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p38-MAPK and CDK5,signaling pathways in neuroinflammation:a potential therapeutic intervention in Alzheimer's disease?

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Neural Regeneration Research 2024年第8期19卷 1649-1650页

作者： Vlad Ionut Viorel Ylenia Pastorello Nosherwan Bajwa mark slevin George Emil Palade University of Medicine PharmacyScience and TechnologyTârgu MuresRomania Department of Anatomy and Embryology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu MuresRomania DIAKO Hospital FlensburgGermany Center for Advanced Medical and Pharmaceutical Research(CCAMF) George Emil Palade University of MedicinePharmacyScience and TechnologyTârgu MuresRomania Manchester Metropolitan University ManchesterUK

Alzheimer’s disease(AD),the most common type of dementia,affects millions of people worldwide,putting a significant strain on healthcare infrastructure and societal *** is characte rized by the build-up of amyloid-be... 详细信息

关键词： Alzheimer Aβ tau

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The role of small vessel disease in development of Alzheimer's disease

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Neural Regeneration Research 2010年第4期5卷 310-320页

作者： Marta Grau-slevin Adria Arboix John Gaffney mark slevin School of Biology Chemistry and Health ScienceManchester Metropolitan University Cerebrovascular Division Department of NeurologyHospital Universitari del Sagrat CorUniversitat de Barcelona

Classically Alzheimer＇s disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms. Cerebrovascular lesions, especially small vessel disease （lacunar infarcts, white matter hyperintensities and microbleeds）, may magnify the effects of mild Alzheimer＇s disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia. ＂Vascular hypothesis＂ of Alzheimer＇s disease would open a window for new approaches and treatments.

关键词： Alzheimer's disease small vessel disease development risk factors diagnosis neuroimaging studies histopathological studies neurodegenerative disease neural regeneration

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Induced pluripotent stem cells as a potential therapeutic source for corneal epithelial stem cells

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 2004-2010页

作者： Jie Zhu mark slevin Bao-Qiang Guo Shou-Rong Zhu Queen Mary School Medical College of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina chool of Healthcare Science Faculty of Science and EngineeringManchester Metropolitan UniversityChester StreetManchester M15GDUnited Kingdom Research Institute of Brain Vascular Disease Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261000Shandong Province China

Corneal blindness caused by limbal stem cell deficiency(LSCD) is one of the most common debilitating eye disorders. Thus far, the most effective treatment for LSCD is corneal transplantation, which is often hindered by the shortage of donors. Pluripotent stem cell technology including embryonic stem cells(ESCs) and induced pluripotent stem cells(iPSCs) have opened new avenues for treating this disease. iPSCs-derived corneal epithelial cells provide an autologous and unlimited source of cells for the treatment of LSCD. On the other hand, iPSCs of LSCD patients can be used for iPSCs-corneal disease model and new drug discovery. However, prior to clinical trial, the efficacy and safety of these cells in patients with LSCD should be proved. Here we focused on the current status of iPSCs-derived corneal epithelial cells used for cell therapy as well as for corneal disease modeling. The challenges and potential of iPSCs-derived corneal epithelial cells as a choice for clinical treatment in corneal disease were also discussed.

关键词： induced pluripotent stem cells corneal epithelial cells limbal stem cell deficiency disease modeling

Potential of adipose derived stem cell preparations in neurological repair and regeneration

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Biophysics Reports 2021年第2期7卷 81-90页

作者： Laura Combes Xenia Sawkulycz Wen-Hui Fang Baoqiang Guo mark slevin Department of Life Sciences Manchester Metropolitan University Department of Biological and Geographical Sciences University of Huddersfield

Stem cell therapy is a promising treatment for neurogenerative disease as well as inflammatory and immune mediated diseases. Decades of preclinical research has demonstrated stem cell ability to differentiate into multiple cell lineages and be utilised in regeneration and repair with their immunomodulatory and immunosuppressive properties. This work has provided the fundamental scientific knowledge needed to launch various clinical trials studying stem cell therapy in autoimmune disorders,stroke, and other tissue injury. Despite the early success many of these promising therapies are yet to breakthrough into clinical use. In this review, we highlight the recent developments in the use of stem cells as therapeutic agents for neurological conditions as well as their failures and how the clinical translation can be improved.

关键词： Adipose derived mesenchymal stem cells Micro-fragmented adipose tissue Suicide gene therapy