检索结果-南通市图书馆

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Forging an easier path through graduation:Improving the patient transition from paediatric to adult critical care

在线全文

学校读者我要写书评

暂无评论

World Journal of Critical Care Medicine 2025年第1期14卷 82-90页

作者： Stephen Warrillow Ben Gelbart Jess Stevens Gordon Baikie mark E Howard Department of Intensive Care Austin HealthHeidelberg 3084VictoriaAustralia Department of Critical Care The University of MelbourneParkville 3010VictoriaAustralia Department of Intensive Care Royal Children’s HospitalParkville 3010VictoriaAustralia Living with Disability Research Centre La Trobe UniversityBundoora 3086VictoriaAustralia Department of Neurodevelopment&Disability Royal Children’s HospitalParkville 3010VictoriaAustralia Department of Paediatrics The University of MelbourneParkville 3010VictoriaAustralia Department of Respiratory and Sleep Medicine Austin HealthHeidelberg 3084VictoriaAustralia Department of Medicine Austin HealthThe University of MelbourneHeidelberg 3084VictoriaAustralia

Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing *** normal experiences are potentially magnified for teenagers living with chronic illness or disability and their *** in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing *** those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of *** the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general *** there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive *** patients may encounter considerable challenges during this *** may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric *** addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health *** challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.

关键词： Paediatric intensive care Disability Adult intensive care Transition Critical care

Protecting miners from coal bursts during development above historic mine workings in Harlan County,KY

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2021年第1期31卷 111-116页

作者： Christopher mark Mine Safety and Health Administration PittsburghPA 15236USA

In order to reach a large,untapped reserve of high-quality coal,D8 Cloverlick Mine proposed to mine a corridor nearly 600 m deep beneath the Benham Spur of Black Mountain,Kentucky’s highest peak.D8 Cloverlick Mine was extracting the Owl seam,but the corridor’s route lay approximately 20 m above century-old mine workings in the C–(Darby)*** to the concern,three serious coal bursts had recently occurred in nearby Owl seam *** of the old workings seemed to indicate that the underlying C–seam had been fully ***,two of the coal bursts had occurred above areas where the C–Seam was also shown as mined *** Safety and Health Administration(MSHA)Technical Support therefore investigated the records of past mining to better understand the old mine *** conditions observed in current Owl seam workings were also compared with the maps of the old C–seam *** study concluded that the presence of hazardous underlying remnants could not be ruled *** mitigate the burst risk,D8 Cloverlick Mine adopted a strategy of stress probe drilling.A self-propelled coal drill was used to auger 11.5-m-long,small diameter holes in advance of *** each hole was drilled,the cuttings were measured to detect the presence of highly stressed *** the crossing was successfully completed without incident.

关键词： Coal bursts Underground mining Room-and-pillar Destressing

Performance analysis and design of loitering munitions: A comprehensive technical survey of recent developments

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2022年第3期18卷 325-343页

作者： mark Voskuijl Faculty of Military Sciences Netherlands DefenceAcademyDenHelderThe Netherlands

Loitering munitions are increasingly used in armed *** extensive database of loitering munitions is developed based on information available in the public *** database includes dimensions,weights,and performance parameters such as flight endurance and communication *** upon this dataset,6 categories of loitering munitions are identified and statistical trends in the form of equations are provided for each *** statistical trends are supported by aircraft performance theory tailored to loitering munitions ***,the combination of the database,statistical trends and aircraft performance theory can be used to analyse the flight performance and design considerations of new loitering munitions of which only limited non-technical information is available in the public domain such as pictures and news *** on the statistical trends and aircraft performance theory it is concluded that for long range applications,the preferred design solution is the conventional *** cruciform configuration is beneficial in case precision flight path control is of prime *** tandem wing configuration combines the benefits of a canister launch and relatively high aspect ratio wings suitable for long range ***,the delta wing design provides a large internal volume and a high terminal attack *** example case studies are included to illustrate the flight performance capabilities of two types of loitering munitions used in the current conflict in Yemen(a long range conventional design and a delta wing configuration).

关键词： Loitering munition Unmanned aerial vehicle Flight performance Design

An updated empirical model for ground control in *** coal mines

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2021年第2期31卷 163-174页

作者： Christopher mark Mine Safety and Health Administration PittsburghPA 15217USA

Multiple seam interactions are a major source of ground instability in several *** methods are well suited for this problem,because while the mechanics multiple seam interactions are very complex and poorly understood,many mining case histories are available for *** study makes use of an updated database that includes 356 multiseam case histories,including 67 unsuccessful *** paper describes in detail the process used to design the study,collect the data,conduct the statistical analysis,and develop the quantitative *** model can be used for mine planning in multiple seam situations,and has been made available as a module within the Analysis of Coal Pillar Stability(ACPS)computer program.

