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Factors Influencing Staff Performance in the Implementation of Project Activities in Governmental and Non-Governmental Organisations in Sierra Leone

Factors Influencing Staff Performance in the Implementation ...

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作者： marion Sesay 山东大学

学位级别：硕士

Staff performance has ’been a critical sensation and posed several challenges in competitive *** and discovering elements that constitute effective performance encompass a whole lot of issues bothering around staff *** construct of this study stemmed from experience gain from projects implementation which led to unfruitful *** study was constructed on the influential factors of staff performance in project activities in governmental and non-governmental organisations *** *** effective assembly of the structure of this study,mixed method of data collection was employed so that theories can be examined,coupled with first-hand information to establish objective *** the secondary method,information was extracted from published work,journals,books and other relevant materials that are meaningful for the construct of this *** materials were critically reviewed and thoroughly analysed to set the pace for further *** data was generated with the aid of questionnaires to obtain first-hand information from participants who availed satisfactory data that led to the discussion of *** data was analysed using cross tabulation of variables to determine percentages or respondents actions in the survey process with the aid of statistical package for social sciences（SPSS）.From the analysis conducted,relevant information disclosed how important the conduct of this study is and outlined the following factors influencing staff performance in governmental and non-governmental organisations:Training and development,coaching and mentoring,high employee engagements,financial rewards,employee satisfaction and *** aforementioned factors will aid practising project management specialists in the execution of their *** is noteworthy to know that this study is not only relevant to the case studies,but also to all sectors of development since achieving strategic objectives

关键词： Staff Performance Factors Influencing Non-Governmental Organisations Governmental Organisations Retention Mechanisms Sierra Leone

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Magic Mushrooms: Screening for Novel Biocatalysts in the Phylum Basidiomycota

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Advances in Bioscience and Biotechnology 2016年第11期7卷 446-453页

作者： Christoph Loderer marion B. Ansorge-Schumacher Technische Universitä t Dresden Dresden Germany

The ascending application of enzymes in organic synthesis creates a growing demand for novel biocatalysts. The applied methods for their identification range from microbial enrichment cultures over metagenome screenings to solely computational methods. In this communication, we demonstrate a straightforward screening approach for the detection of novel biocatalysts in fungi belonging to the phylum Basidiomycota. It basically relies on mincing of the whole fruit bodies of freshly collected mushrooms with subsequent direct screening. Suitability was demonstrated with eight different mushrooms which were investigated for carbonyl reductase activity on sterically demanding carbonyl compounds. The results indicate the presence of potentially useful carbonyl reductases (KREDs) in all tested fungi. Closer characterization of the preparation from pigskin poison puffball (Scleroderma citrinum) showed the presence of KRED exhibiting a broad substrate range. Thus, applicability of this low-tech screening approach could be verified in this study.

关键词： Biocatalysis Carbonyl Reduction Screening Biological Source

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基于空气悬浮芯微结构光纤的高灵敏度荧光检测系统

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中国激光 2018年第5期45卷 253-259页

作者：张炤王秀翃乔鹏飞刘倩倩 Lang marion 冯宪王璞北京工业大学激光工程研究院北京市激光应用技术工程技术研究中心北京100124

当空心微结构光纤纤芯的尺寸和波长相近时,光在纤芯中的传输大大增强,并会在纤芯周围产生很强的倏逝场。报道了一种新型的纤芯直径仅为2μm的空气悬浮芯微结构光纤,该光纤通过薄片堆积法拉制而成,具有大倏逝场和微米级孔径的单元结构,在... 详细信息

当空心微结构光纤纤芯的尺寸和波长相近时,光在纤芯中的传输大大增强,并会在纤芯周围产生很强的倏逝场。报道了一种新型的纤芯直径仅为2μm的空气悬浮芯微结构光纤,该光纤通过薄片堆积法拉制而成,具有大倏逝场和微米级孔径的单元结构,在532nm波长处的损耗为0.16dB/cm,非常适合用于生化物质的传感探测。以该光纤作为传感探针,结合激光技术搭建了一套简易的荧光光谱探测系统,使用此系统对纳升量级的生物荧光标记材料CdTe/CdS/ZnS量子点进行荧光探测分析。利用该系统可探测荧光量子点的极限约为1nmol/L,相当于3.78×107个量子点,实现了高灵敏度、快速探测。基于空气悬浮芯微结构光纤的荧光检测系统为量子点标记的生物材料的灵敏检测提供了新的方法和思路。

