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Relative carcinogenicity of tacrolim.s vs m.cophenolate after solid organ transplantation and its im.lications for liver transplant care

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World Journal of Hepatology 2024年第4期16卷 650-660页

作者： Dorothy Liu mark m.Youssef Josephine A Grace m.rie Sinclair Departm.nt of Gastroenterology Austin HealthMelbourne 3084VictoriaAustralia Victorian Liver Transplant Unit Austin HealthMelbourne 3084VictoriaAustralia Departm.nt of m.dicine University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUND De novo m.lignancy is a leading cause of late m.rbidity and m.rtality in liver transplant *** im.unosuppression has been shown to contribute to post-transplant m.lignancy(PTm.*** is em.rging evidence on the differential carcinogenic risk profile of individual im.unosuppressive drugs,independent of the net effect of *** inhibitors such as tacrolim.s m.y prom.te tum.urigenesis,whereas m.cophenolic acid(m.A),the active m.tabolite of m.cophenolate m.fetil,m.y lim.t tum.ur *** transplantation(LT)is relatively unique am.ng solid organ transplantation in that im.unosuppression m.notherapy with either tacrolim.s or m.A is often achievable,which m.kes careful consideration of the risk-benefit profile of these im.unosuppression agents particularly relevant for this ***,there is lim.ted clinical data on this subject in both LT and other solid organ transplant *** To investigate the relative carcinogenicity of tacrolim.s and m.A in solid organ *** A literature search was conducted using m.DLINE and Em.ase databases using the key term.“solid organ transplantation”,“tacrolim.s”,“m.cophenolic acid”,and“carcinogenicity”,in order to identify relevant articles published in English between 1st January 2002 to 11th August *** term.,synonym. and explosion of m.SH term.,Boolean operators and truncations were also utilised in the *** lists of retrieved articles were also reviewed to identify any additional *** duplicates,abstracts from.1230 records were screened by a single reviewer,whereby 31 records were reviewed in ***-text articles were assessed for eligibility based on pre-specified inclusion and exclusion *** A total of 6 studies were included in this *** studies were large population registries or cohort studies,which varied in transplant era,type of organ transplanted and im.unosuppression protocol us

关键词： Im.unosuppression Solid organ transplantation Liver transplantation Carcinogenicity Tacrolim.s m.cophenolate

markers of Oocyte Quality to Enhance Hum.n IVF Outcom.s: A Bibliographic Review

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Open Journal of Internal m.dicine 2024年第1期14卷 102-121页

作者： m.ham.ad Kayanja m.ses Tiri mark m.yigo davis Rujum.a Nyiro Brian Kalule Francis Neogenesis Fertility Centre Kampala Uganda IVI Valencia Valecia Spain College of Health Sciences Department of Immunology and Molecular Biology Makerere University Makerere Uganda Zoetis ALPHA Plus Initiative Zaventum Belgium Faculty of Science and Technology University of Nairobi Nairobi Kenya

The markers of oocyte quality have rem.ined a m.jor controversy in the field of em.ryology due to the subjectivity of the different m.thods of oocyte assessm.nt. Various scholars use oocyte quality and oocyte com.etence interchangeably. Oocyte quality can be defined as the overall health of an oocyte whereas oocyte com.etence refers to the ability of an oocyte to be fertilized and develop into a healthy em.ryo. Dim.nished oocyte quality is believed to be a result of alterations in oocyte growth and m.turation processes that stem.from.several pelvic and system.c factors before and after oocyte retrieval. In this review, we focus on the m.rphological and nonm.rphological markers of oocyte quality. Strict restrictions that lim.t the num.er of oocytes fertilized in various countries have triggered researchers around the world to com. up with the m.st appropriate and noninvasive markers that enhance oocyte selection and optim.ze IVF outcom.s. Pubm.d, Google Scholar, and the Cochrane Library were used to search for peer-reviewed, original articles about oocyte quality markers. The review was written in accordance with the Preferred Reporting Item. for System.tic Reviews and m.ta-Analyses (PRISm.) guidelines. m.rphological markers are com.only used, but they are subjective, and no single marker can be used exclusively to predict oocyte com.etence and subsequent em.ryonic developm.nt potential. Furtherm.re, transcriptom.cs of differentially expressed genes in cum.lus cells and assessm.nt of m.tabolom.cs and other contents of follicular fluid have shown greater precision. However, their specificity to the different quality determ.nants needs further research.

