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Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

Neural Regeneration Research 2020年第12期15卷 2207-2216页

作者： Francisco Bosch-Morell Victoria Villagrasa Teresa Ortega Nuria Acero Dolores Muñoz-Mingarro MEugenia González-Rosende Encarna Castillo MAmparo Sanahuja Pilar Soriano Isabel Martínez-solís Biomedical Sciences Institute Universidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Biomedical Sciences Faculty of Health SciencesUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Pharmacy Faculty of Health SciencesUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Pharmacology Pharmacognosy and BotanyUniversidad Complutense de MadridMadridSpain Department of Pharmaceutical and Health Sciences Faculty of PharmacyUniversidad San Pablo-CEUCEU UniversitiesMadridSpain Department of Chemistry and Biochemistry Faculty of PharmacyUniversidad San Pablo-CEUCEU UniversitiesMadridSpain ICBiBE-Botanical Garden University of ValenciaValenciaSpain

The retina may suffer neurodegenerative damages,as other tissues of the central nervous system do,and serious eye diseases may *** of them is age-related macular degeneration,which causes progressive loss of vision due to retina *** of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds,among others,that prevent/diminish oxidative stress and reduce neovascularisation *** phytochemicals,medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor *** review article presents the most investigated plants and natural products in relation to age-related macular degeneration,such as saffron,ginkgo,bilberry and blueberry,curcuma or turmeric,carotenoids,polyphenols,and vitamins C and *** study provides up-to-date information on the effects,treatments,safety and efficiency of these phytotherapy products.

关键词： age-related macular degeneration bilberry blueberry curcuma carotenoids ginkgo polyphenols saffron vitamins

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Participation of Auxin Transport in the Early Response of the Arabidopsis Root System to Inoculation with Azospirillum brasilense

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Phyton-International Journal of Experimental Botany 2022年第11期91卷 2383-2401页

作者： Elizabeth Carrillo-Flores Jonanci Arreola-Rivera DenníMariana Pazos-solís Moisés Bocanegra-Mondragón Grisel Fierro-Romero MaElena Mellado-Rojas Elda Beltrán-Peña Laboratorio de Transducción de Señales Edificio B3Instituto de Investigaciones Químico-Biológicas de la Universidad Michoacana de San Nicolás de HidalgoCiudad UniversitariaMorelia58030México Tecnológico de Monterrey School of Engineering and SciencesCampus QuerétaroSan PabloQuerétaro76130México School of the Environment Florida A&M UniversityTallahassee32307USA

The potential of Plant Growth Promoting Rhizobacteria(PGPR)has been demonstrated in the case of plant inoculation with bacteria of the genus Azospirillum which improves *** produces a wide variety of molecules,including the natural auxin indole-3-acetic acid(IAA),as well as other ***,several studies have suggested that auxin induces changes in plant development during their interaction with the *** effects of *** Sp245 on the development of Arabidopsis thaliana root were investigated to help explain the molecular basis of the *** results obtained showed a decrease in primary root length from the first day and remained so throughout the exposure,accompanied by a stimulation of initiation and maturation of lateral root primordia and an increase of lateral *** enhanced auxin response was evident in the vascular tissue and lateral root meristems of inoculated ***,after five days of bacterization,the response disappeared in the primary root *** role of polar auxin transport(PAT)in auxins relocation involved the PGP1,AXR4-1,and BEN2 proteins,which apparently mediated ***-induced root branching of Arabidopsis seedlings.

关键词： Auxin Azopirillum brasilense Arabidopsis auxin transport lateral roots

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Experimental model standardizing polyvinyl alcohol hydrogel to simulate endoscopic ultrasound and endoscopic ultrasoundelastography

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World Journal of Gastroenterology 2020年第34期26卷 5169-5180页

作者： Elymir S Galvis-García Sergio Sobrino-Cossío Arturo Reding-Bernal Yesica Contreras-Marín Karina solórzano-Acevedo Patricia González-Zavala Rosa M Quispe-Siccha Unidad de Endoscopía Gastrointestinal Hospital General de México"Dr.Eduardo Liceaga"Mexico 06720Mexico Unidad de Endoscopia y Fisiología Digestiva HospitalÁngeles del PedregalMexico 10700Mexico Dirección de Investigación Hospital General de México“Dr.Eduardo Liceaga”Mexico 06720Mexico Unidad Profesional Interdisciplinaria de Biotecnología and Unidad de Investigación y Desarrollo Tecnológico Instituto Politécnico Nacional and Hospital General de México"Dr.Eduardo Liceaga"Mexico 06720Mexico Instituto de Investigaciones en Materiales and Unidad de Investigación y Desarrollo Tecnológico Universidad Nacional Autónoma de México and Hospital General de México"Dr.Eduardo Liceaga"Mexico 06720Mexico Unidad de Investigación y Desarrollo Tecnológico Hospital General de México"Dr.Eduardo Liceaga"Mexico 06720Mexico

