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Targeting Janus tyrosine kinase 3 （JAK3） with an inhibitor induces secretion of TGF-β by CD4＋ T cells

Cellular & Molecular Immunology 2012年第4期9卷 350-360页

作者： marina Cetkovic-Cvrlje Marin Olson Ketaki Ghate Department of Biological Sciences St. Cloud State University St. Cloud MN USA Laboratory for Immunology St. Cloud State University St. Cloud MN USA

Regulatory T cells （Tregs） are critical for the peripheral maintenance of the autoreactive T cells in autoimmune disorders such as type 1 diabetes （TID）. Pharmacological inhibition of Janus tyrosine kinase 3 （JAK3） has been proposed as a basis for new treatment modalities against autoimmunity and allogeneic responses. Targeting JAK3 with an inhibitor has previously been shown to exhibit protective action against the development of T 1D in non-obese diabetic （NOD） mice. As the mechanism of such preventative action has been unknown, we hypothesized that JAK3 inhibition induces generation of Tregs. Here, we show that the JAK3 inhibitor 4-（4＇-hydroxyphenyl）-amino-6,7-dimethoxyquinazoline （WHI-P131） suppresses proliferation of short-term cultured NOD CD4＋ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It was found that the surviving cells were not of the CD4＋CD25＋FoxP3＋ phenotype. They secreted decreased amounts of IL-IO, IL-4 and interferon （IFN）-y compared to the cells not exposed to the optimal concentrations of JAK3 inhibitor. However, an elevated transforming growth factor （TGF）-β secretion was detected in their supernatants. In vivo treatment of prediabetic NOD mice with WHI-P131 did not affect the frequency and number of splenic and pancreatic lymph node CD4＋FoxP3＋ Tregs, while generating an elevated numbers of CD4＋FoxP3- TGF-β-secreting T cells. In conclusion, our data suggest an induction of TGF-β-secreting CD4＋ T cells as the underlying mechanism for antidiabetogenic effects obtained by the treatment with a JAK3 inhibitor. To our knowledge, this is the first report of the JAK3 inhibitor activity in the context of the murine Tregs.

关键词： FoxP3 Janus tyrosine kinase 3 (JAK3) inhibition regulatory T cells (Tregs) TGF-β type 1 diabetes (TID)

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Tunneling of Relativistic Bosons Induced by Magnetic Fields in the Magnetar’s Crust

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Chinese Physics Letters 2015年第10期32卷 26-29页

作者： marina-Aura Dariescu Ciprian Dariescu Denisa-Andreea Mihu Faculty of Physics Alexandru Ioan Cuza University of Iasi Bd

The present work is devoted to the study of bosons evolving in the frozen magnetar＇s crust endowed with an ultra-strong magnetic field orthogonal to an electric field, both described by periodic functions. We discuss the quantum tunneling process through the one-dimensional potential barrier along Oz. The solutions to the Klein- Gordon equation are expressed in terms of Mathieu＇s functions which, for computable particle＇s energy range, are turning from oscillatory to exponentially growing modes along Oz. Within the Jeffreys Wentzel Kramers- Brillouin framework, the transmission coefficient is computed for the particle momentum in the middle of the instability range.

关键词： Tunneling of Relativistic Bosons Induced by Magnetic Fields in the Magnetar’s Crust

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Sediment regime of the Danube River in Serbia

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International Journal of Sediment Research 2013年第4期28卷 470-485页

作者： marina BABIC MLADENOVIC Vasiljka KOLAROV Vanja DAMJANOVIC Jaroslav Cerni Institute for the Development of Water Resources Department for River Engineering

The total length of the Danube section in Serbia is 587.5 km,and it has three specific sections:(1) Pannonian Plain Danube(or the Middle Danube) has all characteristics of lowland *** stretch downstream of Novi Sad is under the influence of the Iron Gate 1 backwater during low water flows;(2) Iron Gate Danube,where the river is confined in the *** it is a reservoir,with completely altered natural characteristics.(3) Western Pontic Danube(or the Lower Danube),downstream of the *** paper presents the sediment regime in the Serbian sector of the Danube River,both upstream and within the Iron Gate *** field investigation data were used to describe the most important parameters of sediment transport and deposition processes,including riverbed composition and suspended sediment characteristics(grain size and concentration).The influence of large tributaries of the Danube(the Tisza,the Sava,and the Velika Morava) is also *** conducted in the Iron Gate 1reservoir under the Sediment Regime and Morphological Changes Monitoring Program is also *** obtained during implementation of the Program form the basis for the description of changes in the Danube sediment regime that occurred following erection of the Iron Gate *** revealed that the most important consequence of the Iron Gate I IIPNS Dam is permanent deposition of sediment in the Iron Gate Gorge portion of the reservoir,the water and environmental management implications of which are becoming increasingly ***,upstream stretches of the reservoir are not subject to uniform sedimentation processes;instead,the sediment regime depends on current hydrologic and hydraulic conditions within the watercourse and/or the hydro-power plant operating mode.

