Polymeric hydrogels for burn wound care:Advanced skin wound dressings and regenerative templates

作     者：Marta Madaghiele Christian Demitri Alessandro Sannino Luigi Ambrosio 

作者机构：Department of Engineering for InnovationUniversity of SalentoLecceRomeItaly Department of Chemicals Science and Materials TechnologyNational Research Council of ItalyRomeItaly 

出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)

年 卷 期：2014年第2卷第4期

页      面：153-161页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

主　　题：Burns hydrogels skin regeneration wound healing wound dressing 

摘      要：Wound closure represents a primary goal in the treatment of very deep and/or large wounds,for which the mortality rate is particularly ***,the spontaneous healing of adult skin eventually results in the formation of epithelialized scar and scar contracture(repair),which might distort the tissues and cause lifelong deformities and *** clinical evidence suggests that wound closure attained by means of skin regeneration,instead of repair,should be the true goal of burn wound *** traditional concept of temporary wound dressings,able to stimulate skin healing by repair,is thus being increasingly replaced by the idea of temporary scaff olds,or regenerative templates,able to promote healing by *** wound dressings,polymeric hydrogels provide an ideal moisture environment for healing while protecting the wound,with the additional advantage of being comfortable to the patient,due to their cooling eff ect and non-adhesiveness to the wound *** importantly,recent advances in regenerative medicine demonstrate that bioactive hydrogels can be properly designed to induce at least partial skin regeneration in *** aim of this review is to provide a concise insight on the key properties of hydrogels for skin healing and regeneration,particularly highlighting the emerging role of hydrogels as next generation skin substitutes for the treatment of fullthickness burns.