BACKGROUND Endoscopic ultrasound(EUS)and endoscopic ultrasound elastography(EUS-E)simulation lessens the learning curve;however,models lack realism,diminishing *** To standardize the mechanical properties of polyvinyl alcohol(PVA)hydrogel for simulating organs and digestive *** PVA hydrogel(Sigma Aldrich,degree of hydrolysis 99%)for simulating EUS/EUS-E lesions was investigated in Unidad de Investigación y Desarrollo Tecnológico at Hospital General de México“*** Liceaga”,Mexico *** evaluated physical,contrast,elasticity and deformation coefficient characteristics in lesions,applying Kappa’s concordance and satisfaction questionnaire(Likert 4-points).RESULTS PVA hydrogel showed stable mechanical *** depended on molecular weight(MW)and concentration(C).PVA bblocks with the greatest density showed lowest tensile strength(r=-0.8,P=0.01).Lesions were EUSgraphically *** and heterogeneous examples were created from PVA blocks or PVA phantoms,exceeding(MW2=146000-186000,C9=15%and C10=20%)with a density under(MW1=85000-124000,C1=7%and C2=9%).We calculated elasticity and deformation parameters of solid(blue)areas,contrasting with the norm(Kappa=0.8;high degree of satisfaction).CONCLUSION PVA hydrogels were appropriate for simulating organs and digestive lesions using EUS/EUS-E,facilitating practice and reducing *** amplified skills,while reducing the learning curve.

关键词： Endoscopic ultrasound simulators in endoscopy Polyvinyl alcohol Endoscopic ultrasound Endoscopic ultrasound elastography Strain Elasticity

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Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in nonalcoholic steatohepatitis patients

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Acta Pharmaceutica Sinica B 2023年第1期13卷 1-28页

作者： solène Marie Kayla L.Frost Raymond K.Hau Lucy Martinez-Guerrero Jailyn M.Izu Cassandra M.Myers Stephen H.Wright Nathan J.Cherrington College of Pharmacy Department of Pharmacology&ToxicologyUniversity of ArizonaTucsonAZ 85721USA College of Medicine Department of PhysiologyUniversity of ArizonaTucsonAZ 85724USA

The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and ***-alcoholic steatohepatitis(NASH)causes disease-specific alterations to the absorption,distribution,metabolism,and excretion(ADME)processes,including a decrease in protein expression of basolateral uptake transporters,an increase in efflux transporters,and modifications to enzyme *** can result in increased drug exposure and adverse drug reactions(ADRs).Our goal was to predict drugs that pose increased risks for ADRs in NASH *** research identified 71 drugs with reported ADRs in patients with liver disease,mainly non-alcoholic fatty liver disease(NAFLD),54 of which are known substrates of transporters and/or metabolizing *** NASH is the progressive form of NAFLD but is most frequently undiagnosed,we identified other drugs at risk based on NASH-specific alterations to ADME ***,we present another list of 71 drugs at risk of pharmacokinetic disruption in NASH,based on their transport and/or metabolism *** encompasses drugs from various pharmacological classes for which ADRs may occur when used in NASH patients,especially when eliminated through multiple pathways altered by the ***,these results may inform clinicians regarding the selection of drugs for use in NASH patients.

关键词： Non-alcoholic steatohepatitis Hepatic elimination Transporter Enzyme Pharmacokinetics Drug-drug interaction Liver Adverse drug reaction

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流连一生——从纽约到上海

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大美术 2006年第9期 138-143页

作者： sol

纽约的FIFTH AVENUE的盛名早已远近皆知,它以鲜明的纽约特色和浓烈的美国文化吸引了全球的瞩目。上海有潜力进入国际商业街行列的新天地,格调高雅、人文荟萃、意蕴丰富,已定格为繁华与高贵的象征,予人联想。这里充满了过去和现代的碰撞... 详细信息

纽约的FIFTH AVENUE的盛名早已远近皆知,它以鲜明的纽约特色和浓烈的美国文化吸引了全球的瞩目。上海有潜力进入国际商业街行列的新天地,格调高雅、人文荟萃、意蕴丰富,已定格为繁华与高贵的象征,予人联想。这里充满了过去和现代的碰撞,充满着繁华和安静的对比,也充满着民族和世界的交融。

关键词：文化吸引人文荟萃闹中取静高端商业旅游书商业城市世界声誉杰奎琳第五大道法拉利

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Tailored BiVO_(4)/In_(2)O_(3)nanostructures with boosted charge separation ability toward unassisted water splitting

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Carbon Energy 2023年第6期5卷 45-59页

作者： Mi Gyoung Lee Jin Wook Yang Ik Jae Park Tae Hyung Lee Hoonkee Park Woo Seok Cheon sol ALee Hyungsoo Lee Su Geun Ji Jun Min Suh Jooho Moon Jin Young Kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Country Department of Applied Physics Sookmyung Women's UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Yonsei UniversitySeoulRepublic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwonRepublic of Korea

