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Current HPV Vaccination Strategies in Brazil

Health 2023年第2期15卷 107-121页

作者： Durval Silva Tavares Filho Camille Marcele Resende Rocha Elizabeth Bacha Ádamo Newton Marinho Andrade Daniel Diniz Porto pereira Letícia Mayer Nunes Luma Dória Passos Pollyana Thaise Santos Braz Paula Andreia Santos Braz Antônia Iva Sampaio Bisneta Francisco Expedito Ramos Aguiar Sobrinho Centro Universitário Tiradentes (UNIT) Maceió Brazil Universidade de Pernambuco (UPE) Recife Brazil

Cervical cancer is one of the most preventable and treatable malignancies, however, it still has high incidence and mortality rates, especially in less developed countries. For Brazil, the estimate is more than 16,000 new cases and more than 6000 deaths annually. Despite this, vaccines against HPV (responsible for cervical cancer) are effective and promote a significant decrease in infections and neoplastic lesions of the cervix. As recommended by the World Health Organization, girls aged 9 to 14 should be vaccinated before becoming sexually active. Although the vaccine was developed in 2006, in Brazil immunization only started to be carried out in 2014, initially only for girls between 9 and 11 years old. The present work is an integrative review, with the objective of explaining the current situation of vaccination against HPV throughout the country. Using the PubMed, MED-LINE and Google Scholar databases, a search for scientific articles was carried out during the year 2022, using the descriptors “Vaccine”, “HPV” and “Brazil”, simultaneously selecting 17 articles. The Brazilian recommendations for vaccination against HPV have undergone several strategic changes over time, in the following points: age group and gender of the target population, major site of application of vaccines and number of doses to be applied. Currently, in Brazil, the recommendation for vaccination against HPV is neutral in gender, between 9 and 14 years old and in immunosuppressed people up to 45 years old, with a vaccination schedule of 2 doses with an interval of 6 months between them, and 3 doses for those from 15 years and immunocompromised individual (0 - 2 - 6 months). The tetravalent vaccine offered by public funding continues to be applied at health centers, despite several favorable criticisms of the return of application in schools. Even though the vaccine is available free of charge, studies point to the difficulty in achieving and maintaining vaccination coverage, especially for

关键词： Brazil HPV Vaccine Update Cervical Cancer

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Fluid Leakage in Submerged Offshore Pipeline: An Analysis of Oil Dispersion in Seawater

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Open Journal of Fluid Dynamics 2020年第2期10卷 95-121页

作者： Gicelia Moreira Hortência L. Fernandes Magalhães Daniela P. Simões de Almeida Tavares Balbina R. de Brito Correia Boniek E. Leite Adriana B. da Costa pereira Severino R. de Farias Neto Antonio G. Barbosa de Lima Department of Chemical Engineering Federal University of Campina Grande Campina Grande Brazil

Leakages in oil pipelines can cause financial losses and several environmental damages, where large-scale offshore oil and gas exploration results in large releases of oil and gas into ocean waters. In the event of oil leakage, an immediate and adequate response is required to reduce environmental damage, such as containment barriers, for example, which depends on the agglomeration of oil particles, velocity and tendency to propagation. Thus, the understanding of the fluid flow behavior around of subsea pipeline at different depths is crucial. On the other hand, the knowledge of interfacial phenomena of immiscible liquids allows the process of adjective migration in submarine pipelines. Consequently, this science enables the prediction of the behavior and the geometric shape of the water-oil interface and provides a phenomenological foundation concerning the theories of perturbation, the stability criteria and mathematical modeling, as well as the flow patterns in the neighborhoods and submerged pipelines. From this perspective, this work aims to study the oil dispersion in sea water caused by leakage in a submerged pipeline. Here, a two-dimensional mathematical model based on the mass and linear momentum conservation equations and the standard k-ε turbulence model, was developed. The dynamic behavior of the oil and water phases is evaluated by pressure fields, surface velocity, volumetric fraction and velocity vectors. Simulation results show the presence of oil flux from the pipe to the marine stream and vice-versa. Further, the increase in oil velocity at the pipe inlet leads to an increase in pressure drop.

