检索结果-南通市图书馆

Helicobacter pylori infection and gastric carcinoma:Not all the strains and patients are alike

World Journal of Gastrointestinal Oncology 2016年第1期8卷 40-54页

作者： natale figura luigi marano elena moretti antonio ponzetto department of medical surgical and neurological sciencesuniversity of siena and policlinico s.maria alle scotte53100 SienaItaly general minimally invasive and robotic surgerydepartment of surgeryhospital san matteo degli infermi06049 SpoletoPerugiaItaly department of molecular and developmental medicine university of siena53100 SienaItaly department of medical sciences university of torino10126 TorinoItaly

Gastric carcinoma(GC) develops in only 1%-3% of Helicobacter pylori(H. pylori) infected people. The role in GC formation of the bacterial genotypes, gene polymorphisms and host's factors may therefore be important. The risk of GC is enhanced when individuals are infected by strains expressing the oncoprotein CagA, in particular if CagA has a high number of repeats containing the EPIYA sequence in its C'-terminal variable region or particular amino acid sequences flank the EPIYA motifs. H. pylori infection triggers an inflammatory response characterised by an increased secretion of some chemokines by immunocytes and colonised gastric epithelial cells; these molecules are especially constituted by proteins composing the interleukin-1beta(IL-1β) group and tumour necrosis factor-alpha(TNF-α). Polymorphisms in the promoter regions of genes encoding these molecules, could account for high concentrations of IL-1β and TNF-α in the gastric mucosa, which may cause hypochlorhydria and eventually GC. Inconsistent results have been attained with other haplotypes of inflammatory and anti-inflammatory cytokines. Genomic mechanisms of GC development are mainly based on chromosomal or microsatellite instability(MSI) and deregulation of signalling transduction pathways. H. pylori infection may induce DNA instability and breaks of double-strand DNA in gastric mucocytes. Different H. pylori strains seem to differently increase the risk of cancer development run by the host. Certain H. pylori genotypes(such as the cagA positive) induce high degrees of chronic inflammation and determine an increase of mutagenesis rate, oxidative-stress, mismatch repair mechanisms, down-regulation of base excision and genetic instability, as well as generation of reactive oxygen species that modulate apoptosis; these phenomena may end to trigger or concur to GC development.

关键词： Helicobacter pylori infection CagA CagAgene polymorphism Haplotype Human gene mutation Genemethylation Gastriccarcinoma Inflammatorycytokine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Can Helicobacter pylori infection influence human reproduction?

引用

World Journal of Gastroenterology 2014年第19期20卷 5567-5574页

作者： elena Moretti Natale Figura Giulia Collodel Antonio Ponzetto Collodel Department of Molecular and Developmental MedicineUniversity of Siena53100 SienaItaly Department of Medical Surgical and Neurological SciencesUniversity of Siena and Policlinico S Maria alle Scotte53100 SienaItaly Department of Internal Medicine University of Torino10126 TorinoItaly

Helicobacter pylori (H. pylori) infection could be associated with extra-digestive diseases. Here, we report the evidences concerning the decrease in reproductive potential occurring in individuals infected by H. pylori, especially by strains expressing CagA. This infection is more prevalent in individuals with fertility disorders. Infected women have anti-H. pylori antibodies in cervical mucus and follicular fluid that may decrease sperm motility and cross react immunologically with spermatozoa, conceivably hampering the oocyte/sperm fusion. Infection by CagA positive organisms enhances the risk of preeclampsia, which is a main cause of foetus death. These findings are supported by the results of experimental infections of pregnant mice, which may cause reabsorption of a high number of foetuses and alter the balance between Th1 and Th2 cell response. Infected men have decreased sperm motility, viability and numbers of normally shaped sperm and augmented systemic levels of inflammatory cytokines, such as tumor necrosis factor-α, which may damage spermatozoa. In countries where parasitic infestation is endemic, detrimental effects of infection upon spermatozoa may not occur, because the immune response to parasites could determine a switch from a predominant Th1 type to Th2 type lymphocytes, with production of anti-inflammatory cytokines. In conclusion, the evidences gathered until now should be taken into consideration for future studies aiming to explore the possible role of H. pylori infection on human reproduction.

