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Genotype specific peripheral lipid profile changes with hepatitis C therapy

World Journal of Gastroenterology 2016年第46期22卷 10226-10231页

作者： mark R Pedersen Amit Patel David Backstedt Myunghan Choi Anil B Seetharam Department of Internal Medicine Banner University Medical Center University of Arizona College of Medicine Phoenix AZ 85006 United States Department of Gastroenterology Banner University Medical Center University of Arizona College of Medicine Phoenix AZ 85006 United States Arizona State University College of Nursing and Health Care Innovation Banner Phoenix AZ 85006 United States Transplant and Advanced Liver Disease Center University of Arizona College of Medicine Phoenix AZ 85006 United States

AIM To evaluate magnitude/direction of changes in peripheral lipid profiles in patients undergoing direct acting therapy for hepatitis C by *** Mono-infected patients with hepatitis C were treated with guideline-based DAAs at a university-based liver clinic. Patient characteristics and laboratory values were collected before and after the treatment period. Baseline demographics included age, ethnicity, hypertension, diabetes, hyperlipidemia, treatment regimen, and fibrosis stage. Total cholesterol(TCHOL), high density lipoprotein(HDL), low density lipoprotein(LDL), triglycerides(TG), and liver function tests were measured prior to treatment and ETR. Changes in lipid and liver function were evaluated by subgroups with respect to genotype. Mean differences were calculated for each lipid profile and liver function component(direction/magnitude). The mean differences in lipid profiles were then compared between genotypes for differences in direction/magnitude. Lipid profile and liver function changes were evaluated with Levene's test and student's t test. Mean differences in lipid profiles were compared between genotypes using ANOvA, post hoc analysis via the Bonferroni correction or Dunnett *** Three hundred and seventy five patients enrolled with 321(85.6%) achieving sustained-viral response at 12 wk. 72.3% were genotype 1(GT1), 18.1% genotype 2(GT2), 9.7% genotype 3(GT3). Baseline demographics were similar. Significant change in lipid profiles were seen with GT1 and GT3(ΔGT1, p and ΔGT3, p), with TCHOL increasing(+5.3, P = 0.005 and +16.1, P v. ΔGT2 v. ΔGT3, ANOvA), significant mean differences were seen with TCHOL(+5.3 v. +0.1 v. +16.1, P = 0.017) and HDL(+12.3 v. +2 v. +7.9, P = 0.040). Post-hoc, GT3 was associated with a greater increase in TCHOL than GT

关键词： Hepatitis C genotypes Lipids Metabolic syndrome

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甲油盛装出行

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花样盛年 2013年第8期 76-80页

作者： v mark

看美甲一如既往的高调,那是即将步入高级定制的华丽姿态。同色闪片淡淡的粉蓝色系过于含蓄保守,可以选择在无名指的指甲上做出特别的闪片效果。配合偏珊瑚色调的暖色裸妆,散发低调的魅惑。

关键词：同色对撞高级定制色彩感红唇亚光红色系

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金属色当道

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花样盛年 2013年第7期 88-91页

作者： v mark

银光晕染淡粉裸色眼睑上大面积的银光色晕染是整个淡雅裸妆的点睛之笔。出席私家 party,含蓄的银光色浓妆淡抹总相宜。1. shu uemura 毛孔柔细泡沫隔离液 SPF30+/PA+++ RMB 3902. GUERLAIN 一触倾心唇膏RMB3103. MAKE UP FOR EvER 防水... 详细信息

银光晕染淡粉裸色眼睑上大面积的银光色晕染是整个淡雅裸妆的点睛之笔。出席私家 party,含蓄的银光色浓妆淡抹总相宜。1. shu uemura 毛孔柔细泡沫隔离液 SPF30+/PA+++ RMB 3902. GUERLAIN 一触倾心唇膏RMB3103. MAKE UP FOR EvER 防水眼线笔 RMB2204. benefit 糖衣炮弹蜜粉RMB 290金色和银色是百变时装界始终不变的主题。金属质感的眼妆时尚、奢华、闪耀,给它上点色彩是神来之笔。

