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Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis

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World Journal of Gastroenterology 2009年第20期15卷 2512-2519页

作者： Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e silva Robson Augusto souza dos Santos Laboratory of Hypertension Department of Physiology Biological Sciences institute Federal University of Minas Gerais Av. Antonio Carlos 6627 Belo Horizonte MG 31270-901 Brazil Laboratory of Endocrinology Department of Medicine Faculty of Medicine Federal University of Minas Gerais Av. Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil Hospitalar Foundation of the State of Minas Gerais FHEMIG Belo Horizonte MG Brazil Department of Pediatrics Faculty of Medicine Federal University of Minas Gerais Av.Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil

AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic ***: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS ***: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis.

关键词：血管紧张素血流动力学肝硬化人类

Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives

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World Journal of Clinical Pediatrics 2022年第2期11卷 105-119页

作者： maria Luísa Cordeiro Santos Ronaldo Teixeira da silva Júnior Breno Bittencourt de Brito Filipe Antônio França da silva Hanna Santos Marques Vinícius Lima de souzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use.

关键词： Functional abdominal pain disorder Pediatrics Rome IV Behavioral intervention Nonpharmacological treatment Complementary medicine

Tandem running by foraging Pachycondyla striata workers in field conditions vary in response to food type,food distance,and environmental conditions

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Current Zoology 2021年第5期67卷 541-549页

作者： Janiele Pereira silva Lohan VALADARES maria Eduarda Lima VIEIRA Serafino TESEO Nicolas CHALINE LEEEIS Departamento de Psicologia ExperimentalInstituto de Psicologia ExperimentalUniversidade de Sao PauloSao PauloSPCEP 05508-030Brazil Programa de pos-graduacao em Psicologia Experimental USPSao PauloSPCEP 05508-030Brazil Evolution GenomesBehavior and EcologyCNRS1 Avenue de la TerrasseGifsur-Yvette 91987France LBC Departamento de Fisiologia e ComportamentoCentro de BiocienciasUniversidade Federal do Rio Grande do NorteNatalRNCEP 59078-970Brazil School of Biological Sciences Nanyang Technological University60 Nanyang DriveSingapore 637551Singapore

Ants show collective and individual behavioral flexibility in their response to immediate context,choosing for example between different foraging *** Pachycondyla striata,workers can forage solitarily or recruit and guide nestmates to larger food sources through tandem *** considered more ancestral and less efficient than pheromone trail-laying,this strategy is common especially in species with small colony *** is not known is how the decision to recruit or follow varies according to the immediate *** is,how fine adjustments in information transfer affect immediate foraging decisions at the colony ***,we studied individually marked workers and evaluated their foraging decisions when food items varied in nature(protein versus carbohydrate),size,and distance from the nest at different temperatures and humidity *** results show that tandem run leaders and potential followers adjust their behavior according to a combination of external *** 84.2%of trips were solitary,most ants(81%)performed at least 1 tandem ***,tandem runs were more frequent for nearby resources and at higher relative ***,when food items were located far away,tandem runs were more successful when heading to protein sources(75%)compared with carbohydrate sources(42%).Our results suggest that the social information transfer between leaders and followers conveys more information than previously thought,and also relies on their experience and motivation.

关键词： collective behavior decision-making emotional states flexibility Ponerinae social learning

β-defensins and the epididymis： contrasting influences of prenatal, postnatal, and adult scenarios

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Asian Journal of Andrology 2016年第2期18卷 323-328,J0008页

作者： Camilla M Ribeiro Erick JR silva Barry T Hinton maria Christina W Avellar Section of Experime.ntaI.Endocrinology Department of Pharmacology Universidade Federal de Sao Paulo - Escola Paulista de Medicina Sao Paulo Brazil Department of Cell Biology University of Virginia School of Medicine Charlottesville Virginia USA Present address: Department of Pharmacology Institute Of Biosciences of BotucatuUniversidade Estadual Paulista 'Julio de Mesquita Filho' Botucatu Sao Paulo 186).8-970 Brazil.

β-defensins are components of host defense, with antimicrobial and pleiotropic immuno-modulatory properties. Research over the last 15 years has demonstrated abundant expression of a variety of β-defensins in the postnatal epididymis of different species. A gradient of region- and cell-specific expression of these proteins is observed in the epithelium of the postnatal epididymis. Their secretion into the luminal fluid and binding to spermatozoa as they travel along the epididymis has suggested their involvement in reproduction-specific tasks. Therefore, continuous attention has been given to various β-defensins for their role in sperm function and fertility. Although β-defensins are largely dependent on androgens, the underlying mechanisms regulating their expression and function in the epididymis are not well understood. Recent investigation has pointed out to a new and interesting scenario where β-defensins emerge with a different expression pattern in the Wolffian duct, the embryonic precursor of the epididymis, as opposed to the adult epididymis, thereby redefining the concept concerning the multifunctional roles of β-defensins in the developing epididymis. In this review, we summarize some current views of β-defensins in the epididymis highlighting our most recent data and speculations on their role in the developing epididymis during the prenatal-to-postnatal transition, bringing attention to the many unanswered questions in this research area that may contribute to a better understanding of epididymal biology and male fertility.

