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In the name of the rose:a roadmap for rose research in the genome era

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Horticulture Research 2019年第1期6卷 948-964页

作者： marinus j.m.smulders Paul Arens Peter m.Bourke Thomas Debener marcus Linde jan De Riek Leen Leus Tom Ruttink Sylvie Baudino Laurence Hibrant Saint-Oyant jeremy Clotault Fabrice Foucher Plant Breeding Wageningen University and ResearchP.O.Box 3866700 AJ WageningenThe Netherlands Faculty of Natural Sciences Institute for Plant GeneticsMolecular Plant BreedingLeibniz University of HannoverHerrenhäuser Strasse 230419 HannoverGermany ILVO Plant Sciences UnitFlanders Research Institute for AgricultureFisheries and FoodCaritasstraat 399090 MelleBelgium BVpam CNRS FRE 3727UJM-Saint-ÉtienneUniv.LyonSaint-EtienneFrance IRHS Agrocampus-OuestINRAUniversitéd’AngersSFR 4207 QuaSaV42 rue Georges Morel BP 6005749071 BeaucouzéFrance

The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting *** to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in *** cultivars are highly heterogeneous and *** vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical *** can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding *** paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be *** outline possible approaches for a number of these questions.

关键词： breeding cultivar linkage

High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array

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Horticulture Research 2016年第1期3卷 68-75页

作者： mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter m Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris maliepaard marinus j m smulders Wageningen UR Plant Breeding Wageningen University&ResearchWageningenNL-6700 AJThe Netherlands Roath BV EindhovenThe Netherlands Pheno Geno Roses D.O.O.Bulevar oslobođenja 65a 21000 Novi SadSerbia

Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted *** tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homolog... 详细信息

Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted *** tetraploid rose,the existing linkage maps includemarkers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental *** rose breeding,crosses with unintended parents occur *** developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one *** of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal *** densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cm at an average marker distance of 0.9 *** with the strawberry(Fragaria vesca)genome was *** ICm1 corresponded to *** pseudochromosome 7(Fv7),ICm4 to Fv4,ICm5 to Fv3,ICm6 to Fv2 and ICm7 to *** ICm2 corresponded to parts of *** pseudochromosomes 1 and 6,whereas ICm3 is syntenic to the remainder of Fv6.

关键词： breeding linkage dosage

Consumer transparency in the production chain for plant varieties produced using new genomic techniques

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aBIOTECH 2024年第2期5卷 239-246页

作者： j.m.Lukasiewicz C.C.m.van de Wiel L.A.P.Lotz m.j.m.smulders Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic techniques(NGTs)currently fall under the Genetically modified Organisms Directive(2001/18/EC)in the European *** the proposal of the European Commission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinction between two categories of NGT plants:NGT-1 and ***-1 category plants are considered equal to plants obtained through conventional breeding *** plants will not be labelled for the consumer,although they will be labelled as ***-2 category plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the products,would mean that most steps in the production chain are transparent,but not the last step towards ***“right to know”and increasing knowledge of gene-edited food is a common theme in food labelling towards ***,we describe current labelling regimes and registers and how these may be applied to provide transparency on gene-edited products to ***,we also look into consumer studies,which indicate a greater acceptance of gene-edited food among consumers,especially when additional benefits such as sustainability are mentioned.

关键词： Labelling New genomic techniques Consumer transparency Plant products

A culture model to analyze the acute biomaterial-dependent reaction of human primary neutrophils in vitro

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Bioactive materials 2023年第2期20卷 627-637页

作者： marinus A.Wesdorp Andrea Schwab Ezgi Irem Bektas Roberto Narcisi David Eglin martin j.Stoddart Gerjo j.V.m.Van Osch matteo D’Este AO Research Institute Davos AO FoundationDavos PlatzSwitzerland Department of Orthopaedics and Sports medicine Erasmus MCUniversity Medical Center Rotterdamthe Netherlands mines Saint-Étienne Univ LyonUniv Jean MonnetINSERMU1059 SainbioseSaint-ÉtienneFrance Department of Biomaterials Science and Technology University of TwenteEnschedethe Netherlands Department of Otorhinolaryngology Erasmus MCUniversity Medical Center Rotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritimeand Materials EngineeringDelft University of Technologythe Netherlands Department of Oral and maxillofacial Surgery Erasmus MCUniversity Medical Center Rotterdamthe Netherlands

Neutrophils play a pivotal role in orchestrating the immune system response to biomaterials,the onset and resolution of chronic inflammation,and macrophage ***,the neutrophil response to biomaterials and the consequent impact on tissue engineering approaches is still scarcely ***,we report an in vitro culture model that comprehensively describes the most important neutrophil functions in the light of tissue *** isolated human primary neutrophils from peripheral blood and exposed them to a panel of hard,soft,naturally-and synthetically-derived *** overall trend showed increased neutrophil survival on naturally derived constructs,together with higher oxidative burst,decreased myeloperoxidase and neutrophil elastase and decreased cytokine secretion compared to neutrophils on synthetic *** culture model is a step to better understand the immune modulation elicited by *** studies are needed to correlate the neutrophil response to tissue healing and to elucidate the mechanism triggering the cell response and their consequences in determining inflammation onset and resolution.

