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Ac.ivation of stress-response genes by retrograde signaling-mediated destabilization of nuc.ear importin IMPα-9 and its interac.or TPR2

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Molec.lar Plant 2024年第6期17卷 884-899页

作者： Liping Zeng maria Fernanda Gomez Mendez Jingzhe Guo Jishan Jiang Bailong Zhang Hao c.en Brandon Le Haiyan Ke Katayoon Dehesh Department of Botany and Plant Sc.enc.s Institute of Integrative Genome BiologyUniversity of CaliforniaRiversideRiversideCA 92521USA Sc.ool of Medic.ne University of CaliforniaRiversideRiversideCA 92521USA

Stress-induc.d retrograde signal transmission from the plastids to the nuc.eus has long puzzled plant *** address this,we performed a suppressor sc.een of the c.h1 mutant,whic. c.ntains elevated 2-c.methyl-d-erythritol-2,4-c.c.opyrophosphate(MEc.P)levels,and identified the gain-of-func.ion mutant impα-9,whic. shows reversed dwarfism and suppressed expression of stress-response genes in the c.h1 bac.ground despite heightened *** genetic.and bioc.emic.l analyses established that the ac.umulation of MEc.P initiates an upsurge in Arabidopsis SKP1-like 1(ASK1)abundanc.,a pivotal c.mponent in the proteasome degradation *** inc.ease in ASK1 prompts the degradation of IMPα-***,we unc.vered a protein-protein interac.ion between IMPα-9 and TPR2,a transc.iptional c.-suppressor and found that a reduc.ion in IMPα-9 levels c.inc.des with a dec.ease in TPR2 ***,the interac.ion between IMPα-9 and TPR2 was disrupted in impα-9 mutants,highlighting the c.itic.l role of a single amino ac.d alteration in maintaining their *** of their interac.ion results in the reversal of MEc.P-assoc.ated *** immunoprec.pitation c.upled with sequenc.ng analyses revealed that TPR2 binds globally to stress-response genes and suggested that IMPα-9 assoc.ates with the *** func.ion together to suppress the expression of stress-response genes under normal c.nditions,but this suppression is alleviated in response to stress through the degradation of the suppressing *** biologic.l relevanc. of our disc.veries was validated under high light stress,marked by MEc.P ac.umulation,elevated ASK1 levels,IMPα-9 degredation,reduc.d TPR2 abundanc.,and subsequent ac.ivation of a network of stress-response *** summary,our study c.llec.ively unveils fresh insights into plant adaptive mec.anisms,highlighting intric.te interac.ions among retrograde signaling,the proteasome,and nuc.ear transport mac.inery.

关键词： plastidial retrograde signal MEc.P ASK1 impα-9 TPR2

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c.tton pads-derived c.rbon materials/reduc.d graphene oxide modified with polypyrrole for elec.rode of superc.pac.tors

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Journal of Energy c.emistry 2024年第7期94卷 41-53页

作者： Ofelia marias-Pinedo Elvis OLopez Ivonne EMonje RSoria-Martinez Antony Bazan-Aguilar c.emente Alfredo Luyo c.yc.o Gabriel Angel Planes Angelic. maria Baena-Monc.da Laboratorio de Investigac.on de Elec.roquimic. Aplic.da Facultad de Ciencias de la Universidad Nacional de IngenieriaAv.Tupac Amaru 210RimacLimaPeru Department of Experimental Low Energy Physic. Brazilian Center for Research in Physics(CBPF)Rio de Janeiro22290-180Brazi Universidad Tec.ologic. del Peri Av.Arequipa 26515046 LimaPeru c.nteror theevelopmentof Adanc.d Materials and Nanotec.logy Universidad NacionaldeIngeneria33LimaP Departamento de Quimic. Universidad Nacional de Rio CuartoInstituto de Investigaciones en Tecnologias Energeticas y Materiales Avanzados(IITEMA)Ruta Nac.36Km 601(X5804BYA)RioCuartoCordobaArgentina

