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Automation 5.0: The Key to Systems Intelligence and Industry 5.0

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1723-1727页

作者： Ljubo Vlacic Hailong Huang mariagrazia Dotoli Yutong Wang Petros A.Ioannou Lili Fan Xingxia Wang Raffaele Carli Chen Lv Lingxi Li Xiaoxiang Na Qing-Long Han Fei-Yue Wang Institute of Intelligent and Integrated Systems and the School of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Information Engineering Polytechnic of Bari70126 BariItaly State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190and also with the Qingdao Academy of Intelligent IndustriesQingdao 266114China Department of Electrical Engineering-Systems University of Southern CaliforniaLos AngelesCA 90007 USA School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Beijing Huairou Academy of Parallel Sensing Beijing 101499China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndianapolisIN 46202 USA Department of Engineering University of CambridgeCB21TN CambridgeU.K. School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Dazhou Artificial Intelligence Institute Dazhouand the Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao 999078China

AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with *** rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:***,***,***,***,***,***,***,***,***,***,***,Q.-***,and F.-***,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA ***,vol.11,no.8,pp.1723-1727,Aug.2024.

关键词： Automation machinery intelligence

Decentralized Control for Residential Energy Management of a Smart Users' Microgrid with Renewable Energy Exchange

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 641-656页

作者： Raffaele Carli mariagrazia Dotoli IEEE the Department of Electrical and Information Engineering of the Polytechnic of Bari

This paper presents a decentralized control strategy for the scheduling of electrical energy activities of a microgrid composed of smart homes connected to a distributor and exchanging renewable energy produced by individually owned distributed energy resources. The scheduling problem is stated and solved with the aim of reducing the overall energy supply from the grid, by allowing users to exchange the surplus renewable energy and by optimally planning users' controllable loads. We assume that each smart home can both buy/sell energy from/to the grid taking into account time-varying non-linear pricing signals. Simultaneously, smart homes cooperate and may buy/sell locally harvested renewable energy from/to other smart homes. The resulting optimization problem is formulated as a non-convex non-linear programming problem with a coupling of decision variables in the constraints. The proposed solution is based on a novel heuristic iterative decentralized scheme algorithm that suitably extends the Alternating Direction Method of Multipliers to a non-convex and decentralized setting. We discuss the conditions that guarantee the convergence of the presented algorithm. Finally, the application of the proposed technique to a case study under several scenarios shows its effectiveness.

关键词： Alternating direction method of multipliers decentralized control energy management microgrid non-convex optimization renewable energy residential energy management smart homes

Activation of β2 adrenergic receptors promotes adult hippocampal neurogenesis

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Neural Regeneration Research 2020年第12期15卷 2258-2259页

作者： Valeria Bortolotto mariagrazia Grilli Laboratory of Neuroplasticity Department of Pharmaceutical SciencesUniversity of Piemonte OrientaleNovaraItaly

The subgranular zone (SGZ) of the hippocampal dentate gyrus is one of the few central nervous system regions where generation of adult born neurons occurs *** process,referred to as adult hippocampal neurogenesis (ahN... 详细信息

关键词： progenitor adult adrenergic

Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells

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Neural Regeneration Research 2017年第3期12卷 354-357页

作者： Valeria Bortolotto mariagrazia Grilli Laboratory of Neuroplasticity Department of Pharmaceutical SciencesUniversity of Piemonte OrientaleNovaraItaly

Within the CNS nuclear factor-kappa B（NF-κB） transcription factors are involved in a wide range of functions both in homeostasis and in *** the years,our and other groups produced a vast array of information on the complex involvement of NF-κB proteins in different aspects of postnatal neurogenesis In particular,several extracellular signals and membrane receptors have been identified as being able to affect neural progenitor cells（NPC） and their progeny via NF-κB activation.A crucial role in the regulation of neuronal fate specification in adult hippocampal NPC is played by the NF-κB p50 ***-κB p50 KO mice display a remarkable reduction in adult hippocampal neurogenesis which correlates with a selective defect in hippocampal-dependent short-term *** absence of NF-κB p50 can profoundly affect the in vitro proneurogenic response of adult hippocampal NPC（ahN PC） to several endogenous signals and *** we briefly review the current knowledge on the pivotal role of NF-κB p50 in the regulation of adult hippocampal *** addition we discuss more recent data that further extend the relevance of NF-κB p50 to novel astroglia-derived signals which can influence neuronal specification of ahN PC and to astrocyte-NPC cross-talk.