关键词： androgens embryogenesis epididymis organogenesis β-defensins

Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital

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World Journal of Clinical Cases 2023年第8期11卷 1761-1770页

作者： Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Hospital Geral de Vitória da Conquista Vitória da Conquista 45030-160BahiaBrazil Departamento de Ciências da Saúde Universidade Estadual do Sudoeste da Bahia(UESB)Vitória da Conquista 45083-900BahiaBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern *** that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and *** To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease *** This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian *** The patients had a median age of 65.60±15.78 *** was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the *** least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with *** and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective *** This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected *** associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features.

关键词： COVID-19 Epidemiology Symptoms Comorbidities Laboratory parameters

Diversity of mycorrhizal fungi and soil indicative species in coastal plantations of northeast Brazil

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Journal of Forestry Research 2021年第3期32卷 1203-1211页

作者： Olmar Baller Weber maria Cátia Barroso da silva Cristiane Figueira da silva Diva Correia Deborah dos Santos Garruti Marcela Claudia Pagano Embrapa Agroindústria Tropical Rua Dra.Sara Mesquita2270PiciFortalezaCeará60511-110Brazil Centro de Ciências E Tecnologia Universidade Estadual Do CearáAv.Dr.Silas Munguba1700Campus do ItaperiFortaleza 60740-000Brazil Universidade Federal Rural Do Rio de Janeiro BR 465 Km 7 Seropédica RJSeropédicaRio de Janeiro CEP 23890-000Brazil Universidade Federal de Minas Gerais Av.Antonio Carlos6627PampulhaBelo Horizonte 31270-001Brazil

The aim of this work was to evaluate arbuscular mycorrhizal(AM)fungi as soil indicators and the mycorrhization of native and exotic tree species planted in the Acaraúbasin,a transition area from the coast to the Brazilian semiarid *** with 6-year-old trees of four native and three non-native species as well as one non-forested area were evaluated in terms of the diversity of AM fungi in the mycorrhizosphere and the root colonization by AM and ectomycorrhizal(EcM)***-four AM fungi were identified;Claroideoglomus etunicatum,Glomus sinuosum,Paraglomus albidum,Acaulospora laevis,and Acaulospora brasiliensis were abundant in the forest ***,dominance,evenness and richness indices of AM fungi were higher in plots with native *** root samples were colonized by AM fungi and only A nadenanthera colubrina,Acacia mangium,Casuarina equisetifolia and Eucalyptus urophylla formed associations with EcM *** morphotypes served as soil indicators for coverings with the native species Astronium fraxinifolium and Colubrina *** species may favor the proliferation of rarer AM *** fungi–plant relationships may be important in the management of forest systems,and the evidence with mycorrhizal associations allows the inclusion of Brazilian species in tropical reforestation.

关键词： Acacia mangium Arbuscular mycorrhizal fungi Brazilian species Casuarina equisetifolia Ectomycorrhizal fungi Eucalyptus urophylla

Respiratory muscle training with electronic devices in the postoperative period of hepatectomy:A randomized study

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World Journal of Hepatology 2023年第5期15卷 688-698页

作者： Marcelo Gustavo Pereira Aurea maria Oliveira silva Fernanda Diório Masi Galhardo Beatriz Dellamutta Miranda Almeida Railaine Lais Lopes Ilka de Fatima Santana Ferreira Boin Hospital de Clínicas Universidade Estadual de CampinasCampinas 13076-4151São PauloBrazil Faculdade de Ciências Médicas Universidade Estadual de CampinasCampinas 13083-887São PauloBrazil Hospital de Clínicas da Unicamp Universidade Estadual de CampinasCampinas 13083-888São PauloBrazil

