检索结果-南通市图书馆

The immunomodulating effect of bifidobacteria is modified by the anticoagulant acenocoumarol

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

food Bioscience 2023年第2期52卷 1166-1174页

作者： Sabrina E.Assad Melisa fragomeno Martin Rumbo Jessica Minnaard Pablo f.perez Centro de Investigacion y Desarrollo en Criotecnologia de Alimentos-UNLP-CONICET CCT La PlataArgentina Catedra de Microbiologia FCEUNLPCalle 47 y 116CP 1900La PlataBs.AsArgentina Instituto de Estudios Inmunologicos y fisiopatologicos-UNLP-CONICET-CCT La PlataArgentina

Bifidobacteria are health promoting microorganisms that can interact with drugs in the intestinal tract thus modifying the activation of immune cells and host *** study the effect of acenocoumarol on the interaction between bifidobacteria and THP-1 cells or intestinal epithelial *** bifidum CIDCA 5310 and *** CIDCA 5317 were grown in MRS broth in anaerobic *** experiments were done in the presence of ***-labeled bacteria were incubated with THP1 cells differentiated with PMA(THP1-PMA),and phagocytosis and intracellular localization of bacteria were assessed by flow cytometry and confocal laser microscopy,***,expression of macrophage surface molecules in THP1 and THP1-PMA cells was assessed by flow *** using the Caco-2 ccl20:luc reporter system innate immune response was analysed by determining luciferase expression induced by *** decreased phagocytosis of bifidobacteria but intracellular routing was not ***,anticoagulant reduced the expression of HLA-DR and CD64 induced by bifidobacteria in both THP1-PMA and THP1 ***,the decrease in the expression of CD206 and CD23 was dependent on differentiation status of THP1 *** increased CCL20 expression and it was partially abrogated by strain CIDCA *** of acenocoumarol modifies the interaction between bifidobacteria and eukaryotic cells thus suggesting that the expected modulation of immune response by probiotic foods can be different in persons under anticoagulant treatment.

关键词： Bifidobacterium Acenocoumarol THP-1 cells Caco-2 ccl20:luc reporter system Immune response Anticoagulant

Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres fontalba-Navas francisco Pozo Muñoz Rogelio Garcia Cisneros maria Jose Garcia Larrosa maria del Mar Callejon Gil Ignacio Garcia Delgado maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2018年第12期24卷 912-919页

作者： Rosa Martha perez Gutierrez Jose maria Mota flores Natural Products Research Laboratory Higher School of Chemical Engineering and Extractive IndustriesInstituto Politecnico Nacional (IPN) Professional Unit Adolfo Lopez Mateos Av. Instituto Politécnico NacionalS/N

Objective： To examine the effect of metanol extract of Petiveria alliacea （PM） on airway inflammation in a murine model of chronic asthma. Methods： Two-month-old male BALB/c mice （n=6-8/group） were sensitized on days 0 and 14 by intraperitoneal injection of 20μg ovalbumin （OVA）. On day 25, the mice received an airway challenge with OVA （3%, w/v, in phosphate buffered saline）. PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline （PBS） to induce a model of asthma. At the end of the test, respiratory reactivity was assayed, the total cell number, interleukin-4 （IL-4）, IL-5, IL-13, tumor necrosis factor-alpha （TNf-α） and reactive oxygen species （ROS） in the bronchoalveolar lavage fluid （BALf） were determined and the levels of serum IgE, intercellular cell adhesion molecule 1 （ICAM-1） and eotoxin were measured. In addition, lung tissue was used to qualify the IL-4, IL-5, IL-13, TNf-α and transforming growth factor beta 1 （TGf-β1）. Histologic examination was performed to observe inflammatory cellular infiltration. Results： The administration of PM in comparison with the OVA-only treated group significantly attenuated the infiltration of eosinophUs and other inflammatory cells （P〈0.01）. Airway resistance （RI） in the OVA-only induced group was significantly higher than that of the PBS control group （P〈0.01） when methacholine was added. TNf-α, IgE, TGf-β1 and cytokine levels IL-4, IL-5, IL-β in the BALf decreased compared to control mice （P〈0.01 or P〈0.05）. PM treatment also inhibited the production of chemokines, eotaxin and ICAM-1 in BALf （P〈0.01）, which improved lung function. Histopathological examination revealed that the sensitized treated PM groups had significant lower in inflammatory scores similar to dexamethasone treatments and the untreated group. Conclusion： Administration of PM could inhibit airway inflammation, regulate cyt

