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Polymeric hydrogels for burn wound care:Advanced skin wound dressings and regenerative templates

Burns & Trauma 2014年第4期2卷 153-161页

作者： marta madaghiele Christian Demitri Alessandro Sannino Luigi Ambrosio Department of Engineering for Innovation University of SalentoLecceRomeItaly Department of Chemicals Science and Materials Technology National Research Council of ItalyRomeItaly

Wound closure represents a primary goal in the treatment of very deep and/or large wounds,for which the mortality rate is particularly ***,the spontaneous healing of adult skin eventually results in the formation of epithelialized scar and scar contracture(repair),which might distort the tissues and cause lifelong deformities and *** clinical evidence suggests that wound closure attained by means of skin regeneration,instead of repair,should be the true goal of burn wound *** traditional concept of temporary wound dressings,able to stimulate skin healing by repair,is thus being increasingly replaced by the idea of temporary scaff olds,or regenerative templates,able to promote healing by *** wound dressings,polymeric hydrogels provide an ideal moisture environment for healing while protecting the wound,with the additional advantage of being comfortable to the patient,due to their cooling eff ect and non-adhesiveness to the wound *** importantly,recent advances in regenerative medicine demonstrate that bioactive hydrogels can be properly designed to induce at least partial skin regeneration in *** aim of this review is to provide a concise insight on the key properties of hydrogels for skin healing and regeneration,particularly highlighting the emerging role of hydrogels as next generation skin substitutes for the treatment of fullthickness burns.

关键词： Burns hydrogels skin regeneration wound healing wound dressing

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