The development of new heterostructures with high photoactivity is a breakthrough for the limitation of solar-driven water ***,we first introduce indium oxide(In_(2)O_(3))nanorods(NRs)as a novel electron transport layer for bismuth vanadate(BiVO_(4))with a short charge diffusion ***_(2)O_(3)NRs reinforce the electron transport and hole blocking of BiVO_(4),surpassing the state-of-the-art photoelectrochemical performances of BiVO_(4)-based ***,a tannin-nickel-iron complex(TANF)is used as an oxygen evolution catalyst to speed up the reaction *** final TANF/BiVO_(4)/In_(2)O_(3)NR photoanode generates photocurrent densities of 7.1 mAcm^(−2) in sulfite oxidation and 4.2 mA cm^(−2) in water oxidation at 1.23 V versus the reversible hydrogen ***,the“artificial leaf,”which is a tandem cell with a perovskite/silicon solar cell,shows a solar-to-hydrogen conversion efficiency of 6.2%for unbiased solar water *** reveal significant advances in the photoactivity of TANF/BiVO_(4)/In_(2)O_(3)NRs from the tailored nanostructure and band structure for charge dynamics.

关键词： bismuth vanadate heterojunction indium oxide nanostructure photoelectrochemical water splitting

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Meteorological and Climate Modelling Services Tailored to Viticulturists

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Atmospheric and Climate Sciences 2021年第1期11卷 148-164页

作者： Ignasi Porras Josep Maria solé Raül Marcos Raúl Arasa Meteosim SL Barcelona Spain Barcelona Supercomputing Center (BSC) Barcelona Spain

Grape production is likewise inherently interconnected to climate and weather, and, although grapes may grow worldwide, premium wine-grape production occurs in Mediterranean-like climate ranges. Changes in climate and weather patterns are threatening premium wine-grapes, directly affecting the European wine industry. This is because grapevines are extremely sensitive to their surrounding environment, with seasonal variations in yield much higher than other common crops, such as cereals. With a view to making South European wine industry resilient to climate change, VISCA (Vineyards Integrated Smart Climate Application) project has deployed a Climate Service (CS) Decision Support System (DSS) tool that provides to wine producers with well-founded information to be able to apply correctly adaptation strategies on specific grape varieties and locations, and to achieve optimum production results (e.g., yield and quantity). In this paper we show the meteorological, seasonal and climatic models and data sets used to answer the viticulturist needs;from short-term and mid-term forecast to seasonal forecast and climate projections.

关键词： Weather Extreme Events Adaptation to Climate Change Climate Services Wine Industry VISCA

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宇宙是如何运转的

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2019年

作者： (西)sol90公司

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Rationally designed graphene channels for real-time sodium ion detection for electronic tongue

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InfoMat 2023年第7期5卷 43-58页

作者： Chung Won Lee Sang Eon Jun Seung Ju Kim Tae Hyung Lee sol A.Lee Jin Wook Yang Jin Hyuk Cho Shinyoung Choi Cheol-joo Kim Soo Young Kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwonRepublic of Korea

Monitoring taste-inducing ions and molecules continuously in liquids or solutions is of great considerable matter for the realization of the electronic tongue(E-tongue).Particularly from the five major tastes,the highly selective,sensitive detection of Na^(+)in real-time is *** is due to the saltiness of food is the key ingredient in most ***,existing Na^(+)detecting devices have relatively low performances of selectivity,sensitivity,and lack of on–off ***,conventional devices significantly deteriorate in capac-ity due to repetitive usage or lifetime shortage by degradation of the sensing ***,a graphene-based channel was rationally designed by the facile decoration of Calix[4]arene and Nafion to address this *** act as a receptor and a molecular sieve,respectively,to enhance selectivity and sensitivity and elon-gate the life expectancy of the *** device was merged with a microfluidic channel to control the injection and withdrawal of solutions to fulfill dynamic on–off *** fabricated device has highly selective,sensitive Na^(+)detection properties compared to other 10 molecule/ionic *** on–off functions of the device were available,also possesses a long lifespan of at least 220 ***,it can precisely discriminate real beverages containing Na^(+),which can be observed by principal component analysis *** features offer the possibility of ascending to a platform for E-tongues in near future.

关键词： electronic tongue graphene microfluidic channels Na^(+)sensors solution-gated field-effect transistors

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Ethyl Levulinate Obtained from Lignocellulosic Waste Material with Previous delignification by Ultrasonic-Assisted Technique

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Journal of Agricultural Chemistry and Environment 2017年第1期6卷 93-103页

作者： Jorge Ernesto solá-Pérez Hugo Saldarriaga-Norena Mario Murillo-Tovar Centro de Investigaciones Químicas ICCBAUniversidad Autónoma del Estado de MorelosCuernavacaMéxico

Ultrasound-assisted pretreatment under mild operating conditions has been investigated for intensification of delignification to facilitate the obtaining of ethyl levulinate from biomass. The effect of pH (2 - 12), temperature (30°C - 70°C) and pretreatment time (0 - 120 minutes) has been studied for different biomass samples. The most favorable conditions were basic pH, temperature of 70°C and pretreatment time of 2 h, obtaining values of delignification near 80 percent. The ethyl levulinate is obtained in microwave directly via from samples before and after delignification and analyzed for GC-MS. The results evidenced better yields for the delignified samples.

关键词： Ethyl Levulinate delignification Wheat Straw Sugarcane Bagasse Maguey Bagasse

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