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International Journal of Intelligence Science 2019年第3期9卷 67-91页

作者： maria del carmen Cabrera-Hernandez Marco Antonio Aceves-Fernandez Juan Manuel Ramos-Arreguin Jose Emilio Vargas-Soto Efren Gorrostieta-Hurtado Faculty of Engineering Universidad Autónoma de Querétaro Cerro de las Campanas S/N Querétaro Mexico

The airborne pollutants monitoring is an overriding task for humanity given that poor quality of air is a matter of public health, causing issues mainly in the respiratory and cardiovascular systems, specifically the PM10 particle. In this contribution is generated a base model with an Adaptive Neuro Fuzzy Inference System (ANFIS) which is later optimized, using a swarm intelligence technique, named Bacteria Foraging Optimization Algorithm (BFOA). Several experiments were carried with BFOA parameters, tuning them to achieve the best configuration of said parameters that produce an optimized model, demonstrating that way, how the optimization process is influenced by choice of the parameters.

关键词： Air Pollution Bacterial Foraging Optimization Algorithm (BFOA) Swarm Intelligence ANFIS

Renin Angiotensin System Components and Cancer: Reports of Association

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Journal of Biosciences and Medicines 2016年第5期4卷 65-75页

作者： maria del carmen Garcia Molina Wolgien Silvana Aparecida Alves Correa Pedro Alexandre Federico Breuel Afonso Celso Pinto Nazário Gil Facina Division of Mastology Department of Gynecology Federal University of Sao Paulo Paulista School of Medicine (UNIFESP-EPM) Sao Paulo Brazil Division of Mastology Departament of Gynecology Municipal Hospital and Maternity School Vila Nova Cachoeirinha Sao Paulo Brazil Division of Plastic Surgery Department of Surgery Federal University of Sao Paulo Paulista School of Medicine (UNIFESP-EPM) Sao Paulo Brazil Facvest University Center (UNIFACVEST) Post-Graduation Public Health Division Lages Santa Catarina Brazil Department of Teaching and Research Municipal Hospital and Maternity School Vila Nova Cachoeirinha Sao Paulo Brazil

Renin-Angiotensin System (RAS) is involved with hypertension and other cardiovascular diseases. However, the association of RAS components to cancer still causes suspicion. To try to clarify this, here we aimed to show this association for three important components: Angiotensin Converting Enzyme 1 (ACE1), Angiotensin Type 1 Receptor (AGTR1) and Angiotensin Type 2 Receptor (AGTR2). The first articles show that association of RAS components with cancer dates back to the 70’s. ECA1 and AGTR1 have close association with cancer and ACE1 inhibitors or AGTR1 blockers are candidates to treatment of some tumors. Moreover, the action of AGTR2 is still controversial, but most studies show that the increased expression of AGTR2 can attack the cancer cells. In breast cancer, these components have also been widely studied and many works have shown that the correlation exists. Therefore specific target using these RAS components could be a beneficial, novel therapy to various tumors.

关键词： Renin-Angiotensin System Angiotensin Converting Enzyme Angiotensin Type 1 Receptor Angiotensin Type 2 Receptor Breast Cancer Cancer

Current stage in inflammatory bowel disease: What is next?

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World Journal of Gastroenterology 2015年第40期21卷 11282-11303页

作者： Gonzalo Jesús Gómez-Gómez ángeles Masedo carmen Yela maria del Pilar Martínez-Montiel Begona Casís Unidad de Enfermedad Inflamatoria Intestinal Hospital 12 de Octubre

In recent years,the incidence of inflammatory bowel disease(IBD) has been on the rise,extending to countries where it was infrequent in the past. As a result,the gap between high and low incidence countries is decreasing. The disease,therefore,has an important economic impact on the healthcare system. Advances in recent years in pharmacogenetics and clinical pharmacology have allowed for the development of treatment strategies adjusted to the patient profile. Concurrently,new drugs aimed at inflammatory targets have been developed that may expand future treatment options. This review examines advances in the optimization of existing drug treatments and the development of novel treatment options for IBD.