关键词： Antigenic mimicry Helicobacter pylori infection Human sperm Inflammatory cytokines Preeclampsia Reproductive disorders

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Testing visible ozone injury within a Light Exposed Sampling Site as a proxy for ozone risk assessment for European forests

引用

Journal of Forestry Research 2021年第4期32卷 1351-1359页

作者： Pierre Sicard Yasutomo Hoshika Elisa Carrari Alessandra De Marco elena Paoletti ARGANS 260 route du Pin Montard06410 BiotFrance IRET-CNR Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Agriculture FoodEnvironment and Forestry(DAGRI)University of FlorenceFlorenceItaly ENEA Via Anguillarese 30100123 Santa Maria di GaleriaItaly

Biologically meaningful and cost-effective indicators are needed for assessing and monitoring the impacts of tropospheric ozone(0_(3)) on vegetation and are required in Europe by the National Emission Ceilings Directive(2016).However,a clear understanding on the best suited indicators is *** MOTTLES(MOnitoring ozone injury for seTTing new critical LEvelS) project set up a new generation network for 0_(3) monitoring in forest plots in order to:1) estimate the stomatal 0_(3) fluxes(Phytotoxic Ozone Dose above a threshold Y of uptake,PODY);and 2) collect visible foliar 0_(3) injury,both within the forest plot(ITP) and along the Light Exposed Sampling Site(LESS) along the forest *** forest sites at high 0_(3) risk were selected across Italy over 2017-2019 and significant correlations(p <0.05) were found between the percentage of symptomatic plant species within the LESS,and POD1(PODY,with Y=1 nmol 0_(3) m^(-2) s^(-1)) calculated for mixed forest species(r=0.53)and with the occurrence and severity of visible foliar 0_(3) injury on the dominant species in the plots(r=0.65).A generic flux-based critical level for mixed forest species was derived within the LESS and it was recommended using11 mmol m^(-2) POD1 as the critical level for forest protection against 0_(3) injury,similar to the critical level obtained in the ITP(12 mmol m^(-2) POD1).It was concluded that the frequency of symptomatic plant species within a LESS is a suitable and effective plant-response indicator of phytotoxic 0_(3) levels in forest *** is a non-destructive,less complex and less time-consuming approach compared to the ITP for monitoring foliar 0_(3) injury in the long *** visible foliar 0_(3) injury in the ITP might only underestimate the 0_(3) risk assessment at individual *** results are biologically meaningful and useful to monitoring experts and environmental policy makers.

关键词： Cost-effective indicator Forest monitoring Light-Exposed Sampling Site Ozone Phytotoxic ozone dose Visible injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beneficial effects of saffron(Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases

引用

Neural Regeneration Research 2020年第8期15卷 1408-1416页

作者： Jose A.Fernandez-Albarral Rosa de Hoz Ana I.Ramirez Ines Lopez-Cuenca elena Salobrar-Garcia maria D.Pinazo-Duran Jose M.Ramirez Juan J.Salazar Instituto de Investigaciones Oftalmologicas Ramon Castroviejo MadridSpain Departamento de Inmunologia Oftalmologia y ORLFacultad de Optica y OptometriaMadridSpain Departamento de Inmunologia Oftalmologia y ORLFacultad de MedicinaMadridSpain Unidad de Investigacion Oftalmologica Santiago Grisolia Universidad de ValenciaValenciaSpain

Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal *** currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as anticonvulsant,antidepressant,anxiolytic,hypolipidemic,anti-atherogenic,anti-hypertensive,antidiabetic,and anti-cancer *** addition,saffron has remarkable beneficial properties,such as anti-apoptotic,anti-inflammatory and antioxidant activities,due to its main metabolites,among which crocin and crocetin stand ***,increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,both in experimental models and in clinical studies in ***,saffron supplementation is being tested for ocular neurodegenerative pathologies,such as diabetic retinopathy,retinitis pigmentosa,age-related macular degeneration and glaucoma,among others,and shows beneficial *** present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular *** review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.

关键词： AMD crocetin crocin Crocus sativus L. diabetic retinopathy glaucoma neuroprotection ocular diseases retinitis pigmentosa saffron safranal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Social Accounting Matrix on the Base of the Mexican System of National Accounting

引用

Economics World 2016年第3期4卷 111-127页

作者： Dora elena Ledesma-Carrion Lidia Hernandez-Hernandez maria Teresa Leonor Mucino-Porras Instituto Nacional de Estadistica y Geografia Ciudad de Mexico Mexico

Links between institutional sectors and economic activities with National Accounting System of Mexico are studied used accounting multipliers. Key sectors had changed to strategic or leading as oil and gas extraction and dairy product manufacturing, i.e., Mexico went from a producer of goods to a service provider country, losing value added in their production chains. The mixed income is leading/independent economic activity for woman whose income is between 1 and 5 minimum wages. This is really important in the domestic economy through its impact on solidarity activities： providing care and support and providing food. Moreover, non-financial corporations and households of 10 or more minimum wages for income investing in strategic sectors such as retail trade and wholesale and manufacturing products derived from oil and coal. This is evidence of two Mexicos： the traditional and industrialized.