关键词： Computational Fluid Dynamics Submerged Offshore Pipeline Leakage CFX

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Effect of Growth Regulators in Production and Rooting of Coffea arabica ***

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American Journal of Plant Sciences 2018年第4期9卷 628-636页

作者： Paulo Fernando Marques Cavalcanti Filho Diego Corona Baitelle Sílvio de Jesus Freitas Waldinei Souza da Silva Paulo Cesar dos Santos Weverton pereira Rodrigues Silverio de Paiva Freitas Ismael Lourenco de Jesus Freitas Tamara Locatelli Abraao Carlos Verdin Filho Guilherme Bessa Miranda Department of Plant Science State University of Northern Rio de JaneiroCampos dos GoitacazesRio de Janeiro StateBrazil

The plants of C. arabica do not naturally produce a large number of orthotropic sprouts, hindering clonal multiplication by cutting, which would be the simplest technique with a lower cost of production compared to other methods of vegetative propagation. An alternative form, used successfully in the propagation of eucalyptus, is propagation by minicutting, which consists of pruning the shoot apex of the plant, forming the ministumps, which in variable time interval emits the shoots that will be used to make minicutting. In C. arabica plants the number of shoots can be increased with the application of growth regulators and fertilizers. So, the purpose of this work was to verify the effect of growth regulators and foliar fertilizers on the emission and development of orthotropic shoots of C. arabica. The experiment was installed in a randomized complete block design, with ten treatments composed by growth regulators and fertilizers: T1 (Control);T2 (Stimulate + Sturdy + Enervig);T3 (Stimulate + Vitakelp + Biozyme);T4 (Tiba + Sturdy + Enervig);T5 (Tiba + Vitakelp + Biozyme);T6 (Brs + Sturdy + Enervig) T7 (Brs + Vitakelp + Biozyme);T8 (Stimulate);T9 (TIBA);T10 (Brs-Brassinoesteroid), each plot consisting of two plants. Biometric and physiological parameters were evaluated for the ministumps, as well as the biometric parameters of the shoots and plant survival. The results showed that there was no influence of the treatments on the biometric parameters of the ministumps. A greater number of orthotopic sprouts were obtained in treatments with the TIBA growth regulator, as well as a greater plant survival of the minicuttings, after 25 days of transplanting in a greenhouse. It was concluded that TIBA treatments influenced the production and quality of clonal minicuttings of C. arabica.

关键词： Arabica Coffee Ministumps Clonal Propagation

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Bredemeyera floribunda Wild Elemental Content and Comparison with Nutritional Recommendation for Adults:Medicinal Plant Used by the Brazilian Rural Population to Treat Fatigue and Exhaustion

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American Journal of Plant Sciences 2020年第3期11卷 323-343页

作者： Paula Fabiana Saldanha Tschinkel Elaine Silva de Padua Melo Daniela Granja Arakaki Valdir Aragao do Nascimento Melina Ribeiro Fernandes Nayara Vieira Lima Luana Carolina Santos Leite Hugo Santos pereira Kassia Roberta Nogueira da Silva Francisco Jose Mendes dos Reis Valter Aragao do Nascimento Group of Spectroscopy and Bioinformatics Applied to Biodiversity and Health School of MedicinePostgraduation Program in Health and Development in the Midwest RegionFederal University of Mato Grosso do SulSchool of MedicineCampo GrandeBrazil Institute of Chemistry of the Federal University of Mato Grosso do Sul Campo GrandeBrazil