关键词： Sediment regime Morphological changes Danube Serbia

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Vulnerability Factors of Afghan Rural Women to Disasters

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International Journal of Disaster Risk Science 2019年第4期10卷 573-590页

作者： marina Hamidazada Ana Maria Cruz Muneta Yokomatsu Disaster Prevention Research Institute (DPRI) Kyoto UniversityKyoto 611-0011 Japan

Disaster management is a global challenge, but disasters do not affect men and women equally. In most of the world’s disasters, more females are impacted than males, and in Afghanistan the disparity between female and male victims is even greater. This study identifies and maps the relationships between the factors that make Afghan rural women more vulnerable to natural hazard-induced disasters. Data for this study were obtained through focus group discussions with rural women and men, as well as person-to-person interviews with employees of government and nongovernmental organizations at the national and local levels in Afghanistan. The study uses Grounded Theory and Interpretive Structural Modeling, not widely used before for this type of study, to analyze the data collected and to map the factors of vulnerability identified and their relationships. In agreement with previous studies,our findings show that insufficient disaster education,inadequate protection measures, and powerful cultural issues, both pre-and post-disaster, increase women’s vulnerability during and after disasters. In particular, cultural issues play a role after disasters by affecting women’s security, access to disaster aid, and health care. The study also found that perception regarding these cultural issues and how they affect women during disasters differs among men and women. Finally, by using Interpretive Structural Modeling, we show how the importance of the factors and their interrelationships change in predisaster and post-disaster situations. We conclude the article with some policy recommendations such as finding ways to allow women to participate in disaster planning activities and decision-making processes related to disaster risk reduction, as well as securing dedicated funds for the mainstreaming of gender in disaster risk reduction policies in Afghanistan.

关键词： Afghanistan Disaster vulnerability Gender roles Grounded Theory Rural area Women’s vulnerability

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Impact of drilling waste pollution on land cover in a high subarctic forest-tundra zone

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Pedosphere 2022年第3期32卷 414-425页

作者： Anatoly OPEKUNOV marina OPEKUNOVA Stepan KUKUSHKIN Sergey LISENKOV Institute of Earth Sciences St.Petersburg State UniversitySt.Petersburg 199178(Russia)

Global climate changes can lead to the destruction of the permafrost zone and contribute to the active transfer of pollutants to natural *** can be especially pronounced in the areas of oil and gas production in the *** study aimed to define the landscape components(i.e.,groundwater,soil water,soil,and indicator plant species)of chemical pollution with metals,oil hydrocarbons,and polycyclic aromatic hydrocarbons,from the discharge of drill *** at two sites in the forest-tundra zone of Western Siberia(Russia)were carried out within two years of *** migration was found in peaty-gley heavy loamy soils and iron-illuvial clayey podburs,but lateral migration of different pollutants did not exceed 200 ***,radial migration was practically absent owing to the high buffering capacity of the soil organic horizon and the upward flow of matter in the seasonal melt *** main indicators of drilling waste pollution were high concentrations of Sr,Ba,petroleum hydrocarbons,and Cl^(-)*** the waste disposal sites,the concentration of Ba and Sr in the soil water were 1150 and 1410μg L^(-1),respectively;in groundwater,they reached 721 and 2360μg L^(-1),*** the soil,Ba and Sr accumulated in the peaty horizon(798 and 706 mg kg^(-1),respectively).The concentration of Cl^(-)ions in the soil water at the site of waste discharge was 1912 mg L^(-1),and at a distance of 200 m,it decreased to 77.4 mg L^(-1).The Cl^(-)concentration in the groundwater was lower,and at a distance of 200 m,it was 38.9 mg L^(-1).The highest concentration of petroleum hydrocarbons in the surface layer was found in the peaty-gley soils(up to 2400 mg kg^(-1)).In glandular-illuvial podburs,it was 420 mg kg^(-1).In horizons BH and BC,it was close to the background values(27 and 33 mg kg^(-1),respectively).Alkalinization of soils and water under the influence of drill cuttings led to the death of oligotrophic and acidophilic vegetation at a distanc

关键词： metal petroleum hydrocarbons plant indicator species pollutant migration in soil polycyclic aromatic hydrocarbon

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Large Eddy Simulation of the By-pass Transition Process under Different Inlet Turbulence Conditions

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Journal of Thermal Science 2021年第6期30卷 2112-2121页

作者： BARSI Dario COSTA Carlo LENGANI Davide SIMONI Daniele UBALDI marina DIME-University of Genova Via Montallegro 11-16145 GenovaItaly

