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Screening of Type 2 Diabetes in the City of Belo Horizonte: Differences between Genders

Open Journal of Endocrine and Metabolic Diseases 2016年第4期6卷 141-149页

作者： Braulio Roberto Gonçalves Marinho Couto Katiussia Brito Porto Fabiane de Freitas Sales Deborah Campos Oliveira Larissa da Silva Pacheco Lídia Christina Guimarães pereira Talita Santos de Almeida Geiza Francielle Rodrigues de Souza Mariana Santos Romualdo Jaqueline Paulino de Souza Clara Araújo Veloso Instituto de Ciências Biológicas e da Saúde (ICBS) Centro Universitário de Belo Horizonte Brasil

Introduction: Diabetes mellitus is a major public health problem that carries a high social and economic burden. Its diagnosis is unknown in half of individuals who have the disease. The diagnosis of the risk factors should be done in the beginning, since changes in lifestyle and hyperglycemic correction may delay the appearance of the disease and its complications. In this context, screening has been considered an important tool for an early detection of diabetes in asymptomatic adults. Objective: The objective is to track diabetes in people from BH, comparing genders. Patients and methods: People were interviewed with questions concerning the risk factors associated with the development of diabetes. According to the risk factors present, they were classified as non-diabetic [ND], pre-diabetic [PD] or diabetic [DM]. Statistical analyses were performed considering p ≤ 0.05 as significant. Results: 1264 individuals participated (5.5% DM, 6.5% PD, 88.0% ND). When grouped, PD and DM males were more prevalent than PD and DM females. Those in the DM group had higher blood pressure, age, glycaemia, number of past smokers, first-degree relatives with diabetes than either PD or ND. Both males and females in DM and PD groups had a higher waist circumference than did either ND males or females. ND men had a higher intake of fried food and smoked more in the past than ND women. Both ND and PD males had higher blood pressure than women from the same groups. Conclusion: Screening for diabetes is very important for an early diagnosis and to avoid future complications in patients. It’s possible to infer that women are more conscientious when it comes to taking care of themselves than men.

关键词： Diabetes Mellitus Screening Gender Risk Factors

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个体化循环肿瘤DNA标志物动态预测妇科肿瘤患者治疗和预后效果

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国际妇产科学杂志 2016年第4期43卷 478-478页

作者： pereira E 秦娟

背景与目的：髙级别卵巢癌和子宫内膜癌是全球范围？＇内致死率较髙的女性生殖系统恶性肿瘤,近一半患者会在18个月内复发,且大多会在5年内死亡.目前常用的血清标志物CA125,对于妇科恶性肿瘤的疗效判断和复发的早二期监测尚缺乏较好的敏... 详细信息

背景与目的：髙级别卵巢癌和子宫内膜癌是全球范围？＇内致死率较髙的女性生殖系统恶性肿瘤,近一半患者会在18个月内复发,且大多会在5年内死亡.目前常用的血清标志物CA125,对于妇科恶性肿瘤的疗效判断和复发的早二期监测尚缺乏较好的敏感度和特异度,而且计算机断层扫描（computedtomography,CT）等影像学方法敏感度较低,并存在不确定性,不易早期诊断疾病的进展.

关键词：妇科肿瘤患者血清标志物循环肿瘤DNA 动态预测生殖系统恶性肿瘤计算机断层扫描治疗个体

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基于改进型PCNN的不规则图像自适应分割算法研究

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计算机应用 2008年第3期28卷 650-652页

作者：冯登超杨兆选王哲 J．M．Dias Rereira 天津大学信息学院天津300072 太原理工大学信息学院太原030024 塞图巴尔理工大学系统信息系葡萄牙塞图巴尔2910-761

针对不规则图像成分复杂、特征形状无法采用经典模型拟合等问题,提出了基于改进型脉冲耦合神经网络(PCNN)的自适应分割算法。该算法在原有PCNN模型基础上,对神经元反馈输入函数和动态阈值函数进行了修正,同时对神经元的输出采用多级输... 详细信息

针对不规则图像成分复杂、特征形状无法采用经典模型拟合等问题,提出了基于改进型脉冲耦合神经网络(PCNN)的自适应分割算法。该算法在原有PCNN模型基础上,对神经元反馈输入函数和动态阈值函数进行了修正,同时对神经元的输出采用多级输出模型,从而实现对不规则图像的分割。仿真实验表明,改进后的算法能够实现不规则图像的自适应分割,鲁棒性较好。

