检索结果-南通市图书馆

Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2016年第1期2卷 329-340页

作者： mariangela Torniai Silvia Rinaldi Francesca Morgese Giulia Ricci Azzurra Onofri Christian Grohé Rossana Berardi Department of Medical Oncology UniversitàPolitecnica delle Marche60100 AnconaItaly Department of Respiratory Diseases Ev.Lungenklinik BerlinUniversitätsmedizin ChariteLindenberger Weg 2713125 BerlinGermany

Neuroendocrine tumors(NETs)represent a spectrum of rare neoplasms arising in different organism *** on the site of onset,they also can be distinguished using lab exams(secreting ***),clinical symptoms(functioning ***),behavioral,morphological characteristics(tumor cells’architectural growth patterns,mitotic and Ki-67 index,presence of necrosis),and grade of cellular *** aim of this review is to focus on the main signaling pathways targeted by medical treatments of advanced sporadic gastro-entero-pancreatic(GEP)and bronchopulmonary(BP)neuroendocrine *** scientific literature regarding treatment of advanced GEP and BP-NETs has been extensively reviewed using MEDLINE and PubMed databases,selecting principal and more recent research articles,clinical trials,and updated *** analogues represent a valid approach to control symptoms in functioning tumors and to inhibit tumor progression in certain categories on the basis of the typical somatostatin receptor expression observed in *** pathogenesis of NETs has been the subject of increased interest in recent *** driver mutations pathway genes have been identified as important factors in the carcinogenesis process and,therefore,as potential targets for new anticancer *** mutations have been shown in epidermal growth factor receptor,stem cell factor receptor,platelet-derived growth factor receptor,vascular endothelial growth factor,basic-fibroblastic growth factor,transforming growth factor,insulin-like growth factor-1,and their *** M-Tor inhibition pathway modulation has led to the approval of drugs in this field such as *** drugs and several combination regimens with targeted and newer biological agents are being developed and tested in recently conducted and ongoing trials.

关键词： Gastrointestinal and bronchopulmonary neuroendocrine tumors advanced disease medical treatment targeted agents

Functional Starter Cultures for Meat: A Case Study on Technological and Probiotic Characterization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2015年第5期6卷 511-522页

作者： Antonio Bevilacqua Maria Rosaria Corbo Barbara Speranza Barbara Di Maggio mariangela Gallo Milena Sinigaglia Department of the Science of Agriculture Food and Environment University of Foggia Foggia Italy

The selection of a starter is a complex process, involving different steps, like a preliminary characterization under laboratory conditions, the selection of the most promising strains, a lab validation and the final validation in a large-scale fermentation;the selection of a functional starter includes a further step, dealing with the assessment of the functional traits. This paper proposes a case study on how use a step-by-step approach, based on some rapid protocols, to select promising starter cultures with probiotic abilities. Nine strains, isolated from a commercial preparation, were studied in relation to some enzymatic activities (slime and acetoin production, reduction of nitrates, proteolytic activity and hydrolysis of tributyrin), technological (acidification and growth at different temperatures, pHs and salt amounts) and probiotic traits (hydrophobicity, co-aggregation towards Salmonella sp. and Escherichia coli, survival at pH 2.5 and in presence of bile salts, antibiotic resistance) and compared to some collection isolates. As a final step, a multivariate approach was used to select the most promising isolates. The isolates from the commercial preparation were able to perform the fermentation (e.g. acidification) at low temperatures with some interesting traits in terms of bioactivity towards E. coli O157:H7, whilst some interesting probiotic traits in terms of hydrophobicity and survival in conditions that mimicked the gut were found for the collection isolates.

关键词： Commercial Starter Screening Protocols Technological Performances Functional Traits Multivariate Approach

家兔角巩膜缘局部应用5-FU的效果观察(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际眼科杂志 2007年第2期7卷 291-293页

作者： Lucieni C.B.Ferraz Silvana A.Schellini mariangela E.A.Marques 巴西圣保罗Botucatu医学院眼科巴西圣保罗Botucatu医学院病理科

目的:观察家兔角巩膜缘局部应用5-氟尿嘧啶(5-FU)的治疗效果。方法:家兔角巩膜缘区域局部应用5-FU,家兔被立即处死或在7,15,30d后分别处死,处死后即进行组织学检查。结果:在手术刚结束时,所有家兔眼5-FU的应用区域附近都表现为角巩膜组... 详细信息

目的:观察家兔角巩膜缘局部应用5-氟尿嘧啶(5-FU)的治疗效果。方法:家兔角巩膜缘区域局部应用5-FU,家兔被立即处死或在7,15,30d后分别处死,处死后即进行组织学检查。结果:在手术刚结束时,所有家兔眼5-FU的应用区域附近都表现为角巩膜组织上皮脱失,术后4d此处区域的溃疡愈合。组织学检查表现为上皮缺失伴轻微水肿。1wk后,2个动物仍表现为上皮缺损、上皮增厚且具有较大的基底细胞、染色质疏松及轻微的上皮下水肿。其余各组没有上述类似改变。结论:角巩膜缘局部应用5-FU能够延迟组织的上皮化。

