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Tissue-source effect on mesenchymal stem cells as living biodrugs for heart failure:Systematic review and meta-analysis

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World Journal of Cardiology 2024年第8期16卷 469-483页

作者： Moaz Safwan mariam Safwan Bourgleh Mohamed Aldoush Khawaja Husnain Haider Department of Basic Sciences Sulaiman Al Rajhi UniversityAl Bukairiyah 51941Saudi Arabia

BACKGROUND Mesenchymal stem cells(MSCs),as living biodrugs,have entered advanced phases of clinical assessment for cardiac function restoration in patients with myocardial infarction and heart *** MSCs are available from diverse tissue sources,bone-marrow-derived MSCs(BM-MSCs)remain the most wellstudied cell type,besides umbilical-cord-derived MSCs(UC-MSCs).The latter offers advantages,including noninvasive availability without ethical *** To compare the safety and efficacy of BM-MSCs and UC-MSCs in terms of left ventricular ejection fraction(LVEF),6-min walking distance(6MWD),and major adverse cardiac events(MACEs).METHODS Five databases were systematically searched to identify randomized controlled trials(RCTs).Thirteen RCTs(693 patients)were included using predefined eligibility *** mean differences and odds ratio(OR)for the changes in the estimated treatment *** UC-MSCs significantly improved LVEF vs controls by 5.08%[95%confidence interval(CI):2.20%-7.95%]at 6 mo and 2.78%(95%CI:0.86%-4.70%)at 12 ***,no significant effect was observed for BM-MSCs vs *** significant changes were observed in the 6MWD with either of the two cell ***,no differences were observed for MACEs,except rehospitalization rates,which were lower only with BM-MSCs(odds ratio 0.48,95%CI:0.24-0.97)vs *** UC-MSCs significantly improved LVEF compared with *** advant-Safwan M et ***-source and MSCs as living biodrugs ageous characteristics position them as a promising alternative to MSC-based therapy.

关键词： Cardiovascular disease Heart disease Mesenchymal stem cells Umbilical cord stem cells

FAIR Machine Learning Model Pipeline Implementation of COVID-19 Data

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Data Intelligence 2022年第4期4卷 971-990,1036页

作者： Sakinat Folorunso Ezekiel Ogundepo mariam Basajja Joseph Awotunde Abdullahi Kawu Francisca Oladipo Abdullahi Ibrahim Department of Mathematical Sciences Olabisi Onabanjo UniversityP.M.B 2002Ago-IwoyeOgun StateNigeria 120005Nigeria Data Science Nigeria Lagos 105102Nigeria Leiden University 1011NCAmsterdamthe Netherlands Department of Computer Science University of IlorinIlorinKwara State240103Nigeria Department of Computer Science Ibrahim Badamosi UniversityLapaiNiger State911101Nigeria Kampala International University 260101Uganda Federal University Lokoja Nigeria Virus Outbreak Data Network-Africa

Research and development are gradually becoming data-driven and the implementation of the FAIR Guidelines(that data should be Findable, Accessible, Interoperable, and Reusable) for scientific data administration and stewardship has the potential to remarkably enhance the framework for the reuse of research data. In this way, FAIR is aiding digital transformation. The ‘FAIRification’ of data increases the interoperability and(re)usability of data, so that new and robust analytical tools, such as machine learning(ML) models, can access the data to deduce meaningful insights, extract actionable information, and identify hidden patterns. This article aims to build a FAIR ML model pipeline using the generic FAIRification workflow to make the whole ML analytics process FAIR. Accordingly, FAIR input data was modelled using a FAIR ML model. The output data from the FAIR ML model was also made FAIR. For this, a hybrid hierarchical k-means (HHK) clustering ML algorithm was applied to group the data into homogeneous subgroups and ascertain the underlying structure of the data using a Nigerian-based FAIR dataset that contains data on economic factors, healthcare facilities, and coronavirus occurrences in all the 36 states of Nigeria. The model showed that research data and the ML pipeline can be FAIRified, shared, and reused by following the proposed FAIRification workflow and implementing technical architecture.