关键词： Petiveria alliacea allergy antiinflammation asthma

In vitro antioxidant,antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2018年第4期16卷 255-262页

作者： Carola Analla Torres Cristina Marisel perez Zamora maria Beatriz Nunez Ana maria Gonzalez Laboratory of Microbiology and Pharmaceutical Technology Department of Basic and Applied SciencesNational University of Chaco AustralPresidencia Roque Saenz Pena 3700ChacoArgentina National Council for Scientific and Technical Research(CONICET) Godoy Cruz 2290Buenos Aires C1425FQBArgentina Institute of Botany of the Northeast(IBONE-CONICET) Sargento Juan Bautista Cabral 2131CorrientesArgentina

Objectives： This study aimed to evaluate the in vitro antioxidant capacity, to determine the anti-inflammatory effect due to lipoxygenase inhibition and to test the antimicrobial activity of ethanolic extracts from leaves of seven climbing species belonging to the Bignoniaceae family. These species are Adenocalyrnrna rnarginatum （Cham.） DC., Amphilophium vauthieri DC., Cuspidaria convoluta （VEIL） A. H. Gentry, Dolichandra dentata （K. Schum.） L. G. Lohmann, fridericia caudigera （S. Moore） L. G. Lohmann, fridericia chica （Bonpl.） L. G. Lohmann and Tanaecium selloi （Spreng.） L. G. Lohmann. Methods： The antioxidant activity was evaluated using three methods, 2,2＇-azino-bis（3-ethylbenzothiazo line-6-sulfonic acid）（ABTS）, 2,2-diphenyl-l-picrylhydrazyl （DPPH）, and ferric reducing antioxidant power. Lipoxygenase-inhibiting activity was assayed spectrophotometrically; the result was expressed as percent inhibition. The antimicrobial activity was assessed using the agar disk diffusion method. Minimal inhibitory concentration （MIC） and minimal bactericidal]fungicidal concentration were also determined for each extract against 12 pathogenic bacterial strains of Staphylococcus aureus and seven fungal strains of the Candida genus. The identification of the major compounds present in the most promising extract was established by high-performance liquid chromatography-tandem mass spectrometry. Results： C convoluta, f. caudigera, and f. chica exhibited the best antioxidant activity by scavenging DPPH and ABTS~ radicals and reducing fe3＋ ion. These extracts showed a notable inhibition of lipnxygenase. f. caudigera was found to have the lower MIC value against S. aureus strains and six Candida species. The extracts of f. caudigera and C. convoluta were active even against methicillin-resistant S. aureus. C convoluta had higher total phenol content, better antioxidant activity and superior anti- inflammatory and antimicrobial activity. The main phenolic compounds found in this extract

关键词： Cuspidaria fridericia Antioxidants Lipoxygenase Antimicrobials Herbal drugs free radical scavengers

Recent advances in phosphoric acid-based membranes for high-temperature proton exchange membrane fuel cells

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第12期30卷 393-429,I0010页

作者： Zunmin Guo maria perez-Page Jianuo Chen Zhaoqi Ji Stuart M.Holmes Department of Chemical Engineering and Analytical Science The University of Manchester.Ml39PLUnited Kingdom

