检索结果-南通市图书馆

Catalytic atroposelective synthesis of indolyl quinazolinones bearing N-N/C-C diaxes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Ning-Yi Wang Shuo Gao Zhu-Di Shu bei-bei Cheng Chun Ma Yu-Chen Zhang Feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials Science Jiangsu Normal University School of Petrochemical Engineering Changzhou University School of Chemistry and Chemical Engineering Henan Normal University

The first catalytic atroposelective synthesis of indole derivatives bearing N-N/C-C diaxes has been established by the strategy of de novo ring formation. By this strategy, various indolyl quinazolinones bearing vicinal N-N/C-C diaxes were synthesized in high yields with overall good diastereoselectivities and excellent enantioselectivities via chiral phosphoric acid-catalyzed onepot asymmetric formal (5+1) cycloaddition/oxidation reaction. Moreover, such indolyl quinazolinones bearing vicinal N-N/CC diaxes have good configurational stability and could be converted into new chiral ligands with applications in asymmetric catalysis. Therefore, this work not only offered a new member for the family of diaxial atropisomers, but also provided a powerful strategy for catalytic asymmetric synthesis of atropisomers bearing N-N/C-C diaxes.

关键词：

Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Shi Chen Yuanyuan He Lejun Lv bei Liu Cheng Li Hongkui Deng Jun Xu Department of Cell Biology School of Basic Medical Sciences Peking University Stem Cell Research Center Peking University Health Science Center Peking University Academy of Advanced Interdisciplinary Studies Peking University beiCell Therapeutics School of Life Sciences Center for Bioinformatics Center for Statistical Science Peking University MOE Engineering Research Center of Regenerative Medicine School of Basic Medical Sciences State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University

Human primed pluripotent stem cells are capable of generating all the embryonic ***,their extraembryonic trophectoderm potentials are *** remains unclear how to expand their developmental potential to trophectoderm *** we show that transient treatment with a cocktail of small molecule epigenetic modulators imparts trophectoderm lineage potentials to human primed pluripotent stem cells while preserving their embryonic *** chemically treated cells can generate trophectoderm-like cells and downstream trophoblast stem cells,diverging into syncytiotrophoblast and extravillous trophoblast *** and CUT&Tag analyses reveal that these induced cells share transcriptional profiles with in vivo trophectoderm and cytotrophoblast,and exhibit reduced H3K27me3 modification at gene loci specific to trophoblast lineages compared with primed pluripotent *** exploration highlighted the critical roles of epigenetic modulators HDAC2,EZH1/2,and KDM5s in the activation of trophoblast lineage *** findings demonstrate that transient epigenetic resetting activates unrestricted lineage potential in human primed pluripotent stem cells,and offer new mechanistic insights into human trophoblast lineage specification and in vitro models for studying placental development and related disorders.

关键词：

高质量发展是全面建设社会主义现代化国家的首要任务

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 43-49,F0002页

作者：金碚中国社会科学院工业经济研究所北京100006

党的二十大报告提出以中国式现代化全面推进中华民族伟大复兴,形成对中国式现代化的系统性认知,强调高质量发展是全面建设社会主义现代化国家的首要任务。改革开放以来,在中国共产党的领导下,我国逐步摆脱观念桎梏和教条约束,坚持一切... 详细信息

党的二十大报告提出以中国式现代化全面推进中华民族伟大复兴,形成对中国式现代化的系统性认知,强调高质量发展是全面建设社会主义现代化国家的首要任务。改革开放以来,在中国共产党的领导下,我国逐步摆脱观念桎梏和教条约束,坚持一切从国情出发,创造了人类文明新形态。经济全球化势不可挡,世界必然是和而不同的全球格局,不同文明形态、不同经济体制、不同行为方式共存形成人类命运共同体。这是中国式现代化的底层逻辑,体现了中国经济高质量发展的世界意义。从中国式现代化视角透视高质量发展的深刻叙事,有助于深刻诠释中国式现代化的核心意涵。

关键词：高质量发展中国式现代化体制机制供需相宜因地制宜新质生产力

Early identification of stroke through deep learning with multi-modal human speech and movement data

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Metal-organic frameworks (MOFs) in aqueous batteries (ABs):unlocking potential through innovative materials design

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Bo Han Erhai Hu bei-Er Jia Ziyang Liu Shuen Tso Afriyanti Sumboja Ivandini T.Anggraningrum Anne Zulfia Syahrial Qingyu Yan SCARCE Laboratory Energy Research Institute NTU (ERIN) Nanyang Technological University School of Materials Science and Engineering Nanyang Technological University Material Science and Engineering Research Group Faculty of Mechanical and Aerospace Engineering Institut Teknologi Bandung Department of Chemistry University of Indonesia Metallurgical & Materials Engineering Department Fakultas Teknik Universitas Indonesia

Metal-organic frameworks (MOFs) represent a revolutionary class of materials in the field of energy storage,particularly for aqueous batteries (ABs).Distinguished by their large surface area,tuneable porosity,and adaptable chemical activity,MOFs offer significant advantages over conventional materials in battery *** article provides a thorough analysis of the crucial role that MOFs play in improving the efficiency of *** includes a concise review of the current research progress,emphasizing the fundamental processes by which MOFs enhance electrochemical ***,the review examines the synthesis and design strategies for the structure of MOFs to maximize ion transport,improve conductivity,and enhance *** structural advantages,chemical versatility,stability,durability and functionalization potential of MOFs are comprehensively ***,we explore the distinct advantages of MOFs in overcoming common challenges encountered in ABs,such as declining capacity,inadequate cycling stability,and limited energy *** paper also highlights the future research directions needed to fully harness their *** goal is to develop a fundamental understanding and stimulate further progress in the use of MOFs for advanced energy storage solutions.

