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Potential risk genes for primary sjogren's syndrome from a meta-analysis by linear regression and random forest classification

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Genes & Diseases 2024年第3期11卷 128-131页

作者： Tomas Cerdo Teresa Torres Moral Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Reina Sofia University HospitalUniversity of CordobaCordoba 14004Spain Centre for Rheumatology Research Division of MedicineUniversity College LondonLondon W1T 4JFUK Faculty of Computer sciences Multimedia and TelecommunicationUniversitat Oberta de CatalunyaBarcelona 08018Spain Dermatology Department Melanoma UnitAugust Pi i Sunyer Biomedical Research Institute(IDIBAPS)and Hospital ClinicBarcelona 08036Spain Center for Networked Biomedical Research on Rare Diseases(CIBERER) Carlos II Health InstituteMadrid 28029Spain

Primary sjogren's syndrome(pss)is one of the most widespread autoimmune diseases with unknown origin,characterized by a lymphocytic infiltrate of the exocrine glands and the production of anti-ssA/Ro and anti-ssB/La antibodies that cause dysfunction and destruction mainly of salivary and lachrymal glands,leading to dry eyes and dry *** the absence of a standardized evidence-based screening tool to decide which patients with dry eye must be referred for study of this pathology.

关键词： sjogren lymphocytic salivary

Origins of the problematic E in sEIR epidemic models

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Infectious Disease Modelling 2024年第3期9卷 673-679页

作者： Donald s.Burke Distinguished University Professor Emeritus of Health science and Policy Department of EpidemiologySchool of Public HealthUniversity of PittsburghUSA

During the COVID-19 pandemic,over one thousand papers were published on“susceptible-Exposed-Infectious-Removed”(sEIR)epidemic computational *** English word“exposed”in its vernacular and public health usage means a state of having been in contact with an infectious individual,but not necessarily *** contrast,the term“exposed”in sEIR modeling usage typically stands for a state of already being infected but not yet being infectious to others,a state more properly termed“latently infected.”In public health language,“exposed”means possibly infected,yet in sEIR modeling language,“exposed”means already *** paper retraces the conceptual and mathematical origins of this terminological disconnect and concludes that epidemic modelers should consider using the“sLIR”notational short-hand(L for Latent)instead of sEIR.

关键词： sEIR model Exposed Latent infection History Notation

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Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi N Jincy M.Jose sreelata B.Nair Prabha s.N Pappachan s Department of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline super specialty Hospital PathanamthittaKerala 691523India

Alagille syndrome(ALGs;OMIM#118450)is a highlyvariable,multi-systemic,autosomal dominant disorder,caused by mutations in the Jagged Canonical Notch Ligand 1(JAG1)gene(20p12.2)or in the Neurogenic locus notch homolog protein 2(NOTCH2)gene(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidney,skin,vertebrae,and skeleton.^(1,2)The JAG1 gene has 26 exons and about 90%of the ALGs cases result from pathogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases Notch

A review of control strategies used for morphing aircraft applications

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Chinese Journal of Aeronautics 2024年第4期37卷 436-463页

作者： Muhammed s.PARANCHEERIVILAKKATHIL Jafar s.PILAKKADAN Rafic M.AJAJ Mohammadreza AMOOZGAR Davood AsADI Yahya ZWEIRI Michael I.FRIsWELL Department of Aerospace Engineering Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Aerospace Engineering Advanced Research and Innovation Center(ARIC)Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Mechanical Materials&Manufacturing EngineeringUniversity of NottinghamNottingham NG72RDUK Department of Aerospace Engineering Adana Alparslan Turkes Science and Technology UniversityTurkey College of Engineering Swansea UniversitySwansea SA18ENUK

This paper reviews the various control algorithms and strategies used for fixed-wing morphing aircraft applications. It is evident from the literature that the development of control algorithms for morphing aircraft technologies focused on three main areas. The first area is related to precise control of the shape of morphing concepts for various flight conditions. The second area is mainly related to the flight dynamics, stability, and control aspects of morphing aircraft. The third area deals mainly with aeroelastic control using morphing concepts either for load alleviation purposes and/or to control the instability boundaries. The design of controllers for morphing aircraft/wings is very challenging due to the large changes that can occur in the structural, aerodynamic, and inertial characteristics. In addition, the type of actuation system and actuation rate/speed can have a significant effect on the design of such controllers. The aerospace community is in strong need of such a critical review especially as morphing aircraft technologies move from fundamental research at a low Technology Readiness Level(TRL) to real-life applications. This critical review aims to identify research gaps and propose future directions. In this paper, research activities/papers are categorized according to the control strategy used. This ranges from simple Proportional Integral Derivative(PID) controllers at one end to complex robust adaptive controllers and deep learning algorithms at the other end. This includes analytical, computational, and experimental studies. In addition, the various dynamic models used and their fidelities are highlighted and discussed.

