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Clinical-based phenotypes in children with pediatric post-COVID-19 condition

World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij Jelle M.Blankestijn Coen R.Lap marlies a.van houten Giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud I.Abdel-Aziz Johannes B.van Goudoever Mattijs W.Alsem Caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters Long COVID Pediatric Phenotypes Post-COVID syndrome

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The European Working Conditions Survey( EWCS) :a growing instrument: a reflection on the methodology,the reasons for and the use of the survey

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中国安全生产科学技术 2014年第S1期10卷 315-323页

作者： Agnès Parent-Thirion Greet Vermeylen Gijs van houten Jorge Cabrita Sophia Mac Goris Victoria Rahm Milos Kankaras Eurofound European Foundation for the Improvement of Living and Working Conditions

The European Working Conditions(the EWCS)Series Eurofound,the European Foundation for the improvement of working and living conditions is a European tripartite agency which contributes to the improvement of working and living conditions.A key instrument to do so is the *** EWCS aims to comparably measure working conditions across European countries and *** allows for the analysis of relationships between different aspects of working conditions,the identification of groups at risk and issues of concern,as well as areas of progress and the monitoring of trends over *** analyses contribute to European policy development,in particular on issues with regard to the quality of work and *** earlier editions of the EWCS in1991,1995,2000,2005 and 2010,a sixth wave of the survey will be fielded in *** develops the questionnaire and outlines the design of the survey as well as a strict quality assurance *** actual preparation and implementation of fieldwork is contracted *** development of the questionnaire is user *** users of the survey are key in setting priorities for *** questionnaire of the 6th EWCS maintain many trend questions which allow mapping changes over *** a number of new questions will be included in the 6th editions which cover recent changes in work,sustainability of work,boundaryless work,work life balance,organisational justice,engagement,sleeping problems,chronic diseases,blurring frontiers in employment *** over time On average there are little changes:this is because work situations and working conditions are becoming more diverse and inequalities in working conditions are *** average,workers work less and less workers work long *** also work less"atypical"working *** is taking place in more collective environment(clients,devolution of coordination tasks down to employee level etc.).Yet employment relations are more ***

关键词： EWCS questionnaire working conditions

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蠕虫在膜生物反应器和活性污泥法中的污泥减量研究

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环境科学学报 2004年第3期24卷 405-412页

作者：魏源送 R.T.van houten A.R.Borger D.H.Eikelboom 樊耀波雷开宇中国科学院生态环境研究中心水污染控制技术研究室北京100085 荷兰应用科学研究院环境能源和过程创新研究所厦门大学生命科学院厦门361005

通过长达345d的中试规模试验,研究比较了蠕虫在膜生物反应器(MBR)和活性污泥法(CAS)的生长状况及其导致的污泥减量效果.CAS中的蠕虫生长状况明显优于MBR的蠕虫生长状况.MBR曝气池中平均蠕虫密度(10条·mg-1)远低于CAS曝气池中平均蠕虫密... 详细信息

通过长达345d的中试规模试验,研究比较了蠕虫在膜生物反应器(MBR)和活性污泥法(CAS)的生长状况及其导致的污泥减量效果.CAS中的蠕虫生长状况明显优于MBR的蠕虫生长状况.MBR曝气池中平均蠕虫密度(10条·mg-1)远低于CAS曝气池中平均蠕虫密度(71条·mg-1),并且CAS中蠕虫连续保持高密度(>30条·mg-1)生长达***中红斑瓢体虫和仙女虫交替成为优势蠕虫.蠕虫生长对MBR的污泥产率(0 40kg·kg-1)和污泥沉降性能(污泥沉降指数133mL·g-1)影响很小,但却能显著减少CAS的污泥产率(0 17kg·kg-1)和改善污泥沉降性能(污泥沉降指数为60mL·g-1).仙女虫比红斑瓢体虫能更大地减少污泥产量和更好地改善污泥沉降性能.蠕虫生长不影响MBR的COD去除率和出水水质,但却显著影响CAS的COD去除率和出水水质.