关键词： inflammation healing culture

酸雨和UV-B对玉米幼苗光合速率和抗氧化酶活性的影响

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生态学报 2009年第9期29卷 4956-4966页

作者：龙云刘芸钟章成 marinus j.A.Werger 西南大学生命科学学院三峡库区生态环境教育部重点实验室重庆400715 西南大学资源环境学院重庆400715 荷兰乌德列支大学植物生态学系乌德列支800843508

以玉米(Zeamays L.)的两个品种渝糯7号和苏玉糯为研究材料,研究酸雨与UV-B辐射单一因子和复合处理对植物光合作用及抗氧化酶活性的影响机理,模拟酸雨[pH6.5(A0),4.5(A1)和3.5(A2)]和增强UV-B辐射[0(B0),2.88(B1)和5.76(B2)kj·m-·2d-1... 详细信息

以玉米(Zeamays L.)的两个品种渝糯7号和苏玉糯为研究材料,研究酸雨与UV-B辐射单一因子和复合处理对植物光合作用及抗氧化酶活性的影响机理,模拟酸雨[pH6.5(A0),4.5(A1)和3.5(A2)]和增强UV-B辐射[0(B0),2.88(B1)和5.76(B2)kj·m-·2d-1]及其复合作用下,玉米叶片光合速率,膜脂过氧化程度,抗氧化酶活性的变化。结果表明,与对照相比,酸雨或增强UV-B辐射单因素处理下两个品种的玉米幼苗所测生理指标有相似的变化,基本表现为:净光合速率和过氧化氢酶(CAT)活性降低,质膜透性与丙二醛(mDA)含量增加,过氧化物酶(POD)活性亦增加,超氧化物歧化酶(SOD)活性随处理时间延长先升高后降低。复合处理下,两个品种的玉米幼苗所测生理指标与对照相比也与单因素处理表现相似,且随处理组合的不同,复合胁迫下各指标的效果可能表现为协同效应,但更多地表现为拮抗作用。以上结果说明,模拟UV-B辐射升高和酸雨pH值降低促进了玉米叶片活性氧的代谢速率,导致了抗氧化酶系统的紊乱,抑制了光合作用。在复合处理下,两个因子对不同指标在不同处理时间和复合水平下,表现出一定的协同或拮抗效应可能与作物对环境变化产生一定的抗逆性和适应性有关。在不同时期两玉米品种对紫外辐射与酸雨敏感性不同。与苏玉糯相比,渝糯7号对外界环境变化的抗性更大。

关键词： UV-B辐射酸雨复合作用玉米光合速率膜脂质过氧化抗氧化酶活性

Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance

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journal of Sport and Health Science 2023年第2期12卷 194-201页

作者： Wouter m.A.Franssen Charly Keytsman Nastasia marinus Kenneth Verboven Bert O.Eijnde Lisa van Ryckeghem Paul Dendale Renate Zeevaert Guy massa Dominique Hansen Rehabilitation Research Centre(REVAL) Faculty of Rehabilitation SciencesHasselt UniversityHasselt 3500Belgium Biomedical Research Institute(BIOmED) Faculty of Medicine and Life SciencesHasselt UniversityHasselt 3500Belgium ADLON Sports medical Center Hasselt 3500Belgium Heart Centre Hasselt Jessa HospitalHasselt 3500Belgium Department of Pediatric Endocrinology and Diabetology Jessa HospitalHasselt 3500Belgium

Background:Adults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing,which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular *** is unknown whether cardiac chronotropic incompetence(CI)during maximal exercise is already present in obese adolescents and,if so,how that relates to cardiometabolic ***:Sixty-nine obese adolescents(body mass index standard deviation score=2.23±0.32,age=14.1±1.2 years;mean±SD)and 29lean adolescents(body mass index standard deviation score=-0.16±0.84,age=14.0±1.5 years)performed a maximal cardiopulmonary exercise testing from which indicators for peak performance were *** resting heart rate and peak heart rate were used to calculate the maximal chronotropic response ***(lipid profile,glycemic control,inflammation,and leptin)was studied in fasted blood samples and during an oral glucose tolerance test within obese *** analyses were applied to examine associations between the presence of CI and blood or exercise capacity parameters,respectively,within obese ***:CI was prevalent in 32 out of 69 obese adolescents(46%)and 3 out of 29 lean adolescents(10%).C-reactive protein was significantly higher in obese adolescents with CI compared to obese adolescents without CI(p=0.012).Furthermore,peak oxygen uptake and peak cycling power output were significantly reduced(pmore common in the current cohort of obese adolescents,and is related to systemic inflammation and exercise intolerance.

关键词： Adolescents Cardiometabolic health Exercise tolerance Heart rate Obesity

Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

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World journal of Gastroenterology 2009年第8期15卷 955-960页

作者： muhammed Hadithi Chris jj mulder Frank Stam joshan Azizi j Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo m smulders Department of Gastroenterology VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Department of Internal medicine VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Laboratory of Immunogenetics Department of Pathology VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Department of Internal medicine Academic Hospital Maastricht P. Debyelaan 25 6229 HX Maastricht The Netherlands

AIm: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. mETHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (mTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P min B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P min B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the mTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management.

