Current status and future perspectives on stem cell transplantation for spinal cord injury
作者机构：Division of NeurosurgeryDepartment of Medical and Surgical SpecialtiesRadiological Sciences and Public HealthUniversity of BresciaBrescia 25123Italy Department of OphthalmologyUniversity Hospital of UdineUdine 33100Italy Department of Medical and Surgical SpecialtiesRadiological Sciencesand Public HealthUniversity of BresciaBrescia 25123BSItaly Neurosurgery UnitHead-Neck and NeuroScience DepartmentUniversity Hospital of UdineUdine 33100Italy
出 版 物：《World Journal of Transplantation》 (世界移植杂志)
年 卷 期：2024年第14卷第1期
页 面：189-209页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Spinal cord injury Stem cell therapy Adverse events Functional outcomes Systematic review
摘 要：BACKGROUND Previous assessments of stem cell therapy for spinal cord injuries(SCI)have encountered challenges and *** research primarily emphasizes safety in early-phase clinical trials,while systematic reviews prioritize effectiveness,often overlooking safety and translational *** situation prompts inquiries regarding the readiness for clinical *** To offer an up-to-date systematic literature review of clinical trial results concerning stem cell therapy for *** A systematic search was conducted across major medical databases[PubMed,Embase,Reference Citation Analysis(RCA),and Cochrane Library]up to October 14,*** search strategy utilized relevant Medical Subject Heading(MeSH)terms and keywords related tospinal cord,injury,clinical trials,stem cells,functional outcomes,andadverse events.Studies included in this review consisted of randomized controlled trials and non-randomized controlled trials reporting on the use of stem cell therapies for the treatment of *** In a comprehensive review of 66 studies on stem cell therapies for SCI,496 papers were initially identified,with 237 chosen for full-text *** them,236 were deemed eligible after excluding 170 for various *** studies encompassed 1086 patients with varying SCI levels,with cervical injuries being the most common(42.2%).Bone marrow stem cells were the predominant stem cell type used(71.1%),with various administration ***-up durations averaged around 84.4 *** 32.7%of patients showed functional improvement from American spinal injury association Impairment Scale(AIS)A to B,40.8%from AIS A to C,5.3%from AIS A to D,and 2.1%from AIS B to *** improvements were observed in 30.9%of patients.A relatively small number of adverse events were recorded,including fever(15.1%),headaches(4.3%),muscle tension(3.1%),and dizziness(2.6%),highlighting the potential for SCI recovery with stem cell *** In
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