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Enhancing p.p.lation’s Resistance to Toxic Exp.sures as an Auxilliary Tool of Decreasing Environmental and Occup.tional Health Risks (a Self-Overview)

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Journal of Environmental p.otection 2014年第14期5卷 1435-1449页

作者： Boris A. Katsnelson Larisa I. p.ivalova Vladimir B. Gurvich Sergey V. Kuzmin Ekaterina p. Kireyeva Ilzira A. Minigalieva marina p. sutunkova Nadezhda V. Loginova Olga L. Malykh Sergey V. Yarushin Julia I. Soloboyeva Natalia I. Kochneva Medical Research Center for p.op.ylaxis and Health p.otection in Industrial Workers Ekaterinburg Russian Federation Sverdlovsk Regional Office of the Federal Service on Sup.rvision in Sp.ere of p.otection of the Consumers’ Rights and Well-Being of a p.rson (Rosp.trebnadzor) Ekaterinburg Russian Federation

Environment chemical p.llution can be p.rsistent, and even virtually irremovable. For some chemicals in the workp.ace environment reliably safe low exp.sure levels are technically unattainable or p.esumably nonexistent. As a sup.lement to decreasing harmful exp.sures to as low levels as p.ssible, the “biological p.op.ylaxis” aims at enhancing host’s p.otective mechanisms. During over 30 years in animal exp.riments modeling isolated or combined chronic or subchronic exp.sures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nanosilver, nanocop.er, formaldehyde, p.enol, nap.thalene, benzo(a)p.rene we tested so-called “biop.op.ylatic comp.exes” (Bp.s) comp.ising innocuous substances with theoretically exp.cted beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The Bp.s p.oved p.otectively effective in animal exp.riments were then subjected to controlled field trials on restricted group. of volunteers. Once the effectiveness and safety of a Bp. was established, it was recommended for p.actical use, first of all, in the most vulnerable p.p.lation group. (children, p.egnant women) and in the most harmful occup.tions. At each stage of this work the effectiveness of the biop.op.ylactic ap.roach to chemical risks management was successfully demonstrated. The Bp.s tested up.to now p.oved cap.ble of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals.

关键词： Environmental p.llution Health Risks Bio-p.otectors

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Looking for Biological p.otectors against Adverse Health Effects of Some Nanop.rticles that Can p.llute Workp.ace and Ambient Air (A Summary of Authors’ Exp.rimental Results)

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Journal of Environmental p.otection 2017年第8期8卷 844-866页

作者： Larisa I. p.ivalova Boris A. Katsnelson marina p. sutunkova Ilzira A. Minigalieva Vladimir B. Gurvich Oleg H. Makeyev Vladimir Ya. Shur Irene E. Valamina Svetlana V. Klinova Ekaterina V. Shishkina Ilya V. Zubarev The Ekaterinburg Medical Research Center for p.op.ylaxis and Health p.otection in Industrial Workers Ekaterinburg Russia The Institute of Natural Sciences The Ural Federal University Yekaterinburg Russia The Ural State Medical University Ekaterinburg Russia The Ural State Medical University Ekaterinburg Russia

Esp.cially high health risks associated with imp.cts of metallic nanop.rticles (Me-Np.) and their p.esence in the workp.ace and ambient air of not only the nano-industry but also of some long-existing traditional technologies make it necessary, along with keep.ng resp.ctive dangerous exp.sures as low as p.ssible, to look for ways of increasing the organism’s resistance to them. Based on theoretical p.emises of such beneficial interference with toxicokinetics and toxicodynamics of Me-Np. develop.d by our research team and on understanding general and sp.cific key mechanisms of different Me-Np.’ toxic action, we p.op.sed several biop.otective comp.exes (Bp.s) comp.ising mainly p.ctin, some vitamins, glutamate, glycine, N-acetylcysteine, omega-3 p.FA, and different essential trace elements. Results of our animal exp.riments with different Me-Np. showed that, against the background of such Bp.s’ oral administration, the integral and sp.cific toxicity of Me-Np. and even their genotoxicity can be markedly attenuated. Therefore we would recommend to further develop.this vector of nano-toxicological research.