关键词： adult neurogenesis hippocampus astrocyte neural progenitor cell NGAL/LCN-2 conditioned medium 24p3R

β_(2) and α_(2) adrenergic receptors mediate the proneurogenic in vitro effects of norquetiapine

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Neural Regeneration Research 2021年第10期16卷 2041-2047页

作者： Valeria Bortolotto Pier Luigi Canonico mariagrazia Grilli Laboratory of Neuroplasticity University of Piemonte OrientaleNovaraItaly Department of Pharmaceutical Sciences University of Piemonte OrientaleNovaraItaly

Positive modulation of adult hippocampal neurogenesis may contribute to the therapeutic effects of clinically relevant antidepressant drugs,including atypical ***,an antipsychotic which represents a therapeutic option in patients who are resistant to classical antidepressants,promotes adult hippocampal neurogenesis in preclinical ***,the key active metabolite of quetiapine in humans,has a distinctive receptor profile than the parent *** drug is indeed a high affinity norepinephrine transporter inhibitor and such activity has been proposed to contribute to its antidepressant *** present,no information is available on the effects of norquetiapine on adult *** extensively investigated the activity of quetiapine and norquetiapine on adult murine neural stem/progenitor cells and their ***,selective antagonists for β_(2)/α_(2) adrenergic receptors allowed us to evaluate if these receptors could mediate quetiapine and norquetiapine *** demonstrated that both drugs elicit in vitro proneurogenic effects but also that norquetiapine had distinctive properties which may depend on its ability to inhibit norepinephrine transporter and involve β_(2)/α_(2) adrenergic *** care and experimental procedures were approved by the Institutional Animal Care and Use Committees(IACUC)at University of Piemonte Orientale,Italy(approval No.1033/2015PR)on September 29,2015.

关键词： adrenergic receptors adult neurogenesis antidepressants antipsychotics depression neural progenitor cells norquetiapine quetiapine

Not only a bad guy:potential proneurogenic role of the RAGE/NF-κB axis in Alzheimer's disease brain

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Neural Regeneration Research 2016年第12期11卷 1924-1925页

作者： Valeria Bortolotto mariagrazia Grilli Laboratory of Neuroplasticity Department of Pharmaceutical SciencesUniversity of Piemonte Orientale "Amedeo Avogadro"

The receptor for advanced glycation endproducts（RAGE）is a receptor of the immunoglobulin superfamily of cell surface molecules which plays important contributions under both physiological and pathological *** the years extensive research work supported the detrimental role of RAGE in Alzheimer’s disease（AD）pathophysiology,ranging from its involvement in beta amyloid（Aβ）brain influx and clearance,

关键词： RAGE Not only a bad guy B axis in Alzheimer’s disease brain NPC

Safety,immunogenicity,efficacy,and acceptability of COVID-19 vaccination in people with multiple sclerosis:a narrative review

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Neural Regeneration Research 2023年第2期18卷 284-288页

作者： Fioravante Capone mariagrazia Rossi Alessandro Cruciani Francesco Motolese Fabio Pilato Vincenzo Di Lazzaro Neurology Neurophysiology and Neurobiology UnitDepartment of MedicineCampus Bio-Medico of Rome UniversityRomeItaly

