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SARS-coV-2 productively infects primary human immune system cells in vitro and in coviD-19 patients

Journal of Molecular cell Biology 2022年第4期14卷 51-64页

作者： marjorie c.pontelli italo A.castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele c.Nascimento camila M.Silva Ricardo S.cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda c.Vitti Diego B.caetite Mikhael H.F.de Lima Spencer D.Stumpf cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela c.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio c.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo c.Santana Fernando c.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.cunha Rodrigo T.calado Joséc.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.cunha Eurico Arruda Virology Research center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Biochemistry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Molecular Microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-covV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(coVID-19)*** rates of SARS-cov-2-infected monocytes in peripheral blood mononuclear cells from coVID-19 patients increased over time from symptom onset,with SARS-coV-2-positive monocytes,B cells,and cD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-coV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-coV-2 coVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMc) lymphocytes monocytes apoptosis

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A Meditation on Education in Honour of Dewey’s One Hundred and Fiftieth Birthday,celebrated in the Land of Kongzi

A Meditation on Education in Honour of Dewey’s One Hundred ...

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The Mid-term conference of Research committee on the Sociology of Leisure (ISA Rc 13) and 2009 china Annual Symposium on Leisure and Social Progress

作者： marjorie c.Miller Professor Department of Philosophy Purchase CollegeSUNYU.S.A Currently a Fulbright Senior Lecturer in PhilosophyPusan National UniversityPusanKorea

＜正＞Dewey shares with confucius a strange characteristic:both of the great teachers induced the development of educational systems "honoured" by association with their names:confucian education describes the educational system utilized by East Asians for thousands of years;whereas the educational system of the United States （and others countries who followed） is known,for roughly the period from the late 1930s to the present,as Dewey’s progressive

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Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro

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cellular & Molecular Immunology 2018年第10期15卷 917-933页

作者： Jacobo Lopez-Abente Adrián Prieto-Sanchez Maria-Ángeles Muñoz-Fernandez Rafael correa-Rocha marjorie Pion Laboratorio de Inmuno-Regulación Immunology DepartmentPabellón de Medicina y Cirugía ExperimentalHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)Calle Máiquez9Madrid 28009Spain Laboratorio de Inmuno-Biología Molecular Immunology DepartmentHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)C/Dr.Esquerdo 46Madrid 28007Spain Networking Research center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)C/Monforte de Lemos 3-5Pabellón 11Madrid 28029Spain

Individuals infected with human immunodeficiency virus type-1(HIV-1)usually show a general dysregulation and hyper-activation of the immune system.A direct influence of HIV-1 particles on B-cell phenotypes and functions has been previously ***,the consequences of B-cell dysregulation are still poorly *** evaluated the phenotypic changes in primary B cells after direct contact with HIV-1 particles in comparison with different types of *** functionality of treated B cells was challenged in co-culture experiments with autologous cD4+and cD8+T *** demonstrated that HIV-1 induces a phenotypic change in B cells towards a regulatory B-cell phenotype,showing a higher level of IL-10,TGF-β1,EBI3 or IL-12(p35)mRNA expression and acquiring an immunosuppressive *** acquisition of a Breg phenotype was confirmed by co-culture experiments where HIVtreated B cells reduced the proliferation and the TNFαproduction of cD4+or cD8+T *** suppressive ability of HIV-treated B cells was dependent on cell-to-cell contact between these B cells and effector *** our knowledge,these data provide the first evidence that HIV-1 can directly induce a regulatory B cell-like immunosuppressive phenotype,which could have the ability to impair specific immune *** dysregulation could constitute one of the mechanisms underlying unsuccessful efforts to develop an efficient vaccine against HIV-1.

关键词： HIV-1 immune hyper-activation regulatory B cells

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Microwave Plasma Treatment for catalyst Preparation: Application to Alumina Supported Silver catalysts for ScR NO<sub>x</sub>by Ethanol

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Modern Research in catalysis 2013年第3期2卷 68-82页

作者： marjorie Foix cédric Guyon Michael Tatoulian Patrick Da costa chimie Paristech LGPPTS Plasma Chemical Engineering Laboratory Paris France UPMc Paris 6 Sorbonne University IJLRA JEan Le Rond d’Alembert Institute Saint Cyr L’Ecole France

Thermal treatment either in the presence of oxygen (calcination) or of a reducing agent (reduction) result is all the time a key issue within the preparation of a catalyst. In this work, a microwave plasma treatment was chosen as an alternative to typical calcinations, because it is a more energy efficient process. Thus, a Microwave Fluidized Bed Plasma reactor (MFBP) was employed in catalyst synthesis process under different gas compositions, such as argon and argon/oxygen mixtures over g-alumina supported silver catalysts, which are generally used for selective reduction of NOx by ethanol. After the first catalytic tests performed in the presence of plasma treated catalyst, it can be concluded that plasma treatment process represents an interesting alternative to conventional calcination during catalyst synthesis, resulting in a more sustainable process, moreover in view of its industrial application. In order to understand the particular effect of plasma treatment, the catalysts submitted to this treatment were carefully characterized by means of thermo gravimetric analysis (TGA), differential thermal analysis (DTA) and UV-VIS-NIR.