High-temperature proton exchange membrane fuel cells(HT-PEMfCs)are pursued worldwide as efficient energy conversion *** efforts have been made in the area of designing and developing phosphoric acid(PA)-based proton exchange membrane(PEM)of *** review focuses on recent advances in the limitations of acid-based PEM(acid leaching,oxidative degradation,and mechanical degradation)and the approaches mitigating the membrane *** multilayer or polymers with continuous network,adding hygroscopic inorganic materials,and introducing PA doping sites or covalent interactions with PA can effectively reduce acid *** oxidative degradation can be alleviated by synthesizing crosslinked or branched polymers,and introducing antioxidative groups or highly oxidative stable *** to get a compact structure,blending with stable polymers and inorganic materials,preparing polymer with high molecular weight,and fabricating the polymer with PA doping sites away from backbones,are recommended to improve the membrane mechanical ***,by comparing the running hours and decay rate,three current approaches,*** via thermally curing or polymeric crosslinker,*** hygroscopic inorganic materials,*** membrane layers or introducing strong basic groups and electron-withdrawing groups,have been concluded to be promising approaches to improve the durability of *** overall aim of this review is to explore the existing degradation challenges and opportunities to serve as a solid basis for the deployment in the fuel cell market.

关键词： High-temperature proton exchange membrane fuel cells Acid leaching Oxidative degradation Mechanical degradation Durability

Oxidation and Coatings for Power Generation： New Super Ultra Critical Steam Turbines

在线全文

学校读者我要写书评

暂无评论

中国腐蚀与防护学报 2009年第4期29卷 318-319页

作者： f. J. perez Grupo de Investigacion de Ingenieria de Superficies y Materiales Nanoestructurados U. C. M. N°910627 facultad de Ciencias Quimicas Universidad Complutense de Madrid. 28040 Madrid Spain

The steels with chromium contents between 9%and 12%wt are used for power plants with advanced steam oxidation *** present good creep properties as 9%Cr steels and good oxidation resistance,at the temperatures range between 500℃～600℃.In the last years numerous investigation in development of coatings has been realized with the aim the protected them against the oxidation in order to allow operation of steam turbines at 650℃.In this study,Al-Hf protective coatings were deposited by CVD-fBR on ferritic steel HCM-12A followed by a diffusion heat treatment,have shown to be protective at 650℃under steam for at least 3000 hours of laboratory steam exposure under atmospheric *** and composition of coatings were characterized by different techniques, such as scanning electron microscopy(SEM),electron probe microanalysis,and X-ray diffraction(XRD). On the other hand,volatile species by mass spectrometry(MS) and thermogravimetric measurements (TG) during the initial stages oxidation of the P92 ferritic steel without and of Al and Al/Si coating by chemical vapour deposition in fluidized bed reactors(CVD-fBR) at 650℃in Ar+20%H_2O for 150 h were *** order to go forward to coatings design the Thermocalc code is used as base for the MSdata. TG-MS experiments were conducted in a closed steam loop in order to obtain information about the oxyhydroxides formation as reaction between coatings and *** those results the role of the different coating element could be established and optimized for the coating *** oxidation mechanism based on the TG-MS results is *** morphology/composition and structure of the oxidized samples were also studied using SEM/EDS and XRD techniques.

关键词：氧化金属腐蚀防护

Synthesis of phosphonated graphene oxide by electrochemical exfoliation to enhance the performance and durability of high-temperature proton exchange membrane fuel cells

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2023年第1期76卷 448-458,I0011页

作者： Jianuo Chen Zunmin Guo maria perez-Page Yifeng Jia Ziyu Zhao Stuart M.Holmes Department of Chemical Engineering and Analytical Science University of ManchesterOxford RoadManchester M139PLUnited Kingdom Chemistry Research Laboratory Department of ChemistryUniversity of Oxford12 Mansfield RoadOxford OX13TAUnited Kingdom

The doping of functionalized graphene oxide(GO)in the membranes becomes a promising method for improving the performance of high-temperature proton exchange membrane fuel cells(HT-PEMfC).Phosphonated graphene oxide(PGO)with a P/O ratio of 8.5%was quickly synthesised by one-step electrochemical exfoliation based on a three-dimensiaonal(3D)printed reactor and natural graphite *** with the GO prepared by the two-step electrochemical exfoliation method,the PGO synthesized by the one-step electrochemical exfoliation can better improve the performance of the membrane-electrode-assembly(MEA)based on the polybenzimidazole(PBI)membrane in the *** doping of 1.5 wt%GO synthesised by electrochemical exfoliation with the 2-step method or reactor method in PBI increased the peak power density by 17.4%or 35.4%compared to MEA based on pure PBI membrane at 150℃,*** addition,the doping of PGO in PBI improves its durability under accelerated stress test(AST).