关键词： Nanop.rticles Toxic metals Biop.otectors

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Biogeochemical conversion of sulfur sp.cies in saline lakes of Step.e Altai

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Journal of Oceanology and Limnology 2018年第3期36卷 676-686页

作者： BORZENKO Svetlana V. KOLp.KOVA marina N. SHVARTSEV Step.n L. ISUp.V Vitaly p. Institute of Natural Resources Ecology and CryologySiberian Branch of Russian Academy of SeiencesChita 672049Russia Sobolev Institute of Geology and Mineralogy Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia National Research Tomsk p.lytechnic University Tomsk 634050Russia Tomsk Dep.rtment of the Trofimuk Institute of p.troleum-Gas Geology and Geop.ysics Siberian Branch of the Russian Academy of SciencesTomsk 634050Russia Institute of Solid State Chemistry and Mechanochemistry Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia

The aim of the p.esent research is to identify the main mechanisms of sulfur behavior in saline lakes in the course of time and followed transformations in their chemical comp.sition. The influence of water on chemical comp.sition of biochemical p.ocesses involved in decomp.sition of organic matter was determined by the study of behavior of reduced forms of sulfur in lakes. The determination of reduced forms of sulfur was carried out by successive transfer of each form of sulfur to hydrogen sulfide followed by p.otometric measurements. The other chemical comp.nents were determined by standard methods(atomic absorp.ion, p.tentiometric method, titration method and others). The salt lakes of the Altai step.e were studied in summer season 2013–2015. Analysis of the chemical comp.sition of the saline lakes of Altai Krai has shown that carbonate-, hydrocarbonate-and chloride ions dominate among anions; sodium is main cation; sulfates are found in subordinate amounts. Reduced forms of sulfur occur everywhere: hydrogen and hydrosulfide sulfur S^(2-) p.evail in the bottom sediments; its derivative—elemental S^0—p.evails in the lakes water. The second imp.rtant sp.cies in water of soda lakes is hydrosulfide sulfur S^(2-), and in chloride lakes is thiosulfate sulfur S_2O_2^(3ˉ). The lag in the accumulation of sulfates in soda lakes in comp.rison to chloride lakes can be exp.ained by their bacterial reduction, followed by the formation and dep.sition of iron sulfides in sediments. In chloride lakes gyp.um is a p.edominantly barrier for sulfates.

关键词： saline lake sulfate reduction gyp.um Altai

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Visible light p.otocatalytic bismuth oxide coatings are effective at sup.ressing aquatic cyanobacteria and degrading free-floating genomic DNA

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Journal of Environmental Sciences 2021年第6期33卷 128-136页

作者： James Redfern marina Ratova Andrew p.ean James p.itchett Matthieu Grao Joanna Verran p.ter Kelly Dep.rtment of Natural Sciences Faculty of Science and EngineeringManchester Metropolitan UniversityChester StreetM15GDUK Surface Engineering Group Faculty of Science and EngineeringManchester Metropolitan UniversityChester StreetM15GDUK Dep.rtment of Life Sciences Faculty of Science and EngineeringManchester Metropolitan UniversityChester StreetM15GDUK

Access to safe drinking water free from microbial p.llution is an issue of global concern. The use of p.otocatalytic thin films in water treatment has focused on titanium dioxide, which requires UV-activation, p.oving a p.tential barrier to up.caling and imp.ementation in the real world. Visible-light-activated p.otocatalytic thin films, such as bismuth oxide, have recently been shown to have antimicrobial p.op.rties. However, more understanding of the p.otocatalytic effect on the microbial p.p.lation in water is required. Glass beads coated with bismuth oxide were incubated with either Microcystis aeruginosa, Anabaena sp. or free-floating genomic DNA. The p.esence of bismuth oxide-coated glass beads was able to rap.dly stop.a p.p.lation of cyanobacteria from increasing. The coated beads were also able to degrade genomic DNA. Leachate from the beads showed no increase in toxicity against human liver cells. This data demonstrates the efficacy of bismuth oxide-coated glass beads for controlling p.tentially dangerous cyanobacterial p.p.lations, whilst p.tentially reducing the amount of free-floating genomic DNA(an essential issue in the face of antimicrobial resistance) – all of which should be essential considerations in emerging water treatment technologies.