关键词： Microwave Plasma Fluidized Bed Reactor catalyst Synthesis Silver catalyst NOx Reduction

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Major bleeding events in octagenarians associated with drug interactions between dabigatran and P-gp inhibitors

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Journal of Geriatric cardiology 2019年第11期16卷 806-811页

作者： marjorie Bernier Sarah-Line Lancrerot Fanny Rocher Elise K Van-Obberghen Pierre Olivier Thibaud Lavrut Nadège Parassol-Girard Milou-Daniel Drici Department of Pharmacology and Toxicology PharmacoVigilance CenterUniversity of Nice Côte d'Azur Medical CenterHôpital de Cimiez4 Avenue Reine VictoriaBP 117906003NiceFrance Emergency Department Short Stay Unit University of Nice Côte d'Azur Medical CenterHôpital Pasteur 230Voie Romaine 06001NiceFrance

Background The direct oral anticoagulant dabigatran does not require any routine therapeutic drug ***,concerns about possible drug interactions susceptible to increase its inherent bleeding risk,especially in very elderly patients,have been raised *** aim of our study was to evaluate to what extent the co-prescription of P-gp inhibitors with dabigatran may increase its plasma levels and lead to bleeding complications,in usual conditions of care of the very *** Fifty-eight patients over 85 years old with non valvular atrial fibrillation receiving dabigatran were included in a prospective *** were screened for the presence of P-gp inhibitors(Group A)or not(Group B).Results Patients from Group A had increased dabigatran mean plasma concentrations as compared with patients from Group B(A vs.B:182.2±147.3 vs.93.7±64.9 ng/m L).One third of the patients from Group A had dabigatran concentrations that were deemed"out of range"versus none in Group B(P=0.05).This was associated with more frequent bleeding complications in Group A(A:30.4%,B:8.6%,P=0.04).conclusion In our cohort of very elderly patients,at least,the co-prescription of dabigatran with P-gp inhibitors in usual conditions of care resulted in higher dabigatran plasma concentrations and more frequent bleeding occurrences.

关键词： Dabigatran Drug interaction Hemorrhage P-gp inhibitors,The elderly

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蛋白c与恶性肿瘤

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上海医学检验杂志 1990年第1期5卷 11-13页

作者：蒋贝子 Mahendra Rupani marjorie Sirridge 上海第二医科大学附属仁济医院美国杜鲁门医院美国密苏里勘萨斯大学医学院

本文测定了32例恶性肿瘤病人血浆蛋白c抗原水平,结果表明转移性肿瘤病大(20例)的蛋白c抗原水平明显升高(120.92±26.46%),和对照组(33例)(94±18.62%)相比较,有显著性差异(P0.05) 本研究提示,连续随访蛋白c抗原水平有利于对恶性肿瘤的... 详细信息

本文测定了32例恶性肿瘤病人血浆蛋白c抗原水平,结果表明转移性肿瘤病大(20例)的蛋白c抗原水平明显升高(120.92±26.46%),和对照组(33例)(94±18.62%)相比较,有显著性差异(P0.05) 本研究提示,连续随访蛋白c抗原水平有利于对恶性肿瘤的随访。

关键词：蛋白c 恶性肿瘤

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Information on Mapping and Vaccination Data in a Locality System

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E-Health Telecommunication Systems and Networks 2023年第3期12卷 49-60页

作者： Hilarion Jr. carunggay Raganas Jay Boy D. Metante Rhea Jean A. Aballe Fritz R. Boro Jonel D. Gelig Leonard c. Balabat marjorie O. Reso Windel A. Pelayo Joel c. Lim Shiela L. Tirol Ariel O. Tinapay college of computer Studies Cebu Roosevelt Memorial Colleges Bogo City Philippines

During the pandemic, technological innovation provided a platform with a range of uses, including in the healthcare industry. Technology is currently being used in vaccination drives run by many governments across the world to help spread vaccines quickly and efficiently. The technology makes healthcare personnel more effective at their professions and greatly raises the standard of service in the industry. The researchers undertook this study to create a suitable and long-lasting immunization database with a mapping method to give a better perspective of the immunization status. To gather essential information for this study, the researchers spoke with the local health officer in the targeted area. The obtained data then served as the basis for the system’s capabilities and features, becoming the target problems addressed by the developers. The investigation found that the majority of procedures and interactions are carried out manually and recorded on an unprotected, antiquated Excel spreadsheet. The researchers’ technology also shows to be a superior way to deal with the problems and difficulties while making their health-related transactions and operations quicker, safer, and much more effective.