关键词： 5-氟尿嘧啶抗有丝分裂制剂家兔局部应用组织病理

Risk Analysis： A Methodology Applicable to the Building Inspection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Civil Engineering and Architecture 2016年第9期10卷 1052-1058页

作者： Mauricio Noya Ana Lucia Torres Seroa da Motta mariangela Moura Rafael Carvalho de Souza Bruno Barzellay Programa de Pos-graduacao em Engenharia Civil Universidade Federal Fluminense Rio de Janeiro 22211-200 Brazil Departamento de Engenharia Civil da Universidade Federal do Rio de Janeiro-Campus Macae Rio de Janeiro 22211-200 Brasil

The lack of care related to maintenance management is directly linked to the absence of plans for maintenance of buildings. Because of that, there is a big incidence of building accidents caused by the negligence of managers and the lack of investment. The research has shown that, although building inspection is a consolidated building maintenance tool, managers do not prepare their building maintenance plan, nor use building inspection as a tool, leading the buildings to the premature obsolescence. The research calls attention to the building inspection technique that can be used to evaluate building maintenance and conservation. It is also a tool for analysis and investment planning based on actions to solve failures and anomalies that might come out during the building inspection. Those failures and anomalies are classified according to their degree of risk, determining the technical priorities of the investment adjustment in the maintenance plan. The paper presents a risk analysis methodology which classifies inspect elements in a building, determining the priority order of services to be executed on a scale from minimum risk （1） to imminent risk （5）. The method shows a tool for building inspection, and it serves as a guideline for building maintenance interventions.

关键词： Civil engineering risk analysis building inspection building maintenance.

Optimizing the Dose Distribution in Stereotactic Body Radiotherapy with Standard Multileaf Collimator(MLC) ： A Planning Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肿瘤预防与治疗 2017年第2期30卷 79-84页

作者： Francesco DEODATO Savino CILLA Gabriella MACCHIA Cinzia DIGES Anna IANIRO mariangela BOCCARDI Vincenzo VALENTINI Alessio G.MORGANTI Radiotherapy Unit Fondazione di Ricerca e Cura"Giovanni Paolo Ⅱ"Università Cattolica del S.Cuore Medical Physics Unit Fondazione di Ricerca e Cura "Giovanni Paolo Ⅱ"Università Cattolica del S.Cuore Radiotherapy Department "A.Gemelli"HospitalCatholic University Radiation Oncology Unit Department of ExperimentalDiagnostic and Specialty MedicineDIMES University of BolognaS.Orsola-Malpighi Hospital

导读：体部立体定向放射治疗（SBRT）可实现靶区剂量的集中、精准和生物有效性，同时避开重要的正常器官。它在当今放疗世界扮演着越来越重要的地位。为了得到更好的剂量优化，目前有很多关于定位、处方剂量技术的研究，运用IMRT可实现S... 详细信息

导读：体部立体定向放射治疗（SBRT）可实现靶区剂量的集中、精准和生物有效性，同时避开重要的正常器官。它在当今放疗世界扮演着越来越重要的地位。为了得到更好的剂量优化，目前有很多关于定位、处方剂量技术的研究，运用IMRT可实现SBRT的剂量优化，但各个放疗中心的结果却不尽相同，尚未完全统一。

关键词：体部立体定向放射治疗放射学肿瘤临床治疗

Gastro-entero-pancreatic neuroendocrine tumors:Is now time for a new approach?

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2016年第2期7卷 131-134页

作者： Rossana Berardi mariangela Torniai Agnese Savini Silvia Rinaldi Stefano Cascinu Department of Medical Oncology Università Politecnica delle Marche

Gastro-entero-pancreatic tumors(GEP-NETs) are rare neoplasms often characterized by an overexpression of somatostatin ***,radiolabeled somatostatin analogues have showed an increasing relevance both in diagnosis and treatment,especially in low-and intermediate-differentiated *** evidences have led to a growing development of new functional imaging techniques as 68 Ga-DOTATATE positron emission tomography/computed tomography(PET/CT) proved useful in the management of these *** these tumors have a heterogeneous behavior also modifying their aggressiveness through *** sometimes 18 F-fluorodeoxyglucose PET/CT appears to be more appropriate to obtain a better assessment of the *** to these considerations,the combination of different functional imaging techniques should be considered in the management of GEP-NETs patients allowing clinicians to choose the tailored therapeutic approach among available options.