关键词： FAIRification Semantic data model Cluster analysis FAIR data Metadata Machine learning model

BioPerine Encapsulated Nanoformulation for Overcoming Drug-Resistant Breast Cancers

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Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 701-712页

作者： Sindhu C Pillai Ankita Borah Amandeep Jindal Eden mariam Jacob Yohei Yamamoto D.Sakthi Kumar Bio-Nano Electronics Research Centre Graduate School of Interdisciplinary New ScienceToyo UniversitySaitama 350-8585Japan Department of Materials Science Faculty of Pure and Applied SciencesUniversity of TsukubaTsukubaIbaraki 305-8573Japan

The evolving dynamics of drug resistance due to tumor heterogeneity often creates impediments to traditional therapies making it a challenging issue for cancer *** cancer often faces challenges of current therapeutic interventions owing to its multiple complexities and high drug resistivity,for example against drugs like trastuzumab and *** resistance in the majority of breast cancer is often aided by the overtly expressed P-glycoprotein(P-gp)that guides in the rapid drug efflux of chemotherapy *** continuous endeavors and ground-breaking achievements in the pursuit of finding better cancer therapeutic avenues,drug resistance is still a menace to hold *** newer therapeutic approaches,the application of phytonutrients such as alkaloids to suppress P-gp activity in drug-resistant cancers has found an exciting niche in the arena of alternative cancer *** this work,we would like to present a black pepper alkaloid derivative known as Bio Perine-loaded chitosan(CS)-polyethylene glycol(PEG)coated polylactic acid(PLA)hybrid polymeric nanoparticle to improve the bioavailability of Bio Perine and its therapeutic efficacy in suppressing P-gp expression in MDA-MB 453 breast cancer cell *** findings revealed that the CS-PEG-Bio PerinePLA nanoparticles demonstrated a smooth spherical morphology with an average size of316 nm,with improved aqueous solubility,and provided sustained Bio Perine *** nanoparticles also enhanced in vitro cytotoxicity and downregulation of P-gp expression in MDA-MB 453 cells compared to the commercial inhibitor verapamil hydrochloride,thus promising a piece of exciting evidence for the development of Bio Perine based nano-drug delivery system in combination with traditional therapies as a crucial approach to tackling multi-drug resistance in cancers.

关键词： Drug Resistant cancer P-glycoprotein BioPerine Chitosan PLA nanoparticle

Effect of thermal and chemical modifications on the mechanical and release properties of paracetamol tablet formulations containing corn, cassava and sweet potato starches as filler-binders

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Asian Pacific Journal of Tropical Biomedicine 2015年第7期5卷 576-580页

作者： mariam Vbamiunomhene Lawal Michael Ayodele Odeniyi Oludele Adelanwa Itiola Department of Pharmaceutics & Industrial Pharmacy University of Ibadan

Objective: To investigate the effects of acetylation and pregelatinization of cassava and sweet potato starches on the mechanical and release properties of directly compressed paracetamol tablet formulations in comparison with official corn ***: The native starches were modified by acetylation and pregelatinization. The tablets were assessed using friability(Fr), crushing strength(Cs), disintegration time(Dt) and dissolution parameters. Results: Starch acetylation produced paracetamol tablets that were stronger and had the best balance of mechanical and disintegration properties, while pregelatinization produced tablets that were more friable but had a better overall strength in relation to disintegration than formulations made from natural starches. Correlations mainly existed between Dt and the dissolution parameters t80, t2 and k1 in the formulations. Conclusions: Modification of the experimental starches improved the mechanical and release properties of directly compressed paracetamol tablet formulations. Thus, they can be developed for use as pharmaceutical excipients in specific formulations.

关键词： Starch modification Direct compression Filler-binders Mechanical and release properties

Evaluation of leptin,interleukin-1 beta and tumor necrosis factor alpha in serum of malaria patients as prognostic markers of treatment outcome

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Asian Pacific Journal of Tropical Biomedicine 2014年第6期4卷 441-445页

作者： mariam Abdulrhman Al-Fadhli Mohammad Ahmed Saraya Jafar Abdulrida Qasem Department of Medicine.Infectious Disease Hospital Ministry of Health Department of Tropical Medicine.Faculty of Medicine.Zagazig University Department of Applied Medical Sciences College of Health SciencesPublic authority for Applied Education and Training

