BioPerine Encapsulated Nanoformulation for Overcoming Drug-Resistant Breast Cancers

作     者：Sindhu C Pillai Ankita Borah Amandeep Jindal Eden Mariam Jacob Yohei Yamamoto D.Sakthi Kumar Sindhu C Pillai;Ankita Borah;Amandeep Jindal;Eden Mariam Jacob;Yohei Yamamoto;D.Sakthi Kumar

作者机构：Bio-Nano Electronics Research CentreGraduate School of Interdisciplinary New ScienceToyo UniversitySaitama 350-8585Japan Department of Materials ScienceFaculty of Pure and Applied SciencesUniversity of TsukubaTsukubaIbaraki 305-8573Japan 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2020年第15卷第6期

页      面：701-712页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Ministry of Education,Culture,Sports,Science and Technology(MEXT),Japan Inoue Enryo Research Grant,Toyo University respectively for the financial support provided to carry out this work 

主　　题：Drug Resistant cancer P-glycoprotein BioPerine Chitosan PLA nanoparticle 

摘      要：The evolving dynamics of drug resistance due to tumor heterogeneity often creates impediments to traditional therapies making it a challenging issue for cancer *** cancer often faces challenges of current therapeutic interventions owing to its multiple complexities and high drug resistivity,for example against drugs like trastuzumab and *** resistance in the majority of breast cancer is often aided by the overtly expressed P-glycoprotein(P-gp)that guides in the rapid drug efflux of chemotherapy *** continuous endeavors and ground-breaking achievements in the pursuit of finding better cancer therapeutic avenues,drug resistance is still a menace to hold *** newer therapeutic approaches,the application of phytonutrients such as alkaloids to suppress P-gp activity in drug-resistant cancers has found an exciting niche in the arena of alternative cancer *** this work,we would like to present a black pepper alkaloid derivative known as Bio Perine-loaded chitosan(CS)-polyethylene glycol(PEG)coated polylactic acid(PLA)hybrid polymeric nanoparticle to improve the bioavailability of Bio Perine and its therapeutic efficacy in suppressing P-gp expression in MDA-MB 453 breast cancer cell *** findings revealed that the CS-PEG-Bio PerinePLA nanoparticles demonstrated a smooth spherical morphology with an average size of316 nm,with improved aqueous solubility,and provided sustained Bio Perine *** nanoparticles also enhanced in vitro cytotoxicity and downregulation of P-gp expression in MDA-MB 453 cells compared to the commercial inhibitor verapamil hydrochloride,thus promising a piece of exciting evidence for the development of Bio Perine based nano-drug delivery system in combination with traditional therapies as a crucial approach to tackling multi-drug resistance in cancers.