关键词： Celiac disease Homocysteine Vitamin supplements

α-NAA和UV-B辐射对栝楼幼苗光合色素及保护酶活性的影响

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生态学报 2003年第1期23卷 8-13页

作者：刘芸钟章成 marinus j.A. Werger 操国兴尹克林龙云西南师范大学生命科学学院荷兰乌德列支大学植物生态学系乌德列支800843508 西南农业大学园艺系重庆400716

温室条件下研究 UV- B辐射 ( 0 .0 2 9j/( m2·s) )和外施 α-萘乙酸 ( α- NAA) ( 2 mg/L)对栝楼叶片光合色素及保护酶活性的影响。实验结果表明 :外施α- NAA,能提高栝楼幼苗叶片叶绿素及类胡萝卜素的含量 ,提高保护酶 SOD、CAT、POD... 详细信息

温室条件下研究 UV- B辐射 ( 0 .0 2 9j/( m2·s) )和外施 α-萘乙酸 ( α- NAA) ( 2 mg/L)对栝楼叶片光合色素及保护酶活性的影响。实验结果表明 :外施α- NAA,能提高栝楼幼苗叶片叶绿素及类胡萝卜素的含量 ,提高保护酶 SOD、CAT、POD、ASP的活性 ,细胞膜相对透性和膜脂过氧化产物 mDA含量相对稳定。UV- B辐射单独处理 ,则极显著地降低叶绿素 a的含量 ,叶绿素 b含量也呈明显地下降趋势 ,类胡萝卜素含量稍有下降 ,极显著降低栝楼幼苗叶片 SOD、POD、CAT、ASP活性 ,引起细胞膜相对透性明显增大 ,mDA含量显著增加。α- NAA与 UV- B辐射共同处理栝楼幼苗 ,与 UV- B辐射处理相比 ,叶绿体色素含量都有不同程度增加 ,而细胞膜相对透性、mDA含量则有不同程度降低 ,SOD、POD、ASP活性上升 ,CAT活性显著上升。以上结果暗示 ,UV- B辐射对生长的影响可能是 :( 1 )破坏光合色素而导致光合能力下降 ;( 2 )降低保护酶 SOD、POD、CAT、ASP活性 ,导致膜脂过氧化 ,膜结构遭到破坏 ,膜透性增加。而外施α- NAA,能部分减轻由增强的 UV- B辐射对栝楼幼苗造成的这种伤害 ,其原因可能是 α- NAA提高了保护酶活性 ,维持了活性氧产生与清除之间的平衡 ,即是维持了膜结构的稳定性。可见 ,α- NAA能增加栝楼对 UV- B辐射的抗性。

关键词： α-NAA UV-B辐射栝楼幼苗光合色素保护酶活性

α-NAA及UV-B辐射对栝楼幼苗生长及蒸腾作用的影响

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植物生态学报 2003年第4期27卷 454-458页

作者：刘芸钟章成龙云操国兴 marinus j.A.WERGER 西南师范大学生命科学学院西南农业大学农学及生命科学学院重庆400716 荷兰乌德列支大学植物生态学系乌德列支800843508

研究了温室条件下紫外线-B(UV-B)辐射(0.029 j·m^(-2)·s^(-1))和外施a-萘乙酸(a-NAA)(2 mg·L^(-1))相互作用对栝楼(Trichosanthes kirilowii)幼苗生长及蒸腾速率的影响。本实验设一个对照(T_0)和3个处理:外施a-NAA(T_1),增加UV-B辐射(T_2),增加UV-B辐射并外施a-NAA(T_3)。实验结果:增强UV-B辐射明显降低栝楼的株高及叶面积,根、茎、叶重均较对照低,因而总生物量也较对照低,干物质积累量减少。UV-B辐射增强,对栝楼植株含水量几乎无影响,但却明显增加叶气孔阻力,降低蒸腾速率。与对照(T_0)相比,外施a-NAA(T_1)明显增加株高及叶面积,根、茎、叶重均增加,因而单株总生物量较对照增加,但干物质积累量增幅不大,植株水分含量较对照略高;叶气孔阻力呈降低趋势,蒸腾速率呈增大趋势。在有UV-B辐射下外施a-NAA(T_3),与T_2相比,植株高度、叶重及叶面积降低趋势明显减轻,但根、茎生物量,单株总生物量及干物质积累量并无明显增加;叶气孔阻力降低,蒸腾速率增大。分析认为,栝楼幼苗根系发达,根冠比接近1,而UV-B辐射下补充a-NAA对根、茎影响小,同时本试验处理时间短(5周),表现为对生物量增加及干物质积累量的影响效果不明显,但株高、叶面积明显增加,且在一定程度上减小了叶的气孔阻力,增大了蒸腾速率。

关键词： α-NAA UV-B辐射栝楼幼苗生长蒸腾作用 α-萘乙酸紫外线