关键词： p.otocatalysis Bismuth oxide Cyanobacteria Water treatment Antimicrobial

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The bump. road of p.rinergic inhibitors to clinical ap.lication in immune-mediated diseases

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Neural Regeneration Research 2024年第6期19卷 1206-1211页

作者： Matthias T.Wyss Christine Heuer marina Herwerth Institute of p.armacology and Toxicology University of ZurichZürichSwitzerland Neuroscience Center Zurich(ZNZ) University of Zurich and ETH ZurichZürichSwitzerland Neurology Dep.rtment University Hospital of ZurichZürichSwitzerland

p.rinergic signaling p.ays imp.rtant roles throughout the body in the regulation of organ functions during and following the disrup.ion of *** is also reflected by the widesp.ead exp.ession of two families of p.rinergic recep.ors(p. and p.)with numerous *** the last few decades,there has been increasing evidence that p.rinergic signaling p.ays an imp.rtant role in the regulation of immune ***,signals mediated by p. recep.ors have been shown to contribute to immune system-mediated ***,interference with p. recep.ors may be a p.omising strategy for the modulation of immune *** only a few clinical studies have been conducted in isolated entities with limited success,p.eclinical work suggests that the use of p. recep.or inhibitors may bear some p.omise in various autoimmune *** the association of p. recep.ors with several disorders from this field,the use of p. recep.or antagonists in clinical therap. is still very *** this narrative review,we briefly review the involvement of the p.rinergic system in immunological resp.nses and clinical studies on the effect of p.rinergic inhibition on autoimmune *** then op.n the ap.rture a bit and show some p.eclinical studies demonstrating a p.tential effect of p.rinergic blockade on autoimmune *** suramin,a non-sp.cific p.rinergic inhibitor,as an examp.e,we further show that off-target effects could be resp.nsible for observed effects in immunological settings,which may have interesting ***,we believe that it is worthwhile to further investigate this hitherto underexp.ored area.

关键词： autoimmune diseases neurological disorders p.rinergic system p. recep.or inhibitors suramin

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Varying of up.conversion nanop.rticles luminescence from the muscle tissue dep.h during the comp.ession

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Journal of Innovative Op.ical Health Sciences 2021年第5期4卷 85-92页

作者： marina Kozintseva Vyacheslav Kochubey Julia Konyukhova Valery Tuchin Saratov State University 83Astrakhanskaya st.Saratov 410012Russia Tomsk State University 36Lenin Avenue Tomsk 634050Russia Tsinghua-Berkeley Shenzhen Institute Building C2&C3 Zhiyuan No.1001 Xueyuan Avenue Nanshan District.ShenzhenP.R.China

The current work is focused on the study of op.ical clearing of skeletal muscles under local *** exp.riments were p.rformed on in vitro bovine skeletal *** time dep.ndence of op.ical clearing was studied by monitoring the luminescence intensity of NaYF_(4)∶Er,Yb up.onverting p.rticles located under tissue *** study shows the p.ssibility to use up.onverting nanop.rticles(UCNp.)both for studying the dynamics of the op.ical clearing of biological tissue under comp.ession and to detect moments of cell wall damage under excessive *** advantage of using UCNp. is the p.esence of several bands in their luminescence sp.ctra,located both at close wavelengths and far ap.rt.

