus a transition from a linear to a circular economy lags *** this contribution,resource aspects with respect to the chemical value of crucial materials,which are used for the synthesis of solid-state electrolytes are being ***,an overview of possible approaches in relation to their challenges and opportunities for the recycling of solid-state batteries with respect to different solid-state electrolyte classes by means of pyrometallurgy,hydrometallurgy and direct recycling/dissolution-based separation processes is *** on these considerations and with reference to previous research,it will be shown that different solid-state electrolytes will require individually adapted recycling processes to be suitably designed for a circular economy and that further improvements and investigations will be required.

关键词： solid-state batteries solid-state electrolyte recycling circular economy

Decreased eggshell strength caused by impairment of uterine calcium transport coincide with higher bone minerals and quality in aged laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1258-1277页

作者： Yu Fu Jianmin Zhou martine Schroyen Haijun Zhang Shugeng Wu Guanghai Qi Jing Wang Key Laboratory of Feed Biotechnology Ministry of Agriculture and Rural AffairsInstitute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Precision Livestock and Nutrition Laboratory Gembloux Agro‑Bio TechTERRA Teaching and Research CentreUniversity of LiegeGembloux B‑5030Belgium

Background Deteriorations in eggshell and bone quality are major challenges in aged laying *** study compared the differences of eggshell quality,bone parameters and their correlations as well as uterine physiologi-cal characteristics and the bone remodeling processes of hens laying eggs of different eggshell breaking strength to explore the mechanism of eggshell and bone quality reduction and their interaction.A total of 24074-week-old Hy-line Brown laying hens were selected and allocated to a high(HBS,44.83±1.31 N)or low(LBS,24.43±0.57 N)eggshell breaking strength *** A decreased thickness,weight and weight ratio of eggshells were observed in the LBS,accompanied with ultrastructural deterioration and total Ca *** quality was negatively correlated with eggshell quality,marked with enhanced structures and increased components in the *** the LBS,the mammillary knobs and effective layer grew *** the initiation stage of eggshell calcification,a total of 130 differentially expressed genes(DEGs,122 upregulated and 8 downregulated)were identified in the uterus of hens in the LBS relative to those in the *** DEGs were relevant to apoptosis due to the cellular Ca *** values of p62 protein level,caspase-8 activity,Bax protein expression and lower values of Bcl protein expression and Bcl/Bax ratio were seen in the *** assay and hematoxylin-eosin staining showed a significant increase in TUNEL-positive cells and tissue damages in the uterus of the *** few DEGs were identified at the growth stage,similar uterine tissue damages were also observed in the *** expressions of runt-related transcription factor 2 and osteocal-cin were upregulated in humeri of the *** diameter and more structural damages of endocortical bones and decreased ash were observed in femurs of the *** The lower eggshell breaking strength may be attributed to a declined Ca transport due to uterine tissue damages,which

关键词： Bone parameter Calcium transport Eggshell quality Laying hen Tissue damage

Aberrant expression of CD56 by circulating Sézary syndrome malignant T lymphocytes

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World Journal of Immunology 2013年第3期3卷 68-71页

作者： Nicolas Thonnart Caroline Ram-Wolff martine bagot Armand Bensussan Anne Marie-Cardine INSERM U976 Saint Louis Hospital 75010 Paris France University Paris Diderot Sorbonne Paris Cité 75013 Paris France AP-HP Department of Dermatology Saint Louis Hospital 75010 Paris France

Sézary syndrome(SS) is an aggressive variant of cutaneous T cell lymphoma characterized by the presence of malignant T cells in the skin, peripheral blood and lymph nodes. The tumoral population typically displays a CD3+ CD4+ CD45RO+ memory T cell phenotype. We report a case of SS with an aberrant CD56+ immunophenotype. This patient presented with a generalized erythroderma and palpable small axillary lymph ***(stage IVA) was diagnosed on histological criteria and by the detection of a major T cell clone in skin and blood, an elevated CD4/CD8 T cell ratio and Sézary cells count > 1000/mm3. Beside the Sézary cell marker KIR3DL2, immunostainings revealed that two third of the malignant cells expressed CD56 but no other natural killer(NK) cell marker such as CD16, CD160 or NKp46. This atypical expression was not linked to an activation-dependent process and remained stable during the time course of the disease. No loss of the panT-cell markers CD2, CD3 or CD4 was detected while a complete down-modulation of CD26 was observed. Despite several lines of treatment, no durable amelioration was observed and patient died after 10 mo of follow-up. Because this CD4+ CD56+ SS case is the only one reported so far, the functional significance of CD56 expression remained difficult to assess in terms of aggressiveness and prognosis.

