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Egocentric social network correlates of physical activity

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Journal of Sport and Health Science 2020年第4期9卷 339-344页

作者： Sonja Motteli Simone dohle Department of Health Sciences and Technology(D-HEST) ETH Z€urichZ€urich 8092Switzerland Department of Psychology University of CologneCologne 08215Germany

Background:The social environment might play an important role in explaining people’s physical activity(PA)***,little is known regarding whether personal networks differ between physically active and physically inactive *** study aimed to examine the relationship between personal network characteristics and adults’physical(in)***:An egocentric social network study was conducted in a random sample in Switzerland(n=529,mean age of 53 years,54%females).Individual and personal network measures were compared between regular exercisers and *** extent of these factors’association with PA levels was also ***:Non-exercisers(n=183)had 70%non-exercising individuals in their personal networks,indicating homogeneity,whereas regular exercisers(n=346)had 57%regularly exercising individuals in their networks,meaning more heterogeneous personal ***,having more regular exercisers in personal networks was associated with higher PA levels,over and above individual *** with an entirely active personal network reported,on average,1 day of PA more per week than respondents who had a completely inactive personal *** personal network characteristics,such as network size or gender composition,were not associated with ***:Non-exercisers seem to be clustered in inactive networks that provide fewer opportunities and resources,as well as less social support,for *** effectively promote PA,both individuals and personal networks need to be addressed,particularly the networks of inactive people(e.g.,by promoting group activities).

关键词： Egocentric network Exercise Inactivity Personal network Physical activity Questionnaire Similarity/homogeneity

Testicular biopsy： clinical practice and interpretation

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Asian Journal of Andrology 2012年第1期14卷 88-93,177页

作者： Gert R dohle Saad Elzanaty Niels J van Casteren Department of Urology Erasmus MC 3000 CA Rotterdam The Netherlands Department of General Surgery U rology Section Kristianstad Central Hospital Kristianstad SE 291 85 Sweden

Testicular biopsy was considered the cornerstone of male infertility diagnosis for many years in men with unexplained infertility and azoospermia. Recent guidelines for male infertility have limited the indications for a diagnostic testicular biopsy to the confirmation of obstructive azoospermia in men with normal size testes and normal reproductive hormones. Nowadays, testicular biopsies are mainly performed for sperm harvesting in men with non-obstructive azoospermia, to be used for intracytoplasmic sperm injection. Testicular biopsy is also performed in men with risk factors for testicular malignancy. In a subgroup of infertile men, there is an increased risk for carcinoma in situ of the testis, especially in men with a history of cryptorchidism and testicular malignancy and in men with testicular atrophy. Ultrasonographic abnormalities, such as testicular microlithiasis, inhomogeneous parenchyma and lesions of the testes, further increase the risk of carcinoma in situ （CIS） in these men. For an accurate histological classification, proper tissue handling, fixation, preparation of the specimen and evaluation are needed. A standardized approach to testicular biopsy is recommended. In addition, approaches to the detection of CIS of the testis testicular immunohistochemistry are mandatory. In this mini-review, we describe the current indications for testicular biopsies in the diagnosis and management of male infertility.

关键词： carcinoma in situ of the testis diagnosis male infertility testicular sperm extraction testicular biopsy testicular germ cell malignancies

Etiology and early pathogenesis of malignant testicular germ cell tumors： towards possibilities for preinvasive diagnosis

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Asian Journal of Andrology 2015年第3期17卷 381-393页

作者： Jenny E Elzinga-Tinke Gert R dohle Leendert HJ Looijenga Department of Urology Subsection of Andrology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands Department of Pathoiogy Laboratory of Experimental Patho-Oncology Erasmus MC Cancer institute University Medical Center Rotterdam Rotterdam The Netherlands

Malignant testicular germ cell tumors （TGCT） are the most frequent cancers in Caucasian males （20-40 years） with an 70% increasing incidence the last 20 years, probably due to combined action of （epi）genetic and （micro）environmental factors. It is expected that TGCT have carcinoma in situ （CIS） as their common precursor, originating from an embryonic germ cell blocked in its maturation process. The overall cure rate of TGCT is more than 90%, however, men surviving TGCT can present long-term side effects of systemic cancer treatment. In contrast, men diagnosed and treated for CIS only continue to live without these long-term side effects. Therefore, early detection of CIS has great health benefits, which will require an informative screening method. This review described the etiology and early pathogenesis of TGCT, as well as the possibilities of early detection and future potential of screening men at risk for TGCT. For screening, a well-defined risk profile based on both genetic and environmental risk factors is needed. Since 2009, several genome wide association studies （GWAS） have been published, reporting on single-nucleotide polymorphisms （SNPs） with significant associations in or near the genes KITLG, SPRY4, BAK1, DMRT1, TERT, ATF71P, HPGDS, MAD1L1, RFWD3, TEX14, and PPMIE, likely to be related to TGCT development. Prenatal, perinatal, and postnatal environmental factors also influence the onset of CIS. A noninvasive early detection method for CIS would be highly beneficial in a clinical setting, for which specific miRNA detection in semen seems to be very promising. Further research is needed to develop a well-defined TGCT risk profile, based on gene-environment interactions, combined with noninvasive detection method for CIS.