关键词：不规则图像脉冲耦合神经网络动态阈值自适应分割

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Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder pereira Armando Perez de Prado Cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology Department Hospital Universitario San JuanAlicanteSpain Cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology Department Hospital Universitario Puerta del MarCadizSpain Cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology Department Hospital Universitario de CrucesBilbaoSpain Cardiology Department Hospital Regional Universitario de MálagaMalagaSpain Cardiology Department Hospital Universitario Puerta de HierroMadridSpain Cardiology Department Hospital Alvaro CunqueiroVigoSpain Cardiology Department Hospital Juan Ramon JimenezHuelvaSpain Cardiology Department Hospital Universitario de BadajozBadajozSpain Cardiology Department Hospital Universitario Lucus AugustiLugoSpain Cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology Department Hospital Santa CruzLisboaPortugal Cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology Department Hospital Universitario Miguel ServetZaragozaSpain Cardiology Department Hospital Germans Trias i PujolBadalonaSpain Cardiology Department Hospital de MeridaMeridaSpain Cardiology Department Hospital São BernardoSetúbalPortugal Cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital do Espirito SantoEvoraPortugal Cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology Department Hospital de CabueñesGijonSpain Cardiology Department Hospital Garcia de OrtaAlmadaPortugal Cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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渗透树脂治疗釉质白垩斑即时遮盖效果的临床评价

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中国口腔医学继续教育杂志 2020年第6期23卷 354-359页

作者： Rosa Maria pereira Moises Andrade Tayllan Oliveira Lima Maria Angelica Menezes-Oliveira Ruchele Nogueira Cesar Penazzo Lepri Vinicius Geraldo-Martins 许梦茹(译) 张珊珊郑树国(审) 不详北京大学口腔医院预防科 100081

本研究的目的是在体内评价渗透树脂(IR)治疗釉质白垩斑(WSLs)的即时遮盖效果。研究对象为40名11~23岁的青少年和年轻成人.至少有一颗上颌或下颌恒前牙为活动性白垩斑(ICDAS得分为2分)。在渗透树脂治疗前.使用数字分光光度计(CIElab)对... 详细信息

本研究的目的是在体内评价渗透树脂(IR)治疗釉质白垩斑(WSLs)的即时遮盖效果。研究对象为40名11~23岁的青少年和年轻成人.至少有一颗上颌或下颌恒前牙为活动性白垩斑(ICDAS得分为2分)。在渗透树脂治疗前.使用数字分光光度计(CIElab)对白垩斑和相邻完整釉质(SAE)的颜色进行评估。接着.依据生产商的使用说明对白垩斑应用渗透树脂技术(Icon).临床操作结束时评估渗透树脂的颜色。计算白垩斑和相邻完整釉质(WSL×SAE)、白垩斑和渗透树脂(WSL×IR)以及渗透树脂和相邻完整釉质(IR×SAE)间的颜色差异(△E),然后用单因素方差分析和Turkey’s检验进行分析。用t检验来比较相关样本白垩斑.相邻完整釉质和渗透树脂的L^*、a^*、b^*值(α=5%)。白垩斑和渗透树脂(WSL×IR)比较时△E=5.930.41.渗透树脂和相邻完整釉质间(IR×SAE)的△E=5.770.41.说明治疗后白垩斑的颜色发生改变.但与相邻完整釉质相比.渗透树脂不能完全掩饰白垩斑。相邻完整釉质的明度比渗透树脂高。由此可以得出如下结论:与相邻完整釉质相比.渗透树脂治疗不能遮盖白垩斑的颜色.但可以减弱釉质脱矿引起的变色。

关键词：渗透树脂白垩斑釉质脱矿临床操作单因素方差分析恒前牙颜色差异分光光度计

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Experimentelle Untersuchung zur Effektivit t der Transarteriellen Chemoembolisation im Tiermodell des hepatozellul ren Karzinoms

