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Intra-abdominal abscesses secondary to <i>Streptococcus anginosus</i>infection in a postpartum patient: A case report and review of the literature

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 235-238页

作者： Rehab Shabana Lindsay Berbiglia John Barnwell Ronald Cheek mark wolf Bernard Gonik Department of General Surgery Detroit Medical Center Detroit USA Department of General Surgery Wayne State University School of Medicine/Detroit Medical Center Detroit USA Department of Internal Medicine Detroit Medical Center Detroit USA Department of Obstetrics and Gynecology Wayne State University School of Medicine/Detroit Medical Center Detroit USA

Although rare, infection with Streptococcus anginosus has a known predilection for abscess formation. We report here a case of a 20 year-old, otherwise healthy female patient noted to have developed abdominal and pelvic abscesses secondary to Streptococcus anginosus infection. Although the inciting focus of the pathogen remains unclear in our patient, this case report emphasizes the importance of rapid identification of the organism and highlights the approach to therapeutic options in the management of such cases.

关键词： Streptococcus Anginosus Abdominal Abscess

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LEWIS公关全球企业博客调查

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国际公关 2007年第2期 72-74页

作者： mark van der wolf

许多博客名人和博客营销机构都在宣扬:博客已经彻底改变了已有的媒体形式,你应该利用好它。然而,令人遗憾的是,企业在面对这种新媒体时却无能为力。

关键词：博客企业文化人力资源管理搜索引擎全球企业新媒体公关市场营销公共关系传统媒体

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Improved thromboresistance and analytical performance of intravascular amperometric glucose sensors using optimized nitric oxide release coatings

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Chinese Chemical Letters 2015年第4期26卷 464-468页

作者： Alexander K.wolf Yu Qin Terry C.Major mark E.Meyerhoff Department of Chemistry University of Michigan Department of Chemistry Nanjing University Department of Surgery University of Michigan

In this work, nitric oxide （NO） release coatings designed for intravenous amperometric glucose sensors are optimized through the use ofa polylactic acid （PLA） layer doped with a lipophilic diazeniumdiolated species that releases NO through a proton-driven mechanism. An Elast-Eon E2As polyurethane coating is used to both moderate NO release from the sensor surface and increase the sensor＇s linear detection range toward glucose. These sensors were evaluated for thromboresistance and in vivo glucose performance through implantation in rabbit veins. By maintaining NO flux on a similar scale to endogenous endothelial cells, implanted glucose sensors exhibited reduced surface clot formation which enables more accurate quantitative glucose measurements continuously. An in vivo time trace of implanted venous sensors demonstrated glucose values that correlated well with the discrete measurements of blood samples on a benchtop point-of-care sensor-based instrument. The raw measured currents from the implanted glucose sensors over 7 h time periods were converted to glucose concentration through use of both a one-point in vivo calibration and a calibration curve obtained in vitro within a bovine serum solution. Control sensors, assembled without NO release functionality, exhibit distinctive surface clotting over the 7 h in vivo implantation period.

关键词： Nitric oxide release coatingsGlucose sensorsPolylactic acid layerQuantitative glucose measurements

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沙格列汀在接受沙格列汀为单药或联合治疗的2型糖尿病患者中的心血管安全性

沙格列汀在接受沙格列汀为单药或联合治疗的2型糖尿病患者中的心...

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中华医学会糖尿病学分会第十六次全国学术会议

作者： Robert Frederich mark Donovan Niklas Berglind Susan Harris Roland Chen Robert wolf Bristol-Myers Squibb LawrencevilleNJUSA Bristol-Myers Squibb HopewellNJUSA AstraZeneca WilmingtonDEUSA

目的根据统计,我国总糖尿病患病人数达9千2百万以上,糖尿病前期人数达1亿4千8百万以上。近期降糖药的长期心血管安全性已成为监管机构和大众的仔细审核项目。沙格列汀(SAXA)是一个高效的选择性二肽基肽脢-4(DPP-4)抑制剂,用于2型糖尿病(...