关键词： Electrochemical exfoliation Phosphonated graphene oxide High-temperature fuel cells

在线全文

学校读者我要写书评

暂无评论

复合材料在阿里安上的应用

国外导弹与航天运载器 1989年第11期 48-53页

作者： f.perez 文隆枝

本文提出复合材料在阿里安运载器上扩大应用范围的问题。这包括在阿里安运载器第一代到第四代和阿里安5上的应用,所用的材料包括碳纤维增强塑料和玻璃纤维增强塑料。文章阐明了在这方面所取得的进展并提到一些诸如重量、刚度和成本等参... 详细信息

本文提出复合材料在阿里安运载器上扩大应用范围的问题。这包括在阿里安运载器第一代到第四代和阿里安5上的应用,所用的材料包括碳纤维增强塑料和玻璃纤维增强塑料。文章阐明了在这方面所取得的进展并提到一些诸如重量、刚度和成本等参数。使用这些材料是对技术的和工业的挑战,这些是值得讨论的。文中给出的精确实例包括:断裂准则、正交各向异性影响、热效应和单位成本与质量控制。文章叙述了在这些方面所做的工作并列举了其结果,但有些问题仍然未能解决;作者建议进一步作短期和长期的工作。

关键词：复合材料运载火箭航天器

Intraguild predation and competitive displacement between Nesidiocoris tenuis and Dicyphus maroccanus, two biological control agents in tomato pests

在线全文

学校读者我要写书评

暂无评论

Insect Science 2017年第5期24卷 809-817页

作者： Nadia G. Salas Gervassio Meritxell perez-Hedo maria G. Luna Alberto Urbaneja Centro de Estudios Parasitol6gicos y de Vectores (CEPAVE -CCT La Plata- CONICET-UNLP) Boulevard 120 el 60 y 64 1900 La PlataArgentina Centro de Proteccion Vegetal y Biotecnologia Instituto Valenciano de Investigaciones Agrarias (IVlA) Unidad Asociada de Entomologia UJI-IVIA Carretera de Moncada - N&quera Km. 4.5 46113 Moncada Valencia Spain Unitat Associada d'Entomologia UJI-IVIA Departament de Ciencies Agr&ries i del Medi Natural Universitat Jaume I UJI Campus del Riu Sec E-12071 Castello de laPlana Spain

Dicyphus maroccanus Wagner and Nesidiocoris tenuis Reuter （Hemiptera： Miridae） are 2 biological control agents in tomatoes. Through the crop seasons, a natural shift in the occurrence of both mirids in favor ofN. tenuis has been observed at the end of the cropping cycle in eastern Spain. To better optimize their conservation, the reasons for the observed change, such as intraguild interactions （IGP） or the influence of environmental conditions, are worth elucidating. To do this, we first studied the IGP of adult females on heterospecific nymphs in the laboratory. We next studied exploitative competition between adults and nymphs of each species when feeding on Ephestia kueniella Zeller （Lepidoptera： Pyralidae） eggs in the laboratory. finally, to analyze the competitive displacement between both mirids, we conducted a semifield experiment in which both predators were released together. All experiments were conducted at 2 temperature regimes （20 and 25~C）. Adult- to-nymph intraguild interactions occurred only at 25 ~C at very low levels, showing that N. tenuis attacked and consumed a greater proportion ofheterospecific nymphs. Nesidiocoris tenuis was a better competitor than D. maroccanus when feeding on the shared prey in the presence of its heterospecific nymph at 25 ~C. In semifield conditions, N. tenuis showed a competitive advantage over D. maroccanus at both temperatures. We conclude that there is not direct interference between both species, however, N. tenuis has a greater ability to outcompete, since it is best adapted to higher temperatures and it is able to remove food sources for D. maroccanus.

关键词： competition Mediterranean crops Miridae temperature tomato