In the last two years,a new seve re acute res piratory syndrome coronavirus(SARS-CoV)infection has spread worldwide leading to the death of *** ccination represents the key factor in the global strategy against this pandemic,but it also poses several problems,especially for vulnerable people such as patients with multiple scle *** this review,we have briefly summarized the main findings of the safety,efficacy,and acceptability of Coronavirus Disease 2019(COVID-19)vaccination fo r multiple sclerosis *** the acceptability of COVID-19 vaccines has progressively increased in the last year,a small but significant part of patients with multiple sclerosis still has relevant concerns about vaccination that make them hesitant about receiving the COVID-19 ***,available data suggest that the COVID-19 vaccination is safe and effective in multiple scle rosis patients,even though some pharmacological treatments such as anti-CD20 therapies or sphingosine I-phosphate receptor modulato rs can reduce the immune response to ***,COVID-19 vaccination should be strongly recommended for people with multiple scle rosis and,in patients treated with anti-CD20 therapies and sphingosine I-phosphate receptor modulato rs,and clinicians should evaluate the appropriate timing for vaccine *** studies are necessary to understand the role of cellular immunity in COVID-19 vaccination and the possible usefulness of booster *** the other hand,it is mandatory to learn more about the reasons why people refuse *** would help to design a more effective communication campaign aimed at increasing vaccination coverage among vulnerable people.

关键词： COVID-19 multiple sclerosis SARS-CoV-2 vaccination vaccine

Music therapy and pediatric palliative care:songwriting with children in the end-of-life

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World Journal of Pediatrics 2022年第10期18卷 695-699页

作者： Filippo Giordano Chiara Rutigliano mariagrazia Baroni Massimo Grassi Paola Muggeo Nicola Santoro Department of Emergency and Organ Transplants University of Bari Aldo MoroPiazza G.Cesare 1170124BariItaly Section of Pediatric Hematology-Oncology University Hospital of BariBariItaly Hospice Madonna Dell’Uliveto AlbineaREItaly

Children's needs in pediatric palliative care(PPC)are complex and are determined by age,the course of the disease,family structure,and cultural background[1].The child's family system also has multiple needs which mus... 详细信息

关键词： pediatric assessed palliative

Sperm glyceraldehyde 3-phosphate dehydrogenase gene expression in asthenozoospermic spermatozoa

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Asian Journal of Andrology 2017年第4期19卷 409-413页

作者： Donatella Paoli Marianna Pelloni mariagrazia Gallo Giulia Coltrinari Francesco Lombardo Andrea Lenzi Loredana Gandini Laboratory of Seminology - Sperm Bank Department of Experimental Medicine University of Rome 'La Sapienza' 00161 Rome Italy

It has been suggested that the energy required for sperm motility is produced by oxidative phosphorylation while glycolysis seems to be an important source for ATP transmission along the flagellum. Some studies have investigated the chemical and kinetic properties of the enzyme glyceraldehyde 3-phosphate dehydrogenase to identify any changes in the regulation of glycolysis and sperm motility. In contrast, there are few studies analyzing the genetic basis of hypokinesis. For this reason, we investigated the glyceraldehyde 3-phosphate dehydrogenase gene in human sperm to evaluate whether asthenozoospermia was correlated with any changes in its expression. Semen examination and glyceraldehyde 3-phosphate dehydrogenase gene expression studies were carried out on 116 semen samples divided into two groups - Group A consisted of 58 normokinetic samples and Group B of 58 hypokinetic samples. Total RNA was extracted from spermatozoa, and real-time PCR quantification of mRNA was carried out using specific primers and probes. The expression profiles for the Groups A and B were very similar. The mean delta Ct was as follows - Group A, 5.79 ＋ 1.04; Group B, 5.47 ＋ 1.27. Our study shows that in human sperm, there is no difference in glyceraldehyde 3-phosphate dehydrogenase gene expression between samples with impaired motility and samples with normal kinetics. We believe that this study could help in the understanding of the molecular mechanisms of sperm kinetics, suggesting that hypomotility may be due to a possible posttranscriptional impairment of the control mechanism, such as mRNA splicing, or to posttranslational changes.

关键词： adenosine-5'-triphosphate gene expression sperm glyceraldehyde 3-phosphate dehydrogenase sperm motility