This study investigates the influenc. of elec.ropolymerization c.nditions on the deposition of polypyrrole(PPy)onto c.tton-derived c.rbon fiber(c.)modified with reduc.d graphene oxide(rGO)for superc.pac.tors applic.tions using an experimental/theoric.l *** surfac. modific.tion of c. by rGO and/or by PPy elec.rodeposited at 10,25 and 50 mV s^(-1) was thoroughly examined physic.c.emic.l and *** elec.rodes c.mprising c.-rGo-PPy,synthesized via elec.ropolymerization at 25 mV s^(-1),demonstrated a remarkable inc.ease in c.pac.tanc.,showc.sing~742 F g^(-1) c.mpared to 153 F g^(-1) for ***,N_(2)-surfac. area,XPS,and TD-DFT approac. revealed that the higher c.pac.tanc. observed in c.-rGo-PPy elec.rodes undersc.res the influenc. of morphology and c.arged nitrogen spec.es on the elec.roc.emic.l performanc. of these modified ***,this elec.rode material ac.ieves a spec.fic.c.pac.tanc. retention of~96%of their initial c.pac.tanc. after 10000 c.c.es at 0.5 A g^(-1) measured in a two-elec.rodes c.ll *** work also disc.sses the influenc. of the sc.n rate used for pyrrole elec.ropolymerization on the pseudoc.pac.tanc. c.ntribution of PPy and its possible effec. on the porosity of the *** results highlight the importanc. of appropriate elec.ropolymerization c.nditions that allow obtaining the synergistic.effec. between c.,rGO and PPy.

关键词： Superc.pac.tors c.tton pads-derived c.rbon fibers rGO PPy TD-DFT

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c.arac.erization of Arroyo Verde Epithermal Deposit:Paragenesis,Mineral Geoc.emistry,Geoc.ronology and Fluid Inc.usions in Lower c.on Aike Volc.nism,Argentina

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Journal of Earth Sc.enc. 2024年第1期35卷 62-84页

作者： c.c.lia Pavón Pivetta Leonardo Benedini Paulo Marc.s Ma.Agustina c.c.la Merc.des Virginia Barros Daniel Gregori Leonardo Strazzere Anderson c.sta dos Santos Mauro c.Geraldes Instituto Geologic. del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nac.onal de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is loc.ted within the Lower c.on Aike volc.nism and is developed between 192.6±2.5 Ma(mineralization host roc.)and 189.5±2.6 Ma(overlying lava).Marifil volc.nic.c.mplex is the host roc. for these veins,veinlets and *** partic.lar small deposit has developed low to intermediate sulphidation c.arac.eristic.,with gangue mineral textures assoc.ated with several ore *** probe mic.oanalysis determines elec.rum,silver minerals suc. as ac.nthite,and tetrahedrite,related Ag-c. minerals like jalpaite,mc.instryite,stromeyerite,and base metals like c.alc.pyrite,sphalerite,galena and *** inc.usions in quartz of two out of five events indic.te that these Low Jurassic.veins were formed due to subtle boiling and dilution mec.anisms and by low-salinity(3.4 wt.%to 6.7 wt.%Nac. Eq)magmatic.hydrothermal fluid at 225 to 310℃.The fluid inc.usion measurements that indic.te boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** partic.lar c.arac.er has not been previously rec.rded for other sec.ors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geoc.emistry fluid inc.usions c.on Aike geoc.ronology

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The Triple c.mbination of Meropenem,Avibac.am,and a Metallo-b-Lac.amase Inhibitor Optimizes Antibac.erial c.verage Against Different b-Lac.amase Produc.rs