关键词：光纤光学空气悬浮芯微结构光纤倏逝场荧光光谱量子点光纤生物传感器

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采用应变梯度硬化模型预测黄铜薄板微弯曲弯矩

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上海交通大学学报 2011年第11期45卷 1668-1672,1683页

作者：李河宗董湘怀申昱 Alexander Diehl Hinnerk Hagenah Ulf Engel marion Merklein 上海交通大学塑性成形工程系上海200030 河北工程大学机械电子工程学院河北邯郸056038 纽伦堡大学制造技术研究所德国埃尔兰根91058

通过黄铜板料微弯曲实验,发现其弯曲弯矩存在明显的尺寸效应现象,随板料厚度的减小,弯曲弯矩增大.采用经典塑性理论和不同的应变梯度理论对微弯曲弯矩进行了预测,对比分析结果表明:修正的Nix-Gao模型的预测结果更接近于实验结果,并且得... 详细信息

通过黄铜板料微弯曲实验,发现其弯曲弯矩存在明显的尺寸效应现象,随板料厚度的减小,弯曲弯矩增大.采用经典塑性理论和不同的应变梯度理论对微弯曲弯矩进行了预测,对比分析结果表明:修正的Nix-Gao模型的预测结果更接近于实验结果,并且得出了合理的内禀尺寸表达式;该内禀尺寸与材料的剪切模量、初始屈服极限、柏氏矢量和板料厚度方向上的孪晶数有关.

关键词： CuZn37黄铜微弯曲弯矩应变梯度内禀尺寸

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金属标准物质中杂质的辉光放电质谱法溯源分析

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冶金分析 2012年第2期32卷 6-10页

作者： RECKNAGEL Sebastian KIPPHARDT Heinrich LANGE Britta HOPPE marion 德联邦材料测试研究院

标准物质定值分析的溯源性要求比常规分析高很多。在常规分析中,有证标准物质(CRM)可用于校准以及建立可溯源性。尽管与标准物质生产和认定相关的ISO导则并没有十分明确地提到校准,但众多标准物质生产者在定值分析时却不接受基准标准物... 详细信息

标准物质定值分析的溯源性要求比常规分析高很多。在常规分析中,有证标准物质(CRM)可用于校准以及建立可溯源性。尽管与标准物质生产和认定相关的ISO导则并没有十分明确地提到校准,但众多标准物质生产者在定值分析时却不接受基准标准物质用于校准。这些要求制约了标准物质定值方法的使用,因为这些方法可以采用已知高纯度的标准物质、化学计量法及已知高纯度标准物质的混合物进行校准。有效的固体取样技术,例如通常使用的块状标准物质进行校准的辉光放电质谱法(GD-MS)或火花源发射光谱法(spark-OES),似乎不太适合定值分析。尤其是固体样品中痕量元素分析测定的有力工具辉光放电质谱法,除金属杂质外,使用特定气体混合物,这种方法也可以分析相关的非金属杂质如硫和磷。我们开发了一种可以使用已知高纯度的标准物质混合物和化学计量法的校准方法,这种校准方法同样可用于辉光放电质谱法。与溶液中基体匹配技术类似,此校准方法基于掺杂的粉末压片。本文还结合铜和钢标准物质的定值分析结果进行了陈述。

关键词：标准物质溯源性辉光放电质谱法铜钢铁

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SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 129-146页