关键词： Control strategies Morphing aircraft shape morphing Flight dynamics Aeroelasticity

Turbine Passage secondary Flow Dynamics and Endwall Heat Transfer Under Different Inflow Turbulence

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Journal of Harbin Institute of Technology(New series) 2024年第3期31卷 51-62页

作者： Arjun K s Tide P s Biju N Division of Mechanical Engineering School of EngineeringCochin University of Science&TechnologyKalamassery 682022India

This study presents endwall hydrodynamics and heat transfer in a linear turbine cascade at Re 5×105 at low and high intensities of *** are numerically predicted using the standard ssT model and Reθ-γtransition model as well as using the high-resolution LEs *** major secondary flow components,comprising the horseshoe,corner,and passage vortices are recognized and the impact on heat or mass transfer is *** complicated behavior of turbine passage secondary flow generation and establishment are impacted by the perspective of boundary layer attributes and inflow *** passage vortex concerning the latest big leading-edge vane is generated by the enlargement of the circulation developed at the first instance adjacent to the pressure side becomes powerful and mixes with other vortex systems during its migration towards the suction *** study conclusions reveal that substantial enhancements are attained on the endwall surface,for the entire spanwise blade extension on the pressure surface,and in the highly 3-D region close to the endwall on the suction *** forecasted suction surface thermal exchange depicts great conformity with the measurement values and precisely reproduces the enhanced thermal exchange owing to the development and lateral distribution of the secondary flows along the midspan of the blade passage *** impacts of the different secondary flow structures on the endwall thermal exchange are described in depth.

关键词： turbine vane heat transfer endwall turbulence secondary flow

Optimum Profiles of Endwall Contouring for Enhanced Net Heat Flux Reduction and Aerodynamic Performance

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Journal of Harbin Institute of Technology(New series) 2024年第2期31卷 80-92页

作者： Arjun K s Tide P s Biju N Division of Mechanical Engineering School of EngineeringCochin University of Science&TechnologyKalamassery 682022India

successfully utilized non-axisymmetric endwalls to enhance turbine efficiencies(aerodynamic and turbine inlet temperatures)by controlling the characteristics of the secondary flow in a blade *** is accomplished by steady-state numerical hydrodynamics and deep knowledge of the field of *** of the interaction between mainstream and purge flow contributing supplementary losses in the stage,non-axisymmetric endwalls are highly susceptible to the inception of purge flow exit compared to the flat and any advantage rapidly *** conclusions reveal that the supreme endwall pattern could yield a lowering of the gross pressure loss at the design stage and is related to the size of the top-loss location being productively *** has led to diminished global thermal exchange lowered in the passage of the vane *** reverse flow adjacent to the suction side corner of the endwall is migrated farther from the vane surface,as the deviated pressure spread on the endwall accelerates the flow and progresses the reverse flow core still *** depleted association between the tornado-like vortex and the corner vortex adjacent to the suction side corner of the endwall is the dominant mechanism of control in the contoured end *** this publication,we show that the non-axisymmetric endwall contouring by selective numerical shape change method at most prominent locations is advantageous in lowering the thermal load in turbines to augment the net heat flux reduction as well as the aerodynamic performance using multi-objective optimization.

关键词： endwall contouring turbine vane heat transfer phantom cooling coolant injection net heat flux reduction aerodynamic performance

Complexed amino acid minerals ***-glycinate chelated minerals:Impact on the performance of old laying hens

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Animal Nutrition 2024年第1期16卷 395-408页

作者： Marcos J.B.santos Maria C.M.M.Ludke Leandro M.silva Carlos B.V.Rabello Mércia R.Barros Fabiano s.Costa Clariana s.santos Jamille s.s.Wanderley Department of Animal science Rural Federal University of PernambucoRecifePEBrazil Department of Veterinary science Rural Federal University of PernambucoRecifePEBrazil