关键词：

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

[Determination of eight phthalate metabolites in urine of pregnant women and evaluation of neonatal birth outcomes based on solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry]

在线全文

学校读者我要写书评

暂无评论

Se pu = Chinese journal of chromatography 2025年第1期43卷 60-67页

作者： Zi-Hao Wang Meng-Fei Xu bei-Ni Li Ping Wu Wei Wu Hubei University of Chinese Medicine Wuhan 430065 China.

Phthalates (PAEs) are endocrine-disrupting chemicals that are widely present in everyday life and enter the human body through various pathways. The release of PAEs into the environment through pathways that include leaching, evaporation, abrasion, and the use of personal care products exposes humans to PAEs via ingestion, inhalation, and dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth and development when exposed to PAEs. While the concentrations of PAEs in urine reflect recent exposure levels in humans, urinary levels of phthalate metabolites (mPAEs) are commonly used as biomarkers of internal exposure owing to the relatively short biological half-lives of PAEs (<24 h). In this study, we developed a solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS) method for simultaneously detecting eight mPAEs in the urine of pregnant women. Urine samples were enzymatically hydrolyzed with -glucosidase and then purified using the Bond Elut Plexa SPE column, with subsequent elution, concentration, and redissolved performed prior to HPLC-MS/MS. Separation was achieved using an Agilent Eclipse Plus C18 column (100 mm×3 mm, 3.5 μm), with gradient elution performed using 0.1% acetic acid aqueous solution and 0.1% acetic acid acetonitrile as mobile phases. Multiple reaction monitoring (MRM) mode was used for detection, with quantification performed using the internal-standard method. Good linearities were obtained in the range of 0.1-200 ng/mL for the eight mPAEs, with limits of detection (LODs) and quantification (LOQs) of 0.015-0.048 and 0.050-0.160 ng/mL, respectively. The eight mPAEs exhibited recoveries of 80.2%-99.7% at three spiked levels (1, 10, and 50 ng/mL). This method was subsequently used to analyze the eight mPAEs levels in urine samples of 497 pregnant women from the Ezhou Maternity and Child Health Care Hospital. The participants exhibited widespread exposure t

关键词： birth outcomes high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) phthalate metabolites (mPAEs) urine samples of pregnant women

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

急性胰腺炎并发胆道系统疾病的诊治进展

中华外科杂志 2025年第1期63卷 76-80页

作者：李启元罗岩孙备哈尔滨医科大学附属第一医院胰胆外科哈尔滨

急性胰腺炎是外科常见的急腹症, 其发展过程中往往伴随着严重的局部或全身并发症。胆道系统疾病是急性胰腺炎严重的局部并发症之一, 主要包括急性非结石性胆囊炎和胆管狭窄。急性非结石性胆囊炎常发生在急性胰腺炎的病程后期, 会加重患... 详细信息

急性胰腺炎是外科常见的急腹症, 其发展过程中往往伴随着严重的局部或全身并发症。胆道系统疾病是急性胰腺炎严重的局部并发症之一, 主要包括急性非结石性胆囊炎和胆管狭窄。急性非结石性胆囊炎常发生在急性胰腺炎的病程后期, 会加重患者全身炎症反应, 严重时可导致器官功能衰竭等, 危及生命。胆管狭窄是急性胰腺炎少见的远期严重并发症, 可诱发胆管炎、进行性肝功能损害和继发性胆汁性肝硬化等严重并发症。由于急性胰腺炎的临床症状可掩盖其他症状, 部分发病期间并发胆道系统疾病的患者未能得到及时诊治, 严重时可危及患者生命。目前, 针对急性胰腺炎继发胆道系统并发症的理想治疗策略尚不明确, 缺乏具有指导意义的指南或共识。本文结合近年来国内外相关研究进展, 对急性胰腺炎并发胆道系统疾病的发病机制、诊断及治疗策略进行阐述。

关键词：胰腺炎胆道疾病急性非结石性胆囊炎胆管狭窄

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

思维导向下的情境作文教学结构模型建构

兵团教育学院学报 2025年第1期35卷 72-76页

作者：赵贝贝李保春天津师范大学教育学部天津300380 项城教体局教育发展研究中心河南项城466200

思维导向下的情境作文课堂教学以思维进阶和真实语境写作为核心概念,其中,情境作文课堂为思维锻炼提供了丰富的实践场景,思维提升是情境作文课堂教学的目标旨归。在对情境作文课堂与思维导向内涵及关系认识的基础上,基于课堂实现条件和... 详细信息

思维导向下的情境作文课堂教学以思维进阶和真实语境写作为核心概念,其中,情境作文课堂为思维锻炼提供了丰富的实践场景,思维提升是情境作文课堂教学的目标旨归。在对情境作文课堂与思维导向内涵及关系认识的基础上,基于课堂实现条件和课堂实施进程两个层面,构建了思维导向下的情境作文课堂教学结构模型。课堂实现条件层面主要由情感共鸣下的全情投入、合作交流中的深度参与、结构优化下的过程整合构成;课堂实施进程层面主要由情境创设、认知激活、思维深化、个性表达和能力内化构成。

关键词：思维导向情境作文课堂教学结构