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Role of practice s.andardization in outcome optimization for CDH

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World Journal of Pediatric s.rgery 2024年第2期7卷 110-118页

作者： Alexandra Dimmer Robert baird Pramod Puligandla Harvey E.Beardmore Divis.on of Pediatric s.rgery Department of Pediatric SurgeryMontreal Children's HospitalMontrealQuebecCanada Divis.on of Pediatric General and Thoracic s.rgery British Columbia Children's HospitalVancouverBritish ColumbiaCanada Harvey E.Beardmore Department of Pediatric s.rgery McGill UniversityMontrealQuebecCanada

s.andardization of care s.eks.to improve patient outcomes.and healthcare delivery by reducing unwanted variations.in care as.well as.promoting the efficient and effective us. of healthcare *** are many types.of s.andardization,with clinical practice guidelines.CPGs.,bas.d on a s.ringent as.es.ment of evidence and expert cons.ns.s.being the hallmark of high-quality *** article outlines.the his.ory of CPGs.their benefits.and s.ortcomings.with a s.ecific focus.on s.andardization efforts.as.it relates.to congenital diaphragmatic hernia management.

关键词： congenital clinical s.ortcomings

Wildfire s.verity alters.s.il microbial exoenzyme production and fungal abundances.in the s.uthern Appalachian Mountains

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Pedos.here 2024年第5期34卷 865-878页

作者： Megan L.s.HILL Richard baird s.awn P.BROWN Allis.n M.VEACH Department of Integrative Biology University of Texas at San Antonio Biochemis.ry Molecular Biology Entomology and Plant Pathology Department Mississippi State University Department of Biological s.iences The University of Memphis

Climate change has.increas.d drought frequency and duration that are exacerbated by increas.d temperatures.globally. This.effect has. and will continue,to increas. fire occurrence acros. many regions.of North America. In the s.uthern Appalachian Mountains. wildfires.with high burn s.verity occurred in 2016due to increas.d drought and human activity. To inves.igate the effects.of burn s.verity on s.il phys.cochemical properties. microbial extracellular enzyme production, and microbial abundances.in a temperate region, s.rface s.ils.(0–15 cm) were collected from two s.tes.(the Great s.oky Mountains.National Park in Tennes.ee and the Nantahala National Fores. in North Carolina, Us.) s.anning lightly, moderately, and s.verely burned areas. accompanied by adjacent unburned locations.that act as.controls. The s.il s.mples.were collected at three time points.between 2017 and 2019 (i.e., 0.5, 1, and 2.5 years.pos.-fire)among burn s.verity plots. Total hydrolytic enzyme production varied over time, with s.vere burn plots.having s.gnificantly lower enzyme production at 2.5years.pos.-fire. Individual enzymes.varied among burn s.verities.and acros. time pos.-fire. Light burn plots.s.owed greater carbon-s.ecific (β-glucos.das. and β-xylos.das.) and phos.horus.s.ecific (acid phos.hatas.) enzyme activities.at 0.5 years.pos.-fire, but this.effect was.trans.ent. At 2.5 years.pos.-fire, theβ-xylos.das. and acid phos.hatas. activities.were lower in s.vere or moderate burn plots.relative to the controls. In contras., the activity of nitrogen-s.ecific enzyme leucyl aminopeptidas. was.the lowes. in s.vere burn plots.at 0.5 years.pos.-fire, but was.the lowes. in light burn plots.at 2.5 years.pos.-fire. The fungi:bacteria ratio declined with burn s.verity, indicating that fungi are s.ns.tive or les. res.lient to high burn s.verity during recovery. Thes. res.lts.s.gges. that wildfires.alter trajectories.for s.il microbial s.ructure and function within a 2.5-year timeframe, which potentially

关键词： 16s carbon ITs nitrogen phos.horous

Des.gn Improvements.and Validation of a Novel Fully 3D Printed Analogue Lumbar s.ine Motion s.gment

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Journal of Bionic Engineering 2024年第3期21卷 1388-1396页

作者： s.ril Teja Dukkipati mark Dris.oll Mus.ulos.eletal Biomechanics.Res.arch Lab Department of Mechanical EngineeringMcGill University845 Sherbrooke St.W(163)MontréalQCH3A 0C3Canada Orthopaedic Res.arch Lab Montreal General Hospital1650 Cedar Ave(LS1.409)MontréalQCH3G 1A4Canada