Objective:To analyze scrum leptin levels in patients with malaria falciparum and compare them with healthy controls and correlate with development and outcome of malaria ***:Sixty cases of malaria falciparum were included in this study as *** healthy individuals of comparable age,racial and body mass index were taken as *** patients were diagnosed by clinical picture and the presence of malaria parasites in blood *** of liver function test,kidney function test,complete blood count,fasting blood sugar,fasting serum insulin,pro-inflammatory cytokine tumor necrosis factor alpha(TNFα)and interleukin 1(IL1),estimation of morning serum leptin and calculation of body mass index(kg/m^2)were done in both groups on the day of admission,on discharge and 7 d after ***:At admission,leptin levels were significantly higher in patients group than in control while lasting serum insulin levels were not significantly different between the two *** were significant increases as regard to TNFαand IL1 in malaria *** differences were observed between the control and the patient group for leptin,TNFαand IL1 at the time of admission and *** discharge for 7 d.a significant decline in scrum leptin levels,TNFαand IL1 in the patients group was observed as compared with time of admission and time of discharge,a positive correlation between serum leptin levels and TNFαand ***:Leptin hormone level might play an important role in development and outcome of malaria infection.

关键词： Malaria.Leptin IL-1 Tumor necrosis factor alpha(TNFα) Kuwait

Pancreaticoduodenectomy in the Middle East: Achieving optimal results through specialization and standardization

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 478-483页

作者： Walid Faraj Hussein Nassar Ahmad Zaghal Deborah Mukherji Ali Shamseddine mariam Kanso Rola F. Jaafar Mohamad Khalife Liver Transplantation and Hepatopancreaticobiliary Surgery Department of General SurgeryAmerican University of Beirut Medical CenterBeirutLebanon Department of Oncology American University of Beirut Medical CenterBeirutLebanon

Background: Pancreaticoduodenectomy is a challenging surgical intervention that remains the cornerstone in the treatment of localized peri-ampullary pathologies. The concept of treatment standardization has been well-established in many high-volume centers in the world. Here, we present our experience in pancreaticoduodenectomy from 1994 to 2015. Methods: We performed a retrospective review of the medical charts of patients who underwent pancreaticoduodenectomy at our institution. Data was entered to SPSS statistical software and analyzed. The Mann-Whitney U and Fisher’s exact tests were used to report statistical differences between groups. Results: Of the 370 patients who underwent pacreaticoduodenectomy, 300 were analyzed. The 1-, 3-, 5- and 10-year survival rates were 85%, 35%, 15%, and 7%, respectively with a 30-day mortality rate of 5.0%(15 patients). The median age of the patients was 61 (13-84) years, with 193 (64.3%) males and 107 (35.7%) females. The median operative time was 300 (130-570) min. The median postoperative length of hospital stay was 12 (5-76) days. Thirty-two patients required re-laparotomies;10 for pancreatic leak, 7 for biliary leak and 15 for control of bleeding. Seventy-five (25.0%) patients developed pancreatic fistulae. Delayed gastric emptying was present in 31 (10.3%) patients. A significant improvement in surgical outcome was observed in cases done after 2008 which indicates the important role of specialized team in surgical management. Conclusions: The number of patients undergoing pancreaticoduodenectomy has been increasing annually over the past twenty-two years in our institution with results comparable to published series from high-volume centers. Through standardization of surgical techniques and perioperative management carried out by a specialist team, our results continue to improve despite the increasing complexity of cases referred to our unit.

关键词： Pancreatic cancer Pancreaticoduodenectomy Middle East

Postmortem CT in decedents with SARS-CoV-2 infection.A single institution experience

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Forensic Sciences Research 2022年第2期7卷 255-260页

作者： mariam Thomas Fereidoun Abtin Antoinette Roth Catherine Yim Anokh Pahwa Jeremy Paige Odey Ukpo Radiology UCLA Medical Center Olive ViewLos AngelesCAUSA University of California Los Angeles Los AngelesCAUSA Los Angeles Medical Examiner-Coroner’s Office Los AngelesCAUSA

Coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 produced a global pandemic with significant *** autopsies are not routinely performed on all decedents with SARS-CoV-2 infection,postmortem CT(PMCT)may be valuable to provide additional information on the cause of death and risk factors known to be associated with an increased mortality in *** purpose of this manuscript is to review the PMCT findings in a series of 42 decedents with SARS-CoV-2 infection from our *** analysis of 42 decedents who had a positive postmortem nasopharyngeal swab for SARS-CoV-2 and had a PMCT were included in this *** were reviewed for pulmonary findings seen in COVID-19 and other organ *** the 42 decedents,although the majority had imaging findings in the lungs that would be consistent with COVID-19 and acute respiratory distress syndrome,in 14%of the decedents the SARS-CoV-2 infection was likely coincidental and the PMCT findings suggested that they died from other *** half of the decedents that died from COVID-19 had PMCT findings of vascular *** is useful to identify pulmonary and extra pulmonary findings in decedents with SARS-CoV-2 infection that can provide additional information,which may be useful for the forensic pathologist to help determine the underlying cause of death.