关键词：蠕虫膜生物反应器活性污泥法 CAS 生物处理技术水质温度

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Respiratory distress due to malignant ascites palliated by hyperthermic intraperitoneal chemotherapy

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World Journal of Gastrointestinal Surgery 2015年第3期7卷 39-42页

作者： Marijn Marinus Leonardus van den houten Thijs Ralf van Oudheusden Michael Derek Philip Luyer Simon Willem Nienhuijs Ignace Hubertus Johannes Theodorus de Hingh Department of Surgery Catharina Hospital

Malignant ascites is a common symptom in patients with peritoneal cancer. Current assumption is that anincreased vascular permeability and obstruction of lymphatic channels lead to the accumulation of fluid in the abdominal cavity. This case report describes a severely symptomatic patient with malignant ascites. The previously healthy 73-year-old male was presented with abdominal distention causing respiratory distress. Computed tomography revealed large amounts of ascites, a recto-sigmoidal mass with locoregional lymphadenopathy and an omental cake. Biopsy taken during colonoscopy revealed an adenocarcinoma of the colon with signet cell differentiation. A widespread peritoneal carcinomatosis was found during a diagnostic laparoscopy. The extent of peritoneal disease rendered the patient not suitable for cytoreductive surgery with curative intent. The ascites proved to be refractory to ultrasound-guided paracentesis; thus, a decision was made to perform palliative hyperthermic intraperitoneal chemotherapy without cytoreductive surgery. Consequently, ascites production stopped, and the respiratory distress was relieved thereafter. The postoperative recovery was uneventful. Ascites recurred eight months later, and a second hyperthermic intraperitoneal chemotherapy procedure was performed. The patient was still alive at the time of writing, 16 mo after the initial diagnosis.

关键词： Ascites Intraperitoneal chemotherapy Palliative hyperthermic intraperitoneal chemotherapy Peritoneal carcinomatosis Colorectal cancer

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Synthesis and Luminescence Study of Europium Complexes with Carboxylic Acid and 1,10-Phenanthroline Ligands

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Chemical Research in Chinese Universities 1993年第3期9卷 181-187页

作者： QIAN Dong-jin and ZHANG Shu-zhen (Department of Chemistry, Shandong University, Jinan, 250100)CHEN Zhong (Department of Chemistry, Teacher s College, Yangzhou University, Yangzhou, 225002)J. van houten(Department of Chemistry, St. Michael’s College, Winooski Park, Colchester, VT05439, U. S. A. )

A series of euroPium(Ⅱ)eomPlexes with earboxylie aeids andl,10-Phenantl飞ro-line:Eu(L):·pllen·jHoO,wl:ereL-formate,3-hydroxy-4-metlloxybenzoate,4一metl、oxybenzoate,4一ehloroPhenoxyaeetate,and diPI、enylaeetate,were synthesizedand el、araeterized by elemental analysis,UV sPeetrum,IR speetrum and melting *** da亡a eonfirmed tllat euroPium 15 eoordinated wirh 0 donor atoms in earboxy!ie aeidand N donor atoms inl,10一phenanthroline.A strong ligand一loealized absorption at270 nm!ed to a series of meta!一eentered emission bands between 580 and 710 nm as-signedto ~5D_0-7F_(0.***.2.3.)

关键词： Europium complexes Synthesis Luminescence study

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情报传递的一些新发展

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情报学刊 1990年第3期11卷 234-238页

作者： R van houten 肖君沛肖克东

情报服务的主要功能是向用户预报各种文献中的有关情报,为用户查索并提供所需要的文献。计算机检索和传递文献已经付诸实践,通过一些情报经纪人和计算机化的图书馆网络来进行。当进行文献检索时,联机体系可提供全文文献,利用把论文全文... 详细信息