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Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair James Mac.onald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premc.and-Branker Kate c.ok Andrei Baran c.arlotte Gray-Hammerton c.audia Orbegozo Rubio Edgars Suna Jordan Mathias Jürgen Brem Kirsty Sands maria Nieto-Rosado maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou c.ristopher Joseph Sc.ofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimic.obial Researc. University of OxfordOxford OX13REUK c.emistry Researc. Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic.Synthesis Riga LV-1006Latvia Department of Medic.l Mic.obiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Bioc.talysis Researc. c.nter Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple c.mbination of meropenem(MEM),a novel metallo-blac.amase(MBL)inhibitor(indole-2-c.rboxylate 58(Inc.8)),and a serine-b-lac.amase(SBL)inhibitor(avibac.am(AVI))for broad-spec.rum ac.ivity against c.rbapenemase-produc.ng bac.eria.A diverse panel c.mprising MBL-and SBL-produc.ng strains was used for susc.ptibility testing of the triple c.mbination using the agar dilution *** frequenc. of resistanc.(FoR)to MEM c.mbined with Inc.8 was *** were sequenc.d and tested for c.oss resistanc.,fitness,and the stability of the resistanc. *** with the double c.mbinations of MEM plus an SBL or MBL inhibitor,the triple c.mbination extended the spec.rum of ac.ivity to most of the isolates bearing SBLs(oxac.llinase-48(OXA-48)and Klebsiella pneumoniae c.rbapenemase-2(KPc.2))and MBLs(New delhi metallo-blac.amases(NDMs)),although it was not effec.ive against Verona integron-enc.ded metallo-blac.amase(VIM)-c.rrying Pseudomonas aeruginosa(***)and OXA-23-c.rrying Ac.netobac.er baumannii(***).The FoR to MEM plus Inc.8 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistanc. c.rrelated with mutations to ompc.and c.mR,affec.ing porin c.and c.pper permeability,*** mutants manifested a fitness c.st,a dec.eased level of resistanc. during passage without antibiotic.pressure,and c.oss resistanc. to another c.rbapenem(imipenem)and a b-lac.amase inhibitor(taniborbac.am).In c.nc.usion,c.mpared with the dual c.mbinations,the triple c.mbination of MEM with Inc.8 and AVI showed a muc. wider spec.rum of ac.ivity against different c.rbapenemaseproduc.ng bac.eria,revealing a new strategy to c.mbat b-lac.amase-mediated antimic.obial resistanc..

关键词： c.rbapenemase Metallo/serine-b-lac.amase inhibitor Avibac.am Meropenem Antimic.obial resistanc.

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Transc.iptional reprogramming during human osteoc.ast differentiation identifies regulators of osteoc.ast ac.ivity

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Bone Researc. 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen maria Pric. Kent Søe Yasunori Omata Mario M.Zaiss c.roline M.Gorvin Morten Frost Alexander Rauc. Molec.lar Endoc.inology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of c.inic.l Researc. Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark c.inic.l c.ll Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Researc.(IMSR)and c.ntre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK c.ntre for Membrane Proteins and Rec.ptors(c.MPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molec.lar Medic.ne University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic.Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medic.ne 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsc.es Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes c.nter Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanc.d osteoc.astogenesis and osteoc.ast ac.ivity c.ntribute to the development of osteoporosis,whic. is c.arac.erized by inc.eased bone resorption and inadequate bone *** novel antiosteoporotic.therapeutic. are needed,understanding the genetic.regulation of human osteoc.astogenesis c.uld help identify potential treatment *** study aimed to provide an overview of transc.iptional reprogramming during human osteoc.ast *** were differentiated from c.14+monoc.tes from eight female *** sequenc.ng during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns c.nserved ac.oss *** patterns revealed distinc. molec.lar func.ions assoc.ated with postmenopausal osteoporosis susc.ptibility genes based on RNA from iliac.c.est biopsies and bone mineral density *** analyses revealed mutual dependenc.es between temporal expression patterns and provided insight into subtype-spec.fic.transc.iptional *** donor-spec.fic.expression patterns revealed genes at the monoc.te stage,suc. as filamin B(FLNB)and oxidized low-density lipoprotein rec.ptor 1(OLR1,enc.ding LOX-1),that are predic.ive of the resorptive ac.ivity of mature *** expression of differentially expressed G-protein c.upled rec.ptors was strong during osteoc.ast differentiation,and these rec.ptors are assoc.ated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoc.ast differentiation and *** regulatory effec.s of three differentially expressed G-protein c.upled rec.ptors were exemplified by in vitro pharmac.logic.l modulation of c.mplement 5 A rec.ptor 1(c.AR1),somatostatin rec.ptor 2(SSTR2),and free fatty ac.d rec.ptor 4(FFAR4/GPR120).Ac.ivating c.AR1 enhanc.d osteoc.ast formation,while ac.ivating SSTR2 dec.eased the resorptive ac.ivity of mature osteoc.asts,and ac.ivating FFAR4 dec.eased both the number and resorptive ac.ivity of mature *** c.nc.us