目的根据统计,我国总糖尿病患病人数达9千2百万以上,糖尿病前期人数达1亿4千8百万以上。近期降糖药的长期心血管安全性已成为监管机构和大众的仔细审核项目。沙格列汀(SAXA)是一个高效的选择性二肽基肽脢-4(DPP-4)抑制剂,用于2型糖尿病(T2D)的单药或联合治疗。在临床前研究,SAXA对于ECG、hERG或Purkinje评估没有影响,也没有心脏毒性。40 mg/d或400 mg/d的SAXA剂量不会

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沙格列汀在接受沙格列汀为单药或联合治疗的2型糖尿病患者中的心血管安全性

沙格列汀在接受沙格列汀为单药或联合治疗的2型糖尿病患者中的心...

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中华医学会第十一次全国内分泌学学术会议

作者： Robert Frederich mark Donovan Niklas Berglind Susan Harris Roland Chen Robert wolf Bristol-Myers Squibb LawrencevilleNJUSA Bristol-Myers Squibb HopewellNJUSA AstraZeneca WilmingtonDEUSA

背景和目的根据统计,中国糖尿病患病人数超过九千万人,每十个成年人中就有一例,是世界上糖尿病患者最多的国家。近期降糖药的长期心血管安全性已成为监管机构和大众的仔细审核项目。沙格列汀(SAXA)是一个高效的选择性二肽基肽脢-4(DPP-4...

背景和目的根据统计,中国糖尿病患病人数超过九千万人,每十个成年人中就有一例,是世界上糖尿病患者最多的国家。近期降糖药的长期心血管安全性已成为监管机构和大众的仔细审核项目。沙格列汀(SAXA)是一个高效的选择性二肽基肽脢-4(DPP-4)抑制剂,用于2型糖尿病(T2D)的单药或联合治疗。在临床前研究,SAXA对于ECG、hERG、或Purkinje评估没有影响,也没有心脏毒性。

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Moose at their bioclimatic edge alter their behavior based on weather, landscape, and predators

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Current Zoology 2018年第4期64卷 419-432页

作者： mark A. DITMER Ron A. MOEN Steve K. WINDELS James D. FORESTER Thomas E, NESS Tara R. HARRIS Conservation Department Minnesota Zoo 13000 Zoo Boulevard Apple Valley MN 55124 USA Department of Fisheries Wildlife and Conservation Biology University of Minnesota 2003 Upper Buford Circle Ste 135 St Paul MN 55108 USA Natural Resources Research Institute and Department of Biology University of Minnesota Duluth 5013 Miller Trunk Highway Duluth MN 55811 USA Voyageurs National Park 360 Hwy 11 E International Falls MN 56649 USA

Populations inhabiting the bioclimatic edges of a species＇ geographic range face an increasing amount of stress from alterations to their environment associated with climate change. Moose Alces alces are large-bodied ungulates that are sensitive to heat stress and have exhibited population declines and range contractions along their southern geographic extent. Using a hidden markov model to analyze movement and accelerometer data, we assigned behaviors （rest, forage, or travel） to all locations of global positioning system-collared moose （n = 13, moose-years = 19） living near the southern edge of the species＇ range in and around Voyageurs National Park, MN, USA. We assessed how moose behavior changed relative to weather, landscape, and the presence of predators. Moose sig- nificantly reduced travel and increased resting behaviors at ambient temperatures as low as 15~C and 24~C during the spring and summer, respectively. In general, moose behavior changed season- ally in association with distance to lakes and ponds. Moose used wetlands for travel throughout the year, rested in conifer forests, and foraged in shrublands. The influence of wolves Canis lupus varied among individual moose and season, but the largest influence was a reduction in travel during spring when near a wolf home range core, primarily by pregnant females. Our analysis goes beyond habitat selection to capture how moose alter their activities based on their environment. Our findings, along with climate change forecasts, suggest that moose in this area will be required to further alter their activity patterns and space use in order to find sufficient forage and avoid heat stress.

