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Microsystems & Nanoengineering 2024年第3期10卷 149-158页

作者： Haoqing zhang Xiaocheng Liu Xinlu Wang zhiqiang Yan Ying Xu Martina Gaňová TomášŘezníček marie Korabečná Pavel Neuzil Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’anShaanxi 710072PR China The Key Laboratory of Biomedical Information Engineering of the Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049PR China Bioinspired Engineering and Biomechanics Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049PR China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’anShaanxi 710072PR China Central European Institute of Technology Brno University of TechnologyPurkyňova 12361300 BrnoCzech Republic ITD Tech S.R.O Osvoboditelu100573581 BohumínCzech Republic Institute of Biology and Medical Genetics First Faculty of MedicineCharles University and General University Hospital of PragueAlbertov 412800 PragueCzech Republic

This study elaborates on the design,fabrication,and data analysis details of SPEED,a recently proposed smartphonebased digital polymerase chain reaction(dPCR)*** dPCR chips incorporate partition diameters ranging from 50μm to 5μm,and these partitions are organized into six distinct blocks to facilitate image *** to the superior thermal conductivity of Si and its potential for mass production,the dPCR chips were fabricated on a Si substrate.A temperature control system based on a high-power density Peltier element and a preheating/cooling PCR protocol user interface shortening the thermal cycle *** optical design employs four 470 nm light-emitting diodes as light sources,with filters and mirrors effectively managing the light emitted during *** algorithm is utilized for image processing and illumination nonuniformity correction including conversion to a monochromatic format,partition identification,skew correction,and the generation of an image correction *** validated the device using a range of deoxyribonucleic acid targets,demonstrating its potential applicability across multiple ***,we provide guidance and verification of the design and testing of the recently proposed SPEED device.

关键词： correction smart testing

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen z.J.Chen z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

新型冠状病毒感染康复期IgG抗体水平及疫苗接种关系

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国际呼吸杂志 2024年第1期44卷 79-84页

作者：安树昌刘国田黄新 AGBO Sedine marie Desiree Nina 逄晓莉李兵蔡善花顾红岩刘晓一崔蓉清华大学第一附属医院呼吸与危重症医学科北京100016 清华大学医学院北京100084 清华大学第一附属医院检验科北京100016

目的了解新型冠状病毒感染(COVID-19)康复期IgG抗体水平及其与新型冠状病毒疫苗接种的关系。方法本研究为前瞻性队列研究。采用非随机抽样的方法,选取2023年2月至5月在清华大学第一附属医院呼吸与危重症医学科门诊和病房就诊的185例COVI... 详细信息

目的了解新型冠状病毒感染(COVID-19)康复期IgG抗体水平及其与新型冠状病毒疫苗接种的关系。方法本研究为前瞻性队列研究。采用非随机抽样的方法,选取2023年2月至5月在清华大学第一附属医院呼吸与危重症医学科门诊和病房就诊的185例COVID-19康复者为研究对象。记录患者一般资料、发病时间、病情严重程度、接种新型冠状病毒疫苗情况。收集患者感染后6、8、10、12、14、16、18周不同时间点静脉血,采用半定量磁微粒化学发光法检测血清免疫球蛋白(Ig)G、IgM抗体水平。按照新型冠状病毒疫苗接种情况分为疫苗接种组(接种2剂次以上灭活疫苗,共130例)和疫苗未接种组(因各种原因未能接种疫苗,共55例)。将2组中>75岁康复者分别纳入亚组,疫苗接种亚组(18例)和疫苗未接种亚组(28例)。比较康复者整体、2组和2亚组各时间点的IgG、IgM抗体水平。结果185例COVID-19康复者中男80例,女105例;年龄62.0(40.5,75.0)岁;111例(60.00%)合并基础病。2组患者的性别比较差异无统计学意义(χ^(2)=0.03,P=0.874);疫苗未接种组年龄、合并基础病、重症或危重症比例均较疫苗接种组高,差异均有统计学意义(均P0.05);疫苗未接种亚组合并基础病比例较疫苗接种亚组高,差异有统计学意义(χ^(2)=4.30,P=0.038)。全体康复者体内IgM抗体水平均为阴性。康复者整体IgG抗体水平在感染后第10周达到峰值,之后逐渐下降,于随访期末达最低值。疫苗接种组感染后第6、8、10、12、14、16、18周的IgG抗体水平均高于疫苗未接种组,差异均有统计学意义[157.9(73.4,240.0)比4.7(1.7,17.7),z=2.36;132.0(75.3,213.1)比2.8(0.7,52.6),z=3.77;137.7(79.9,227.0)比1.1(0.4,15.2),z=4.51;134.5(81.4,211.9)比1.0(0.5,2.9),z=3.49;92.4(68.9,112.9)比1.7(1.2,2.4),z=2.84;61.2(33.3,108.7)比2.9(1.3,12.8),z=3.45;57.1(32.7,87.6)比1.1(0.8,8.3),z=4.06;均Pz=2.34;134.5(104.8,283.6)比1.2(0.5,2.9),z=2.74;61.5(10.9,147.8)比1.9(1.2,27.4),z=2.11;均P<0.05]。结论随着康复期延长,COVID-19康复者体内IgG抗体水平在达峰后逐渐下降。完成全程新型冠状病毒疫苗接种人群在患COVID-19后较未接种人群体内能产生更高水平的IgG抗体。