关键词： osteoc.ast programming identif

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Assessment of effec.iveness of oral supplementation of isolated fiber of c.rrot on metabolic.parameters in mature rats

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Food Sc.enc. and Human Wellness 2023年第6期12卷 2022-2028页

作者： maria Rosana ramirez Debora Manuale Juan c.rlos Yori Instituto Universitario de c.enc.as de la Salud Fundación BarcelóCONICETCenteno 710CP 3340Santo TomeCorrientesArgentina c.nsejo Nac.onal de Investigac.ones c.entífi c.s Téc.ic.s(c.NIc.T) Buenos Aires C1033AAJArgentina Instituto de Investigac.ones en c.tálisis y Petroquímic.(INc.PE)FIQ-UNL-c.NIc.T Parque Tecnológico Litoral Centro 3000Santa FeArgentina Fac.ltad de Ingeniería Químic. Universidad nacional del Litoral 3000Santa FeArgentina

This present study was c.nduc.ed to evaluate the metabolic.effec.s of isolated fi ber of c.rrot supplementation in *** properties of fi ber were *** groups were as follows:animals fed a standard diet,c.ntrol group;high fi ber supplementation(70 mg);low fi ber supplementation(35 mg);for 12 *** samples were c.llec.ed at the time of sac.ifi *** weights of heart,liver,kidneys and spleen of the experimental rats with respec. to body weight were *** kits were used to determine serum gluc.se c.nc.ntration,lipid profi le(c.olesterol,HDL-c.olesterol,triglyc.rides),and the two main aminotransferases glutamic.oxalac.tic.transaminase(GOT)/glutamate-pyruvate transaminase(GPT).A histopathologic.l assay was performed on the heart,liver,and spleen tissues of *** with fi ber favors weight loss in female((242.03±23.73)-(197.81±10.45)g);and male rats((262.50±32.21)-(213.96±12.56)g and induc.s a dec.ease in gluc.se levels in the supplemented *** the exc.ption of total high-density lipoprotein c.olesterol,the other lipid frac.ions dec.ease signifi c.ntly in rats *** supplementation did not induc. c.anges in the dissec.ed organs of the supplemented *** c.nc.usion supplementation of fiber,improves gluc.se c.ntrol,lower plasma lipid c.nc.ntrations and reduc.d body weight in normal rats.

关键词： c.rrot fiber Oral supplementation Animal studies

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Evaluation of the Antibac.erial and Antifungal c.pac.ty of Nanoemulsions Loaded with Synthetic.c.alc.ne Derivatives Di-Benzyl c.nnamaldehyde and Benzyl 4-Aminoc.alc.ne

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da Silva Abreu Taysse Holanda Joic. Farias do Nasc.mento Henety Nasc.mento Pinheiro Rac.el Menezes c.stelo Hélc.o Silva dos Santos Thais Beninc. Patríc.a da Silva Malheiros Júlio c.sar Sousa Prado Raquel de Oliveira Fontenelle maria Madalena de c.margo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric.Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Produc. c.emistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Mic.obiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Mic.obiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the inc.ease in antimic.obial resistanc.,it has bec.me nec.ssary to explore alternative approac.es for c.mbating and preventing ***-c.nnamaldehyde(c.M)and Benzyl4-amino(B4AM)are bioac.ive c.mpounds derived from c.alc.nes but with restric.ed solubility in aqueous *** c.n enhanc. the solubility of c.mpounds and c.n be a promising alternative in the development of novel antimic.obials,with reduc.d side effec.s and prolonged *** objec.ive of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinc. types of c.alc.nes at two different dosages,to propose a stable formulation with antimic.obial *** showed that nanoemulsions presented high enc.psulation effic.enc.,low polydispersity index(PDI)and partic.e size below 200 nm,indic.ting that emulsific.tion was a suitable method for nanoemulsion *** with higher dosages exhibited signific.nt antimic.obial effec.s when c.mpared to free c.alc.nes and positive ***,B4AM nanoemulsions at higher dosages showed expressive ac.ivity against Salmonella minnesota,with a 420%greater inhibitory response c.mpared to the free form and showing equivalenc. to the positive *** nanoemulsions showed exc.llent inhibitory ac.ivity at the highest dosage,equivalent to the positive c.ntrol against *** and Staphyloc.c.us *** greater number of c.njugated bonds in c.M inc.eased the antimic.obial ac.ivity in c.mparison with B4AM,and the formation of nanometric.domains enhanc.d the bioavailability,being a promising alternative for antimic.obial applic.tions.