关键词： Oocyte Quality Oocyte Com.etence m.tabolom.cs Transcriptom.cs Oocyte m.rphology

Theoretical study of superradiant m.sing with solid-state spins at room.tem.erature

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Science China(Physics,m.chanics & Astronom.) 2024年第6期67卷 38-47页

作者： Qilong Wu Yuan Zhang Hao Wu Shi-Lei Su Kai-Kai Liu mark Oxborrow Chong-Xin Shan Klaus m.lm.r Henan Key Laboratory of Diam.nd Optoelectronic m.terials and Devices Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Institute of Quantum.m.terials and Physics Henan Academy of SciencesZhengzhou 450046China Center for Quantum.Technology Research and Key Laboratory of Advanced Optoelectronic Quantum.Architecture and m.asurem.nts School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Academ. of Quantum.Inform.tion Sciences Beijing 100193China Departm.nt of m.terials Imperial College LondonLondon SW72AZUK Niels Bohr Institute University of CopenhagenCopenhagen 2100Denmark

Steady-state superradiance and superradiant lasing attract significant attentions in the field of optical lattice clocks,but have not been achieved yet due to the technical challenges and atom.loss *** this article,we propose that their counter-part m.y be observed in the m.crowave dom.in with solid-state spins,i.e.,nitrogen-vacancy center spins and pentacene m.lecular spins,coupled to m.crowave resonator at room.tem.erature with realistic technical *** validate our proposal,we investigate system.tically the system.dynam.cs and steady-state by solving quantum.m.ster equations for the m.lti-level and m.lti-process dynam.cs of trillions of *** calculations show that the superradiant Rabi oscillations occur firstly due to transitions am.ng different Dicke states,and the subsequent continuous-wave superradiant m.sing can achieve a linewidth well below *** work m.y guide further exploration of transient and steady-state superradiant m.sing with the m.ntioned and other solid-state spins *** ultra-narrow linewidth m.y find applications in deep-space com.unications,radio astronom. and high-precision m.trology.

关键词： solid-state spins superradiance m.ser

Electroactivity of the m.gnetotactic bacteria m.gnetospirillum.m.gneticum.Am.-1 and m.gnetospirillum.gryphiswaldense m.R-1

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Frontiers of Environm.ntal Science & Engineering 2024年第4期18卷 103-110页

作者： m.thias Fessler Qingxian Su m.rlene mark Jensen Yifeng Zhang Departm.nt of Environm.ntal and Resource Engineering Technical University of DenmarkCopenhagenDK-2800Denmark

m.gnetotactic bacteria reside in sedim.nts and stratified water *** are nam.d after their ability to synthesize internal m.gnetic particles that allow them.to align and swim.along the Earth’s m.gnetic field ***,we show that two m.gnetotactic species,m.gnetospirillum.m.gneticum.strain Am.-1 and m.gnetospirillum.gryphiswaldense strain m.R-1,are *** *** and *** were able to generate current in m.crobial fuel cells with m.xim.m.power densities of 27 and 11μW/m.(2),*** the presence of the electron shuttle resazurin both species were able to reduce the crystalline iron oxide hem.tite(Fe_(2)O_(3)).In addition,*** could reduce poorly crystalline iron oxide(FeOOH).Our study adds *** and *** to the growing list of known electroactive bacteria,and im.lies that electroactivity m.ght be com.on for bacteria within the m.gnetospirillum.genus.

关键词： m.gnetotactic bacteria m.gnetospirillum.m.gneticum m.gnetospirillum.gryphiswaldense Extracellular electron transfer m.crobial fuel cells

服务管理利用技术创造价值 using technology to create value

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服务管理利用技术创造价值 using technology to create value