关键词： Vaccination Database Mapping Information System cOVID-19 Technology Health Sector

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维生素c强化咖啡粉作为潜在载体的评价研究

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上海师范大学学报（自然科学版） 2021年第2期50卷 133-141页

作者： Mary-Ross L.LAMSEN Penfield P.marjorie Zivanovic SVETLANA 田纳西大学食品科学系美国田纳西州诺克斯韦尔37996-4539

分别对添加了每日膳食营养素推荐供给量标准(RDA为90 mg)的50%,75%和100%维生素c的咖啡粉进行了维生素c的潜在载体的评估研究.旨在评价咖啡冲泡和贮藏3个月后产品中维生素c的稳定性,并探究消费者是否能感知普通咖啡和维生素c强化咖啡之... 详细信息

分别对添加了每日膳食营养素推荐供给量标准(RDA为90 mg)的50%,75%和100%维生素c的咖啡粉进行了维生素c的潜在载体的评估研究.旨在评价咖啡冲泡和贮藏3个月后产品中维生素c的稳定性,并探究消费者是否能感知普通咖啡和维生素c强化咖啡之间的差异.实验结果表明:添加50%RDA水平的咖啡在冲泡过程中损失16%的维生素c;但更高强化水平的咖啡未发现维生素c的损失.室温贮藏3个月后,添加100%RDA水平的强化咖啡未见维生素c降解,而在另两个低强化水平下检测到5%~6%维生素c的损失.每份添加50%或75%RDA维生素c的冲泡咖啡的口感与未强化咖啡不存在显著性差异.因此,添加75%RDA维生素c的强化咖啡粉可确保在不改变其感官特性的情况下,将添加的维生素完全保留在冲泡咖啡饮料中.咖啡粉可用于日常膳食维生素c强化的潜在载体.

关键词： L-抗坏血酸维生素c 咖啡三角检验感官强化

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《放射性秘史:从新发现到新科学》

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科学新闻 2017年第8期 10-10页

作者： marjorie c.Malley

出版社:Oxford University Press出版时间:2011年8月内容简介从1896年一项毫不起眼的发现开始,放射性把研究者带上了一条迷雾重重的求知之路,来到已知和未知的交叉地带。是什么导致某些原子放出不可见的、具有穿透性的射线?放射性释放... 详细信息

出版社:Oxford University Press出版时间:2011年8月内容简介从1896年一项毫不起眼的发现开始,放射性把研究者带上了一条迷雾重重的求知之路,来到已知和未知的交叉地带。是什么导致某些原子放出不可见的、具有穿透性的射线?放射性释放出的巨大能量来自哪里?实验结果迫使研

关键词：放射性研究者

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Experiences of Early and Enhanced clinical Exposure for Postgraduate Neonatal Nursing Students at the University of Zambia, School of Nursing Sciences: Lessons and Implications for the Future

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Open Journal of Nursing 2023年第6期13卷 352-367页

作者： Victoria Mwiinga Kalusopa Patricia Katowa-Mukwato Kabwe chitundu Manasseh Mvula Selestine Nzala marjorie Kabinga-Makukula christabell Mwiinga Emmanuel Musenge Mwila Linda Kampata Micheal Kanyanta Mumba Micheal chiguntap James Sichone concept Kwaleyela Phadaless Phiri Suzan Mutemwa Mildred Zulu chileshe Mwaba-Siwale Ruth Wahila Mukumbuta Nawa Mercy Monde Wamunyima Francina Makondo charity Syatalimi Elliot Kafumukache Fastone Goma School of Nursing Sciences University of Zambia Lusaka Zambia School of Medicine and Health Sciences University of Lusaka Lusaka Zambia School of Medicine University of Zambia Lusaka Zambia School of Public Health University of Zambia Lusaka Zambia School of Health Sciences University of Zambia Lusaka Zambia School of Medicine and Health Sciences Mulungushi University Kabwe Zambia School of Public Health and Environmental Studies Levy Mwanawasa Medical University Lusaka Zambia Medical Library University of Zambia Lusaka Zambia Main Library University of Zambia Lusaka Zambia

Background and Objectives: Early and Enhanced clinical Exposure immediately places postgraduate students in a clinical setting and incorporates continual hands-on instruction throughout their studies. It aims to motivate students by strengthening their academics, improving clinical and communication skills, and increasing their confidence. The underlying principles are to provide a clinical context and to ensure that the patient remains the centre of learning. The School of Nursing Sciences implemented this model in 2021 to produce hands-on Masters-level neonatal practitioners who can work in multidisciplinary clinical contexts. Therefore, this study explored the experiences of postgraduate nursing students on the Early and Enhanced clinical Exposure model and draw implications for the future. Methods: A phenomenological study design was utilized at the University of Zambia, School of Nursing Sciences and comprised of eight Master of Science Neonatal Nursing students in their second year. convenience sampling was used to select the study site and participants. Data was collected between 15th January 2023 and 31st January 2023 using an in-depth interview guide. Audio recording and notes were transcribed immediately after data collection. Data analysis was conducted using thematic analysis and codes and themes were constructed from the coded data. Ethical clearance and permission were sought before conducting the study. Results: Four major themes emerged from the study: identity and role confusion, challenging and hectic experiences, positive educational experiences, and personal and professional growth. These themes contributed to the promotion of evidence-based practice by helping students to assess, diagnose, and treat various conditions, as well as gain interest, experience, knowledge, and exposure. conclusion: The model has a significant impact on motivation to learn, as evidenced by reported increased skill level with potential for use in c

关键词： Experience clinical Exposure Postgraduate Early Enhanced

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