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第2期21卷 115-118页

作者：钱骏冯敢生

Ziel: Evaluation der Effektivit t verschiedener Methodiken der TACE im tierexperimentellen Modell des hepatozellularen Karzinoms. Material und Methoden: Bei mannlichen ACI Ratten erfolgte die Implantation eines soliden Morris Hepatom 3924A subkapsular in den Leberlappen. 12—14 Tage nach Implantation wurden die Tumorvolumina kernspintomographisch bestimmt. Nach Laparotomie und retrograder Katheterisierung der Arteria gastroduodenalis wurden anschlieend unterschiedliche Therapieprotokolle der TACE angewendet: Mitomycin C , Degradiere Starke Mikrospharen , Mitomycin C+DSM , Mitomycin C + Ligatur , Mitomycin C+Lipiodol , Mitomycin C+Lipiodol+Ligatur , Mitomycin C+DSM+Ligatur , Mitomycin C+Poly Laktide co Glykolide , DSM + Ligatur , Lipiodol + Ligatur , Ligatur , Lipiodol , 0,9% NaCl . Zur Effektivitatsbeurteilung der verschiedenen Methodiken erfolgte 12—14 Tage nach Therapie eine erneute kernspintomographische Volumenbestimmung der Tumoren. Ergebnisse: Im Vergleich zur Kontrollgruppe zeigten Gruppe D, E, F, G, H und J eine statistisch signifikant geringere Tumorvolumenzunahme, wahrend Gruppe A, B, C, I, K, L keine statistisch signifikanten Unterschiede hinsichtlich der Tumorvolumenzunahme zeigten. Schlufolgerung: Die Effektivitat der TACE im tierexperimentellen Modell des hepatozellularen Karzinoms wird nur bei kombinierter Applikation von Zytostatikum und Carrier/Ligatur signifikant erhoht. Die alleinige Applikation des Zytostatikums/der Carrier/Ligatur hatte keinen signifikanten Effekt bezuglich der Effektivitat.

关键词： hepatozellul res Karzinom Transarterielle Chemoembolisation ACI Ratte

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1型糖尿病患者的血糖控制,心脏自身免疫和心血管病的长期风险

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中华高血压杂志 2019年第1期27卷 99-99页

作者： Sousa GR Pober D Galderisi A Lv H Yu L pereira AC Doria A Kosiborod M Lipes MA 刘莉叶鹏

血糖控制不佳与1型糖尿病(type 1diabetes mellitus,T1DM)患者的心血管病风险增加有关;然而,对T1DM的特异性机制知之甚少。在T1DM中,心肌损伤可诱发持续的心脏自身免疫。慢性高血糖症引起心肌损伤,高血糖诱导的心脏自身免疫可能导致长... 详细信息

血糖控制不佳与1型糖尿病(type 1diabetes mellitus,T1DM)患者的心血管病风险增加有关;然而,对T1DM的特异性机制知之甚少。在T1DM中,心肌损伤可诱发持续的心脏自身免疫。慢性高血糖症引起心肌损伤,高血糖诱导的心脏自身免疫可能导致长期心血管病并发症的可能性。

关键词：血糖控制心血管病糖尿病患者自身免疫

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Etablierung eines Tiermodells des hepatozellul ren Karzinoms durch den Einsatz von allogenischer Implantationstechnik

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第3期21卷 222-224页

作者：钱骏冯敢生

Etablierung eines tierexperimentellen Modells des hepatozellularen Karzinoms (HCC) bei ACI-Ratten durch den Einsatz von allogenischer Implantationstechnik und Beobachtung durch die MR-Untersuchung. Bei einer mannlichen ACI-Ratte wurde die Tumorzellen von Morris Hepatoma 3924A in die Flanke subkutan injiziert. 13 Tage danach erfolgte die Implantation eines soliden Tumorfragments (1 mm 3 ) aus dem gewachsenen Tumor subkapsular in den linkem Leberlappen bei anderen mannlichen ACI-Ratten (n=12). 14 Tage nach Implantation wurden die Tumorvolumina kernspintomographisch bestimmt. 14 Tage nach Implantation wurde der isolierte und solide Lebertumor bei allen ACI-Ratten kernspintomographisch beobachtet. Das durchschnittliche Tumorvolumen betrug hierbei 0,090±0,008 cm 3 . Die Angehrate der Tumorimplantation war 100 %. Eine auffallende Hypointensitat der Lasion im Vergleich zum umgebenden Lebergewebe im T1w-Bild und eine massig vermehrte Signalintensitat im T2w-Bild mit inhomogener Struktur waren bei allen implantierten Ratten erkennbar. Mit einer guten Angehrate des Implantations und geeignetem Tumorwachstumsverhalten steht dieses Verfahren zur Etablierung eines Tiermodells des HCCs zur Verfugung. Es ist einfach zu kontrollieren und leicht reproduzierbar.

