Renin Angiotensin System Components and Cancer: Reports of Association
Renin Angiotensin System Components and Cancer: Reports of Association作者机构：Division of Mastology Department of Gynecology Federal University of Sao Paulo Paulista School of Medicine (UNIFESP-EPM) Sao Paulo Brazil Division of Mastology Departament of Gynecology Municipal Hospital and Maternity School Vila Nova Cachoeirinha Sao Paulo Brazil Division of Plastic Surgery Department of Surgery Federal University of Sao Paulo Paulista School of Medicine (UNIFESP-EPM) Sao Paulo Brazil Facvest University Center (UNIFACVEST) Post-Graduation Public Health Division Lages Santa Catarina Brazil Department of Teaching and Research Municipal Hospital and Maternity School Vila Nova Cachoeirinha Sao Paulo Brazil
出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)
年 卷 期：2016年第4卷第5期
页 面：65-75页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Renin-Angiotensin System Angiotensin Converting Enzyme Angiotensin Type 1 Receptor Angiotensin Type 2 Receptor Breast Cancer Cancer
摘 要：Renin-Angiotensin System (RAS) is involved with hypertension and other cardiovascular diseases. However, the association of RAS components to cancer still causes suspicion. To try to clarify this, here we aimed to show this association for three important components: Angiotensin Converting Enzyme 1 (ACE1), Angiotensin Type 1 Receptor (AGTR1) and Angiotensin Type 2 Receptor (AGTR2). The first articles show that association of RAS components with cancer dates back to the 70’s. ECA1 and AGTR1 have close association with cancer and ACE1 inhibitors or AGTR1 blockers are candidates to treatment of some tumors. Moreover, the action of AGTR2 is still controversial, but most studies show that the increased expression of AGTR2 can attack the cancer cells. In breast cancer, these components have also been widely studied and many works have shown that the correlation exists. Therefore specific target using these RAS components could be a beneficial, novel therapy to various tumors.
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