关键词： Cutaneous T cell lymphomas Sézary syndrome CD56

The First Global Map of Atmospheric Ammonia(NH_(3)) as Observed by the HIRAS/FY-3D Satellite

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Advances in Atmospheric Sciences 2024年第3期41卷 379-390页

作者： Minqiang ZHOU Zhili DENG Charles ROBERT Xingying ZHANG Lu ZHANG Yapeng WANG Chengli QI Pucai WANG martine De MAZIÈRE Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Royal Belgian Institute for Space Aeronomy(BIRA-IASB) Brussels 1180Belgium National Satellite Meteorology Center China Meteorological AdministrationBeijing 100081China Department of Science&Technology and Climate Change China Meteorological AdministrationBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

Atmospheric ammonia(NH_(3)) is a chemically active trace gas that plays an important role in the atmospheric environment and climate change. Satellite remote sensing is a powerful technique to monitor NH_(3) concentration based on the absorption lines of NH_(3) in the thermal infrared region. In this study, we establish a retrieval algorithm to derive the NH_(3)column from the Hyperspectral Infrared Atmospheric Sounder(HIRAS) onboard the Chinese Feng Yun(FY)-3D satellite and present the first atmospheric NH_(3) column global map observed by the HIRAS instrument. The HIRAS observations can well capture NH_(3) hotspots around the world, e.g., India, West Africa, and East China, where large NH_(3) emissions exist. The HIRAS NH_(3) columns are also compared to the space-based Infrared Atmospheric Sounding Interferometer(IASI)measurements, and we find that the two instruments observe a consistent NH_(3) global distribution, with correlation coefficient(R) values of 0.28–0.73. Finally, some remaining issues about the HIRAS NH_(3) retrieval are discussed.

关键词： ammonia HIRAS/FY-3D satellite thermal-infrared observation remote sensing optimal estimation method

Total Fat, Fatty Acid Composition, Tocopherol and Tocotrienol Profiles in Fermented Beans of Ten Controlled Pollinated Cocoa (Theobroma cacao L.) Hybrids from Cameroon

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American Journal of Plant Sciences 2024年第5期15卷 359-373页

作者： Martin Paul Arnaud Mbida Simon Perrez Akoa Ronelle Fabiola Mbia Manga Ndjaga Jude martine Louise Ondobo Onomo Pierre Effa Department of Biochemistry Faculty of Science University of Yaounde I Yaounde Cameroon Laboratory of Plant Physiology and Biochemistry Department of Biological Science Higher Teacher&#8217s Training College University of Yaounde I Yaounde Cameroon Department of Food Science and Technology Faculty of Agriculture and Veterinary Medecine University of Buea Buea Cameroon National Technology Development Committee Ministry of Scientific Research and Innovation Administrative Center Yaounde Cameroon Department of Agriculture and Agropastoral Higher Technical Teacher&#8217s Training College University of Ebolowa Ebolowa Cameroon

This study aimed to discriminate ten Cameroonian cocoa hybrids according to their total fat, fatty acid composition, tocopherol and tocotrienol profiles. Six cocoa clones from the gene banks of the Cameroon Cocoa Development Corporation were used to create hybrids. The determination of fatty acid composition was carried out by using a gas chromatography (GC) apparatus coupled by a flame ion detector (FID). Tocopherol and tocotrienol analysis was performed by upper high-performance liquid chromatography (UHPLC). Information on the impact of the genotype on the cocoa fat composition was provided. The major fatty acids (FA) in fermented samples are stearic (34.57%), palmitic (26.13%), oleic (34.13%) and linoleic (3.16%) acids. (35.05% to 35.6%). SCA12 × ICS40, SCA12 × SNK13, SNK13 × T79/501 have the least hard cocoa butters. Tocopherols analysis showed a predominance of γ-tocopherols (94.64 ± 1.51 to 292.16 ± 3.17 µg∙g−1), whereas only a small amount of β and δ-tocopherol (from 0.46 to 2.78 µg∙g−1 and 0.12 to 5.82 respectively) was observed. No γ-tocotrienol was found in fermented samples. A differentiation in terms of total fat and tocopherol content was observed amongst hybrids with the same mother-clone, suggesting an impact of pollen on these compounds.