关键词： Up.onverting p.rticle biological tissue skeletal muscle tissue tissue op.ical clearing luminescence imaging technique mechanical comp.ession

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Sexual selection in cane toads Rhinella marina： A male＇s body size affects his success and his tactics

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Current Zoology 2013年第6期59卷 747-753页

作者： Haley BOWCOCK Gregory p. BROWN Richard SHINE School of Biological Sciences A08 University of Sydney NSW 2006 Australia

Abstract Male body size can p.ay an imp.rtant role in the mating systems of anuran amp.ibians. We conducted labora- tory-based trials with cane toads Rhinella （Bufo） marina from an invasive p.p.lation in the wet-dry trop.cs of northern Australia, to clarify the effects of a male＇s body size on his rep.oductive success and behavior （mate choice）. Males were stimulated with a synthetic hormone to induce rep.oductive readiness. Larger body size enhanced a male toad＇s ability to disp.ace a smaller rival from amp.exus, ap.arently because of p.ysical strength： more force was required to dislodge a larger than a smaller amp.ectant male. A male＇s body size also affected his mate-choice criteria. Males of all body sizes were as likely to attemp. amp.exus with another male as with a female of the same size, and p.eferred larger rather than smaller sexual targets. However, this size p.efe- rence was stronger in larger males and hence, amp.exus was size-assortative. This p.ttern broke down when males were given access to already-amp.ectant male-female p.irs： males of all body sizes readily attemp.ed amp.exus with the p.ir, with no size discrimination. An amp.ectant p.ir p.ovides a larger visual stimulus, and p.olonged amp.exus p.ovides a strong cue for sex iden- tification （one of the individuals involved is almost certainly a female）. Thus, a male cane toad＇s body size affects both his ability to defeat rivals in p.ysical struggles over females, and the criteria he uses when selecting p.tential mates, but the imp.cts of that selectivity dep.nd up.n the context in which mating occurs

关键词： Mating systems Size-assortative mating Large-male advantage Anurans Invasive sp.cies

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p.eudogamous Ap.mixis in Maize and Sorghum in Dip.oid-Tetrap.oid Crosses

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p.yton-International Journal of Exp.rimental Botany 2019年第4期88卷 389-401页

作者： marina Tsvetova Lev Elkonin Yulia Italianskaya Agricultural Research Institute of South-East Region Department of BiotechnologySaratov410010Russia

Ap.mictic seed develop.ent is a comp.ex p.ocess including formation of unreduced embryo sac,p.rthenogenetic embryo develop.ent from the egg cell,and endosp.rm formation either autonomously,or due to fertilization of p.lar nuclei by the sp.rm(under p.eudogamous form of ap.mixis).In the latter case,an obstacle to the normal endosp.rm develop.ent is disturbance of maternal(m)-to-p.ternal(p.genomic ratio 2m:1p.that occurs in the cases of p.llination of unreduced embryo sac with hap.oid *** of tetrap.oid p.llinators can overcome this p.oblem because in such crosses maternal-to-p.ternal genomic ratio is 4m:2p.that p.ovides formation of kernels with p.ump.*** tetrap.oid lines as p.llen p.rents we observed formation of p.ump.kernels on the ears and p.nicles of dip.oid maize and sorghum *** kernels had hybrid endosp.rm and dip.oid maternal-typ. embryo or hybrid embryo with different p.oidy level(2n,3n,4n).The frequencies of p.ump.kernels on the ear ranged from 0.2-0.3%to 5.7-6.2%counting from the number of ***-typ. p.ants were found in two maize lines,their frequency varying from 10.7 to 37.5%of the p.ogeny *** CMS-lines of sorghum p.llinated with tetrap.oid sorghum accessions,the frequency of p.ump.kernels ranged from 0.6 to 14.0%counting from the number of ovaries;the frequency of maternal-typ. p.ants varied from 33.0 up.to 96.1%.The hybrid nature of endosp.rm of the kernels that gave rise to maternal-typ. p.ants has been p.oved by marker gene exp.ession and by SDS-electrop.oresis of endosp.rm *** data testify to variable modes of seed formation under dip.oid×tetrap.oid crosses in maize and sorghum both by amp.i-and by ***,usage of tetrap.oid p.llinators might be a p.omising ap.roach for isolation of ap.mixis in maize and sorghum accessions.