关键词： social accounting matrix national accounting linkages accounting multipliers input-output tableau

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

γ-Alumina-Supported Ni-Mo Carbides as Promising Catalysts for CO<sub>2</sub>Methanation

引用

Modern Research in Catalysis 2017年第4期6卷 135-145页

作者： Lu Yao Ye Wang maria elena Galvez Changwei Hu Patrick da Costa Sorbonne Universités UPMC Univ. Paris 6 Institut Jean Le Rond d’Alembert Paris France Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University Chengdu China College of Chemical Engineering Sichuan University Chengdu China

CO2 methanation with Hydrogen to form CH4 offers a solution for off-peak renewable energy storage. γ-alumina-supported Mo and Ni-Mo catalysts were used in CO2 methanation, either in their reduced or in their carburized form. The presence of Ni improved the carburization extent of Mo-species, resulting in increased catalytic activity and selectivity for the catalytic CO2 methanation reaction. Carburization generally enhances the basicity of the materials and thus CO2 absorption on their surface. At 300°C, the conversions of CO2 for the reduced Ni-Mo/Al2O3 catalyst and Ni-Mo2C/Al2O3 catalysts were 5.3% and 13.8% respectively with a corresponding selectivity in CH4 of 10.0% and 98.1%, respectively.

关键词： CO2 Methanation Carbide Catalysts Nickel Molybdenum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy

引用

Translational Neurodegeneration 2019年第1期8卷 290-303页

作者： Chiara maria Giulia De Luca Antonio Emanuele Elia Sara maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa elena De Cecco Joanna Narkiewicz Giulia Salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda Fondazione IRCCS Istituto Neurologico Carlo Besta Unit of Neurology 5 and NeuropathologyMilanItaly Fondazione IRCCS Istituto Neurologico Carlo Besta Unit of Neurology I-Parkinson and Movement Disorders UnitMilanItaly Department of Health Sciences Universitàdegli Studi di MilanoOtolaryngology UnitSan Paolo HospitalMilanItaly Department of Neuroscience Scuola Internazionale Superiore di Studi Avanzati(SISSA)Laboratory of Prion BiologyTriesteItaly Fondazione IRCCS Istituto Neurologico Carlo Besta Scientific DirectorateMilanItaly

Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative *** is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain *** diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the *** evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM *** particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and ***:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same ***,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their ***:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-*** studies are required for(i)estimating sensitivity and specificity of the technique and

关键词： RT-QuIC Olfactory mucosa Parkinson’s disease Neurodegenerative parkinsonisms α-Synuclein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells

引用

World Journal of Clinical Oncology 2022年第6期13卷 505-519页

作者： Alejandro Español Yamila Sanchez Agustina Salem Jaqueline Obregon maria elena Sales Laboratory of Immunopharmacology and Tumor Biology CEFYBO CONICET University of Buenos AiresBuenos Aires C1121ABGArgentina

BACKGROUND Triple negative breast cancer is more aggressive than other breast cancer subtypes and constitutes a public health problem worldwide since it has high morbidity and mortality due to the lack of defined therapeutic *** to chemotherapy complicates the course of patients’*** authors have highlighted the participation of nicotinic acetylcholine receptors(nAChR)in the modulation of conventional chemotherapy treatment in cancers of the ***,in breast cancer,less is known about the effect of nAChR activation by nicotine on chemotherapy treatment in smoking *** To investigate the effect of nicotine on paclitaxel treatment and the signaling pathways involved in human breast MDA-MB-231 tumor *** Cells were treated with paclitaxel alone or in combination with nicotine,administered for one or three 48-h *** effect of the addition of nicotine(at a concentration similar to that found in passive smokers’blood)on the treatment with paclitaxel(at a therapeutic concentration)was determined using the 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** signaling mediators involved in this effect were determined using selective *** also investigated nAChR expression,and ATP“binding cassette”G2 drug transporter(ABCG2)expression and its modulation by the different treatments with Western *** effect of the treatments on apoptosis induction was determined by flow cytometry using annexin-V and 7AAD *** Our results confirmed that treatment with paclitaxel reduced MDA-MB-231 cell viability in a concentration-dependent manner and that the presence of nicotine reversed the cytotoxic effect induced by paclitaxel by involving the expression of functionalα7 andα9 nAChRs in these *** action of nicotine on paclitaxel treatment was linked to modulation of the protein kinase C,mitogen-activated protein kinase,extracellular signal-regulated kinase,and NF-κB signaling pathways,

