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Antitumor effects of electrochemical treatment

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Chinese Journal of Cancer Research 2013年第2期25卷 223-234页

作者： Héctor Manuel Camué Ciria Maraelys Morales González Lisset Ortíz Zamora Luis Enrique Bergues Cabrales Gustavo Victoriano Sierra González Luciana oliveira de oliveira Rodrigo Zanella Antonio Carlos Buzaid Orlando Parise Luciana Macedo Brito Cesar Augusto Antunes Teixeira marina das Neves gomes Gleyce Moreno Venicio Feo da Veiga Marcos Telló Carla Holandino Research Department National Centre of Applied Electromagnetism Oriente University Pharmacy Department Oriente University Finlay Institute La lisa. La Habana Cuba Veterinary Teaching Hospital Federal University of Rio Grande do Sul. Porto Alegre Sírio e Libanês Hospital Faculty of Pharmacy Medicine Department Federal University of Rio de Janeiro Professor Paulo de Góes Institute of Microbiology Federal University of Rio de Janeiro Pontifical Catholic University of Rio Grande do Sul. Porto Alegre

Electrochemical treatment is an alternative modality for tumor treatment based on the application of a low intensity direct electric current to the tumor tissue through two or more platinum electrodes placed within the tumor zone or in the surrounding areas. This treatment is noted for its great effectiveness, minimal invasiveness and local effect. Several studies have been conducted worldwide to evaluate the anfitumoral effect of this therapy. In all these studies a variety of biochemical and physiological responses of tumors to the applied treatment have been obtained. By this reason, researchers have suggested various mechanisms to explain how direct electric current destroys tumor ceils. Although, it is generally accepted this treatment induces electrolysis, electroosmosis and electroporation in tumoral tissues. However, action mechanism of this alternative modality on the tumor tissue is not well understood. Although the principle of Electrochemical treatment is simple, a standardized method is not yet available. The mechanism by which Electrochemical treatment affects tumor growth and survival may represent more complex process. The present work analyzes the latest and most important research done on the electrochemical treatment of tumors. We conclude with our point of view about the destruction mechanism features of this alternative therapy. Also, we suggest some mechanisms and strategies from the thermodynamic point of view for this therapy. In the area of Electrochemical treatment of cancer this tool has been exploited very little and much work remains to be done. Electrochemical treatment constitutes a good therapeutic option for patients that have failed the conventional oncology methods.

关键词： Direct electric current electrochemical treatment antimmoral treatment tumor tumor electrolysis rumor entropy dissipative structure

Graves' Disease Thyroid Color-Flow Doppler Ultrasonography Assessment: Review Article

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Health 2014年第12期6卷 1487-1496页

作者： Thiago Adler Ralho Rodrigues dos Santos Rodrigo Otavio gomes Pina marina Taliberti Pereira de Souza maria Cristina Chammas Service of Ultrasound Department of Radiology Hospital das Clinicas da Faculdade de Medicina da Universidade de S&atilde o Paulo S&atilde o Paulo Brazil

Graves’ disease, as known today, is an autoimmune, diffuse, chronic disease of thyroid gland, as described by Robert Graves in 1835. It presents genetic predisposition and unknown etiology evidence, which is influenced in its development by several factors, including environment (dietary iodine intake, stress, drugs and infections). The disease is characterized by one or more changes: hyperthyroidism, goiter, ophthalmopathy, skin changes and pretibial myxedema, around 5% less common, and other symptoms 90% to 95%. One of the most relevant clinical practice aspects in Graves’ disease patients management is to distinguish Graves’ disease in initial phase, from other types of destructive thyrotoxicosis, in addition to evaluate therapeutic methods and efficient follow up, as well as predict early recurrence or remission of disease. Scintigraphy with pertechnetate (99 mTc) and TSH levels dosage are considered the choice for this purpose. However, they present some technical difficulties, as they are not widely available and have contraindications. In this scenario, thyroid color-flow doppler ultrasonography (US Doppler) presents a viable alternative, as a widely available, low cost, non-invasive and radiation free method, providing initial diagnosis and patients with Graves’ disease follow up. In adittion, this method is used in differential diagnosis with other causes of thyrotoxicosis in the early stage.