关键词： Cocoa Hybrids Lipid Composition UHPLC GC-FID

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

An ensemble deep learning based IDS for IoT using Lambda architecture

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网络空间安全科学与技术(英文) 2023年第3期6卷 1-17页

作者： Rubayyi Alghamdi martine Bellaiche Computer and Software Engineering Department école PolytechniqueMontrealCanada

The Internet of Things(IoT)has revolutionized our world today by providing greater levels of accessibility,connectivity and ease to our everyday *** enables massive amounts of data to be traversed across multiple heterogeneous devices that are all *** phenomenon makes IoT networks vulnerable to various network attacks and *** an Intrusion Detection System(IDS)for IoT networks is challenging as they enable a massive amount of data to be aggregated,which is difficult to handle and analyze in real time mainly because of the heterogeneous nature of IoT *** inefficient,traditional IDS approach accentuates the need to develop advanced IDS techniques by employing Machine or Deep *** paper presents a deep ensemble-based IDS using Lambda architecture by following a multi-pronged classification *** classification uses Long Short Term Memory(LSTM)to differentiate between malicious and benign traffic,while the multi-class classifier uses an ensemble of LSTM,Convolutional Neural Network and Artificial Neural Network classifiers to detect the type of *** model training is performed in the batch layer,while real-time evaluation is carried out through model inferences in the speed layer of the Lambda *** proposed approach gives high accuracy of over 99.93%and saves useful processing time due to the multi-pronged classification strategy and using the lambda architecture.

关键词： IoT IDS Lambda architecture Cyber-attacks Deep learning Ensemble learning

Mechanisms of species divergence through visual adaptation and sexual selection:Perspectives from a cichlid model system

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Current Zoology 2010年第3期56卷 285-299页

作者： martine E.MAAN Ole SEEHAUSEN Institute of Ecology & Evolution University of Bern Eawag Centre of Ecology Evolution and Biogeochemistry(CEEB)

The theory of ecological speciation suggests that assortative mating evolves most easily when mating preferences aredirectly linked to ecological traits that are subject to divergent selection. Sensory adaptation can play a major role in this process,because selective mating is often mediated by sexual signals: bright colours, complex song, pheromone blends and so on. Whendivergent sensory adaptation affects the perception of such signals, mating patterns may change as an immediate ***, mating preferences can diverge as a result of indirect effects: assortative mating may be promoted by selectionagainst intermediate phenotypes that are maladapted to their (sensory) environment. For Lake Victoria cichlids, the visual environmentconstitutes an important selective force that is heterogeneous across geographical and water depth gradients. We investigatethe direct and indirect effects of this heterogeneity on the evolution of female preferences for alternative male nuptial colours(red and blue) in the genus Pundamilia. Here, we review the current evidence for divergent sensory drive in this system, extractgeneral principles, and discuss future perspectives [Current Zoology 56 (3): 285-299, 2010].

关键词： Cichlid Sexual selection Species divergence Visual adaptation

New generation of breast cancer clinical trials implementing molecular profiling

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Cancer Biology & Medicine 2016年第2期13卷 226-235页

作者： Dimitrios Zardavas martine Piccart-Gebhart Breast International Group(BIG) Brussels 100Belgium Medicine Department Institue Jules BordetUniversite Libre de BruxellesBrussels 100Belgium

The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnerabilities. In particular, there is an increasing list of molecularly targeted anticancer agents undergoing clinical development that aim to block specific molecular aberrations. This leads to a paradigm shift, with an increasing list of specific aberrations dictating the treatment of patients with cancer. This paradigm shift impacts the field of clinical trials, since the classical approach of having clinico-pathological disease characteristics dictating the patients' enrolment in oncology trials shifts towards the implementation of molecular profiling as prescreening step. In order to facilitate the successful clinical development of these new anticancer drugs within specific molecular niches of cancer diagnoses, there have been developed new, innovative trial designs that could be classified as follows: i)longitudinal cohort studies that implement(or not) "nested" downstream trials, 2) studies that assess the clinical utility of molecular profiling, 3) "master" protocol trials, iv) "basket" trials, v) trials following an adaptive design. In the present article, we review these innovative study designs, providing representative examples from each category and we discuss the challenges that still need to be addressed in this era of new generation oncology trials implementing molecular profiling. Emphasis is put on the field of breast cancer clinical trials.

关键词： Clinical trial molecular profiling breast cancer study design