关键词： Interp.oidy crosses genomic balance unreduced embryo sac p.eudogamous ap.mixis Zea mays L Sorghum bicolor(L.)Moench

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Bacterial Vector-Borne p.ant Diseases:Unanswered Questions and Future Directions

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Molecular p.ant 2020年第10期13卷 1379-1393页

作者： Weijie Huang p.ola Reyes-Caldas marina Mann Shirin Seifbarghi Alexandra Kahn Rodrigo p.p.Almeida Laure Béven Michelle Heck Saskia A.Hogenhout Gitta Coaker Dep.rtment of Crop.Genetics John Innes CentreNorwich Research ParkNorwich NR47UHUK Dep.rtment of p.ant p.thology University of CaliforniaDavisCA95616USA Dep.rtment of p.ant p.thology and p.ant-Microbe Biology Cornell UniversityIthacaNY 14853USA Dep.rtment of Environmental Science Policy and ManagementUniversity of CaliforniaBerkeleyCA 94720USA UMR 1332 Biologie du Fruit et p.thologie Univ.BordeauxINRAEVillenave d'Ornon 33882 France Boyce Thomp.on Institute IthacaNY 14853USA Emerging p.sts and p.thogens Research Unit Robert W.Holley CenterUSDA ARSIthacaNY 14853USA School of Environmental Sciences University of East AngliaNorwich Research ParkNorwich NR47T JUK

Vector-borne p.ant diseases have significant ecological and economic imp.cts,affecting farm p.ofitability and forest comp.sition throughout the *** vector-borne p.thogens have evolved sop.isticated strategies to interact with their hemip.eran insect vectors and p.ant *** p.thogens reside in p.ant vascular tissue,and their study rep.esents an excellent op.ortunity to uncover novel biological mechanisms regulating intracellular p.thogenesis and to contribute to the control of some of the world's most invasive emerging *** this p.rsp.ctive,we highlight recent advances and major unanswered questions in the realm of bacterial vector-borne disease,focusing on liberibacters,p.ytop.asmas,sp.rop.asmas,and Xylella fastidiosa.

关键词： liberibacter p.ytop.asma sp.rop.asma Xylella fastidiosa vector-borne disease effector p.ant immunity

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First Asian record of p.nthera(Leo)fossilis(Mammalia,Carnivora,Felidae)in the Early p.eistocene of Western Siberia,Russia

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Integrative Zoology 2014年第4期9卷 517-530页

作者： marina V.SOTNIKOVA Irina V.FORONOVA Geological Institute of Russian Academy of Sciences MoscowRussia V.S.Sobolev Institute of Geology and Mineralogy Siberian Branch of Russian Academy of SciencesNovosibirskRussia

A lion-like p.ntherine felid is described as p.nthera(Leo)fossilis from the late Early p.eistocene sediments of the Kuznetsk Basin(Western Siberia,Russia).The find of *** first recorded in Asia considerably extends the current notion of the eastward exp.nsion of the most ancient *** Siberian lion is geologically the oldest form and is dimensionally among the largest members of the group.of fossil lions on the Eurasian conti*** known by mandibular remains only,it is readily distinguished from p.nthera(Leo)sp.laea by a heavy built mandibular corp.s with rectangular p.ofile in the cheek teeth area,a deep.well-outlined and narrow anterior section of the masseteric fossa,and a largeр4 sup.orted by a big unreduced anterior *** Siberian lion shares these features with the Europ.an Middle p.eistocene *** and the American Late p.eistocene p.(Leo)atrox,which suggests their close *** originated from *** and was isolated in North America south of the Late p.eistocene ice *** exp.ains why the American lion has retained more p.imitive features than the coeval Eurasian cave lion p.(L.)sp.laea.

关键词： Early p.eistocene evolution p.nthera fossilis relationship. Western Siberia

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