关键词： 18F-fluorodeoxyglucose positron emission tomography/computed tomography Gastro-enteropancreatic neuroendocrine tumor 68Ga-DOTATATE positron emission tomography/computed tomography Diagnosis Imaging

Antioxidant Properties and Chemical Composition Relationship of Europeans and Brazilians Propolis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2013年第1期4卷 46-51页

作者： Sabrina Fabris mariangela Bertelle Oxana Astafyeva Elena Gregoris Roberta Zangrando Andrea Gambaro Giuseppina Pace Pereira Lima Roberto Stevanato Department of Molecular Sciences and Nanosystems University Ca’Foscari of VeniceVeniceItaly Depatment of Biotechnology and Bioecology Astrakhan State University(ASU)AstrakanRussia Institute for the Dynamics of Environmental Processes CNRUniversity Ca’Foscari of VeniceVeniceItaly Department of Environmental Sciences Informatics and StatisticsUniversity Ca’Foscari of VeniceVeniceItaly Institute of Biosciences Sao Paulo State UniversityBotucatuBrazil

The antioxidant activity of ethanol extracts of propolis, bee glue, of various climate and orographic characteristics, collected from Italy, Brazil and Russia, was evaluated measuring their inhibitory action on peroxidation of linoleic acid, radical scavenging ability towards 2,2’-diphenyl-1-picrylhydrazyl, total phenolic content and reducing capacity by enzymatic and Folin method respectively. Propolis samples were chemically characterized by HPLC-MS/MS in order to find a possible correlation between antioxidant activity and polyphenols composition and quantification. The results obtained indicate that Italian and Russian propolis samples have similar polyphenolic composition and, as a consequence, almost similar antioxidant activity, while Brazilian propolis evidence lower polyphenolic and antioxidant characteristics. Climate and orography reasons of these differences are also suggested.

关键词： Propolis Antioxidant Properties Chemical Composition

Using the Mini Nutritional Assessment to Evaluate the Profile of Elderly Patients in a Geriatric Outpatient Clinic and in Long-Term Institutions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2011年第5期2卷 582-587页

作者： Valéria Maria Caselato-Sousa Maria Elena Guariento Gilberto Crosta mariangela Antunes da Silva Pinto Valdemiro Carlos Sgarbieri 不详

INTRODUCTION: The Mini Nutritional Assessment (MNA) is a scale developed to evaluate the risk of malnutrition in senior citizens and to identify those who might benefit from early intervention. The objective of this study was to verify the nutritional profile of elderly individuals through the application of the MNA in three different locations: at the Geriatric outpatient clinic and two long-term institutions. METHODS: Through transversal observation study the MNA was applied to 90 elderly people of both genders over 60 years of age. The MNA version modified by Rubenstein et al. [4] and translated into Portuguese was used to evaluate the patients for this study. The descriptive analysis of variables is shown as the average ± one standard deviation (SD). RESULTS: At the AG, the risk of malnutrition was found to be 72.73% ± 3.77%, while 27.27% ± 3.77% of the patients were eutrophic;no malnourished elderly patients were found. At the ASVP, 15.38% ± 11.28% of elderly patients were found to be malnourished, 35.90% ± 15.10% were found to be at risk of malnutrition and 48.72% ± 15.72% were eutrophic. At the PMI, 42.50% ± 15.30% of the elderly patients were found to be malnourished, 25% ± 13.40% were at risk of malnutrition and 32.50% ± 14.50% were eutrophic. CONCLUSIONS: Due to the high prevalence of elderly patients that were malnourished or at risk of malnutrition, a more detailed evaluation of their nutritional states is required, as well as a regular follow up of those patients and a dietary intervention to reverse the situation.

关键词： Aging Malnutrition Nutritional Status Nutritional Assessment Geriatric Assessment

Review on microbiota and effectiveness of probiotics use in older

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2015年第2期3卷 156-162页

作者： mariangela Rondanelli Attilio Giacosa Milena Anna Faliva Simone Perna Francesca Allieri Anna Maria Castellazzi Department of Applied Health Sciences Azienda di Servizi alla Persona di PaviaUniversity of Pavia Department of Public Health Experimental and Forensic MedicineSchool of MedicineUniversity of PaviaAzienda di Servizi alla Persona di Pavia Department of Gastroenterology Policlinico di Monza Department of Clinical-Surgical Diagnostic and Pediatrics SciencesUniversity of Pavia

The aim of the present systematic review is to summarize the existing knowledge about the human microbiota in the elderly and the effects of probiotics in elderly population. The elderly subjects, compared to adult population, show a reduction in the diversity of the microbiota, characterized by a large interindividual variability, with lower numbers of Firmicutes, Bifidobacteria, Clostridium cluster XIV, Faecalibacterium Prausnitzii, Blautia coccoides-Eubacterium rectal and higher presence of Enterobacteriaceae and Bacteroidetes. These differences of the intestinal microbiota of the elderly may not necessarily be caused by aging, but they could be associated with the decline of the general state of health with malnutrition and with increased need for medication, such as antibiotics and nonsteroidal antiinflammatory drugs, situations that occur frequently in the elderly. Differences have been demonstrated in the composition of the microbiota between healthy elderly subjects and hospitalized or institutionalized elderly subjects. These findings which further indicates that the living conditions, health status, nutrition and drugs have a significant effect on the composition of the microbiota. According to the available knowledge, the use of probiotics is safe and could represent an useful intervention to prevent or treat antibioticassociated diarrhea, in addition to reducing the severity of symptoms, other than to help the management of constipation.

关键词： Microbiota Elderly Probiotics Antibioticassociated diarrhea Constipation