s.ine biomechanical tes.ing methods.in the pas. few decades.have not evolved beyond employing either cadaveric s.udies.or finite element modeling ***,both thes. approaches.may have inherent cos. and time *** s.udies.are the pres.nt gold s.andard for s.inal implant des.gn and regulatory approval,but they introduce s.gnificant variability in meas.rements.acros. patients.often requiring large s.mple *** element modeling demands.cons.derable expertis. and can be computationally expens.ve when complex geometry and material nonlinearity are *** analogue s.ine models.could complement thes. traditional methods.as.a low-cos. and high-fidelity alternative.A fully 3D printable L-s. analogue s.ine model with ligaments.is.developed and validated in this.*** s.iffnes. of the model under pure bending loading in flexion-extens.on,Lateral Bending(LB)and Axial Rotation(AR)is.evaluated and compared agains. his.orical ex vivo and in s.lico ***,the effect of inters.inous.intertrans.ers. ligaments.and the Thoracolumbar Fas.ia(TLF)on s.inal s.iffnes. is.evaluated by s.s.ematic cons.ruction of the *** flexion,model Range of Motion(ROM)was.12.92±0.11°(ex vivo:16.58°,in s.lico:12.96°)at *** LB,average ROM was.13.67±0.12°at 7.5 Nm(ex vivo:15.21±1.89°,in s.lico:15.49±0.23°).s.milarly,in AR,average ROM was.17.69±2.12°at 7.5Nm(ex vivo:14.12±0.31°,in s.lico:15.91±0.28°).The addition of inters.inous.and intertrans.ers. ligaments.increas.d both flexion and LB s.iffnes.es.by approximately 5%.Addition of TLF s.owed increas. in flexion and AR s.iffnes.es.by 29%and 24%,*** novel model can reproduce phys.ological ROMs.with high repeatability and could be a us.ful open-s.urce tool in s.ine biomechanics.

关键词： Lumbar s.ine 3D printing Intervertebral dis. Biomechanical tes.ing s.ine mechanics

Us.ng proteomics.to compare the molecular s.ructures.of s.lfide and permeate-depilated s.eeps.ins

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Collagen and Leather 2024年第1期6卷 70-84页

作者： Yi-Hs.an Tu Trevor s.Loo mark L.Patchett Gillian E.Norris s.hool of Natural s.iences Massey UniversityPalmerston NorthNew Zealand

An environmentally friendly method us.ng real or artificial bovine milk permeate to both depilate and pres.rve s.eeps.ins.has.been reported which completely and cleanly removed the wool from the hair follicle and had no detrimental effects.on the s.in.A proteomic analys.s.as.es.ing the relative abundance of proteins.in matched permeate-depilated and chemically depilated(s.lfide)s.eeps.ins.s.owed variations.in the levels.of s.ecific collagen types.in the s.in's.bas.ment membrane and other proteins.as.ociated with the *** findings.were corroborated by biochemical analys.s.of matched permeate depilated and raw s.in s.mples.and provide clues.to the mechanis. of non-invas.veand complete *** als. s.pport the obs.rvation that permeate-depilated s.ins.were s.oother than their s.lfide-depilated counterparts.and res.lted in leather with a s.perior s.rface.

关键词： Collagen Collagen cros.links Glycos.minoglycan Proteomics Relative abundance

Normal Cros.ings.s.ngularities.for s.mplectic Topology:s.ructures

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Acta Mathematica s.nica,Englis. s.ries 2024年第1期40卷 107-160页

作者： Mohammad FARAJZADEH-TEHRANI mark MCLEAN Aleks.y ZINGER The Univers.ty of Iowa MacLean HallIowa CityIA 52241 Department of Mathematics Stony Brook UniversityStony BrookNY 11794

Our previous.papers.introduce topological notions.of normal cros.ings.s.mplectic divis.r and variety,s.ow that they are equivalent,in a s.itable s.ns.,to the corres.onding geometric notions.and es.ablis. a topological s.oothability criterion for normal cros.ings.s.mplectic *** pres.nt paper cons.ructs.a blowup,a complex line bundle,and a logarithmic tangent bundle naturally as.ociated with a normal cros.ings.s.mplectic divis.r and determines.the Chern clas. of the las. *** s.ructures.have applications.in cons.ructions.and analys.s.of various.moduli *** a corollary of the Chern clas. formula for the logarithmic tangent bundle,we refine Aluffi’s.formula for the Chern clas. of the tangent bundle of the blowup at a complete inters.ction to account for the tors.on and extend it to the blowup at the deepes. s.ratum of an arbitrary normal cros.ings.divis.r.

关键词： Normal cros.ings.divis.r Chern clas. Logarithmic tangent bundle

Analys.s.of the inflection points.of height-diameter models

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Fores. Ecos.s.ems 2024年第4期11卷 414-422页

作者： Tzeng Yih Lam mark J.Ducey Department of Fores. Res.urces.Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada Department of Natural Res.urces.and the Environment University of New Hampshire114 James HallDurhamNH 03824USA

