Malignant melanoma in the pediatric population

作     者：John Psaltis Eric Reintgen Ali Antar Mark Giori Leah Alvin Alyssa Benjamin Bridget Budny Taylor Gianangelo Aaron Gruman Anna Stamas Michael Reintgen Rosemary Giuliano Jeff Smith Douglas Reintgen 

作者机构：Department of Surgery Morsani School of Medicine University of South Florida Department of Pathology Florida Hospital-N Pinellas 

出 版 物：《World Journal of Surgical Procedures》 (世界外科手术杂志)

年 卷 期：2015年第5卷第3期

页      面：229-234页

学科分类：10[医学] 

主　　题：Pediatric pigmented skin lesions Sentinel lymph node biopsy Melanoma 

摘      要：Controversial pigmented lesions in children are a problem for pathologist, clinicians and families that are confronted with this dilemma. Some skin lesions in this population defy diagnosis with pathologists split between a benign diagnosis and a cancer diagnosis. Three cases of controversial pigmented lesions in the pediatric population are presented. Three patients underwent radical resection of the controversial pigmented lesion, intra-operative lymphatic mapping and sentinel lymph node(SLN) biopsy. Due to the low morbidity of the SLN procedure a case is made to perform lymphatic mapping in this clinical scenario. If the SLNs are negative, not much is lost except for the scar and this becomes another line of evidence that perhaps the original lesion was benign. If the SLN shows metastatic cells, then the original skin lesion must be malignant and the patient is offered stage Ⅲ recommendations that would include complete node dissections and adjuvant Interferon therapy. This strategy provides for adequate treatment of the worse-case scenario, that the skin lesion is malignant. The cost to the patient is a low morbidity procedure, the SLN biopsy.