BACKGROUND Many studies have been developed with a focus on surgical techniques and drugs,but few that address the importance of rehabilitation in the pre and postoperative period,and the specific benefits for each surgical procedure or type of neoplasm,aiming to minimize respiratory complications in the postoperative *** To compare the strength of the respiratory muscles in the pre and postoperative periods of hepatectomy by laparotomy and to verify the incidence of postoperative pulmonary complications among the groups *** Prospective,randomized,clinical trial study that compared the inspiratory muscle training group(GTMI)with the control group(CG).After the collection of sociodemographic and clinical data,in both groups,preoperatively,on the first and fifth postoperative days,vital signs and pulmonary mechanics were evaluated and *** and bilirubin values were recorded for the albumin-bilirubin(ALBI)*** randomization and allocation of participants,those in the CG underwent conventional physical therapy and those in the GTMI underwent conventional physical therapy plus inspiratory muscle,in both groups for five postoperative *** Of 76 subjects met eligibility *** collection of 41 participants was completed:20 in the CG and 21 in the *** most frequent diagnosis was 41.5%with liver metastasis,followed by 26.8%with hepatocellular *** for respiratory complications in the GTMI,there was no *** the CG,there were three respiratory *** in the CG classified as ALBI score 3 presented,statistically,a higher energy value compared to patients classified as ALBI score 1 and 2(P=0.0187).Respiratory variables,measured preoperatively and on the first postoperative day,had a significant drop in both groups from the preoperative to the first postoperative day(P≤0.0001).When comparing the preoperative period and the fifth postoperative day between the GTMI and the CG,the maximal inspira

关键词： postoperative shorter fifth

Case report of a criminal dismemberment in Northeast Brazil

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Forensic Sciences Research 2022年第4期7卷 637-642页

作者： Evelyne Pessoa Soriano maria do Socorro Dantas de Araújo Francisca de Assis Nascimento Pereira Francisca Divina Silveira de Melo Cristiane Helena da silva Barbosa Freire Marcus Vitor Diniz de Carvalho Medico-legal Institute of João Pessoa ParaíbaBrazil Faculty of Dentistry(FOP) Center for Studies in Forensic Anthropology(CEAF)University of Pernambuco(UPE)RecifeBrazil

Several decomposed body parts were received for examination by the Forensic Anthropology section of the Medico-legal Institute of João Pessoa,Paraíba,*** portions of the lower and upper limbs,ribs,vertebrae,and a skull were thoroughly *** biological profile indicated a male individual with an estimated age range between 23 and 57 years and a mean age of 35.2 years(SD=9.4;phase IV,Suchey-Brooks).The skeleton showed injuries caused by sharp force and sharp-blunt force trauma that affected all body ***,the lesions are mainly in the diaphyseal segments of the long bones,sacrum,pelvis,mandible,maxilla,scapulae,sternum,vertebrae,the distal epiphysis of the left fibula,and the distal epiphysis of the left tibia displayed characteristics compatible with injuries produced *** was not possible to determine the cause of *** resulted in a positive *** of common difficulties faced in forensic practice,it is often not possible for forensic anthropologists to go to the crime scene,X-ray or body scanners are frequently unavailable,and the victim’s medical and/or dental records are sometimes *** difficulties make identification ultimately depend on genetic analysis,which is more time-consuming than other identification *** this,bone fragment examination in dismemberment cases is a complex *** Anthropology can shed light on cases involving the identification of dismembered remains,which are challenging because of the number of traumatic injuries,as well as different injury patterns,on bones.

关键词： Forensic sciences forensic anthropology dismemberment human identification

Clusia nemorosa的叶提取物通过肾上腺素系统依赖机制对大鼠的镇痛作用(英文)

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中国天然药物 2013年第4期11卷 385-390页

作者： Jamylle Nunes de souza Ferro Juliane Pereira da silva Lucia maria Conserva Emiliano Barreto Laboratório de Biologia Celular Universidade Federal de AlagoasMaceió 57072-970ALBrazil Laboratório de Pesquisa em Química dos Produtos Naturais Universidade Federal de AlagoasMaceió 57072-970ALBrazil

Previous studies on the genus Clusia have shown anti-inflammatory and antiproliferative effects of the leaf extracts,but its antinociceptive activity has never been *** the present study,the antinociceptive activity of the hexane extract of the leaves of Clusia nemorosa ***,called HECn,was *** activity was evaluated using acetic acid-induced writhing,formalin,and hot-plate *** experiments were carried out on male Swiss *** extract(1 400 mg kg 1),given by intraperitoneal route(i.p.) 1 h prior to testing,produced a dose-dependent inhibition on the number of abdominal writhings,with an ID50 of 62 mg kg *** addition,HECn was able to prevent the visceral pain induced by acetic acid in mice for at least 2 *** the formalin test,HECn had no effect in the first phase,but produced an analgesic effect on the second phase with the inhibition of licking *** HECn did not show a significant analgesic effect in the hot plate *** with yohimbine attenuated the antinociceptive effect induced by HECn in the writhing ***,naloxone,atropine,or haloperidol did not affect antinociception induced by HECn in the writhing ***,these results indicate that the extract from the leaves of Clusia nemorosa produces antinociception in models of chemical pain through mechanisms that suggest participation of the adrenergic systems pathway.

关键词：实验药理学药理病理作用天然药物