β_(2) and α_(2) adrenergic receptors mediate the proneurogenic in vitro effects of norquetiapine

作     者：Valeria Bortolotto Pier Luigi Canonico Mariagrazia Grilli Valeria Bortolotto;Pier Luigi Canonico;Mariagrazia Grilli

作者机构：Laboratory of NeuroplasticityUniversity of Piemonte OrientaleNovaraItaly Department of Pharmaceutical SciencesUniversity of Piemonte OrientaleNovaraItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第10期

页      面：2041-2047页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：This work was partially supported by the pharmaceutical company Astra Zeneca and by Fondazione Generali 

主　　题：adrenergic receptors adult neurogenesis antidepressants antipsychotics depression neural progenitor cells norquetiapine quetiapine 

摘      要：Positive modulation of adult hippocampal neurogenesis may contribute to the therapeutic effects of clinically relevant antidepressant drugs,including atypical ***,an antipsychotic which represents a therapeutic option in patients who are resistant to classical antidepressants,promotes adult hippocampal neurogenesis in preclinical ***,the key active metabolite of quetiapine in humans,has a distinctive receptor profile than the parent *** drug is indeed a high affinity norepinephrine transporter inhibitor and such activity has been proposed to contribute to its antidepressant *** present,no information is available on the effects of norquetiapine on adult *** extensively investigated the activity of quetiapine and norquetiapine on adult murine neural stem/progenitor cells and their ***,selective antagonists for β_(2)/α_(2) adrenergic receptors allowed us to evaluate if these receptors could mediate quetiapine and norquetiapine *** demonstrated that both drugs elicit in vitro proneurogenic effects but also that norquetiapine had distinctive properties which may depend on its ability to inhibit norepinephrine transporter and involve β_(2)/α_(2) adrenergic *** care and experimental procedures were approved by the Institutional Animal Care and Use Committees(IACUC)at University of Piemonte Orientale,Italy(approval No.1033/2015PR)on September 29,2015.