关键词： hepatozellulres Karzinom ACI-Ratte Tiermodell Implantation

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Maternal Predictors for Quality of Life during the Postpartum in Brazilian Mothers

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Health 2015年第3期7卷 371-380页

作者： Mirna Fontenele de Oliveira Leslie Parker Hyochol Ahn Hellen Lívia Oliveira Catunda Elizian Braga Rodrigues Bernardo Mara Fontenele de Oliveira Samila Gomes Ribeiro Cinthia Gondim pereira Calou Franz Janco Antezana Paulo César Almeida Régia Christina Moura Barbosa Castro Priscila de Souza Aquino Ana Karina Bezerra Pinheiro College of Nursing University of Florida Gainesville USA Department of Nursing Federal University of Ceará Fortaleza Brazil

Introduction: The postpartum period can have a significant physical, emotional, and social impact on the quality of a woman’s life. Most postpartum research has focused on physical complications and only a few studies have specifically investigated quality of life. The purpose of this study was to explore predictors affecting the quality of life of postpartum Brazilian mothers. Study Design and Methods: A cross-sectional Quality of Life survey was performed in 210 Brazilian mothers during the early postpartum period. Data were collected using an interview technique and two instruments: 1) a maternal questionnaire and the 2) Maternal Postpartum Quality of Life tool/Brazilian version. The association between maternal characteristics and quality of life in the post-partum period was investigated with bivariate and multivariable analyses. Results: Mothers who had the best Quality of Life were white, registered students, 30 - 40 years of age, who were married or living with a partner, and without physical complaints;in addition, they had at least an 8th grade education, more than 4 children, and had attended more than 8 prenatal visits with a nurse. The stepwise model indicated that white race (p < 0.05) and married or living with a partner (p < 0.05) were the best predictors of Quality of Life in postpartum women. Conclusions and Clinical Implications: Marital status and race conditions may predict quality of life in postpartum Brazilian mothers. In addition, improved knowledge concerning the postpartum, maternal experience may help develop health interventions to enhance the quality of life of this population.

关键词： Mothers Postpartum Quality of Life Predictors

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Brown Algae <i>Himantothallus grandifolius</i>(Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells

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Advances in Biological Chemistry 2014年第2期4卷 98-108页

作者： Gabriela Gambato érico G. Baroni Charlene S. C. Garcia Rafaele Frassini Caroline O. S. Frozza Sidnei Moura Cláudio M. P. pereira Mutue T. Fujii Pio Colepicolo Ana Paula F. Lambert Joã o A. P. Henriques Mariana Roesch-Ely Botanical Institute SMA S&atilde o Paulo Brazil Faculty of Pharmacy University of Caxias do Sul Caxias do Sul Brazil Institute of Chemistry and Geosciences Federal University of Pelotas Pelotas Brazil Institute of Chemistry University of S&atilde o Paulo S&atilde o Paulo Brazil Laboratory of Biotechnology of Natural and Synthetic Products Biotechnology Institute University of Caxias do Sul Caxias do Sul Brazil Laboratory of Genomics Proteomics and DNA Repair Biotechnology Institute University of Caxias do Sul Caxias do Sul Brazil

Marine algae have been used as food since ancient times and today are consumed as a regular part of the diet. In this study, we hypothesized that H. grandifolius phlorotannins-enriched extract exerts cytotoxic selective effects against tumor cell lines promoting cell death trough apoptosis mechanisms. The aim of the present study is to characterize chemically and investigate the selective cytotoxic effect of the H. grandifolius extract on epithelial tumour cell lines (A375, A549, Hep-2, HeLa) compared to non-malignant cell line (Hek-293), and evaluate possible molecular mechanisms involved in the programmed cell death pathway. High-resolution directly-infusion mass spectrometry (HR-DIMS) analysis with electrospray ionization (ESI) was performed in positive and negative mode. Cytotoxicity was evaluated through colorimetric assay and morphological alterations were observed in giemsa stained cells after extract treatment. Apoptosis was further evaluated by annexin V staining. Spectra showed peaks m/z between 370 and 430 and molecular formula was defined upon isotopic ratio. Extract showed selectivity to the non-tumor line with enhanced cytotoxicity in tumor cells according to the concentration and exposure time. After 72 h treatment, the HeLa strain was more susceptible to the extract, followed by lines Hep2, A375 and A549. Morphological changes by giemsa were observed after increased doses of extracts and staining for annexin V showed majority of tumor cells at early stages of the apoptotic process. Here, selective anti-tumor activity of extract taken from the alga H. grandifolius was able to suppress proliferation and promote apoptosis-mediated cell death with induction of initial stages of apoptosis in different cell lines.

关键词： Algae Cytotoxicity Apoptosis Cancer in Vitro

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