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Epidural pressure measurement using a fiber-optic sensor(proof-of-principle in vivo animal trial)

Animal models and Experimental medicine 2024年第5期7卷 769-776页

作者： Susanne Barz marvin Friedemann Sebastian Voigt markus melloh Thomas Barz Department of Anaesthesiology Intensive Care Medicine and Pain TherapyRostock University Medical CenterUniversitätsmedizin RostockRostockGermany Chemnitz University of Technology ChemnitzGermany School of Public Health and Social Work Queensland University of TechnologyBrisbaneQueenslandAustralia Orthopedic Department University of GreifswaldGreifswaldGermany

Background:An increase in epidural pressure around the stenosis has been observed in patients with lumbar spinal stenosis(LSS)with positive signs of sedimentation or redundant nerve *** analysis of the pressure conditions in the stenotic area would be of great *** hypothesized that it would be possible to determine the physiological parameters of the epidural pulse wave and its course in pathological stenosis as a basis for objective identification of LSS based on pressure using a new measuring method with continuous spatial and temporal ***:We performed a single-case proof-of-principle in vivo animal trial and used a newly developed hybrid pressure-measurement probe with a fiber-tip Fabry-Pérot interferometer and several fiber Bragg gratings(FBG).Results:With reproducible precision,we determined the mean epidural pressure to be 7.5 mmHg and the peak-to-peak value to be 4-5 *** analyzing the pres-sure measured by an FBG array,both the heart and respiratory rates can be precisely *** study was the first to measure the pulse wave velocity of the cer-ebrospinal fluid pressure wave as 0.97 m/s using the newly developed pressure probe.A simulated LSS was detected in real time and located ***:The developed fiber-optic pressure sensor probe enables a new objec-tive measurement of epidural *** confirmed our hypothesis that physiologi-cal parameters of the epidural pulse wave can be determined and that it is possible to identify an LSS.

关键词： animal cerebrospinal fluid pressure pulse wave velocity spinal stenosis

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Ultrafast imaging of terahertz electric waveforms using quantum dots

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Light(Science & Applications) 2022年第1期11卷 63-68页

作者： moritz B.Heindl Nicholas Kirkwood Tobias Lauster Julia A.Lang markus Retsch Paul mulvaney Georg Herink Experimental Physics VIII-Ultrafast Dynamics University of BayreuthBayreuthGermany ARC Centre of Excellence in Exciton Science School of ChemistryUniversity of MelbourneMelbourneAustralia Physical Chemistry I University of BayreuthBayreuthGermany

microscopic electric fields govern the majority of elementary excitations in condensed matter and drive electronics at frequencies approaching the Terahertz(THz)***,only few imaging schemes are able to resolve sub-wavelength fields in the THz range,such as scanning-probe techniques,electro-optic sampling,and ultrafast electron ***,intrinsic constraints on sample geometry,acquisition speed and field strength limit their ***,we harness the quantum-confined Stark-effect to encode ultrafast electric near-fields into colloidal quantum dot *** approach,termed Quantum-probe Field microscopy(QFIm),combines far-field imaging of visible photons with phase-resolved sampling of electric *** capturing ultrafast movies,we spatio-temporally resolve a Terahertz resonance inside a bowtie antenna and unveil the propagation of a Terahertz waveguide excitation deeply in the sub-wavelength *** demonstrated QFIm approach is compatible with strong-field excitation and sub-micrometer resolution—introducing a direct route towards ultrafast field imaging of complex nanodevices inoperando.

关键词： antenna waveguide quantum

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Biliary tract cancer stem cells-translational options and challenges

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World Journal of Gastroenterology 2017年第14期23卷 2470-2482页

作者： Christian mayr matthias Ocker markus Ritter martin Pichler Daniel Neureiter Tobias Kiesslich Department of Internal medicine I Paracelsus Medical University Laboratory for Tumour Biology and Experimental Therapies Institute of Physiology and PathophysiologyParacelsus Medical University Tanslational medicine Oncology Department of Gastroenterology CBF CharitéUniversity Medicine Berlin Laboratory for Tumour Biology and Experimental Therapies(TREAT) Laboratory for Functional and Molecular Membrane PhysiologyParacelsus Medical University Department for Radon Therapy Research Ludwig Boltzmann Cluster for Arthritis and RehabilitationInstitute of Physiology and PathophysiologyParacelsus Medical University Research Unit for Non-coding RNA and genome editing in cancer Division of OncologyDepartment of Internal MedicineMedical University of Graz Institute of Pathology Paracelsus Medical University Cancer Cluster Salzburg

management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells-the cancer stem cells-possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells.