Bredemeyera floribunda Wild (Polygalaceae), also known as pau-de-ovo is a medicinal plant used to treat snakebites, as tonic and fortifiers to treat fatigue and exhaustion. The aim of the present study was to document the knowledge of herbal sellers in the preparation of the so-called “B. floribunda fortifier” and to compare the plant root content with the recommended nutritional values and the permitted limit for medicinal plants. The study revealed that, unlike other regions of Brazil, in the Midwest region, the root of the plant is used as food to treat fatigue and exhaustion. The contents in B. floribunda root decreased in the following order: Ca > K > P > Na > Fe > Mg > Si > Mn > Zn > Cu. Daily intake of 30 grams of B. floribunda roots are considered as an excellent source of Cr, Cu, Mn and Se for people 19 to 50 years of age according to the RDA. In addition, Cu and Fe showed content above the established limit for medicinal plants stipulated by other countries. The root of the plant has low K, Mg, P, Na and Zn content. When the contents in roots of the plant are below the oral dose of reference, consumption of this plant can be considered safe and without risk to human health. On the other hand, concentration of elements such as Cu, Fe, Ni, Al, Cr and Se exceeding the allowable limit may cause serious health problems due to prolonged ingestion and large amounts consumed daily. The Brazilian legislation does not establish a permissible limit of macro- and micro-elements in medicinal plants;thus, the results presented in this study will contribute to the Brazilian public health policy on medicinal plants.

关键词： Macroelements Microelements Bredemeyera floribunda Wild Pau-De-Ovo ICP OES

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Auditory Health and Risk Factors in Rural Workers Exposed to Pesticides in Piedade de Caratinga County-Minas Gerais

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Journal of Biosciences and Medicines 2017年第7期5卷 37-55页

作者： Paula Critina da Silva Botelho Valdênia Gomes Rocha Tamires Ribeiro Dutra Júlio César Alves Feitosa Ricardo Campos de Assis Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Daniel Almeida da Costa Lina Claudia pereira Lopes Lamara Laguardia Valente Rocha Department of Nursing University Center of Caratinga Caratinga Brazil Graduating in medicine University Center of Caratinga Caratinga Brazil Graduating in Psychology University Center of Caratinga Caratinga Brazil The Medical School at the Center of Higher Education of Valenca Valenca Brazil Department of Medicine Graduate Program in Medicine Faculty of Medicine of Valencia Brazil Speech Therapist The Medical School at the Center of Higher Education of Valenca Valenca Brazil Department of Morphology University Center of Caratinga Caratinga Brazil

In Brazil, the amount of pesticides consumed doubled in the last 10 years. Thus, in 2008 it assumed the lead position in the world. However, its indiscriminate application in agriculture without the use of the necessary care has contributed to environmental degradation and increased occupational exposures, making it a serious health problem in the country. The recent study looked to evaluate the auditory health and risk factors in rural workers exposed to pesticides in Piedade de Caratinga County—MG, and chart their socioeconomic profile and lifestyle while identifying the types of crops and the use and management of pesticides. Developed, then, a descriptive and exploratory study involving 23 men, rural workers, exposed to pesticides, with no history of exposure to noise, with changes in meatoscopy and aged ≤50 years of age. The results show the sample consisted of 23 men with a mean age of 36.7 ± 9.3, whom have low education, with a monthly income of 1 minimum wage, working in the fields for over 15 years. There was a predominance of horticulture using organophosphate pesticides and pyrethroids. Part of the sample shows auditory loss, the most common sensorineural conductive loss. It is essential that the population exposed to this type of risk is informed and receives guidance from educational campaigns developed by the multidisciplinary team of basic health units.

关键词： Auditory Health Pesticides Audiometry and Rural Workers

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Transcranial direct current stimulation in psychiatric disorders

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World Journal of Psychiatry 2015年第1期5卷 88-102页

