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Pathogenesis and clinical management of arboviral diseases

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World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich Juan Marcos Caram Costa marina Maria Gomes Leite oliveira Carlos Eduardo oliveira Aguiar Luis Guilherme de oliveira Silva Marcel Silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(deNV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(deNV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

Antitumor effects of electrochemical treatment

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Chinese Journal of Cancer Research 2013年第2期25卷 223-234页

作者： Héctor Manuel Camué Ciria Maraelys Morales González Lisset Ortíz Zamora Luis Enrique Bergues Cabrales Gustavo Victoriano Sierra González Luciana oliveira de oliveira Rodrigo Zanella Antonio Carlos Buzaid Orlando Parise Luciana Macedo brito Cesar Augusto Antunes Teixeira marina das Neves Gomes Gleyce Moreno Venicio Feo da Veiga Marcos Telló Carla Holandino Research department National Centre of Applied Electromagnetism Oriente University Pharmacy department Oriente University Finlay Institute La lisa. La Habana Cuba Veterinary Teaching Hospital Federal University of Rio Grande do Sul. Porto Alegre Sírio e Libanês Hospital Faculty of Pharmacy Medicine Department Federal University of Rio de Janeiro Professor Paulo de Góes Institute of Microbiology Federal University of Rio de Janeiro Pontifical Catholic University of Rio Grande do Sul. Porto Alegre

Electrochemical treatment is an alternative modality for tumor treatment based on the application of a low intensity direct electric current to the tumor tissue through two or more platinum electrodes placed within the tumor zone or in the surrounding areas. This treatment is noted for its great effectiveness, minimal invasiveness and local effect. Several studies have been conducted worldwide to evaluate the anfitumoral effect of this therapy. In all these studies a variety of biochemical and physiological responses of tumors to the applied treatment have been obtained. By this reason, researchers have suggested various mechanisms to explain how direct electric current destroys tumor ceils. Although, it is generally accepted this treatment induces electrolysis, electroosmosis and electroporation in tumoral tissues. However, action mechanism of this alternative modality on the tumor tissue is not well understood. Although the principle of Electrochemical treatment is simple, a standardized method is not yet available. The mechanism by which Electrochemical treatment affects tumor growth and survival may represent more complex process. The present work analyzes the latest and most important research done on the electrochemical treatment of tumors. We conclude with our point of view about the destruction mechanism features of this alternative therapy. Also, we suggest some mechanisms and strategies from the thermodynamic point of view for this therapy. In the area of Electrochemical treatment of cancer this tool has been exploited very little and much work remains to be done. Electrochemical treatment constitutes a good therapeutic option for patients that have failed the conventional oncology methods.

关键词： Direct electric current electrochemical treatment antimmoral treatment tumor tumor electrolysis rumor entropy dissipative structure

Gastric partitioning for the treatment of malignant gastric outlet obstruction

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World Journal of Gastrointestinal Oncology 2019年第12期11卷 1161-1171页

作者： Marcus Fernando Kodama Pertille Ramos Leandro Cardoso Barchi Rodrigo Jose de oliveira marina Alessandra Pereira Donato Roberto Mucerino Ulysses Ribeiro Jr Bruno Zilberstein Ivan Cecconello department of Gastroenterology Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao Paulo

BACKGROUND Gastric outlet obstruction(GOO)is one of the main complications in stage IV gastric cancer *** condition is usually managed by gastrojejunostomy(GJ).However,gastric partitioning(GP)has been described as an alternative to overcoming possible drawbacks of GJ,such as delayed gastric emptying and tumor *** To compare the outcomes of patients who underwent GP and GJ for malignant *** We retrospectively analyzed 60 patients who underwent palliative gastric bypass for unresectable distal gastric cancer with GOO from 2009 to *** clinicopathological characteristics including age,nutritional status,body mass index,and performance status were *** symptoms were graded according to GOO score(GOOS).Surgical outcomes evaluated included duration of the procedure,surgical complications,mortality,and length of hospital *** of oral diet after the procedure,weight gain,and overall survival were the long-term outcomes *** GP was performed in 30 patients and conventional GJ in the other 30 *** mean follow-up was 9.2 ***-nine(81.6%)patients died during that *** variables were similar between groups,with the exception of worse performance status in GP *** mean operative time was higher in the GP group(161.2 vs 85.2 min,Pdemonstrated that GOOS 2 and GOOS 3 were the main prognostic factors for survival(hazard ratio:8.90,95%confidence interval:3.38-23.43,Pdes similar surgical outcomes with a trend to better solid diet accep