关键词： Biliary tract cancer cancer stem cells Cancer stem cell markers Tumor microenvironment micro-RNAs

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Study of the influence of pavement unevenness on the mechanical response of asphalt pavement by means of the finite element method

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第3期5卷 169-180页

作者： Pengfei Liu Visaagan Ravee Dawei Wang markus Oeser Institute of Highway Engineering RWTH Aachen University School of Transportation Science and Engineering Harbin Institute of Technology

Pavement unevenness affects the vehicle operating cost, speed, riding comfort, safety, pavement service life and etc. The current mechanistic-empirical （m-E） design procedure of asphalt pavements is based on the computational model of a flat pavement instead of uneven pavement as it is the case in reality. In this paper, a tire-pavement-interaction FE model is developed to investigate the influence of pavement unevenness on the mechanical responses of asphalt pavements. For both winter and summer conditions, the strain at the bottom of the asphalt layer due to the tire load is found to decrease as the wavelength of the unevenness increases. moreover, the strain is larger at lower speeds and decreases as the speed increases. It is found that the stress levels are higher in summer conditions than under winter conditions for the same pavement irrespective of wavelength. The fatigue life increases with increase in speed of the tire for a pavement and also increases with increase in the wavelength of the pavement unevenness. The results indicate that pavement unevenness significantly influence the mechanical responses of asphalt pavements and thus influences the service life of asphalt pavements. As a result, the current m-E design algorithm of asphalt pavements should be modified to consider the pavement unevenness to allow better design processes for asphalt pavement.

关键词： Pavement Unevenness mechanics Finite element method (YEm) Interaction

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Prevention of thromboembolic events after radical prostatectomy in patients with hereditary thrombophilia due to a factor V Leiden mutation by multidisciplinary coagulation management

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Asian Journal of Urology 2024年第1期11卷 42-47页

作者： Randi m.Pose Sophie Knipper Jonas Ekrutt mara Kölker Pierre Tennstedt Hans Heinzer Derya Tilki Florian Langer markus Graefen martini-Klinik Prostate Cancer Centre University Hospital Hamburg-EppendorfGermany Department of Urology University Hospital Hamburg-EppendorfGermany Department of Hematology and Oncology University Medical Centre Hamburg-EppendorfHamburgGermany

Objective:To examine the perioperative impact of factor V Leiden mutation on thromboembolic events'risk in radical prostatectomy(RP)*** an incidence of about 5%,factor V Leiden mutation is the most common hereditary hypercoagulability among Caucasians and rarer in *** increased risk of thromboembolic events is three-to seven-fold in heterozygous and to 80-fold in homozygous ***:Within our prospectively collected database,we analysed 33006 prostate cancer patients treated with RP between December 2001 and December *** those,patients with factor V Leiden mutation were *** patients received individualised recommendation of haemostaseologists for perioperative *** complications(deep vein thrombosis and pulmonary embolism)were assessed during hospital stay,as well as according to patient reported outcomes within the first 3 months after ***:Overall,85(0.3%)patients with known factor V Leiden mutation were *** age was 65(interquartile range:61-68)*** was at least one thrombosis in 53(62.4%)patients and 31(36.5%)patients had at least one embolic event in their medical history before *** all 85 patients with factor V Leiden mutation,we experienced no thromboembolic complications within the first 3 months after ***:In our cohort of patients with factor V Leiden mutation,no thromboembolic events were observed after RP with an individualised perioperative coagulation management *** may reassure patients with this hereditary condition who are counselled for RP.