作者： Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni Service of Interdisciplinary Neuromodulation Laboratory of Neurosciences (LIM-27)Department and Institute of PsychiatryUniversity of Sao Paulo Interdisciplinary Center for Applied Neuromodulation University HospitalUniversity of Sao Paulo Psychology Department Advanced School in NeuropsychologyUniversità degli Studi Milano Bicocca Department of Physiology Pharmacology and Neuroscience Sophie Davis School of Biomedical Education City University of New York (CUNY) Obsessive Compulsive Disorder Project (PROTOC) Department and Institute of PsychiatryUniversity of Sao Paulo Unit of Psychiatry Department of Neurosciences Reproductive and Odontostomatological Sciences University of Naples Federico II Université de Lyon Université Claude Bernard Lyon I Centre Hospitalier le Vinatier National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) Department of Psychiatry Department and Institute of PsychiatryUniversity of Sao Paulo Santa Casa de Sao Paulo Medical School Institute of Physical Medicine and Rehabilitation Clinics Hospital of the University of Sao Paulo Medical School

The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.

关键词： Non-invasive brain stimulation Transcranial direct current stimulation Psychiatry disorders Review

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Risk Factors Associated with Acinetobacter baumannii Infections in Patients in an Intensive Care Unit of a Public Hospital in Paraná

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Advances in Infectious Diseases 2022年第1期12卷 90-105页

作者： Mirian Carla Bortolamedi da Silva Maria Helena Brandeleiro Werlang Valdir Spada Júnior Guilherme Welter Wendt Ana Paula Vieira Franciele Ani Caovilla Follador Léia Carolina Lucio Cleide Viviane Busanello Martins Kérley Braga pereira Bento Casaril Paulo Cezar Nunes Fortes Lirane Elize Defante Ferreto Post-Graduante Program Health Sciences University of Wester Paraná (UNIOESTE) Francisco Beltr&#227 o Brazil State of the Health of Paraná (SESA-PR) Francisco Beltr&#227 o Brazil

To identify risk factors for A. baumannii infection in patients hospitalized in an Intensive Care Unit (ICU) of a tertiary public hospital in Paraná, Brazil, a retrospective paired case-control study (ratio 1:2) was conducted from January 2018 to December 2020. Patients in the case group were hospitalized in the ICU with A. baumanni (n = 68 cases) and were compared with patients in the control group, without infection by A. baumannii (n = 136). Both were matched by age (±10 years), sex, and ICU stay (±5 days). Conditional multiple logistic regression was used to determine statistically significant risk factors based on the results of bivariate analyses. Mortality was higher in infected (cases) than in non-infected patients (51.5% vs. 39.7%). The incidence and bacterial resistance increased annually. At bivariate analysis, cases had longer hospital stays (median 35 vs. 22 days, p A. baumannii and antimicrobial resistance. There is need for surveillance, and constant evaluation of control actions. Risk factors were colonization, previous hospitalization, and hospitalization time. This is essential for the decision-making of professionals and optimization of prevention, control, and therapeutic management actions.

关键词： Acinetobacter baumannii Risk-Factors Infection Intensive Care

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4种微波消融设备的比较:离体牛肝脏的实验研究

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国际医学放射学杂志 2013年第5期 469-470页

作者： R.Hoffmann H.Rempp L.Erhard G.Blumenstock P.L.pereira C.D.Claussen 董帜 Department of Diagnostic and Interventional Radiology Eberhard-Karls-University

摘要目的行离体牛肝脏实验,比较基于4种不同技术原理的商用微波消融治疗设备产生的凝固区体积、球度以及短轴直径,并建立相应的数学模型预测这些数值。方法 2种高功率设备(A和B)、1种可以同时使用3根微波天线的设备(C)和1种非灌注冷却... 详细信息

摘要目的行离体牛肝脏实验,比较基于4种不同技术原理的商用微波消融治疗设备产生的凝固区体积、球度以及短轴直径,并建立相应的数学模型预测这些数值。方法 2种高功率设备(A和B)、1种可以同时使用3根微波天线的设备(C)和1种非灌注冷却法的自动调节功率和频率的设备(D)分别在离体牛肝脏进行消融实验,共获得108个消融灶。测量各消融灶凝固组织体积、球度和平均短轴直径。建立适用于各设备的数学模型,测定决定系数(R2)。采用方差分析和Tukey检验方法分析比较5 min、10 min以及最大推荐消