关键词： Stomach neoplasms Gastric outlet obstruction Palliative surgery Gastrojejunostomy Gastric cancer

Numerical Modeling of Air Pollutants Emitted by Waterway Transportation

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Journal of Geoscience and Environment Protection 2016年第6期4卷 123-136页

作者： Marilia Mitidieri Fernandes de oliveira Nelson Francisco Favilla Ebecken Jorge Luiz Fernandes de oliveira marina Aires Center of Technology Federal University of Rio de Janeiro-Civil Engineering Postgraduate Program-COPPE/UFRJ Rio de Janeiro Brazil Geography Postgraduate Program Geoscience Institute of Fluminense Federal University-UFF Niterói Brazil Meteorology Postgraduate Program Geoscience Institute Department of Meteorology of Federal University of Rio de Janeiro-UFRJ Rio de Janeiro Brazil

The world maritime transportation is suffering a large increase in recent years and as a result of this increased on global trade, there is a consequent increase in waterway transportation and demand for fossil fuels, resulting in emissions of air pollutants. Consequently, the impact of transport emissions on climate change was put on the list of priorities. It has a high fuel demand as a result of continuous use of main engines for propulsion, electricity and heat production. The highest exposure levels of air pollution are found in ports and near them because most of the world fleet is positioned in these areas. The port of Rio de Janeiro city, in the Southeast Brazilian coastal, is inserted in the Guanabara Bay (GB), where the breezes recirculate pollutants in Metropolitan Region of Rio de Janeiro (MRRJ). Therefore, the aim of this research was to use the Brazilian Regional Atmospheric Modeling System (BRAMS) to generate the wind fields in the MRRJ and to calculate the trajectories of pollutants emitted on GB related to the waterway transportation, using a 3D kinematic trajectories model. Results demonstrated that for the periods analysed, the Central and west areas in the coastal region of the Rio de Janeiro city were the local most affected in the summer. In winter the trajectories reached the cities of the Rio de Janeiro and Duque de Caxias. Both in summer and winter, the trajectories followed towards the South Atlantic Ocean in the morning. Conclusions about this study show the need of decision-making process for better management of waterway transportation sector, improving the harmful effects on air quality in cities located in coastal regions.

关键词： Maritime Transport Ship Emissions Air Pollution Meteorological Models Guanabara Bay

Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 714-719页

作者： Marta oliveira Policarpo Ademar Sales Junior Maria Joao Rodrigues marina dellaGreca Luisa Barreira Silvane Maria Fonseca Murta Alvaro Jose Romanha Luisa Custodio Center of Marine Sciences (CCMAR) University of AlgarveCampus de Gambelas 8005-139 FaroPortugal Centro de Pesquisas Rene Rachou FIOCRUZ Belo HorizonteMinas GeraisBrazil Dipartimento di Chimica Organica e Biochimica Universita` Federico Ⅱ Complesso Universitario Monte Sant'AngeloVia Cintia 4I-80126NapoliItaly

Objective:To evaluate the in vitro anti-Trypanosoma cruzi（***） activity of organic extracts prepared from halophyte species collected in the southern coast of Portugal（Algarve）,and chemically characterize the most active ***:Acetone,dichloromethane and methanol extracts were prepared from 31 halophyte species and tested in vitro against trypomastigotes and intracellular amastigotes of the Tulahuen strain of *** most active extract was fractionated by preparative HPLC-DAD,affording 11 *** most selective fraction was fully characterized by ***:From 94 samples tested,one was active,namely the root dichloromethane extract of Juncus acutus(IC50 dentified in fraction 8 are likely responsible for the observed anti parasitic *** research is in progress aiming to isolate and identify the specific active *** the best of our knowledge,this is the first report on the in vitro anti *** activity of halophyte species.

