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Contribution of molecular cladistics to the taxonomy of Rutaceae in China

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Journal of Systematics and Evolution 2009年第2期47卷 144-150页

作者： paul pui-Hay BUT Alice Wing-Sem pOON pang-Chui SHAW mark p.simmons Harald GREGER Department of Biology Chinese University of Hong Kong Department of Biochemistry Chinese University of Hong Kong Department of Biology Colorado State UniversityFort Collins Comparative and Ecological phytochemistry Faculty Center of BotanyUniversity of Vienna

The treatment of Rutaceae in the Chinese flora chose to follow Engler in recognizing Rutoideae and Toddalioideae as two separate *** and chemical comparisons,however,suggested group-ing those two subfamilies in one subfamily,*** move has received support from molecular phyloge-netic analyses,which also showed that the Chinese taxa in Euodia should be placed in Tetradium and Melicope following *** into the chemistry and molecular phylogeny of Murraya also indicated that the species in the section Bergera without yuehchukene should be removed from *** findings clearly show the value of molecular cladistics to the taxonomy of Rutaceae in China and also directions for further inves-tigations.

关键词： Bergera Euodia Melicope Murraya Rutaceae Rutoideae Tetradium Toddalioideae

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAps).

关键词： function supporting

Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

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Nano Research 2015年第10期8卷 3307-3315页

作者： Daniela p. Lobo Alan M. Wemyss David J. Smith Anne Straube Kai B. Betteridge Andrew H. J. Salmon Rebecca R. Foster Hesham E. Elhegni Simon C. Satchell Haydn A. Little Raul pacheco-Gomez mark J. simmons Matthew R. Hicks David O. Bates Alison Rodger Timothy R. Dafforn Kenton p. Arkill DepartmentofChemistryandWarwickAnalyticalScienceCentre UniversityofWarwickCoventryCV47ALUK MOACDoctoralTrainingCentre UniversityofWarwickCoventryCV47ALUK Mathematics UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK CentreforMechanochemicalCellBiology WarwickMedicalSchoolUniversityofWarwickCoventryCV47ALUK physiologyandpharmacology UniversityofBristolUniversityWalkBristolBS81TDUK ClinicalSciences WhitsonStreetUniversityofBristolBristolBS13NYUK SchoolofChemistry UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK Biosciences UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK ChemicalEngineering UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK SchoolofMedicine UniversityofNottinghamQueen'sMedicalCentreNottinghamNG27UHUK Biochemistry UniversityofBristolUniversityWalkBristolBS81TDUK

The wall shear stress （WSS） that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology （e.g. angiogenesis） and affects the microvasculature＇s primary function of molecular transport. points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage M13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics.

关键词： microfluidics nanoparticle M13 bacteriophage wall shear stress fluorescent microscopy

Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis

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National Science Review 2019年第5期6卷 993-1003页

作者： Xiaocui Xu Guoqiang Li Congru Li Jing Zhang Qiang Wang David K.simmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru paola Oliveri Yong E.Zhang mark Q.Martindale Jiang Liu CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Apiculture Research Chinese Academy of Agriculture Sciences Whitney Laboratory for Marine Bioscience University of Florida College of Life Sciences Yantai University CAS Key Laboratory of Genomics and precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences Institute of Zoology Chinese Academy of Sciences Biology Department Woods Hole Oceanographic Institution Departments of Genetics Evolution and Environment and Cell and Developmental Biology University College London CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates and vertebrates, with numerous spectacular *** search for the molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across *** focused on gametes and early embryos, where the methylomes are known to evolve divergently between fish and ***, we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects, but clearly presents in deuterostomes such as echinoderms and invertebrate chordates, and then becomes more evident in *** association analysis suggests that DNA methylation reprogramming is associated with development, reproduction and adaptive immunity for vertebrates, but not for ***, the single HOX cluster of invertebrates maintains unmethylated status in all stages *** contrast, the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate ***, the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in *** study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution, especially after the evolutionary transitions from invertebrates to vertebrates, and then to mammals.