关键词：离体牛肝短轴直径球度

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Advancing One Health education:integrative pedagogical approaches and their impacts on interdisciplinary learning

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Science in One Health 2024年第1期3卷 90-94页

作者： Chang Cai Yong-Sam Jung Richard Van Vleck pereira Michael S.M.Brouwer Junxia Song Bennie Irve Osburn Joanna McKenzie Wim H.M.van der Poel Yingjuan Qian MOE Joint International Research Laboratory of Animal Health and Food Safety College of Veterinary MedicineNanjing Agricultural UniversityNanjingChina One Health Laboratory College of Veterinary MedicineNanjing Agricultural UniversityNanjingChina School of Veterinary Medicine University of CaliforniaDavisCaliforniaUSA Wageningen Bioveterinary Research Wageningen University and ResearchLelystadThe Netherlands Food and Agriculture Organization of the United Nations(FAO)Headquarters RomeItaly Western Institute for Food Safety and Security University of CaliforniaDavisCaliforniaUSA School of Veterinary Science Massey UniversityPalmerston NorthNew Zealand

One Health is an integrative approach that emphasizes the interconnectedness of human,animal,and environmental health,advocating for collaborative,multidisciplinary efforts to address health challenges,particularly amid globalization and emerging *** paper examines the integration of One Health principles into global health education,highlighting the importance of interdisciplinary collaboration and innovative pedagogical *** evaluates various teaching methods,including problem-based learning(PBL),team-based learning(TBL),simulation-based education(SBE),case-based learning(CBL),interdisciplinary workshops and seminars(IWS),and service-learning(SL),analyzing their strengths and weaknesses in fostering interdisciplinary understanding and practical application of One Health *** these methods enhance learning by promoting critical thinking,collaboration,and real-world application,they also face challenges such as resource constraints,variability in group dynamics,and the complexity of assessing long-term learning *** paper also discusses the role of global partnerships,such as the Global One Health Research Partnership(GOHRP),in advancing One Health education through collaborative research and educational *** challenges in curriculum integration and interdisciplinary collaboration is crucial for the effective implementation of One Health education,ensuring that future health professionals are equipped to tackle complex global health challenges.

关键词： One Health education Interdisciplinary collaboration Global health integration Pedagogical approaches Curriculum integration Global partnerships

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Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study

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Reproductive and Developmental Medicine 2022年第2期6卷 98-103页

作者： Juliana Herrero da Silva Ana Claudia pereira Tercas-Trettel Juliano Andre Boquett Giovanny Vinicius Araujo Franca Augusto Cesar Cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia Nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini Prefeitura Municipal de Tangara da Serra Secretaria de SaudeVigilancia EpidemiologicaTangara da SerraBrazil Programa de Pos-Graduacao em Genetica e Biologia Molecular Universidade Federal do Rio Grande do SulPorto AlegreBrazil Universidade do Estado de Mato Grosso Tangara da SerraBrazil Programa de Pos-Graduagcao em Saude Coletiva Universidade Federal de Mato GrossoCuiabaBrazil Instituto Nacional de Genetica Medica Populacional-INaGeMP Servico de Genetica MedicaHospital de Clinicas de Porto Alegre(HCPA)Porto AlegreBrazil Programa de Pos-Graduacao em Saude da Crianga e do Adolescente Universidade Federal do Rio Grande do SulPorto AlegreBrazil Secretaria de Vigilancia em Saude Ministerio da SaudeBrasiliaBrazil Laboratorio de Visualizacao Avangada e Geoinformatica(VIZLab) Programa de Pos-Graduacao em Computacao AplicadaUniversidade do Vale do Rio dos SinosSao LeopoldoBrazil Programa de Pos-Graduacao em Ciencia da Informacao Universidade Federal do Rio Grande do SulPorto AlegreBrazil Clinica Santa Luzia Tangara da SerraBrazil

Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth ***::Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth ***::Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before ***::This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.

关键词： Epidemiology Live births Microcephaly Zika virus

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