Effects of Arterially Infused Hydroalcoholic <i>Agaricus blazei</i>Extracts on Perfusion Pressure and Oxygen Uptake in the Bivascularly Perfused Rat Liver

作     者：Andrea Luiza de Oliveira Valoto Jorgete Constantin Fabrício Bracht Rosane Marina Peralta Adelar Bracht 

作者机构：Faculdade Integrado de Campo Mourao Campo Mourao Brazil Department of Biochemistry Universidade Estadual de Maringá (UEM) Maringá Brazil Universidade Técnica Federal do Paraná (UTFPR) Campo Mourao Brazil 

出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)

年 卷 期：2015年第3卷第10期

页      面：74-79页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Agaricus blazei Purinergic Action Hemodynamics Oxygen Uptake 

摘      要：In a preceding work we have reported experiments showing that an hydroalcoholic exctract of Agaricus blazei is able to exert purinergic effects in the isolated perfused rat liver when it is infused into the portal vein in monovascular perfusion (entry: portal vein;exit: hepatic vein). In the present communication we are presenting and discussing experiments done with the bivascularly perfused rat liver (entry: portal vein + hepatic artery;exit: hepatic vein) in order to verify if the hemodynamic effects also occur in the arterial bed. It was found that the A. blazei extract is also active when infused into the hepatic arterial bed, with differences in both sensitivity and nature of the effects on either perfusion pressure or oxygen consumption. Constriction of the arterial bed required much higher concentrations of the extract than the portal bed. The kinetics of the response was also different, with a biphasic instead of a monophasic response. These results provide a promising starting point for future studies aiming to bring to light more mechanistic details about these and possibly other effects.