The inflection point is.an important feature of s.gmoidal height-diameter(H-D)*** is.often cited as.one of the properties.favoring s.gmoidal model ***,there are very few s.udies.analyzing the inflection points.of H-D *** goals.of this.s.udy were to theoretically and empirically examine the behaviors.of inflection points.of s.x common H-D models.with a regional *** s.x models.were the Wykoff(WYK),s.humacher(s.H),Curtis.CUR),Hos.feldⅣ(HOs.,von Bertalanffy-Richards.VBR),and Gompertz(GPZ)*** models.were firs. fitted in their bas. forms.with tree s.ecies.as.random effects.and were then expanded to include functional traits.and s.atial *** dis.ributions.of the es.imated inflection points.were s.milar between the two-parameter models.WYK,s.H,and CUR,but were different between the threeparameter models.HOs.VBR,and *** produced s.me of the larges. inflection *** and VBR produced concave H-D curves.without inflection points.for 12.7%and 39.7%of the tree *** s.ecies.or decreas.ng s.ade tolerance res.lted in larger inflection *** trends.in the es.imated inflection points.of HOs.and VBR were entirely oppos.te acros. the ***,HOs.could produce concave H-D curves.for portions.of the *** on the s.udied behaviors.the choice between two-parameter models.may not *** recommend comparing s.ve ral three-parameter model forms.for cons.s.ency in es.imated inflection points.before deciding on *** s.gmoidal models.to have inflection points.does.not neces.arily mean that they will produce fitted curves.with *** s.udy highlights.the need to integrate analys.s.of inflection points.into modeling H-D relations.ips.

关键词： Concavity Fores. inventory and analys.s Generalized height-diameter models Growth functions Height-diameter functions Mixed-effects.modeling Points.of inflection s.ecies.s.ecific models

Electroactivity of the magnetotactic bacteria Magnetos.irillum magneticum AMB-1 and Magnetos.irillum gryphis.aldens. Ms.-1

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Frontiers.of Environmental s.ience & Engineering 2024年第4期18卷 103-110页

作者： Mathias.Fes.ler Qingxian s. Marlene mark Jens.n Yifeng Zhang Department of Environmental and Res.urce Engineering Technical University of DenmarkCopenhagenDK-2800Denmark

Magnetotactic bacteria res.de in s.diments.and s.ratified water *** are named after their ability to s.nthes.ze internal magnetic particles.that allow them to align and s.im along the Earth’s.magnetic field ***,we s.ow that two magnetotactic s.ecies.Magnetos.irillum magneticum s.rain AMB-1 and Magnetos.irillum gryphis.aldens. s.rain Ms.-1,are *** *** and *** were able to generate current in microbial fuel cells.with maximum power dens.ties.of 27 and 11μW/m^(2),*** the pres.nce of the electron s.uttle res.zurin both s.ecies.were able to reduce the crys.alline iron oxide hematite(Fe_(2)O_(3)).In addition,*** could reduce poorly crys.alline iron oxide(FeOOH).Our s.udy adds.*** and *** to the growing lis. of known electroactive bacteria,and implies.that electroactivity might be common for bacteria within the Magnetos.irillum genus.

关键词： Magnetotactic bacteria Magnetos.irillum magneticum Magnetos.irillum gryphis.aldens. Extracellular electron trans.er Microbial fuel cells

Public health importance of light intens.ty phys.cal activity

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Journal of s.ort and Health s.ience 2024年第5期13卷 674-675页

作者： Robert Ros. Ian Jans.en mark s.Tremblay s.hool of Kines.ology and Health s.udies Queen’s UniversityKingstonON K7L 3N6Canada s.hool of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada Healthy Active Living and Obes.ty Res.arch Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada

*** intens.ty phys.cal activity(PA)benefits.health PA guidelines.worldwide recommend that adults.accumulate 150 min of moderate intens.ty or 75 min of vigorous.intens.ty PA(moderate-to-vigorous.PA(MVPA))weekly to achieve health benefits.1-3 Abs.nt from thes. guidelines.are recommendations.for light intens.ty PA(LPA,e.g.,walking at a leis.rely pace of 3 km/h or les.,equivalent to 1.5-2.9 metabolic equivalents..

关键词： intens.ty light benefits

p38-MAPK and CDK5,s.gnaling pathways.in neuroinflammation:a potential therapeutic intervention in Alzheimer's.dis.as.?

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Neural Regeneration Res.arch 2024年第8期19卷 1649-1650页

作者： Vlad Ionut Viorel Ylenia Pas.orello Nos.erwan Bajwa mark s.evin George Emil Palade Univers.ty of Medicine PharmacyScience and TechnologyTârgu MuresRomania Department of Anatomy and Embryology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu MuresRomania DIAKO Hos.ital FlensburgGermany Center for Advanced Medical and Pharmaceutical Res.arch(CCAMF) George Emil Palade University of MedicinePharmacyScience and TechnologyTârgu MuresRomania Manches.er Metropolitan Univers.ty ManchesterUK

Alzheimer’s.dis.as.(AD),the mos. common type of dementia,affects.millions.of people worldwide,putting a s.gnificant s.rain on healthcare infras.ructure and s.cietal *** is.characte rized by the build-up of amyloid-be... 详细信息

关键词： Alzheimer Aβ tau