关键词： DNA methylation evolution development reprogramming

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生日歌：致雷切尔

英语学习 2009年第5期 44-45页

作者： James simmons 张剑(译)

在你生命的每一年。我们都把你的蛋糕上的蜡烛点燃，以此记录一种简单的进步，任何人都能够取得的进步。然后，为了测试你的胆量，为了正确绘出死亡的景象，你被要求用自己的气息，吹灭蜡烛，一根代表一年。

关键词：英语阅读材料翻译方法语法

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在线反思性交互的评估

开放教育研究 2004年第5期10卷 23-25页

作者： mark Hawkes Terry Dennis 熊秋娥项国雄美国南达科他州州立大学教育学院江西师范大学传播学院

交互是在线学习的关键要素,同(异)步交互工具可拓展教学交互的深度与广度,而科学、有效的评估能促进交互。本文在比较多种异步交互评估方法后,以建构主义学习理论为基础,引用simmons的反思性思维评价量规,详尽地描述了反思性交互的激励... 详细信息

交互是在线学习的关键要素,同(异)步交互工具可拓展教学交互的深度与广度,而科学、有效的评估能促进交互。本文在比较多种异步交互评估方法后,以建构主义学习理论为基础,引用simmons的反思性思维评价量规,详尽地描述了反思性交互的激励式评估在案例中的实施过程。

关键词：在线学习交互评估反思性思维激励机制网络教育

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在线反思性交互的激励式评估

现代教育技术 2004年第6期14卷 17-19,31页

作者： mark Hawkes Terry Dennis 熊秋娥项国雄江西师范大学传播学院，江西南昌330027

交互是在线学习的关键要素。教育中的同(异)步交互工具可拓展教学交互的广度与深度,而科学有效的评估能促进交互。本文在比较多种异步交互评估方法后,以建构主义学习理论为基础,引用 simmons 的反思性思维评价量规,详尽地描述了反思性... 详细信息

交互是在线学习的关键要素。教育中的同(异)步交互工具可拓展教学交互的广度与深度,而科学有效的评估能促进交互。本文在比较多种异步交互评估方法后,以建构主义学习理论为基础,引用 simmons 的反思性思维评价量规,详尽地描述了反思性交互的激励式评估在案例中的实施过程。

关键词：教学交互反思性思维评价量规建构主义学习理论在线学习关键要素激励异步描述工具

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场所的健康

中国园林 2010年第6期26卷 13-18页

作者：弗雷德里克.斯坦纳史蒂芬.温德哈格马克.T.西蒙斯达尼埃尔.皮耶拉农齐阿伦.W.希勒赵智聪德克萨斯大学奥斯汀分校建筑学院德克萨斯大学奥斯汀分校伯德.约翰逊夫人野花中心清华大学建筑学院景观学系

廉价的能源和建筑技术的进步造成了室内外环境之间的鸿沟,建筑物不再依赖自然气候,相反,如今建筑物影响天气模式并产生温室气体,从而影响气候变化。在北美,大约有75%的温室气体和能源消耗来自人造环境。全球的城市化进程使我们不能再像2... 详细信息

廉价的能源和建筑技术的进步造成了室内外环境之间的鸿沟,建筑物不再依赖自然气候,相反,如今建筑物影响天气模式并产生温室气体,从而影响气候变化。在北美,大约有75%的温室气体和能源消耗来自人造环境。全球的城市化进程使我们不能再像20世纪那样建设城市和坚持其文化。总结了全球温室效应趋势和人工建造环境之间的关系,并介绍了一个有关"可持续场地倡议"的评价体系,以鼓励更好的风景园林实践。从3个案例:华盛顿特区、澳大利亚的珀斯和华盛顿州的西雅图,来说明这一倡议可以提供更好的生态系统服务。

关键词：风景园林温室气体管理气候变化可持续场地倡议 LEED