关键词： Chagas disease Halophytes Trypanosoma cruzi Phenanthrenes Juncunol

Effects of Arterially Infused Hydroalcoholic <i>Agaricus blazei</i>Extracts on Perfusion Pressure and Oxygen Uptake in the Bivascularly Perfused Rat Liver

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Journal of Biosciences and Medicines 2015年第10期3卷 74-79页

作者： Andrea Luiza de oliveira Valoto Jorgete Constantin Fabrício Bracht Rosane marina Peralta Adelar Bracht Faculdade Integrado de Campo Mourao Campo Mourao Brazil department of Biochemistry Universidade Estadual de Maringá (UEM) Maringá Brazil Universidade Técnica Federal do Paraná (UTFPR) Campo Mourao Brazil

In a preceding work we have reported experiments showing that an hydroalcoholic exctract of Agaricus blazei is able to exert purinergic effects in the isolated perfused rat liver when it is infused into the portal vein in monovascular perfusion (entry: portal vein;exit: hepatic vein). In the present communication we are presenting and discussing experiments done with the bivascularly perfused rat liver (entry: portal vein + hepatic artery;exit: hepatic vein) in order to verify if the hemodynamic effects also occur in the arterial bed. It was found that the A. blazei extract is also active when infused into the hepatic arterial bed, with differences in both sensitivity and nature of the effects on either perfusion pressure or oxygen consumption. Constriction of the arterial bed required much higher concentrations of the extract than the portal bed. The kinetics of the response was also different, with a biphasic instead of a monophasic response. These results provide a promising starting point for future studies aiming to bring to light more mechanistic details about these and possibly other effects.

关键词： Agaricus blazei Purinergic Action Hemodynamics Oxygen Uptake

Production of Enzymes and Biotransformation of Orange Waste by Oyster Mushroom, <i>Pleurotus pulmonarius</i>(Fr.) Quél.

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Advances in Microbiology 2015年第1期5卷 1-8页

作者： Fabíola Dorneles Inácio Roselene oliveira Ferreira Caroline Aparecida Vaz de Araujo Rosane marina Peralta Cristina Giatti Marques de Souza Federal Institute of Paraná-Campus Jacarezinho Jacarezinho Brazil Post-Graduation Program of Biological Sciences State University of Maringá Maringá Brazil departament of Biochemistry State University of Maringá Maringá Brazil

The wood-decay fungi are able to bioconvert a wide variety of lignocellulosic residues due to the secretion of extracellular enzymes. The use of agricultural wastes as substrate for mushroom cultivation or enzymes production can help to solve environmental problems caused by inadequate discharge in the nature. The production of hydrolytic and oxidative enzymes by Pleurotus pulmonarius developed in solid state system using orange waste as substrate was evaluated in this work. Among the hydrolytic enzymes, pectinase was the main enzyme produced by the fungus, presenting the highest enzymatic activity of 9.4 U/mL after 35 days of cultivation. Considering the oxidative enzymes, laccase was the main enzyme produced with maximal activity of 12.2 U/mL obtained after 20 days of cultivation. Low enzyme levels of manganese peroxidase, β-glucosidase and β-xy-losidase were detected with activity peaks at the end of the cultivation. The enzymatic levels of amylase, carboxymethyl cellulase and xylanase were similar and less than 1.5 U/mL. No aryl-alcohol oxidase activity was detected. NDF, ADF and cellulose values increased during 45 days of cultivation. There was no lignin degradation during the study period and the fungus culture in orange solid waste caused protein enrichment in the substrate. Our results demonstrate that P. pulmonarius was an efficient producer of two important industrial enzymes, pectinase and laccase in a cheap solid state system using orange waste as substrate.