作者： Jes-Niels Boeckel Maximilian Mobius-Winkler marion Muller Sabine Rebs Nicole Eger Laura Schoppe Rewati Tappu Karoline E.Kokot Jasmin M.Kneuer Susanne Gaul Diana M.Bordalo Alan Lai Jan Haas Mahsa Ghanbari Philipp Drewe-Boss Martin Liss Hugo A.Katus Uwe Ohler Michael Gotthardt Ulrich Laufs Katrin Streckfuss-Bomeke Benjamin Meder Department of Cardiology Angiology and PneumologyUniversity Hospital HeidelbergD-69120 HeidelbergGermany Klinik und Poliklinik fur Kardiologie Universitatskrankenhaus LeipzigD-04103 LeipzigGermany German Center for Cardiovascular Research(DZHK) Partner site HeidelbergD-69120 HeidelbergGermany Clinic for General and Interventional Cardiology/Angiology Herz-und Diabeteszentrum NRWRuhr-Universitat BochumD-32545 Bad OeynhausenGermany Department of Cardiology and Pneumology University HospitalGeorg-August University GoettingenD-37075 GoettingenGermany German Center for Cardiovascular Research(DZHK) Partner site GoettingenD-37075 GoettingenGermany Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine in the Helmholtz AssociationD-10115 BerlinGermany Institute of Biology Humboldt Universitat zu BerlinD-10099 BerlinGermany Neuromuscular and Cardiovascular Cell Biology Max Delbruck Center for Molecular Medicine in the Helmholtz AssociationD-13092 BerlinGermany German Center for Cardiovascular Research(DZHK) Partner site BerlinD-10117 BerlinGermany Stanford Genome Technology Center Department of GeneticsStanford Medical SchoolPalo AltoCA 94304USA

Alternative mRNA splicing is a fundamental process to increase the versatility of the *** humans,cardiac mRNA splicing is involved in the pathophysiology of heart *** in the splicing factor RNA binding motif protein 20(RBM20) cause severe forms of *** identify novel cardiomyopathy-associated splicing factors,RNA-seq and tissue-enrichment analyses were performed,which identified up-regulated expression of Sam68-Like mammalian protein 2(SLM2) in the left ventricle of dilated cardiomyopathy(DCM) *** the human heart,SLM2 binds to important transcripts of sarcomere constituents,such as those encoding myosin light chain2(MYL2),troponin 13(TNNI3),troponin T2(TNNT2),tropomyosin 1/2(TPM1/2),and titin(TTN).Mechanistically,SLM2 mediates intron retention,prevents exon exclusion,and thereby mediates alternative splicing of the mRNA regions encoding the variable proline-,glutamate-,valine-,and lysine-rich(PEVK) domain and another part of the I-band region of *** summary,SLM2 is a novel cardiac splicing regulator with essential functions for maintaining cardiomyocyte integrity by binding to and processing the mRNAs of essential cardiac constituents such as titin.

关键词： Splicing Titin Dilated cardiomyopathy KHDRBS3 SLM2

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三正丁基膦稳定的铜(Ⅰ)β-二酮配合物的合成、表征以及作为前驱物用化学汽相沉积法生长铜膜(英文)

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无机化学学报 2004年第11期20卷 1257-1264页

作者：沈应中 marion Leschke Stefan E. Schulz Ramona Ecke Thomas Gessner Heinrich Lang Technische Universitt Chemnitz Fakultat für Naturwissen-schaften Institut für Chemie Lehrstuhl Anorganische Chemie Straae der Nationen 62 09111 Chemnitz Germany Technische Universitat Chemnitz Fakultat fü Elektrotechnik und Informationstechnik Zentrum fü Mikrotechnologien Reichenhainer Straae 70 09126 Chemnitz Germany

合成了一系列三正丁基膦辅助配体稳定的铜髣β鄄二酮配合物,对合成的配合物用元素分析、红外、核磁共振以及热重和差热等手段进行了表征。筛选出性能优良的配合物为前驱物用化学汽相沉积(CVD)的方法生长出金属铜膜,用SEM和EDX等手段对... 详细信息

合成了一系列三正丁基膦辅助配体稳定的铜髣β鄄二酮配合物,对合成的配合物用元素分析、红外、核磁共振以及热重和差热等手段进行了表征。筛选出性能优良的配合物为前驱物用化学汽相沉积(CVD)的方法生长出金属铜膜,用SEM和EDX等手段对生长的铜膜进行了表征。

关键词：三正丁基膦铜配合物 β-二酮合成前驱物化学汽相沉积法铜膜热分析扫描电镜 ×-射线能量散射

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Mucosal healing progression after acute colitis in mice