The transition process of the boundary layer developing over a flat plate with elevated inlet Free Stream Turbulence Intensity(FSTI)has been studied by means of Large Eddy Simulation(LES).To this purpose,four cases with different inflow disturbances have been tested varying the magnitude and the length scale of *** has been performed by using the finite-volume ANSYS Fluent *** computational domain,which was constituted by a rectangular domain with a zero thickness plate,was based on an ERCOFTAC test case in order to provide a validation with a well-known set of data by comparing the boundary layer integral parameters and mean and fluctuating streamwise velocity *** four cases were discussed within the paper by looking at classical statistical properties as well as advanced post-processing *** was shown that the decrease in the free stream turbulence level postpones the transition location,whereas the variation of the integral length scale has a very low influence on the distribution of the time-mean flow *** Orthogonal Decomposition(POD)has been applied to the instantaneous LES flow fields in order to provide a statistical representation of the structures responsible for transition and their response to free-stream turbulence intensity and length *** presence of vortical filaments parallel to the wall,typically referred as boundary layer streaks,is clearly identified;their characteristic dimensions and how they change as a function of FSTI properties were analyzed within the paper.

关键词： by-pass transition Large Eddy Simulation(LES) Proper Orthogonal Decomposition(POD) boundary layer streaks

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Varying of up-conversion nanoparticles luminescence from the muscle tissue depth during the compression

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 85-92页

作者： marina Kozintseva Vyacheslav Kochubey Julia Konyukhova Valery Tuchin Saratov State University 83Astrakhanskaya st.Saratov 410012Russia Tomsk State University 36Lenin Avenue Tomsk 634050Russia Tsinghua-Berkeley Shenzhen Institute Building C2&C3 Zhiyuan No.1001 Xueyuan Avenue Nanshan District.ShenzhenP.R.China

The current work is focused on the study of optical clearing of skeletal muscles under local *** experiments were performed on in vitro bovine skeletal *** time dependence of optical clearing was studied by monitoring the luminescence intensity of NaYF_(4)∶Er,Yb upconverting particles located under tissue *** study shows the possibility to use upconverting nanoparticles(UCNPs)both for studying the dynamics of the optical clearing of biological tissue under compression and to detect moments of cell wall damage under excessive *** advantage of using UCNPs is the presence of several bands in their luminescence spectra,located both at close wavelengths and far apart.

关键词： Upconverting particle biological tissue skeletal muscle tissue tissue optical clearing luminescence imaging technique mechanical compression

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Levi and Malcev Theorems for Finite-Dimensional Algebras from the Variety Defined by the Identities x^(2)=J(x,y,zu)=0

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Algebra Colloquium 2021年第1期28卷 87-90页

作者： Oscar Guajardo Garza marina Rasskazova Liudmila Sabinina Centro de Investigacion en Ciencias UAEMCuernavacaMexico Omsk State Technical University pr.Mira 11OmskRussia

We study the variety of binary Lie algebras defined by the identities x^(2)=J(x,y,zu)=0,where J(a,b,c)denotes the Jacobian of a,b,*** on previous work by Carrillo,Rasskazova,Sabinina and Grishkov,in the present articl... 详细信息

关键词： Malcev theorem Levi factor splitting algebra binary Lie algebra

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SUPPORTED ZIEGLER-NATTA CATALYSTS FOR ETHYLENE SLURRY POLYMERIZATION AND CONTROL OF MOLECULAR WEIGHT DISTRIBUTION OF POLYETHYLENE

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Chinese Journal of Polymer Science 2008年第5期26卷 553-559页

作者： Vladimir Zakharov Ludmila Echevskaya Tatiana Mikenas Mikhail Matsko Andrey Tregubov marina Vanina marina Nikolaeva Boreskov Institute of Catalysis Novosibirsk 630090Russia

The effect of chemical composition of highly active supported Ziegler-Natta catalysts with controlled morphology on the MWD of PE has been *** was shown the variation of transition metal compound in the MgCl_2-supported catalyst affect of MWD of PE produced in broad range:Vanadium-magnesium catalyst(VMC)produce PE with broad and bimodal MWD(M_w/M_n=14-21).MWD of PE,produced over titanium-magnesium catalyst(TMC)is narrow or medium depending on Ti content in the catalyst(M_w/M_n=3.1-4.8).The oxidation ...

关键词： Polyethylene(PE) Vanadium magnesium catalyst(VMC) Titanium magnesium catalyst(TMC) Gel permeation chromatography(GPC) Molecular weight distribution(MWD).

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HSV gene transfer in the treatment of chronic pain

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生理学报 2008年第5期60卷 610-616页

作者： David J. Fink marina Mata University of Michigan and VA Ann Arbor Healthcare System Ann Arbor Michigan 48109 USA

It has proven difficult to use systemic administration of small molecules to selectively modulate *** the past decade,we and others have developed non-replicating herpes simplex virus(HSV)-based vectors to treat chronic *** inoculation of an HSV vector effectively transduces sensory neurons in the dorsal root ganglion;release of transgene-coded inhibitory neurotransmitters or anti-inflammatory peptides reduces pain-related behaviors in rodent models of chronic inflammatory and neuropathic pain.A phase 1 trial of this therapy in patients is set to begin soon.

关键词： HSV 基因慢性疼痛临床分析病症

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