关键词： Prostatecancer Prostatectomy Factor V Leiden mutation Thromboembolism Thrombophilia

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Fatigability Assessment Using the Fatigue Index Kliniken Schmieder (FKS) Is Not Compromised by Depression

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Health 2016年第14期8卷 1485-1494页

作者： Christian Dettmers markus Riegger Oliver müller manfred Vieten Kliniken Schmieder Konstanz Konstanz Germany Lurija Institut Kliniken Schmieder Allensbach Konstanz Germany Sportwissenschaften Universit?t Konstanz Konstanz Germany Zentrum für Psychiatrie Reichenau Konstanz Germany

Background: Attractor-based kinematic gait analysis using the Fatigue Index Kliniken Schmieder (FKS), have been suggested as a sensitive tool to determine motor fatigability in persons with multiple Sclerosis (pwmS). Hypothesis: Depression does not affect the FKS to a similar degree as in pwmS. methods: We recruited 32 patients with major depression. Data were collected with two accelerometers attached to both ankles. Data were recorded for one minute at the beginning and at the end of the treadmill test. Attractor attributes were used to analyze the data. Results: The mean Fatigue Index Kliniken Schmieder (FKS) was 2.1. The change of the attractor (δm) was 3.7 and the change of variability (δD) was 0.6. mean values were clearly below values of pwmS with fatigability from a previous publication. However, the individual level values from six individuals—five of them showed pain related comorbidity besides depression—fell within the lower pathological range. There was no correlation between Hamilton depression scale and the attractor attributes (δm and δD). Discussion: Depression does not affect gait as motor fatigability does in pwmS. Results from subjects with pain during the treadmill test show a moderately increased variability and moderately altered attractors.

关键词： Accelerometer Assessment Attractor Depression Fatigue Gait Analysis Fatigability multiple Sclerosis

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含Benzo[a]azulene单元的锯齿状梯形共轭聚合物的表面在位合成

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物理化学学报 2024年第8期40卷 1-3页

作者：吴名辉 markus mühlinghaus 李雪超徐超婕陈强张海明 Klaus müllen 迟力峰江苏省碳基功能材料与器件重点实验室苏州大学功能纳米与软材料研究院江苏苏州215123 马克斯ꞏ普朗克高分子研究所美因茨55128德国

梯形共轭聚合物(CLPs)因其独特的光电性质而受到广泛关注。绝大多数CLPs是通过溶液方法合成的,但近年来,在超高真空环境中进行的表面原位合成策略逐渐崭露头角,成为CPL合成的新方法。表面原位合成方法能够克服传统溶液合成的限制,如随... 详细信息

梯形共轭聚合物(CLPs)因其独特的光电性质而受到广泛关注。绝大多数CLPs是通过溶液方法合成的,但近年来,在超高真空环境中进行的表面原位合成策略逐渐崭露头角,成为CPL合成的新方法。表面原位合成方法能够克服传统溶液合成的限制,如随着聚合度增加而受限的溶解度和结构稳定性,从而实现复杂共轭结构的精确合成。Azulene衍生物是在表面合成非苯型CLPs的有吸引力的前体。与传统的只含六元环的CLPs相比,使用烷基取代的azulene作为前体分子,有望获得具有复杂骨架结构的CLPs,从而调控其电子性质,但目前很少有人探索这种策略。本文报道了3,3'-二溴-2,2’-二甲基-1,1’-联薁(DBmA)在Au(111)表面上的热化学反应。在室温的Au(111)衬底上,我们发现沉积的分子在重构表面的fcc(面心立方堆积)区域形成无定型的聚集体,并在100℃以下保持形貌不变。当退火温度高于150℃后,DBmA发生脱溴反应并与金原子络合形成具有复杂空间立体结构的2,2’-二甲基-1,1’-联薁有机金属聚合物,并展现出迥异的图像特征。随后在更高温度下退火,有机金属聚合物脱去金属原子并经历碳碳偶联反应。该过程伴随着甲基与相邻薁单元之间的分子内环化反应,形成了含有benzo[a]azulene单元的梯形共轭聚合物。有趣的是,我们发现当一侧甲基参与反应并在聚合物中形成六元环时,会显著地弯折聚合物链,使得另一侧甲基与薁单元之间的距离增加,并抑制预期的环化过程。我们通过键分辨扫描探针显微镜对反应过程中的相关结构进行了研究,发现反应结果与反应中间结构的应力关联紧密。我们的结果表明,烷基取代的azulene前体可应用于非苯型碳纳米结构的表面合成,并有望实现扩展的非苯型二维碳纳米结构。

关键词：表面在位合成薁非苯型碳纳米结构梯形共轭聚合物扫描探针显微镜键分辨原子力显微镜

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mOVPE-grown AlGaN-based tunnel heterojunctions enabling fully transparent UVC LEDs