关键词： Orange Waste Biotransformation Pleurotus pulmonarius Basidiomycetes

The Action of p-Synephrine on Lipid Metabolism in the Perfused Rat Liver

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Journal of Biosciences and Medicines 2017年第5期5卷 8-21页

作者： Juliany Fontoura da Silva-Pereira Andrea Luiza de oliveira Valoto Livia Bracht Geferson de Almeida Goncalves Rosane marina Peralta Adelar Bracht department of Biochemistry University of MaringaMaringaBrazil Faculdade Integrado Campo MouraoBrazil

p-synephrine and p-octopamine were found to increase lipolysis in adipocytes. The present study approaches the question if these compounds, natural products of the bitter orange (Citrus aurantium fruit), increase lipolysis and fatty acid oxidation in the liver. Experiments were done in the perfused rat liver. Non-recirculating hemoglobin-free perfusion was done using the Krebs/ Henseleit-bicarbonate buffer (pH 7.4) as perfusion fluid. Both p-synephrine and p-octopamine, at the concentrations of 100 μM, were found to stimulate the hepatic triacylglycerol lipase by 40% and 51%, respectively. These seem to be the maximal stimulations possible in the liver. In the perfused liver, p-synephrine, when present at an initial concentration of 500 μM, was able to increase the non-esterified fatty acid release after one hour of recirculating perfusion. The effects of p-synephrine on the oxidation of exogenously supplied [1-14C]octanoate and [1-14C]oleate were minimal. Only oxygen uptake, already stimulated by octanoate or oleate, was additionally increased by the infusion of p-synephrine. These results contrast with those obtained in a previous study with p-octopamine, which increased the production of 14CO2 from both [1-14C]octanoate and [1-14C]oleate. Apparently only the oxidation of endogenous fatty acids is stimulated by p-synephrine. On the other hand, both p-synephrine and p-octopamine stimulate the hepatic triacylglycerol lipase to a much lesser extent than the adipocyte lipase. It can be concluded that p-synephrine affects much more carbohydrate metabolism in the liver than lipid metabolism.

关键词： Hepatic Lipid Metabolism Lipolysis Fatty Acid Release Fatty Acid Oxidation

The likely impact of genetically modified soybeans in the Brazilian collective feeding service

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Agricultural Sciences 2013年第12期4卷 721-728页

作者： Silvia Magalhaes Couto Gabriela Morgado de oliveira Coelho marina de Figueiredo Ferreira Victor Augustus Marin Regina Serrao Lanzillotti Haydée Serrao Lanzillotti Josuéde Castro Nutrition Institute Federal University of Rio de JaneiroRio de Janeiro(RJ)Brazil Nutrition Institute Rio de Janeiro State UniversityRio de Janeiro(RJ)Brazil National Institute of Quality Control on Health-Fiocruz Rio de Janeiro(RJ)Brazil Mathematics and Statistics Institute Rio de Janeiro State UniversityRio de Janeiro(RJ)Brazil

Objective: To expose the likely impact of genetically modified foods in Collective Feeding. Methods: This was a case study conducted on a steel company (SC) in Rio de Janeiro State. The likely impact recognition began with the preparation of a soy food products’ list. Then, we verified these products’ frequency on the Food and Nutrition Unit (FNU) menu from the SC, outlining the offer profile. We calculated odds ratios and binomial distribution probability for assessing exposure to soy that may be transgenic. Food frequency questionnaire (FFQ) regarding soy products was applied. The convergence of daily products’ relative frequency of this population and the population from a reference study about FFQ validation in Rio de Janeiro was verified. Confrontation took place between the classification of foods by the consumers’ likely exposure to soy and the percentage deviation between observed relative frequency of products’ intake offered on the FNU and on the reference study. Results: A list of 51 products were created and 16 of them integrated the menu, e.g. flour, chicken, sausage, maize, instant pudding, bologna, hot dogs and peanuts. Food usually consumed by FNU users and concomitantly consumed in reference study were cookies, flour, spaghetti, bread, cake, instant pudding, sausage and hot dogs. By the classification and percentage deviations results, cookies, breads and pasta were the “villains” of soy’s susceptibility. Coclusion: It was possible to show the likely impact of genetically modified foods in Collective Feeding, confirming that these consumers were exposed to soybeans that may be transgenic.

关键词： Food Security Genetically Modified Food Biotechnology Collective Feeding Food Services