关键词： Inflammatory bowel disease Future directions Pharmacogenetic Pharmacokinetics New drugs

Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment

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Journal of Geriatric Cardiology 2018年第4期15卷 268-274页

作者： Jose maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao carmen Suárez Hospital Carlos III Madrid Spain Hospital Infanta Elena Huelva Spain Hospital Clínico Universitario Lozano Blesa Zaragoza Spain Complejo Hospitalario Universitario de Santiago Santiago de Compostela Spain Hospital Virgen del Camino Sanlucar-Cádiz Spain Centro Socio-Sanitario Vallparadís Terrassa Spain Hospital de Basurto Bilbao Spain Hospital Universitario de La Princesa Madrid Spain

Background Available data regarding clinical profile and management of elderly patients with atrial fibrillation （AF） according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods Cross- sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain. Results A total of 837 patients （83.0 ± 5.0 years; CHA2DS2-VASc： 5.0 ± 1.4; HAS-BLED： 2.1 ± 0.9） were included. 44.4% of patients had some degree of dependency, 43.3% were fragile, and 32.3% had cognitive impairment. Patients with any of these conditions were older, had a worse clinical profile, with more comorbidities and higher risks of thromboembolic and bleeding events. All these conditions were independently associated among them. Overall, 70.8% of patients were taking vitamin K antagonists, the remaining 29.2% direct oral anticoagulants and 9.7% oral antiplatelets. This distribution was independent of the presence of dependency or fragility, but there was a trend to a higher prescription of vitamin K antagonists in those patients with cognitive impairment （75.2% vs. 68.8%; P = 0.05）. Conclusions Approximately 32%-44% of elderly anticoagulated AF patients attended have some degree of dependency, fragility and/or cognitive impairment. Patients with any of these conditions are older and have a worse clinical profile. Ap？proximately 71% of patients are taking vitamin K antagonists, regardless dependency or frailty, but with a trend to higher prescription in patients with cognitive impairment.

关键词： Atrial fibrillation Cognitive impairment Dependency Fragility Oral anticoagulants

Office Furniture Design for Wheelchair User

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Journal of Civil Engineering and Architecture 2012年第11期6卷 1482-1491页

作者： Francisca Jose Castillo Rueda Oscar David de Cozar Macias maria del carmen Ladron de Guevara Munoz Jose Ignacio Jimenez Gonzalez Elidia Beatriz Blazquez Parra Escuela Polit~cnica Superior University of M6laga Mflaga 29071 Spain

There are an estimated 1.19 million wheelchair users in Spain. People use wheelchairs for a variety of reasons, the most common one is paralysis from spinal cord injuries. Current estimates indicate there are around 504,000 people alive in Spain with spinal cord injuries. Among other reasons for using wheelchairs are： fatigue from multiple sclerosis, muscle weakness from muscular dystrophy, lower limb spasticity from cerebral palsy, and missing limbs due to amputation. People who use wheelchairs may encounter a variety of obstacles at their workstations depending on their limitations. Some possible accommodations could be adjustable height desk or table for a person who cannot work comfortably at an existing desk, accessible filing system or office supplies, and frequently used materials on most accessible shelves or drawers for a person who cannot reach upper and lower shelves and drawers. This paper presents the graphical design of a workstation for wheelchair users, in this case, technical, anthropometric, ergonomic, aesthetics and scientists aspects have been analyzed. The design of composite structure conduct to explicit safety constraints applied to office furniture requirements kept continuously current and updated as part of innovation. Finally, results are showed in a three-dimensional model.

关键词： Computers graphics furniture design wheelchair users ergonomic

The Unexpected Capability of Melanin to Split the Water Molecule and the Alzheimer’s Disease

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Neuroscience & Medicine 2011年第3期2卷 217-221页

作者： maria del carmen Arias-Esparza Ruth Isabel Solís Arias Paola Eugenia Solís Arias Martha Patricia Solís Arias A. Solís-Herrera 不详

We began a study about the three main causes of blindness in 1990, because their incidence and prevalence have not changed in the last forty years. Twelve years later we concluded that the main source of energy for the human retina is water, not ATP. And this is also true for the entire human body. Water is the main source of energy. The amazing capability of eukaryotic cells to break or dissociate the water molecule was unsuspected to us because it takes 2000℃ degrees to dissociate water in a laboratory environment, and until today, it was believed that only plants were capable of accomplishing this. Photosynthesis occurs in humans as it does in plants. The water that we drink every day is not just to wash away detritus and toxins;it is not just a cleaner, nor a simple solvent. When our body dissociates the water molecule, cells are able to get their energy from Hydrogen (Hydrogen is the energy carrier that Nature uses the most). Water is our main source of energy. If our body couldn’t acquire energy from water, we would need to eat between 50 - 170 kg (110 - 374 lbs) daily. In any system, when a generalized failure occurs, we must suspect energy first. Parkinson and Alzheimer’s Disease are examples of a generalized failure. That explains why it is not uncommon that patients improve dramatically with pharmacological stimulation of the human photosynthesis process. Recall that the brain needs energy not only to grow or to perform its functions, but also to preserve its form and shape. The best energy for human cells is Hydrogen.