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World Journal of Gastroenterology 2019年第27期25卷 3572-3589页

作者： Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon marion Leclerc Francois Blachier Annaig Lan UMR PNCA AgroParisTechINRAUniversite Paris-SaclayParis 75005France UMR MICALIS INRAUniversite Paris-SaclayJouy-en-Josas 78350France

BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little *** To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced *** C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA *** The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammat

关键词： Colon luminal environment Dextran sodium sulfate-induced colitis Dysbiosis Epithelial repair Acute colitis

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细胞激光器研究进展及应用综述

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激光与光电子学进展 2018年第12期55卷 1-12页

作者：杜梦聪刘倩倩 marion Lang 王秀翃王璞北京工业大学激光工程研究院北京100124 北京市激光应用技术工程技术研究中心北京100124

细胞激光器是激光光子学和生命科学交叉领域的前沿研究方向,其工作原理是,在流体环境中,将荧光蛋白、生物兼容的荧光染料及荧光素等和细胞有机结合在一起,在谐振腔光反馈作用下使弱信号得到振荡放大实现细胞的激光输出。详细阐述了基于... 详细信息

细胞激光器是激光光子学和生命科学交叉领域的前沿研究方向,其工作原理是,在流体环境中,将荧光蛋白、生物兼容的荧光染料及荧光素等和细胞有机结合在一起,在谐振腔光反馈作用下使弱信号得到振荡放大实现细胞的激光输出。详细阐述了基于法布里-珀罗腔和回音壁模式微腔的细胞激光器的研究现状和基本原理,由于谐振腔对光信号的反馈放大作用,与传统的荧光信号相比,激光信号能够有效增强传感探测的灵敏度,提高分辨率。通过分析细胞等生物组织中发射激光的光谱和模式等信息来研究细胞内部的生理变化过程,为医学治疗诊断、生物材料三维超分辨成像及可集成光源研究等提供新的技术和设计思路。

关键词：激光器细胞激光器法布里-珀罗腔回音壁模式微腔生物传感超分辨成像

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Cyanobacteria Growth in Nitrogen- &Phosphorus-Spiked Water from a Hypereutrophic Reservoir in Kentucky, USA

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Journal of Environmental Protection 2021年第2期12卷 75-89页

作者： Sarah E. Hughes Jason W. marion Department of Environmental Health Science College of Health Sciences Eastern Kentucky University Richmond KY USA

Cyanobacteria may adversely impact aquatic ecosystems through oxygen depletion and cyanotoxin production. These cyanotoxins can also harm human health and livestock. In recent years, cyanobacterial blooms have been observed in several drinking water reservoirs in Kentucky, United States. In Kentucky, the paradigm is that phosphorous is the limiting nutrient for cyanobacteria growth. To explore this paradigm, an indoor microcosm study was conducted using hypereutrophic Guist Creek Lake water. Samples were collected and spiked with various combinations of locally used agricultural grade fertilizers, including ammonium nitrate, urea, and triple phosphate (calcium dihydrogen phosphate). Samples were incubated indoors for the photoperiod-specific to the time of the year. Cyanobacteria density, measured by phycocyanin, did not demonstrate increased growth with the addition of phosphate fertilizer alone. Cyanobacteria growth was enhanced in these conditions by the combined addition of ammonium nitrate, urea, and phosphorus fertilizer. Growth also occurred when using either ammonium nitrate or urea fertilizer with no additional phosphorus input, suggesting that phosphorus was not limiting the cyanobacteria at the time of sample collection. The addition of both nitrogen fertilizers (ammonium nitrate and urea) at the concentrations used in this study, in the absence of phosphorus, was deleterious to both the Chlorophyta and cyanobacteria. The results suggest further studies using more robust experimental designs are needed to explore lake-specific dual nutrient management strategies for preventing cyanobacterial blooms in this phosphorus-rich hypereutrophic lake and possibly other hypereutrophic lakes.

关键词： Nutrient Limitation Eutrophication Harmful Algal Bloom Fertilization Primary Productivity Phosphorous Loading Nitrate Loading Cyanobacteria Bloom

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