The present study was to evaluate the effect of trace minerals(Zn,Mn,and Cu)from complexed amino acid minerals(ZMCAA)and bis-glycinate chelated minerals(ZMCGly)in laying hen diets on performance,internal and external egg quality,yolk mineral deposition,intestinal morphometry,and bone *** 78 to 98 weeks of age,400 White LsL-Lite strain laying hens were distributed in a randomized design with 4 treatments with 10 replicates per *** were distributed in a 2×2 factorial arrangement using either Zn,Mn,and Cu of ZMCAA or ZMCGly source at 2 levels:low(20,20,and 3.5 mg/kg of Zn,Mn,and Cu,respectively)or high(40,40,and 7 mg/kg of Zn,Mn,and Cu,respectively).The analysis of variance was performed,and in cases where differences were observed,the means were compared using Tukey?s test(Psource and level of trace mineral supplementation had a significant impact on the performance of laying *** fed ZMCAA had higher egg production(P=0.01),egg weight(P=0.02),egg mass(P=0.01),and lower feed conversion ratio(P=0.05)compared to those fed *** ZMCAA supplementation showed higher albumen height(P=0.01),albumen weight(P=0.01),and eggshell thickness(Psition of Zn(Ps greater for hens received *** weight(P=0.04)and bone densitometry(Psmall intestine,ZMCAA resulted in longer villi(P=0.02)and shorter crypt depth(P=0.01)in the *** and ileum measurements were influenced by the level and source of trace minerals(Ps fed ZMCAA exhibited superior performance,egg quality,deposition of trace minerals in the egg yolk,and bone density compared to hens fed *** this study,older laying hens supplemented with ZMCAA at lower levels demonstrated adequate levels of supplementation.

关键词： Bis-glycinates Metal-amino acids Radiodensity Trace minerals

Data-Driven Learning Control Algorithms for Unachievable Tracking Problems

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IEEE/CAA Journal of Automatica sinica 2024年第1期11卷 205-218页

作者： Zeyi Zhang Hao Jiang Dong shen samer s.saab the school of Mathematics Renmin University of ChinaBeijing 100872China IEEE the school of Engineering Lebanese American UniversityByblos 2038Lebanon

For unachievable tracking problems, where the system output cannot precisely track a given reference, achieving the best possible approximation for the reference trajectory becomes the objective. This study aims to investigate solutions using the Ptype learning control scheme. Initially, we demonstrate the necessity of gradient information for achieving the best ***, we propose an input-output-driven learning gain design to handle the imprecise gradients of a class of uncertain systems. However, it is discovered that the desired performance may not be attainable when faced with incomplete *** address this issue, an extended iterative learning control scheme is introduced. In this scheme, the tracking errors are modified through output data sampling, which incorporates lowmemory footprints and offers flexibility in learning gain *** input sequence is shown to converge towards the desired input, resulting in an output that is closest to the given reference in the least square sense. Numerical simulations are provided to validate the theoretical findings.

关键词： Data-driven algorithms incomplete information iterative learning control gradient information unachievable problems

Evaluation of the seismic behavior of reinforced concrete structures with flat slab-column gravity frame and shear walls through nonlinear analysis methods

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 713-726页

作者： M.A.Najafgholipour s.Heidarian Radbakhsh E.Erfani Department of Civil and Environmental Engineering Shiraz University of TechnologyShiraz ***Iran Department of Building Civiland Environmental EngineeringConcordia UniversityMontréal H3G 1M8Canada

This paper presents an investigation of the seismic behavior of reinforced concrete(RC)structures in which shear walls are the main lateral load-resisting elements and the participation of flat slab floor systems is not considered in the seismic design *** this regard,the behavior of six prototype structures(with different heights and plan layouts)is investigated through nonlinear static and time history analyses,implemented in the Opensees *** results of the analyses are presented in terms of the behavior of the slab-column connections and their mode of failure at different loading ***,the global response of the buildings is discussed in terms of some parameters,such as lateral overstrength due to the gravity flat slab-column *** to the nonlinear static analyses,in structures in which the slab-column connections were designed only for gravity loads,the slab-column connections exhibited a punching mode of failure even in the early stages of ***,the punching failure was eliminated in structures in which a minimum transverse reinforcement recommended in ACI 318(2019)was provided in the slabs at joint ***,despite neglecting the contribution of gravity flat slab-column frames in the lateral load resistance of the structures,a relatively significant overstrength was imposed on the structures by the gravity frames.

关键词： RC flat slab-column frames seismic behavior nonlinear analysis time history analysis