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Photonics Research 2019年第5期7卷 I0008-I0012页

作者： Christian Kuhn Luca Sulmoni martin Guttmann Johannes Glaab Norman Susilo Tim Wernicke markus Weyers michael Kneissl Technische Universitat Berlin Institute of Solid State Physics Hardenbergstr. 36 EW6-1 10623 Berlin Germany Ferdinand-Braun-Institut Leibniz-Institut fur Hochstfrequenztechnik Gustav-Kirchhoff-Str. 4 12489 Berlin Germany

We report on AlGaN-based tunnel heterojunctions grown by metalorganic vapor phase epitaxy enabling fully transparent UVC LEDs by eliminating the absorbing p-AlGaN and p-GaN layers. Furthermore, the electrical characteristics can be improved by exploiting the higher conductivity of n-AlGaN layers as well as a lower resistance of n-contacts. UVC LEDs with AlGaN:mg/AlGaN:Si tunnel junctions exhibiting single peak emission at268 nm have been realized, demonstrating effective carrier injection into the AlGaN multiple quantum well active region. The incorporation of a low band gap interlayer enables effective tunneling and strong voltage ***, the interlayer thickness is systematically varied. Tunnel heterojunction LEDs with an 8 nm thick GaN interlayer exhibit continuous-wave emission powers >3 m W near thermal rollover. External quantum efficiencies of 1.4% at a DC current of 5 m A and operating voltages of 20 V are measured on-wafer. Laterally homogeneous emission is demonstrated by UV-sensitive electroluminescence microscopy images. The complete UVC LED heterostructure is grown in a single epitaxy process including in situ activation of the magnesium acceptors.

关键词： mOVPE-grown AlGaN-based UVC LEDs

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Hyper spectral resolution stimulated Raman spectroscopy with amplified fs pulse bursts

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Light(Science & Applications) 2024年第3期13卷 566-576页

作者： Hongtao Hu Tobias Flöry Vinzenz Stummer Audrius Pugzlys markus Zeiler Xinhua Xie Aleksei Zheltikov Andrius Baltuška Photonics Institute Technische Universität WienGußhausstraße 27-29Vienna A-1040Austria SwissFEL Paul Scherrer InstituteVilligen PSI 5232Switzerland Institute for Quantum Science and Engineering Department of Physics and AstronomyTexas A&M UniversityCollege StationTX 77843USA

We present a novel approach for Stimulated Raman Scattering(SRS)spectroscopy in which a hyper spectral resolution and high-speed spectral acquisition are achieved by employing amplified offset-phase controlled fs-pulse *** investigate the method by solving the coupled non-linear Schrödinger equations and validate it by numerically characterizing SRS in molecular nitrogen as a model *** spectral resolution of the method is found to be determined by the inverse product of the number of pulses in the burst and the intraburst pulse *** SRS spectrum is obtained through a motion-free scanning of the offset phase that results in a sweep of the Raman-shift *** to high spectral resolution and fast motion-free scanning the technique is beneficial for a number SRS-based applications such as gas sensing and chemical analysis.

关键词： compound spectral resolution

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Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

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Cellular & molecular Immunology 2017年第12期14卷 986-996页

作者： Philipp Blüm Joachim Pircher monika merkle Thomas Czermak Andrea Ribeiro Hanna mannell Florian Krötz Alexander Hennrich michael Spannagl Simone Köppel Erik Gaitzsch markus Wörnle medizinische Klinik und Poliklinik IV InnenstadtKlinikum der Universität München80336 MünchenGermany Walter Brendel Centre of Experimental medicine and munich Heart Alliance Ludwig Maximilians University München80336 MünchenGermany medizinische Klinik und Poliklinik I Klinikum der Universität München80336 MünchenGermany Abteilung für Transfusionsmedizin Zelltherapeutika und HämostaseologieKlinikum der Universität München80336 MünchenGermany

Hepatitis C virus(HCV)infection is a major problem *** is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is ***:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in *** procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet *** addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HmC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as *** protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HmC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HmC but not in *** vivo,protein C inhibits poly(I:C)-induced arteriolar ***,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral ***,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection.

关键词： hepatitis C thrombosis toll-like receptor 3

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