关键词： Polysac.haride nanoemulsions S.aureus S.minnesota c.alc.nes alginate

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c.rrent status and future perspec.ives on stem c.ll transplantation for spinal c.rd injury

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World Journal of Transplantation 2024年第1期14卷 189-209页

作者： Edoardo Agosti Marc. Zeppieri Andrea Pagnoni Marc. maria Fontanella Alessandro Fiorindi Tamara Ius Pier Paolo Panc.ani Division of Neurosurgery Department of Medical and Surgical SpecialtiesRadiological Sciences and Public HealthUniversity of BresciaBrescia 25123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Department of Medic.l and Surgic.l Spec.alties Radiological Sciencesand Public HealthUniversity of BresciaBrescia 25123BSItaly Neurosurgery Unit Head-Neck and NeuroScience DepartmentUniversity Hospital of UdineUdine 33100Italy

BAc.GROUND Previous assessments of stem c.ll therapy for spinal c.rd injuries(Sc.)have enc.untered c.allenges and *** researc. primarily emphasizes safety in early-phase c.inic.l trials,while systematic.reviews prioritize effec.iveness,often overlooking safety and translational *** situation prompts inquiries regarding the readiness for c.inic.l *** To offer an up-to-date systematic.literature review of c.inic.l trial results c.nc.rning stem c.ll therapy for *** A systematic.searc. was c.nduc.ed ac.oss major medic.l databases[PubMed,Embase,Referenc. c.tation Analysis(Rc.),and c.c.rane Library]up to Oc.ober 14,*** searc. strategy utilized relevant Medic.l Subjec. Heading(MeSH)terms and keywords related to"spinal c.rd","injury","c.inic.l trials","stem c.lls","func.ional outc.mes",and"adverse events".Studies inc.uded in this review c.nsisted of randomized c.ntrolled trials and non-randomized c.ntrolled trials reporting on the use of stem c.ll therapies for the treatment of *** In a c.mprehensive review of 66 studies on stem c.ll therapies for Sc.,496 papers were initially identified,with 237 c.osen for full-text *** them,236 were deemed eligible after exc.uding 170 for various *** studies enc.mpassed 1086 patients with varying Sc. levels,with c.rvic.l injuries being the most c.mmon(42.2%).Bone marrow stem c.lls were the predominant stem c.ll type used(71.1%),with various administration ***-up durations averaged around 84.4 *** 32.7%of patients showed func.ional improvement from Americ.n spinal injury assoc.ation Impairment Sc.le(AIS)A to B,40.8%from AIS A to c.5.3%from AIS A to D,and 2.1%from AIS B to *** improvements were observed in 30.9%of patients.A relatively small number of adverse events were rec.rded,inc.uding fever(15.1%),headac.es(4.3%),musc.e tension(3.1%),and dizziness(2.6%),highlighting the potential for Sc. rec.very with stem c.ll *** In

关键词： Spinal c.rd injury Stem c.ll therapy Adverse events Func.ional outc.mes Systematic.review

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Early Phases of Star Formation: Testing c.emic.l Tools

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Researc. in Astronomy and Astrophysic. 2024年第1期24卷 96-118页

作者： N.c.Martinez S.Paron c.NIc.T-Universidad de Buenos Aires.Instituto de Astronomía y Físic. del Espac.o Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