关键词： Forensic sciences postmortem CT COVID-19 virtual autopsy SARS-CoV-2

Can testosterone therapy be offered to men on active surveillance for prostate cancer？ Preliminary results

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Asian Journal of Andrology 2016年第1期18卷 16-20页

作者： Ravi Kacker mariam Hult Ignacio F San Francisco William P Conners Pablo A Rojas William C Dewolf Abraham Morgentaler Men's Health Boston Brookline MA USA Pontifical Catholic University of Chile Santiago Chile Department of Urology Beth Israel Deaconess Medical Center Boston MA USA

This report presents our experience with T therapy in a cohort of T-deficient men on active surveillance （AS） for Gleason 3 ＋ 3 and Gleason 3 ＋ 4 prostate cancer （PCa）. A retrospective chart review identified 28 men with T deficiency who underwent T therapy （T group） for at least 6 months while on AS for PCa. A comparison group of 96 men on AS for PCa with untreated T deficiency （no-T group） was identified at the same institution. The AS protocol followed a modified Epstein criteria and allowed inclusion of men with a single core of low-volume Gleason 3 ＋ 4 PCa. Mean age was 59.5 and 61.3 years, and mean follow-up was 38.9 and 42.4 months for the T and no-T groups, respectively. Of all 28 men in the T group, 3 （10.7%） men developed an increase in Gleason score while on AS. Of 22 men in the T group with Gleason 3 ＋ 3 disease, 7 （31.8%） men developed biopsy progression including 3 men （13.6%） who developed Gleason 3 ＋ 4 PCa. Of 6 men with Gleason 3 ＋ 4 disease at baseline, 2 （33.3%） men developed an increase in tumor volume, and none developed upgrading beyond Gleason 3 ＋ 4. All 96 men in the no-T group had Gleason 3 ＋ 3 disease at baseline and, 43 （44.7%） developed biopsy progression, including 9 men （9.38%） with upgrading to Gleason 7 （3 ＋ 4）. Biopsy progression rates were similar for both groups and historical controls. Biopsy progression in men on AS appears unaffected by T therapy over 3 years. Prospective placebo-controlled trials of T therapy in T-deficient men on AS should be considered given the symptomatic benefits experienced by treated men.

关键词： active surveillance prostate cancer testosterone

Deep Deterministic Policy Gradient to Regulate Feedback Control Systems Using Reinforcement Learning

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Computers, Materials & Continua 2022年第4期71卷 1153-1169页

作者： Jehangir Arshad Ayesha Khan mariam Aftab Mujtaba Hussain Ateeq Ur Rehman Shafiq Ahmad Adel M.Al-Shayea Muhammad Shafiq Department of Electrical&Computer Engineering COMSATS University IslamabadLahore Campus54000Pakistan Department of Electrical Engineering Government College UniversityLahore54000Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Korea

Controlling feedback control systems in continuous action spaces has always been a challenging ***,reinforcement learning is mainly an area of artificial intelligence(AI)because it has been used in process control for more than a ***,the existing algorithms are unable to provide satisfactory ***,this research uses a reinforcement learning(RL)algorithm to manage the control *** propose an adaptive speed control of the motor system based on depth deterministic strategy gradient(DDPG).The actor-critic scenario using DDPG is implemented to build the RL *** addition,a framework has been created for traditional feedback control systems to make RL implementation easier for control *** RL algorithms are robust and proficient in using trial and error to search for the best *** proposed algorithm is a deep deterministic policy gradient,in which a large amount of training data trains the *** the system is trained,the agent can automatically adjust the control *** algorithm has been developed using Python 3.6 and the simulation results are evaluated in the MATLAB/Simulink *** performance of the proposed RL algorithm is compared with a proportional integral derivative(PID)controller and a linear quadratic regulator(LQR)*** simulation results of the proposed scheme are promising for the feedback control problems.

关键词： Feedback control systems reinforcement learning artificial intelligence