关键词：新型冠状病毒感染新型冠状病毒 IgG抗体疫苗接种

Mitochondrial DNA-Based Identification of Developmental Stages and Empty Puparia of Forensically Important Flies(Diptera)in Egypt

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Journal of Forensic Science and Medicine 2018年第3期4卷 129-134页

作者： Hedayat A.Abdel Ghaffar marie z.Moftah Alexandre Favereaux Mohamed Swidan Omar Shalaby Sara El Ramah Reda Gamal Department of zoology Faculty of ScienceAlexandria University department of Life Science University of Bordeauxinterdisciplinary Institute of Neuroscience UMR 5297CNRSBordeauxFrance department of Biology and Geology Faculty of EducationAlexandria UniversityAlexandriaEgypt department of Life Science Faculty of BiologyTechnische Universitat DresdenDresdenGermany

Relying on morphology in the estimation of postmortem intervals is not always accurate for all life phases of flies,especially for immature *** present study demonstrates the application of cytochrome oxidase I sequences,a partial mitochondrial(mt)gene region,to differentiate forensically important flies in Alexandria,***-three adult flies,larvae,and pupae were collected from rabbit *** were used for *** analysis revealed no significant intraspecific divergence in Diptera ***,a neighbor-coining tree using the Kimura 2-parameter model illustrated reciprocal morphology between *** represented five species,four genera,four subfamilies,two families,and one *** herein identify five different species,Chrysomya albiceps,Chrysomya megacephala,Calliphora vicina,Lucilia sericata,and Ophyra capensis,using mt DNA as a species-specific marker for identification in a local database set-up.

关键词： Cytochrome oxidase Diptera mitochondrial DNA phylogenetic analysis

Contribution to the Study of Antibiotic Sensitivity of Streptococcus pneumoniae Strains in Spinal Cerebral Fluids in Bangui from 2017 to 2022

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Journal of Biomedical Science and Engineering 2023年第7期16卷 95-106页

作者： zéphirin-Dalengat Vogbia Ernest Lango Yaya marie Colette-Nganda Banguet Jean de Dieu Longo Clotaire -Rafaï Maurel Anicet Adonis Ouoko Fa-Tigbia Christian Diamant Mossoro Gérard Gresenguet Ministry of Health Epidemiology and National Reference Center for Sexually Transmitted Infections and Anti-Retroviral Therapy Research Service Bangui Central African Republic Faculty of Health Sciences University of Bangui Bangui Central African Republic Ministry of Health National Laboratory of Clinical Biology and Public Health Bangui Central African Republic Emergency Department at the Pediatric University Complex Bangui Central African Republic Ministry of Health Training Project Manager and Head of Public Department Bangui Central African Republic

A prospective and analytical study was carried out from January 2017 to Decem-ber 2022, at the National Laboratory of Clinical Biology and Public Health (LNBCSP) in Bangui. 352 samples of cerebrospinal fluid (CSF) were confirmed out of 2065, coming from the four hospitals in Bangui. This study aimed to evalu-ate the evolution of antibiotic sensitivity to strains of Streptococcus pneumoniae. CSF had been collected from patients who presented with meningeal syndromes. Based on the leukocyte count (White blood cells ≥ 5 mm3), an aliquot was trans-ferred to trans-isolate medium and sent to the LNBCSP for confirmatory testing, culture and determination of antibiotic sensitivity. The antibiotic sensitivity of Streptococcus pneumoniae strains was tested according to the methods recom-mended by the Antibiogram Committee of the French Society of Microbiology. The data collected was entered into Excel 2010 to be analyzed with Epi Info 7.2. Ficher’s exact test, chi2 at the 5% threshold (p ze associations between variables. The average sensitivity rate to β-lactams was 74.43%. The sensitivity rate of Fluoroquinolones was 54.54%. That of levofloxacin was 87%. The average rate of sensitivity to β-lactams for the age group under 5 years old was 79.25%. That of fluoroquinolones was 52.59%. Levofloxacin had 90.37%. The average sensitivity rate to β-lactams for the age group over 5 years old was 76.03%. Fluoroquinolones had 45.16%. Levofloxacin had 69.58%. The average sensitivity rate to β-lactams for males was 76.68%. Fluoroquinolones had 54.26%. That of levofloxacin was 83.40%. The sensitivity rate to β-lactams for females was 74.41%. That of fluoroquinolones was 51.16%. Levofloxacin had 67.44%. Cyclins had 28.68%. The study noted an association between age and sensitivity (p < 0.05;CI [1.05-2.57]). Strains of Streptococcus pneumoniae were always detected in the CSF. The average rate of sensitivity to macrolides was 36.93%;aminoglyc