关键词： Thyroid Graves’ Disease Ultrasonography Color-Flow Doppler

Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center:A retrospective observational cohort study

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World Journal of Clinical Cases 2023年第12期11卷 2740-2752页

作者： Natália Souza Nunes Siqueira Livia Bitencourt Pascoal Bruno Lima Rodrigues marina Moreira de Castro Alan Sidnei Corrêa Martins Dante Orsetti Silva Araújo Luis Eduardo Miani gomes Michel Gardere Camargo maria de Lourdes Setsuko Ayrizono Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(Unicamp)Campinas 13083-878São PauloBrazil

BACKGROUND Although the gastrointestinal tract is the most affected by Crohn’s disease(CD),the condition triggers other consequent manifestations,and iron deficiency anemia(IDA)is one of the most ***(IV)iron replacement is currently available through several drugs,such as ferric hydroxide sucrose and ferric carboxymaltose(FCM).However,the clinical management of these conditions can be *** To elucidate the drug’s effectiveness,the present study analyzed,through medical records,the clinical and epidemiological data of a cohort of patients with active CD who received IV FCM for the IDA *** This retrospective observational study included 25 patients with active CD,severe anemia,and refractory to previous conventional *** were evaluated two times:During the last treatment with ferric hydroxide sucrose and treatment with *** After treatment with FCM,parameters of IDA assessment significantly improved,serum hemoglobin(Hb)levels increased in 93%of patients(P<0.0001),and in 44%,there was an increase of≥2 g/dL in a single *** addition,86%of the patients showed an increase in serum iron(P<0.0001)and ferritin(P=0.0008)and 50%in transferrin saturation(P=0.01).The serum iron levels at baseline showed a negative association with the ileal and colonic CD and use of biologics and a positive association with patients who developed CD later in life after the age of 40(A3)and with a stenosing(B2)and fistulizing(B3)*** values of Hb and hematocrit after ferric hydroxide sucrose treatment remained similar to those found before *** This study demonstrated that FCM is an important therapeutic strategy for treating IDA in CD patients,achieving satisfactory results in refractory cases.

关键词： Ferric carboxymaltose Iron deficiency anemia Crohn’s disease Inflammatory bowel disease Anemia Clinical management

Social Media and the Impact on Alcohol Consumption: A Study among Academics from a Public University in a Western Amazon City, Porto Velho, Brazil

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Social Networking 2019年第3期8卷 113-121页

作者： Rosely Valéria Rodrigues marina gomes Martellet Giovanna Lorena Nery Tavernard Sérgio Valério Escobar Filho Department of Medicine Federal University of Rond&ocirc nia Porto Velho Brazil Academic Nursing Federal University of Rond&ocirc nia Porto Velho Brazil Academic Medicine Federal University of Rond&ocirc nia Porto Velho Brazil

This is a descriptive study of quantitative approach, developed at the Federal University of Rond?nia located in the Western Amazon. With the aim of analyzing the frequency of visualization of alcoholic content in the Facebook, Instagram and Snapchat, patterns of consumption, reasons that lead them to drink, most used social network and to correlate how often the users are exposed to alcoholic publications, determining if there was an important link between individual drinking practice during the beginning period and six months later. The information was obtained through the application of questionnaires for incoming students of the freshmen semester, in two moments: a period from August to December 2016/2, and, asking the same students again, from March to June 2017/1. 52.8% were males in 2016/2 and 57, 9% of females in 2017/1 with age ranging between 18 and 20 years in both periods. Facebook has proven to be the most used platform among college students. In 2016/2, 63.9% reported seeing alcohol content at Facebook and consuming that substance, comparing to Instagram with 70.4%, and to Snapchat with 74.1%. In 2017/2, academics reporting viewing alcoholic content on Facebook and consuming those alcoholic beverages accounted for 65.8%, compared to Instagram, 74.1% and Snapchat 74.4%. “Celebrating a special occasion with friends” is the most cited reason of why claim to consume alcohol. Therelation between exposure to the alcohol content of the virtual media and the network of friends was found imperceptible to the majority of the students, as they mostly do not consider themselves exposed. Many university students start the graduation already consuming alcoholic substances, which explains why there is no significant change in alcohol consumption between the observed moments, although it was found a relationship between the visualization of alcohol content in social networks and consumption, with greater impact on Snapchat.