关键词：金属色睫毛膏金属质感晕染光色 party 浓妆淡抹色晕时装界淡粉

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Simultaneous screening and classification of diabetic retinopathy and age-related macular degeneration based on fundus photos——a prospective analysis of the RetCAD system

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1985-1993页

作者： Christos Skevas Hanah Weindler Max Levering Jonne Engelberts mark van Grinsven Toam Katz University Clinic Eppendorf Hamburg Hamburg 20246Germany Thirona B.v. Toernooiveld 3006525 ECNijmegenThe Netherlands

AIM:To assess the accuracy of an artificial intelligence(AI)based software(Ret CAD,Thirona,The Netherlands)to identify and grade age-related macular degeneration(AMD)and diabetic retinopathy(DR)simultaneously based on fundus ***:This prospective study included 1245 eyes of 630 patients attending an ophthalmology day-care *** photos were acquired and parallel graded by the Ret CAD AI software and by an expert reference examiner for image quality,and staging of AMD and *** was provided by a second expert examiner in case of disagreement between the AI software and the reference *** analysis was performed on eye-level and on patient-level,by summarizing the individual image level-gradings into and eye-level or patient-level score,*** performance of the Ret CAD system was measured using receiver operating characteristics(ROC)analysis and sensitivity and specificity for both AMD and DR were ***:The Ret CAD achieved an area under the ROC(Az)of 0.926 with a sensitivity of 84.6%at a specificity of 84.0%for image *** image level,the Ret CAD software achieved Az values of 0.964 and 0.961 with sensitivity/specificity pairs of 98.2%/79.1%and 83.9%/93.3%for AMD and DR,*** patient level,the Ret CAD software achieved Az values of 0.960 and 0.948 with sensitivity/specificity pairs of 97.3%/73.3%and 80.0%/90.1%for AMD and DR,*** adjudication by the second expert examiner sensitivity/specificity increases on patient-level to 98.6%/78.3%and 100.0%/92.3%for AMD and DR,***:The Ret CAD offers very good sensitivity and specificity compared to manual grading by experts and is in line with that obtained by similar automated grading *** Ret CAD AI software enables simultaneous grading of both AMD and DR based on the same fundus *** sensitivity may be adjusted according to the desired acceptable sensitivity and *** simplicity cloud base i

关键词： RetCAD age-related macular degeneration diabetic retinopathy

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Gigawatt Scale Storage for Gigawatt Scale Renewables

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Journal of Energy and Power Engineering 2018年第2期12卷 105-116页

作者： mark Howitt Storelectric Ltd. 15 Weaver Close Alsager Stoke-on-Trent ST7 2NZ England

Multi-GW renewables need multi-GW storage, or fossil fuelled power stations will be needed to balance for intermittency. For the same reason, such balancing must be able to last for an entire evening peak if renewables are not generating at the same time. Batteries and DSR （demand side response） make very useful contributions and there is a large market for both, but without large scale and long duration storage, they cannot do the job. Interconnectors also contribute to the solution, and storage will make them more profitable, but （taking a UK perspective） Ofgem identified that all our neighbours have similar generation capacity crunches and similar demand patters, so if we need the electricity when they do, we’ll have to pay through the nose for it. Last winter’s ￡ 1,500/MWh prices proved that―even with only 4 GW interconnection. Following exit from the single market, our neighbours will be able to say “our consumers are more important than yours at any price”. We need UK-based storage at the right scale, to store UK-generated electricity for UK use and for export―otherwise we lose security of supply. CAES （compressed air energy storage） and pumped hydro are the only technologies currently able to deliver this scale and duration of storage. Pumped hydro is cost-effective in the long term but there are few sites, and it is （location dependent） over 3x the cost of CAES. Storelectric has 2 versions of CAES： one is a comparable price to existing CAES, but much more efficient （~70% v 50%） and zero emissions （existing CAES emits 50%-60% of the gas of an equivalent sized power station）. The other is retro-fittable to suitable gas power stations, is more efficient （-60% v 50%）, almost halves their emissions, adds storage-related revenue streams and is much cheaper. Both are new configurations of existing and well proven technologies, supported by engineering majors.

