Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

作     者：Larisa I. Privalova Boris A. Katsnelson Marina P. Sutunkova Ilzira A. Minigalieva Vladimir B. Gurvich Oleg H. Makeyev Vladimir Ya. Shur Irene E. Valamina Svetlana V. Klinova Ekaterina V. Shishkina Ilya V. Zubarev 

作者机构：The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers Ekaterinburg Russia The Institute of Natural Sciences The Ural Federal University Yekaterinburg Russia The Ural State Medical University Ekaterinburg Russia The Ural State Medical University Ekaterinburg Russia 

出 版 物：《Journal of Environmental Protection》 (环境保护（英文）)

年 卷 期：2017年第8卷第8期

页      面：844-866页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Nanoparticles Toxic metals Bioptotectors 

摘      要：Especially high health risks associated with impacts of metallic nanoparticles (Me-NPs) and their presence in the workplace and ambient air of not only the nano-industry but also of some long-existing traditional technologies make it necessary, along with keeping respective dangerous exposures as low as possible, to look for ways of increasing the organism’s resistance to them. Based on theoretical premises of such beneficial interference with toxicokinetics and toxicodynamics of Me-NPs developed by our research team and on understanding general and specific key mechanisms of different Me-NPs’ toxic action, we proposed several bioprotective complexes (BPCs) comprising mainly pectin, some vitamins, glutamate, glycine, N-acetylcysteine, omega-3 PUFA, and different essential trace elements. Results of our animal experiments with different Me-NPs showed that, against the background of such BPCs’ oral administration, the integral and specific toxicity of Me-NPs and even their genotoxicity can be markedly attenuated. Therefore we would recommend to further develop this vector of nano-toxicological research.