情报服务的主要功能是向用户预报各种文献中的有关情报,为用户查索并提供所需要的文献。计算机检索和传递文献已经付诸实践,通过一些情报经纪人和计算机化的图书馆网络来进行。当进行文献检索时,联机体系可提供全文文献,利用把论文全文记录在录象磁盘上的方式,一些主要的出版商进入了联机文献提供领域,然后,按照用户的需求检索特定的文献并提供各种原件复制本。进一步发展方向是通过宽带通信网络和新近发展起来的复印技术、传真及终端设备等,实现全文直接传输到用户家里(或办公地)的目的。

关键词：情报传递情报检索计算机

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情报传递的一些新发展

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技术与市场 1990年第3期 234-238页

作者： R van houten 肖君沛肖克东

关键词：磁盘录象电子式计算机外围设备录像最终用户情报

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Fluorescence Studies of Telomere Maintenance Proteins Reveal Protein-DNA Interaction Dynamics at the Single-molecule Level

Fluorescence Studies of Telomere Maintenance Proteins Reveal...

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第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Noah Buncher Greg Gibson Robert Keller Bennett van houten Simon C.Watkins Patricia L.Opresko Neil Kad Department of Environmental and Occupational Health University of Pittsburgh Graduate School of Public HealthPittsburghPA 15219 Center for Biologic Imaging University of PittsburghPittsburgh15261 Department of Biology University of EssexColchesterEssex C04 3SQ UK Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine The University of Pittsburgh Cancer Institute Hillman Cancer CenterPittsburghPennsylvania 15213 Department of Biology University of EssexColchesterEssex CO4 3SQ UK

Telomeres are nucleoprotein structures that cap the ends of linear *** telomeres are important contributing factors in aging and *** a typical human somatic cell,the telomeric repeat sequence TTAGGG is approximately 2-15 kb in length with a 3' single stranded overhang of 100-200 nt.A specialized protein complex called shelterin binds and protects the human telomeric *** humans,this

关键词： Telomere single-molecule fluorescence atomic force microscopy protein-DNA interactions TRF2

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IEC/TC111 HWG3样品拆分工作组介绍

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信息技术与标准化 2006年第12期 15-16页

作者： Maarten ten houten 样品拆分工作组

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Micron-gap spacers with ultrahigh thermal resistance and mechanical robustness for direct energy conversion Samuel

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Microsystems & Nanoengineering 2019年第1期5卷 344-355页

作者： M.Nicaise Chen Lin Mohsen Azadi Tara Bozorg-Grayeli Promise Adebayo-Ige Drew E.Lilley Yann Pfitzer Wujoon Cha Kyana.van houten Nicholas A.Melosh Roger T.Howe Jared W.Schwede Igor Bargatin Mechanical Engineering and Applied Mechanics University of PennsylvaniaPhiladelphiaPA 19104USA Materials Science&Engineering Stanford UniversityStanford 94305 CAUSA Chemical and Biomolecular Engineering University of PennsylvaniaPhiladelphiaPAUSA Spark Thermionics BerkeleyCA 94720USA Electrical Engineering Stanford UniversityStanfordCA 94305USA

In thermionic energy converters,the absolute efficiency can be increased up to 40%if space-charge losses are eliminated by using a sub-10-μm gap between the *** practical way to achieve such small gaps over large device areas is to use a stiff and thermally insulating spacer between the two *** report on the design,fabrication and characterization of thin-film alumina-based spacers that provided robust 3–8μm gaps between planar substrates and had effective thermal conductivities less than those of *** spacers were fabricated on silicon molds and,after release,could be manually transferred onto any *** large-scale compression testing,they sustained compressive stresses of 0.4–4 MPa without ***,the thermal conductance was 10–30 mWcm^(−2)K^(−1)and,surprisingly,independent of film thickness(100–800 nm)and spacer *** explain this independence,we developed a model that includes the pressure-dependent conductance of locally distributed asperities and sparse contact points throughout the spacer structure,indicating that only 0.1–0.5%of the spacerelectrode interface was conducting *** spacers show remarkable functionality over multiple length scales,providing insulating micrometer gaps over centimeter areas using nanoscale *** innovations can be applied to other technologies requiring high thermal resistance in small spaces,such as thermophotovoltaic converters,insulation for spacecraft and cryogenic devices.

关键词： thermal resistance film

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