关键词： Underground Coal Multiseam Ground control Pillar design Empirical

Evolution of airports from a network perspective--An analytical concept

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2017年第2期30卷 513-522页

作者： mark Azzam German Aerospace Center -DLR 53227 Bonn Germany

Analyzing airports＇ role in global air transportation and monitoring their development over time provides an additional perspective on the dynamics of network *** order to understand the different roles airports can play in the network an integrated and multidimensional approach is ***,an approach to airport classification through hierarchical clustering considering several parameters from network theory is presented in this *** applying a 29 year record of global flight data and calculating the conditional transition probabilities the results are displayed as an evolution graph similar to a discrete-time markov *** this analytical concept the meaning of airports is analyzed from a network perspective and a new airport taxonomy is *** presented methodology allows tracking the development of airports from certain categories into others over *** show that airports of equal classes run through similar stages of development with a limited number of alternatives,indicating clear evolutionary *** from giving an overview of the results the paper illustrates the exact data-driven approach and suggests an evaluation *** methodology can help the public and industry sector to make informed strategy decisions when it comes to air transportation infrastructure.

关键词： Airport classification Air transportation Cluster analysis Complexity science Network development Network science

Biomimicry and Theory of Structures-Design Methodology Transfer from Trees to Moment Frames

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2014年第4期11卷 638-648页

作者： mark Grigorian MGA Structural Engineering Inc. 111 N. Jackson St. Glendale CA. 91206 USA

Currently, there are only three classical and a handful of emerging design methodologies available to structural engineers worldwide. None of these methodologies can explain the design concepts involved in the realization of natural structures such as trees, nor can they fully address the design needs of contemporary engineering structures. The recently developed Performance Control （PC） incorporates both the essence of the classical concepts and the newer procedures and addresses the observed performance of the structure during its known history of loading, PC attempts to mimic nature by applying the known theories of structures to the design of case-specific frameworks, rather than investigating their results for compliance against prescriptive criteria. Parametric examples have been provided to illustrate the applications of the conceptual design similarities between trees and manmade moment frames. It has been shown that an understanding of the structural performance of trees can enhance the structural design of moment frames, and that bioinspired PC can lead to minimum weight moment frames under lateral loading. The analogous performances of the natural and manmade structures may help explain the structural response of trees to similar loading scenarios.

关键词： performance control biomimetics trees moment frames lateral loading

Coal bursts that occur during development: A rock mechanics enigma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2018年第1期28卷 35-42页

作者： Christopher mark Safety and Health Administration Pittsburgh 15236USA

Coal bursts are typically associated with highly stressed *** bursts occur during retreat mining(longwall mining or pillar recovery) in highly stressed locations like the tailgate corner of the longwall *** are associated with multiple seam ***, a small but significant percentage of coal bursts have occurred during development or in outby locations unaffected by active *** development bursts have been relatively small, but some have been highly *** theory of coal bursts can be complete if it does not account for this type of *** paper focusses on the development mining coal burst experience in the US, putting it into the context of the entire US coal burst *** first documented development coal burst occurred almost exactly 100 years ago during slope drivage at the Sunnyside Mine in *** subsequently had a long history of bursts, mainly during retreat mining but also during *** Colorado mines have also experienced multiple development ***, but by no means all, of the development bursts in these western US coalfields have been associated with known *** the Central Appalachian coalfields, most development bursts have occurred in multiple seam *** some of these cases, however, there was no retreat mining in either *** paper closes with some lessons from this history, with implications for preventing such events in the future.

关键词： Coal Underground Ground control Bursts Multiple seam

Hydrogen Hubs Arise in the United States

在线全文

学校读者我要写书评

暂无评论

ENGINEERING 2024年第11期42卷 3-5页

作者： Peplow, mark 不详

July 2024 saw the first"hydrogen hub"(H2Hub)officially launched in the United States[1].Centered in the state of California,the hub is one of a group of seven such H2-focused infrastructure projects across the country(Table 1)selected to share 7 billion USD in funding allocated by the Biden-Harris Administration in October 2023[2].The aim for the investment is to accelerate the country’s production and use of H_(2)as a fuel and feedstock chemical;H_(2)combustion releases only water,and many believe that the gas could help to reduce climate-changing CO_(2)emissions by replacing fossil fuels in transportation,the chemicals industry,and other economic sectors.

关键词： release official funding