关键词： Breast cancer Paclitaxel Nicotinic acetylcholine receptors Drug therapy Signal transduction Drug transporter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic hepatitis C virus infection:Serum biomarkers inpredicting liver damage

引用

World Journal of Gastroenterology 2016年第4期22卷 1367-1381页

作者： Pamela Valva Daniela A Ríos elena De Matteo maria V Preciado Laboratory of Molecular Biology Pathology DivisionHospital de Niños Ricardo GutiérrezBuenos Aires C1425EFDArgentina

Currently, a major clinical challenge in the management of the increasing number of hepatitis C virus(HCV) infected patients is determining the best means for evaluating liver impairment. Prognosis and treatment of chronic hepatitis C(CHC) are partly dependent on the assessment of histological activity, namely cell necrosis and inflammation, and the degree of liver fibrosis. These parameters can be provided by liver biopsy; however, in addition to the risks related to an invasive procedure, liver biopsy has been associated with sampling error mostly due to suboptimal biopsy size. To avoid these pitfalls, several markers have been proposed as non-invasive alternatives for the diagnosis of liver damage. Distinct approaches among the currently available non-invasive methods are(1) the physical ones based on imaging techniques; and(2) the biological ones based on serum biomarkers. In this review, we discuss these approaches with special focus on currently available non-invasive serum markers. We will discuss:(1) class?Ⅰ?serum biomarkers individually and as combined panels, particularly those that mirror the metabolism of liver extracellular matrix turnover and/or fibrogenic cell changes;(2) class Ⅱ biomarkers that are indirect serum markers and are based on the evaluation of common functional alterations in the liver; and(3) biomarkers of liver cell death, since hepatocyte apoptosis plays a significant role in the pathogenesis of HCV infection. We highlight in this review the evidence behind the use of these markers and assess the diagnostic accuracy as well as advantages, limitations, and application in clinical practice of each test for predicting liver damage in CHC.

关键词： Serum biomarkers Chronic hepatitis C Liver damage Non-invasive Direct serum markers Indirect serum markers Apoptosis markers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn's disease

引用

World Journal of Gastroenterology 2019年第14期25卷 1764-1774页

作者： Ignacio Alfaro maria Carme Masamunt Nuria Planell Alicia López-García Jesús Castro Marta Gallego Rebeca Barastegui Angel Giner Alejandro Vara Azucena Salas elena Ricart Julián Panés Ingrid Ordás Gastroenterology Department Hospital Clínic de Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona

BACKGROUND Identifying predictors of therapeutic response is the cornerstone of personalized *** To identify predictors of long-term mucosal healing(MH) in patients with Crohn's disease(CD) treated with tumor necrosis factor α(TNF-α) *** Prospective single center study. Consecutive patients with clinically active CD requiring treatment with a TNF-α inhibitor were included. A baseline segmental CD Endoscopic Index of Severity(CDEIS) ≥ 10 in at least one segment or the presence of ulcerations were required for inclusion. Clinical, biological and endoscopic data were obtained at baseline, weeks 14 and 46. Endoscopic response(ER) was defined as a decrease ≥ 50% from baseline CDEIS and MH as partial CDEIS ≤ 5 in all *** Of 62 patients were included. At baseline, median CD Activity Index and CDEIS were 201 and 6.7, respectively with a significant reduction after one year of treatment(53 and 3.0 respectively, P < 0.001). At week 14, 56% of patients achieved ER and 34% MH. At week 46, the corresponding percentages were 52%and 44%. Baseline disease characteristics or biomarkers did not predict MH. A decrease from baseline CDEIS at week 14 of at least 80% was the best predictor of MH at week 46(59% sensitivity and 91% specificity; area under the curve =0.778).CONCLUSION Clinical and biomarker data are not useful predictors of response to TNF-αinhibitors in CD, whereas ER to induction therapy, defined as 80% reduction in global CDEIS, is a robust predictor of long-term MH. Achievement of this endoscopic endpoint may be considered as a therapeutic target for anti-TNF-αtherapy.

关键词： Crohn’s disease Endoscopy Mucosal healing Crohn’s Disease Endoscopic Index of Severity Tumor necrosis factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：