关键词： Melanin Water Dissociation Energy Glucose Alzheimer Biomass

An Unusual Presentation of Aortic Dissection and Aneurysmatic Disease in Marfan Syndrome: A Case Report

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World Journal of Cardiovascular Diseases 2022年第6期12卷 297-303页

作者： Adrian Espejel-Guzman Valente Fernandez-Badillo Javier Serrano-Roman Enrique Solorzano-Pinot Sergio Criales-Vera maria del carmen Lopez-Rodriguez Candace Keirns Daniel Zagal-Cardoso Nilda Espinola-Zavaleta Department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Computed Tomography National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Clinical Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Shelby County Health Department Memphis TN USA Department of Echocardiography ABC Medical Center I.A.P. Mexico City Mexico

Marfan’s syndrome (MFS) is an autosomal dominant disorder characterized by aortic root dilation, mitral valve prolapse and aortic regurgitation. The typical aneurysm location involves the thoracic aorta (60%). Thoracoabdominal aortic dissections are quite infrequent (10%). A type A aortic dissection can have fatal complications, such as aortic rupture and cardiac tamponade, and a prompt diagnosis is crucial. The present case involves a 46-year-old patient with Marfan’s syndrome who was admitted to the emergency department for dyspnea. The patient presented congestive signs and manifestations suggesting acute heart failure. An initial transthoracic echocardiogram (TTE) showed ventricular hypertrophy and diastolic dysfunction. Additionally, TTE showed plurivalvular regurgitation, pulmonary hypertension (42 mmHg), aortic dilatation, and a dissection flap. Coronary computed tomography angiography (CCTA) was performed, confirming the suspicion of ascending aortic dissection. The patient underwent a three-stage intervention for the repair of all the defects, with adequate recovery. This was a rare presentation of aortic dissection in MFS, which was a diagnostic challenge for the heart team.

关键词： Marfan-Syndrome Aortic-Dissection Heart-Failure

Effective prophylaxis with rFVIIa in young haemophiliacs with inhibitors using a schedule similar to FVIII prophylaxis in non-inhibitor patients

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Health 2013年第7期5卷 1151-1157页

作者： maria Fernanda Lopez-Fernandez carmen Altisent Victor Jimenez-Yuste Faustino Garcia-Candel carmen Sedano Ana Cid Eva Mingot Ramiro Nunez maria Jose Paloma Inmaculada Soto Manuel Prieto Haematology Complejo Hospitalario Universitario A CorunaA CorunaSpain Haemophilia Unit Hospital Universitario Vall d’HebronBarcelonaSpain Haemophilia Unit Hospital UniversitarioMadridSpain Haemophilia Unit Hospital Universitario Virgen de la ArreixacaMurciaSpain Haematology Complejo Hospitalario Universitario Marques de ValdecillaSantanderSpain Congenital Coagulophaties Unit Hospital Universitario La FeValenciaSpain Haematology Hospital Universitario Carlos HayaMalagaSpain Haematology Hospital Universitario Virgen del RocíoSevillaSpain Haematology Hospital Virgen del CaminoPamplonaSpain Haematology Hospital General de AsturiasOviedoSpain Haematology Hospital General YagüeBurgosSpain