关键词： Electricity storage CAES compressed air energy storage adiabatic grid balancing renewable.

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Dynamic nitrogen vacancy magnetometry by single-shot optical streaking microscopy

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Photonics Research 2022年第9期10卷 2147-2156页

作者： mark A.KEPPLER ZACHARY A.STEELMAN ZACHARY N.COKER MILOŠNESLÁDEK PHILIP R.HEMMER vLADISLAv v.YAKOvLEv JOEL N.BIXLER Department of Biomedical Engineering Texas A&M UniversityCollege StationTexas 77843USA SAIC JBSA Fort Sam HoustonTexas 78234USA National Research Council Research Associateship Program WashingtonDC 20001USA IMOMEC Division IMECB-3590 DiepenbeekBelgium Institute for Materials Research(IMO) Hasselt UniversityB-3590 DiepenbeekBelgium Czech Technical University in Prague 27201 KladnoCzech Republic Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTexas 77843USA Bioeffects Division Airman System DirectorateAir Force Research LaboratoryJBSA Fort Sam HoustonTexas 78234USA

Nitrogen vacancy diamonds have emerged as sensitive solid-state magnetic field sensors capable of producing diffraction limited and sub-diffraction field ***,for the first time,to our knowledge,we extend those measurements to high-speed imaging,which can be readily applied to analyze currents and magnetic field dynamics in circuits on a microscopic *** overcome detector acquisition rate limitations,we designed an optical streaking nitrogen vacancy microscope to acquire two-dimensional spatiotemporal *** demonstrate magnetic field wave imaging with micro-scale spatial extent and~400μs temporal *** validating this system,we detected magnetic fields down to 10μT for 40 Hz magnetic fields using single-shot imaging and captured the spatial transit of an electromagnetic needle at streak rates as high as 110μm/*** design has the capability to be readily extended to full 3D video acquisition by utilizing compressed sensing techniques and a potential for further improvement of spatial resolution,acquisition speed,and *** device opens opportunities to many potential applications where transient magnetic events can be isolated to a single spatial axis,such as acquiring spatially propagating action potentials for brain imaging and remotely interrogating integrated circuits.

关键词： vacancy utilizing overcome

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Isolated colonic neurofibroma in the setting of Lynch syndrome:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2020年第1期12卷 28-33页

作者： Warren YL Sun Armaan Pandey mark Lee Shawn Wasilenko Shahzeer Karmali Division of General Surgery University of AlbertaEdmonton T6G 2B7AlbertaCanada Cumming School of Medicine University of CalgaryCalgary T2N 4Z6AlbertaCanada Department of Laboratory Medicine&Pathology University of AlbertaEdmonton T5H 3V9AlbertaCanada Division of Gastroenterology University of AlbertaEdmonton T5H 3V9Canada

BACKGROUND Gastrointestinal neurofibromas are commonly found in patients diagnosed with neurofibromatosis type ***,isolated gastrointestinal neurofibromas are a rare entity and only fourteen cases of isolated colorectal neurofibromas have been documented in *** gastrointestinal neurofibromas have not been associated with Lynch syndrome(LS).Patients with LS are at an increased risk of colorectal cancer,and are recommended to undergo screening *** SUMMARY A 33-year-old healthy female with a family history of LS was found to have unresectable polyp in the ascending colon on screening colonoscopy suspicious for *** patient was asymptomatic and had no stigmata of neurofibromatosis.A staging workup for colorectal cancer revealed no evidence of metastatic disease.A discussion with the patient resulted in the decision to undergo a segmental resection with ongoing *** patient underwent a laparoscopic right *** was consistent with a gastrointestinal ***-operatively,the patient recovered *** will not require further treatment with regards to her colonic neurofibroma,but will continue to follow-up for ongoing surveillance of her *** We present the first case of an isolated colonic neurofibroma in a patient with *** case explores considerations for the management of isolated gastrointestinal neurofibromas given the lack of guidelines in literature.