关键词： Social Network Alcohol College Students

Familial Hypercholesterolemia in an Azorean Family:A Novel Mutation in the Low-Density Lipoprotein Receptor Gene

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Advances in Bioscience and Biotechnology 2014年第8期5卷 685-691页

作者： Rita Lourenco Luisa Martins Joao Anselmo marina Rita Soares Ana Medeiros Mafalda Bourbon Rui Cesar Fernanda gomes Department of Pediatrics Hospital do Divino Espírito Santo de Ponta DelgadaAzoresPortugal Department of Endocrinology Hospital do Divino Espirito Santo de Ponta DelgadaAzoresPortugal Instituto Nacional de Saúde Dr.Ricardo Jorge LisbonPortugal

Familial hypercholesterolemia (FH) is one of the most prevalent autosomal dominant inherited disorders. Mutations have been found in at least 3 genes: the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin type 9 (PCSK9). We report on an Azorean family with FH due to a novel mutation in the LDLR gene across three generations. The index-case was first seen at our endocrinology consultation at 12 years old, because of delayed growth and development. Laboratorial investigations revealed a complete failure of the anterior hypophysis due to a congenital malformation of the sella turcica. A total cholesterol of 313 mg/dL (90 - 190 mg/dL) and low-density lipoprotein cholesterol (LDL-C) of 262 mg/dL ( G) causing a premature termination of transcription (stop codon) was identified.

关键词： Familial Hypercholesterolemia LDL Receptor Gene Pediatric Patients Statins

Projections of Precipitation Changes in Two Vulnerable Regions of São Paulo State, Brazil

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American Journal of Climate Change 2017年第2期6卷 268-293页

作者： Iracema F. A. Cavalcanti Lucí H. Nunes José A. Marengo Jorge L. gomes Virginia P. Silveira marina S. Castellano Center of Weather Forecasting and Climate Studies/National Institute for Space Science (CPTEC/INPE) Cachoeira Paulista S.P. Brazil State University of Campinas (UNICAMP) Cachoeira Paulista S.P. Brazil National Center for Monitoring and Early Warning of Natural Disasters (CEMADEN) S&atilde o José dos Campos S.P. Brazil

Weather and climate extremes are part of the natural variability. However, the frequency and intensity of precipitation extremes have increased in the globe following the global warming. Extreme precipitation impacts such as landslides and flooding with implications to vulnerability and adaptation are discussed for two regions of the state of S?o Paulo: the Metropolitan Region of Campinas and the Metropolitan Region of the Baixada Santista, located in southeastern South America. Simulations and projections obtained from four integrations of the Regional Eta model are analyzed to investigate the model behavior during the period of 1961-1990 and the projections within the period of 2011-2100. Uncertainties are discussed based on the standard deviation among the model spread. The projections show precipitation increase in the Metropolitan Region of Campinas during DJF for the near and distant future, while there are more uncertainties in the other seasons. In the Metropolitan Region of Baixada Santista, the precipitation increase is projected to all seasons, except JJA, when there is higher uncertainty. Daily rainfall indices suggest an increase of precipitation during the rainy days, but a reduction in the number of rainy days in both locations. The projections show a reduction of light rains and an increase of heavy rains at both regions. The model identifies the South Atlantic Convergence Zone and frontal systems as precipitation patterns associated with extremes in the two locations. The results can be useful for adaptation actions, since the regions are highly populated and have high vulnerabilities.