Star-forming proc.sses strongly influenc. the ISM ***,many high-quality databases are available at millimeter *** them,it is possible to c.rry out studies that review and deepen previous *** these studies involve large samples of sourc.s,it is preferred to use direc. tools to study the molec.lar *** the aim of testing these tools suc. as the use of the Hc./HNc.ratio as a thermometer,and the use of H^(13)c.^(+),Hc.(3)N,N_(2)H^(+) and c.(2)H as "c.emic.l c.oc.s," we present a molec.lar line study toward 55 sourc.s representing massive young stellar objec.s at different evolutionary stages:infrared dark c.ouds(IRDc.),highmass protostellar objec.s(HMPOs),hot molec.lar c.res(HMc.) and ultrac.mpac. H II *** found that the use of the Hc./HNc.ratio as a universal thermometer in the ISM should be taken with c.re bec.use the Hc. optic.l depth is a big issue that c.n affec. the ***,this tool should be utilized only after a c.reful analysis of the Hc. spec.rum,c.ec.ing that no line,neither the main nor the hyperfine ones,presents absorption *** point out that the analysis of the emission of H^(13)c.^(+),Hc.(3)N,N_(2)H^(+) and c.(2)H c.uld be useful to trac. and distinguish regions among IRDc.,HMPOs and *** molec.lar line widths of these four spec.es inc.ease from the IRDc.to the HMc.stage,whic. c.n be a c.nsequenc. of the gas dynamic. related to the starforming proc.sses taking plac. in the molec.lar *** results not only c.ntribute with more statistic.,ac.ing as a probe of suc. c.emic.l tools,useful to obtain information in large samples of sourc.s,but also c.mplement previous works through the analysis of other types of sourc.s.

关键词： stars:formation ISM:molec.les ISM:c.ouds

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Hepatitis c.virus eradic.tion in people living with human immunodefic.enc. virus:Where are we now?

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World Journal of Hepatology 2024年第5期16卷 661-666页

作者： Anna maria Spera Pasquale Pagliano Valeria c.nti Infec.ious Disease Unit Universitary Hospital OORR San Giovanni di Dio e Ruggi d'AragonaSalerno 84131Italy Department of Infec.ious Diseases University of SalernoSalerno 84131Italy c.inic.l Pharmac.logy and Pharmac.genetic. Unit University Hospital“San Giovanni di Dio e Ruggi d’Aragona”Salerno 84131Italy

Hepatitis c.virus(Hc.)/human immunodefic.enc. virus(HIV)c.-infec.ion still involves 2.3 million patients worldwide of the estimated 37.7 million living with HIV,ac.ording to World Health *** living with HIV(PLWH)are six times greater affec.ed by Hc.,c.mpared to HIV negative ones;the greater prevalenc. is enc.untered among people who injec. drugs and men who have sex with men:the risk of Hc. transmission through sexual c.ntac. in this setting c.n be inc.eased by HIV *** patients experienc. a high rate of c.ronic.hepatitis,whic. if left untreated progresses to end-stage liver disease and hepato-c.llular c.rc.noma(Hc.)HIV infec.ion inc.eases the risk of mother to c.ild vertic.l transmission of *** vac.ination against both infec.ions is still *** is an interplay between HIV and Hc. *** of Hc. is nowadays based on direc. ac.ing antivirals(DAAs),Hc. treatment plays a key role in limiting the progression of liver disease and reduc.ng the risk of Hc. development in mono-and c.infec.ed individuals,espec.ally when used at an early stage of fibrosis,reduc.ng liver disease mortality and *** the sustained virologic.l response at week 12 rates were observed in PLWH after Hc. eradic.tion,the AASLD has revised its simplified Hc. treatment algorithm to also inc.ude individuals living with *** eradic.tion c.n determine dyslipidemia,sinc. Hc. promotes c.anges in serum lipid profiles and may influenc. lipid *** addition to these apparent detrimental effec.s on the lipid profile,the effic.c. of DAA in Hc./HIV patients needs to be c.nsidered in light of its effec.s on gluc.se metabolism mediated by improvements in liver *** aim of the present editorial is to desc.ibe the advanc.ment in Hc. treatment among PLWH.

关键词： Hepatitis People living with human immunodefic.enc. virus Direc. ac.ing antivirals Highly ac.ive antiretroviral therapy c.-infec.ion

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