关键词： carcinoma in situ etiology environmental exposure semen diagnostics single nucleotide polymorphism testicular germcell tumor pathogenesis

The role of varicocele sclerotherapy in men with severe ol igo-astheno-teratozoos perm ia

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Asian Journal of Andrology 2011年第6期13卷 867-871页

作者： Mazen A Ghanem Manal A Safan Ashraf A Ghanem Gert R dohle Department of Urology Menoufiya University 3481 Shebin EI-Kom Egypt Department of Urology Erasmus MC 3000 CA Rotterdam The Netherlands Department of Clinica Biochemistry Menoufiya University 3481 Shebin EI-Kom Egypt Department of Gynaecology and Obstetrics Mansoura University 35515 Mansoura Egypt

The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia （OAT）. The 59 patients with severe OAT in this study underwent antegrade scrotal sclerotherapy for the treatment of varicoceles. The outcome was assessed in terms of improvement in semen parameters and spontaneous conception rate. Semen parameters and reproductive hormones were evaluated before antegrade sclerotherapy （AS） and 6 months after AS. After an average follow-up time of 34.8_＋3.2 months, significant improvement was noted in the mean sperm concentration, motility and morphology in 36 patients （61%）. Spontaneous pregnancy occurred in nine couples （15%）. Six months after treatment, inhibin B levels were significantly higher （P〉0.04）, whereas follicle-stimulating hormone （FSH） levels were significantly lower （P〈0.001） than before treatment. Antegrade internal spermatic vein sclerotherapy can significantly improve seminal parameters and hormonal parameters in men with severe OAT and may even result in spontaneous pregnancy in couples who would otherwise be candidates for intracytoplasmic sperm injection （ICSI）.

关键词： infertility Inhibin B oligo-astheno-teratozoospermia sclerotherapy semen parameters varicocele

Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia？

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Asian Journal of Andrology 2007年第3期9卷 382-387页

作者： Marij Smit Gert R. dohle Mark F. Wildhagen Rob F. A. Weber Andrology Unit of the Department of Urology Erasmus MC 3000 CA Rotterdam the Netherlands Department of Urology and Gynecology Erasmus MC 3000 CA Rotterdam the Netherlands

Aim： To evaluate whether inhibin-B can predict the outcome of a microsurgical epidymal sperm aspiration （MESA） procedure in patients with suspected primary obstructive azoospermia （OA） and if inhibin-B can replace testicular biopsy in the diagnostic work-up of these patients. Methods： Inhibin-B levels and testicular biopsy scores were related to the outcome of MESA in 43 patients with suspected primary OA. MESA was considered to be successful when epididymal sperm could be identified during the procedure. Results： Spermatozoa were present in the epididymal aspirate in 28 out of the 43 patients （65%）. lnhibin-B values were not significantly different in patients with successful or unsuccessful MESA. The modified Johnsen score, however, was significantly lower in patients with unsuccessful MESA （P = 0.003）. A rete testis obstruction or epididymal malfunctioning was found in 15% of patients with suspected primary OA, reflected by unsuccessful MESA despite normal inhibin-B levels and normal testicular histology. Conclusion： Inhibin-B cannot replace testicular biopsy as a diagnostic tool in the work-up of patients with suspected primary OA. Testicular biopsy is useful in identifying patients with spermatogenic arrest, who might have normal inhibin-B values.

关键词： Inhibin B male infertility microsurgical epididymal sperm aspiration primary obstructive azoospermia

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满足未来排放法规要求的MTU解决方案

国外内燃机车 2012年第4期 28-33页

作者： Ulrich dohle 姚琳

所有大型的柴油机制造商的开发重点都放在未来即将生效的废气排放法规上。国际海事组织Stage3标准将规定船用发动机在最大标定转速下的NOx排放限值为2g/kWh。针对机车的将从2012年开始生效的欧盟EUIIIB标准规定,NOx+HC的排放限值为4.0g/... 详细信息

所有大型的柴油机制造商的开发重点都放在未来即将生效的废气排放法规上。国际海事组织Stage3标准将规定船用发动机在最大标定转速下的NOx排放限值为2g/kWh。针对机车的将从2012年开始生效的欧盟EUIIIB标准规定,NOx+HC的排放限值为4.0g/kWh,颗粒物排放量限值在0.025g/kWh以内。美国环保局规定,输出功率超过900kW发电机组的NOx排放限值为0.67g/kWh,颗粒物排放限值为0.10g/kWh。MTUFriedrichafen公司的柴油机产品遍布全球,应用领域十分广泛,因此需要考虑满足各种主流排放参数要求。最大限度地降低寿命周期成本的最佳技术理念已贯穿在每个应用领域的开发中。根据已生效的排放限值、再冷却条件、燃油经济性要求和燃油品质,可以采用不同技术组合,这些技术包括:燃油喷射、涡轮增压、气门定时、废气再循环和排气后处理。本文通过引用一些应用实例来阐述这些技术方案。

关键词：柴油机排放法规废气再循环排气后处理排放限值 NOx 颗粒物