关键词： Climate Change Precipitation Extremes Vulnerable Regions Precipitation Indices Regional Model

Nicotinic cholinergic receptors in esophagus:Early alteration during carcinogenesis and prognostic value

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World Journal of Gastroenterology 2016年第31期22卷 7146-7156页

作者： marina Chianello Nicolau Luis Felipe Ribeiro Pinto Pedro Nicolau-Neto Paulo Roberto Alves de Pinho Ana Rossini Tatiana de Almeida Simao Sheila Coelho Soares Lima Departamento de Bioquímica Instituto de Biologia Roberto Alcantara GomesUniversidade do Estado do Rio de Janeiro Programa de Carcinogênese Molecular Instituto Nacional de CancerCoordenacao de Pesquisa Gastroenterologia Hospital Universitário Pedro ErnestoUniversidade do Estado do Rio de Janeiro

AIM: To compare expression of nicotinic cholinergic receptors(CHRNs) in healthy and squamous cell carcinoma-affected esophagus and determine the prognostic ***: We performed RT-q PCR to measure the expression of CHRNs in 44 esophageal samples from healthy individuals and in matched normal surrounding mucosa, and in tumors from 28 patientsdiagnosed with esophageal squamous cell carcinoma(ESCC). Next, we performed correlation analysis for the detected expression of these receptors with the habits and clinico-pathological characteristics of all study participants. In order to investigate the possible correlations between the expression of the different CHRN subunits in both healthy esophagus and tissues from ESCC patients, correlation matrices were generated. Subsequently, we evaluated whether the detected alterations in expression of the various CHRNs could precede histopathological modifications during the esophageal carcinogenic processes by using receiver operating characteristic curve analysis. Finally, we evaluated the impact of CHRNA5 and CHRNA7 expression on overall survival by using multivariate ***: CHRNA3, CHRNA5, CHRNA7 and CHRNB4, but not CHRNA1, CHRNA4, CHRNA9 or CHRNA10, were found to be expressed in normal(healthy) esophageal mucosa. In ESCC, CHRNA5 and CHRNA7 were overexpressed as compared with patient-matched surrounding non-tumor mucosa(ESCC-adjacent mucosa; P < 0.0001 and P = 0.0091, respectively). Positive correlations were observed between CHRNA3 and CHRNB4 expression in all samples analyzed. Additionally, CHRNB4 was found to be differentially expressed in the healthy esophagus and the normalappearing ESCC-adjacent mucosa, allowing for distinguishment between these tissues with a sensitivity of 75.86% and a specificity of 78.95%(P = 0.0002). Finally, CHRNA5 expression was identified as an independent prognostic factor in ESCC; patients with high CHRNA5 expression showed an increased overall survival, in comparison with those

关键词： Nicotinic cholinergic receptors Esophagus Esophageal squamous cell carcinoma Tobacco Alcohol Gene expression

Diabetes, Obesity and the Nutrition Transition in the Mercosur

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Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 28-37页

作者： Tatiane Andreazza Lucchese Amanda Maia Breis Karine Rucker Vagner Rosa Bizarro Lis marina Mesquita Araújo Alessandre gomes Mikele Torino Paletti Ana Luísa Conceição de Jesus Marcella Garcez Duarte Denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School (IPEMED) Sao Paulo Brazil Brazilian Association of Nutrology (ABRAN) Catanduva Sao Paulo Brazil Visiting Scholar Harvard T. H. Chan School of Public Health Harvard University Boston USA

Diabetes and obesity are major health hazards in Latin America nowadays. Their prevalence has steadily increased since the eighties. Today, more than 50% of the population are overweight, 15% has obesity and 6% to 15% has diabetes. The nutrition transition is a long-term process that brings chronic metabolic diseases as an undesired consequence, whilst ultra processed foods become increasingly part of daily food choices. These changes bring impacts in all fields of daily life, especially in the economic and legal fields—the “Right to Health”—and regarding autonomy of the individual and their choices, when confronted with an ideal of health and well-being. Governments and citizens struggle to propose new pathways and find effective solutions to control both epidemics and solve these issues. This article poses the evolution of diabetes and obesity in the Mercosur, seeking a better understanding of these chronic, non-communicable diseases, and looking for concrete, effective solutions towards health in South America.

关键词： Obesity Diabetes Mercosur Nutrition Transition Right to Health South America