Objective: To assess the role of early prophylaxis with recombinant activated factor VII (rFVIIa) in young haemophiliacs with inhibitors and to determine whether it can reduce bleeding episodes and prevent joint damage. Patients and Methods: Ten severe haemophiliacs, less of three years old, with up to four joint bleeds and inhibitors to FVIII who started early prophylaxis with rFVIIa, were included. A number of haemorrhages/year/patient and haemarthroses/ year/patient were compared before the start of prophylaxis, which include both the time before (initial period) and after inhibitor diagnosis (inhibitor period), with those during prophylaxis (prophylaxis period). Results: The mean time of inhibitor diagnosis was 15.6 months (range: 2.3-34.1). The mean time between inhibitor diagnosis and the start of prophylaxis was 7.1 months (range: 0-23.2), shorter than the time of rFVIIa prophylaxis (mean: 10.3 months;range: 4.1-32.0). Bleeding episodes for the three time periods were 45, 36 and 17, respectively, or 0.29 and 0.51 haemorrhages/year/patient in the two periods prior to prophylaxis compared to 0.17 during prophylaxis. Total haemarthroses for the three-time periods were 7, 5 and 5, respectively. The haemarthroses/year/patient in the pre-prophylaxis period were 0.032 and 0.070, compared to0.049 inthe prophylaxis period. rFVIIa schedules were either 90 μg/kg three times weekly or 90 μg/kg daily. Conclusions: Early prophylaxis with rFVIIa may be efficacious in young haemophiliacs with inhibitors, reducing joint bleeds. After the risky period of inhibitor presence, they are able to continue rFVIII prophylaxis with success assured to prevent arthropathy.

关键词： rFVIIa Haemarthroses Haemophilia Inhibitors Prophylaxis

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废胶粉对热拌沥青混合料疲劳性能的影响

中外公路 2017年第2期37卷 241-245页

作者：勾俊芳韩森杨晓飞牛帅 Fernando MORENO-NAVARRO maria carmen RUBIO-GMEZ Ana JIMNEZ del BARCO-CARRIN 长安大学陕西西安710064 天津市市政工程设计研究院

以废旧轮胎磨成的胶粉颗粒作为改性剂生产橡胶沥青是废物利用的有效措施。该文研究内容包括:沥青混合料疲劳开裂性能的改善措施;橡胶沥青混合料、普通沥青混合料及SBS改性沥青混合料的性能对比。通过借助UGR-FACT与拍照设备,观察裂缝在... 详细信息

以废旧轮胎磨成的胶粉颗粒作为改性剂生产橡胶沥青是废物利用的有效措施。该文研究内容包括:沥青混合料疲劳开裂性能的改善措施;橡胶沥青混合料、普通沥青混合料及SBS改性沥青混合料的性能对比。通过借助UGR-FACT与拍照设备,观察裂缝在每一时刻的传播,研究了4种由相同矿物级配、不同沥青构成的沥青混合料的疲劳性能。结果表明:传统沥青路面一旦出现裂缝,路面损害将迅速发展。而掺入废胶粉延缓了路面表面开裂,因此,橡胶沥青混合料的疲劳开裂寿命远超传统沥青混合料。此外,采用干法工艺在混合料中添加胶粉,比其他添加方式产生的裂缝更窄、更少。

关键词：废胶粉疲劳开裂沥青混合料试验测试

Motor Effects of 1,3-Disubstituted 8-Styrylxanthines as A_(1) and A_(2) Adenosine-Receptor Antagonists in Rats

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Pharmacology & Pharmacy 2013年第3期4卷 303-311页

作者： Ilhuicamina Daniel Limon-Perez de Leon maria del carmen Parra-Cid Alejandro Munoz-Zurita Saul Alejandro Merino-Contreras Sara Montiel-Smith Socorro Meza-Reyes Gerardo Ramirez-Meja Jesus Sandoval-Ramirez Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de PueblaPueblaMexico Instituto Nacional de Rehabili-tacion Unidad de Ingenieria de TejidosTerapia Celular y Medicina RegenerativaMexico DFMexico.

A series of 1,3-substituted 8-styrylxanthines (11a-d) was synthesized, under chemo- and regioselective conditions, in a good overall yield. The compounds showed affinity towards both A1 and A2A-adenosine receptors by radioligand binding by means of in vitro assays. The (E)-3-ethyl-1-propyl-8-styrylxanthine (11a) showed the greatest affinity towards the A2A receptor, whereas (E)-3-pentyl-1-propyl-8-styrylxanthine (11d) showed the greatest affinity for the A1 receptor. When the 8-styrylxanthines 11a (A15Et) and 11c (A15Bu) were administrated in rats, which were previously injured with 6-hydroxydopamine at the substantia nigra pars compacta (SNc), the turning behavior decreased 50%. Based on these results we propose to A15Et as a potential compound to treat some symptoms of Parkinson’s disease.

关键词： Xantines Adenosine Receptors Antagonists Turning Behavior Anti-Parkinsonian Drugs