关键词： Isolated gastrointestinal neurofibroma Colonic neurofibroma Gastrointestinal neurofibromatosis Lynch syndrome Case report

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东特拉华盆地、西得克萨斯和南新墨西哥超压体系的分布和形成

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国外油气勘探 1995年第3期7卷 283-301页

作者： Ming Luo mark R.Baker David v.LeMone 李惠凌江汉油田研究院情报室

在特拉华(Delaware)盆地已确认有三个地下压力体系:一个上部常压体系;一个中部超压体系和一个下部常压体系。超压体系出现在东特拉华盆地,包括得克萨斯州和新墨西哥州的六个县。超压体系的深度范围为3100～5400m。东特拉华盆地的正常流... 详细信息

在特拉华(Delaware)盆地已确认有三个地下压力体系:一个上部常压体系;一个中部超压体系和一个下部常压体系。超压体系出现在东特拉华盆地,包括得克萨斯州和新墨西哥州的六个县。超压体系的深度范围为3100～5400m。东特拉华盆地的正常流体压力梯度为O.0103MPa/m。但是最大的超压梯度接近O.02MPa/m,这与0.0231MPa/m的静岩压力梯度相近。超压体系有一个相对平缓的顶部和一个下凹的底部。在沉积中心,超压体系的最大厚度达2300m,并向边缘减薄。该系统中超压区内的最大超压达600MPa。war-Wink油田下部常压体系中发现了由于开采造成的局部低压区。特拉华盆地东部的超压主要与密西西比系、宾夕法尼亚系和二叠系(狼营统)页岩层序相关。这些页岩也是盆地的主要烃源岩。超压体系内的最初沉积速率为17～90m/Ma。校正后的井底温度测量结果说明超压带的地热梯度是25.1℃/km。这高于21℃/km的盆地平均地热梯度。超压体系的顶部和底部的温度大约分别为80℃和115℃。这个温度范围接近于粘土脱水带的温度。WarWink油田的生油窗和超压体系一致,这说明油气生成和运移在超压体系中很活跃。研究者提出了一个两级的超压模型。烃类成熟过程结合机械压实不平衡及粘土脱水,异常地增加了流体体积和孔隙空间,这是形成超压的初始原因。其次,在已存在的超压体内,由于热传导率降低和流体运移所造成的温度增加,将进一步加强流体热膨胀并引起超压。

关键词：地层压力得克萨斯州石油生成

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Behavioral statistics in action / 3rd ed.

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2002年

作者： mark vernoy Diana Kyle.

来源：畅想之星图书光盘版（南... 评论

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Importance of charge self-consistency in first-principles description of strongly correlated systems

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npj Computational Materials 2021年第1期7卷 1949-1956页

作者： Swagata Acharya Dimitar Pashov Alexander N.Rudenk Malte Rösner mark van Schilfgaarde Mikhail I.Katsnelson Institute for Molecules and Materials Radboud UniversityNijmegen 6525 AJThe Netherlands Theory and Simulation of Condensed Matter King's College LondonThe StrandLondon WC2R2LSUK National Renewable Energy Laboratory Golden80401 ColoradoUSA

First-principles approaches have been successful in solving many-body Hamiltonians for real materials to an extent when correlations are weak or *** the electronic correlations become stronger often embedding methods based on first-principles approaches are used to better treat the correlations by solving a suitably chosen many-body Hamiltonian with a higher level *** success of such embedding theories,often referred to as second-principles,is commonly measured by the quality of self-energy E which is either a function of energy or momentum or ***,E should,in principle,also modify the electronic eigenfunctions and thus change the real space charge *** such practices are not prevalent,some works that use embedding techniques do take into account these *** such cases,choice of partitioning,of the parameters defining the correlated Hamiltonian,of double-counting corrections,and the adequacy of low-level Hamiltonian hosting the correlated subspace hinder a systematic and unambiguous understanding of such ***,for a large variety of correlated systems,strong correlations are largely confined to the charge *** an adequate non local low-order theory is important,and the high-order local correlations embedding contributes become *** we study the impact of charge self-consistency within two example cases,TiSez and CrBrs,and show how real space charge re-distribution due to correlation effects taken *** within a first-principles Green's function-based many-body perturbative approach is key in driving qualitative changes to the final electronic structure of these materials.

关键词： theory charge principles

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