关键词： Alces alces climate change heat stress moose temperature wolves

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Correlates of Age at Initial Diagnosis of Chronic Lymphocytic Leukemia: Exercise, ASA &Emotional Distress

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Open Journal of Medical Psychology 2012年第2期1卷 9-14页

作者： mark W. Ketterer Emily A. Ketterer Bernd Barthel Amr Hanbali Phillip Kuriakose Yue Guo Walter Knysz Consultation/Liaison Psychiatry & Josephine Ford Cancer Center Henry Ford Hospital Detroit MI USA

Objective: No studies of either the cross-sectional or prospective association of behavioral lifestyle characteristics and the onset of Chronic Lymphocytic Leukemia (CLL) exist. Methods: Multiple interview or questionnaire measures of emotional distress and social support, as well as personality characteristics, exercise, sleep quality, aspirin or lipid-lowering medication use, smoking status and history, educational history and farming/pesticide exposure were tested as correlates of age at initial diagnosis of CLL (AAID-CLL) in 183 patients recruited from the electronic records of Henry Ford Hospital or internet support sites. Results: Aspirin use, having always been “Fit” and living alone were positively associated with AAID. Negative associations were observed for farming/pesticide exposure, years of education, being married, self description as a “Lone wolf” or “Worrier”, taking “nerve” or “sleeping” pills, awakenings per night, Packyears of Smoking and the Interpersonal Sensitivity, Depression, Anxiety, Hostility and Paranoia scales of the Symptom Checklist 90 - Revised, as well as the AIAI (anger), Depression and Anxiety scales of the Spouse/Friend Ketterer Stress Symptom Frequency Checklist. Conclusions: Aspirin use and exercise may exert a modifiable delaying influence in the onset of CLL. Conversely, emotional distress and smoking may hasten its onset. Prospective, and interventional, tests of these findings are needed.

关键词： Chronic Lymphocytic Leukemia Stress Aspirin

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家族性主动脉瘤／夹层动脉瘤合并动脉导管未闭的遗传机制

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上海医学 2007年第S1期30卷 65-65页

作者：朱理敏 Roger VRANCKX Philippe KHAU VAN KIEN Alain LALANDE Nicolas BOISSET Flavie MATHIEU mark WEGMAN Luke GLANCY Jean-Marie GASC Francois BRUNOTTE Patrick BRUNEVAL Jean-Eric wolf Jean-Baptiste MICHEL Xavier JEUNEMAITRE 上海交通大学医学院附属瑞金医院高血压科 200025

目的在16p13-12．1位点20 cm的区域内明确致病基因,了解基因型和临床表型的关系。方法采用双向DNA直接测序法筛选候选基因;运用免疫组化和蛋白免疫印迹法等了解突变基因的表达情况。运用质粒重组及体外表达方法获得野生型和突变型蛋白,... 详细信息

目的在16p13-12．1位点20 cm的区域内明确致病基因,了解基因型和临床表型的关系。方法采用双向DNA直接测序法筛选候选基因;运用免疫组化和蛋白免疫印迹法等了解突变基因的表达情况。运用质粒重组及体外表达方法获得野生型和突变型蛋白,使用免疫共沉淀法了解这两者的结合程度。结果在两个家系中发现编码平滑肌肌球蛋白的MYH11基因突变,所有TAAD和PDA患者均为突变基因携带者。在法国家系中发现两个突变。前者为剪切点供体杂合子突变,导致编码71个氨基酸的第32外显子完全缺失:第2个突变为第37外显子上的1个点突变,导致精氨酸变为谷氨酸。在美国家系中发现1个杂合子突变,为第28外显子上编码24个氨基酸的72个碱基缺失。在法国患者的病变动脉标本上运用蛋白免疫印迹法,发现野生型和突变型肌球蛋白蛋白共存,但有异常免疫组化表现。体外实验显示重组野生型和突变型蛋白不能正常结合。结论MYH11基因突变导致家族性TAAD合并PDA,野生型和突变型平滑肌肌球蛋白不能正常结合,推论杂合子突变导致“Dominant-negative”作用。

关键词：夹层动脉瘤主动脉瘤蛋白免疫印迹法平滑肌肌球蛋白族性突变型野生型免疫共沉淀法基因突变体外表达

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