关键词： Streptococcus pneumoniae Sensitivity Antibiotics Central African Republic

News on PHOTOS Monte Carlo:γ~*→π^+π^-(γ) and K~±→π^+π^-e~±ν(γ)

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Chinese Physics C 2010年第6期34卷 889-895页

作者：徐庆君 z.Was Department of Physics Hangzhou Normal University Institute of Nuclear Physics PAN CERN PH-TH

PHOTOS Monte Carlo is widely used for simulating QED effects in decay of intermediate particles and resonances. It can be easily connected to other main process generators. In this paper we consider decaying processes γ＊→π^＋π^-（γ） and K^±→π^＋π^-e^±υ（γ） in the framework of Scalar QED. These two processes are interesting not only for the technical aspect of PHOTOS Monte Carlo, but also for precision measurement of αED（Mz）, g--2, as well as ππ scattering lengths.

关键词： Monte Carlo generator QED radiative corrections ze4 decay

MicroRNA expression profiles and functions in the brain

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Neural Regeneration Research 2008年第12期3卷 1380-1385页

作者： Yanting Qi Yu zhao zhuyin Chen Xiaona Chen marie C. Lin Xiangfu Kong Lihui Lai Institute of Molecular and Chemical Biology East China Normal University Shanghai 200062 China Stanley Ho Centre for Emerging Infectious Diseases Faculty of Medicine The Chinese University of Hong Kong Hong Kong SpecialAdministrative Region China Department of Chemistry Open Laboratory of Chemical Biology University of Hong Kong Hong Kong Special Administrative Region China

MicroRNAs are abundant in the brains of vertebrates and some show a brain-specific or brain-enriched expression pattern. Because microRNAs regulate the expression of hundreds of target genes, it is not surprising that they have profoundly important functions in brain development and pathological processes. For example, miR-124 plays an important role in inducing and maintaining neuronal identity through targeting at least two anti-neural factors. MicroRNAs have also been implicated in brain disorders, including brain tumors and neurodegenerative diseases. This review aims to present an overview of the expression profiles and functions of microRNAs in the developing brains of vertebrates.

关键词： neurogenesis neural cell specification synaptic plasticity posttranscriptional regulator epigenetic control

Trifluoromethyl radical triggered radical cyclization of N-benzoyl ynamides leading to isoindolinones

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Science China Chemistry 2019年第11期62卷 1542-1546页

作者： Maud Cassé Christian Nisole Héloise Dossmann Yves Gimbert Jean-marie Fourquez Laure Haberkorn Cyril Ollivier Louis Fensterbank Sorbonne Université CNRSInstitut Parisien de Chimie MoléculaireIPCM75005 ParisFrance Institut de Recherches Servier 78290 Croissy-sur-SeineFrance Département de Chimie Moléculaire CNRSUniversitéGrenoble Alpes38610 GièresFrance

Under photocatalytic reductive conditions,trifluoromethyl radical addition onto an ynamide followed by cyclization on a benzoyl moiety produces diverse isoindolinone platforms with good *** selectivity of the radical cyclization,N-benzoyl vs.N-benzyl as radical acceptor and the E/z ratio of isomers have been rationalized by modeling.

关键词： ynamides trifluoromethylation photocatalysis cascade reactions tandem processes isoindolinones modeling

Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4^(+) T cell activation

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Cellular & Molecular Immunology 2020年第2期17卷 133-142页

作者： Miguel Álvaro-Benito Eliot Morrison Friederike Ebner Esam T.Abualrous marie Urbicht Marek Wieczorek Christian Freund Laboratory of Protein Biochemistry Department of BiologyChemistry and PharmacyFreie Universität BerlinThielallee 6314195 BerlinGermany Institut für Immunologie Department of Veterinary MedicineFreie Universität BerlinRobert-von-Ostertag-Str.7-1314163 BerlinGermany Computational Molecular Biology Group Institute for MathematicsFreie Universität BerlinBerlinGermany

Classical human leukocyte antigen(HLA)molecules of the major histocompatibility classⅡ(MHCⅡ)complex present peptides for the development,surveillance and activation of CD4^(+) T *** nonclassical MHCⅡ-like protein HLA-DM(DM)catalyzes the exchange and loading of peptides onto MHCⅡmolecules,thereby shaping MHCⅡ*** variations of DM in both chains of the protein(DMA and DMB)have been hypothesized to impact peptide presentation,but no evidence for altered function has been *** we define the presence of DM allotypes in human populations covered by the 1000 Genomes Project and probe their *** functional properties of several allotypes are investigated and show strong enhancement of peptide-induced T cell activation for a particular combination of DMA and *** evidence suggests a broader pH activity profile for the new variant relative to that of the most commonly expressed DM *** analysis indicates that the compartmental activity of the new DM heterodimer extends beyond the late endosome and suggests that the natural variation of DM has profound effects on adaptive immunity when antigens bypass the canonical processing pathway.

关键词： MHC classⅡ Limited polymorphism HLA-DM,Peptide editing Epitope selection Immunopeptidome