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Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon

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Infectious Diseases of Poverty 2018年第1期7卷 448-459页

作者： Virginia Araujo Pereira Juan Camilo Sanchez-Arcila mariana Pinheiro Alves Vasconcelos Amanda Ribeiro Ferreira Lorene de Souza Videira Antonio Teva Daiana Perce-da-Silva maria teresa queiroz marques Luzia Helena de Carvalho Dalma maria Banic Luiz Cristovao Sobrino Porto Joseli Oliveira-Ferreira Laboratory of Immunoparasitology Oswaldo Cruz Institute/FiocruzAv.Brasil 4365ManguinhosRio de JaneiroBrazil Institute of Infectology Emilio Ribas São PauloSao PauloBrazil Laboratory of Immunodiagnosis Departament of Biological SciencesNational School of Public Health/FiocruzRio de JaneiroBrazil Laboratory of Clinical Immunology Oswaldo Cruz Institute/FiocruzRio de JaneiroBrazil Laboratory of Histocompatibility and Cryopreservation–HLA of DHE/IBRAG/UERJ Rio de JaneiroBrazil Molecular Biology and Malaria Immunology Research Group Centro de Pesquisas Rene Rachou/FiocruzBelo HorizonteMinas GeraisBrazil

Background:Brazil has seen a great decline in malaria and the country is moving towards ***,for eventual elimination,the control program needs efficient tools in order to monitor malaria exposure and *** this study,we aimed to evaluate whether seroprevalence to the circumsporozoite protein(CSP)is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian ***:Cross-sectional surveys were conducted in a rural area of Porto Velho,Rondônia *** infection was detected by microscopy and polymerase chain *** to the sporozoite CSP repeats of Plasmodium vivax,***,and ***(PvCS,PfCS,and PmCS)were detected using the enzyme-linked immunosorbent assay *** leukocyte antigen(HLA)-DRB1 and DQB1 genes were typed using Luminex®xMAP®***:The prevalence of immunoglobulin G against *** CSP peptide(62%)was higher than ***(49%)and ***(46%)CSP *** of the studied individuals had antibodies to at least one of the three peptides(72%),34%had antibodies to all three peptides and 28%were *** the majority of the population was not infected at the time of the survey,74.3%of parasite-negative individuals had antibodies to at least one of the ***,among individuals carrying the haplotypes DRB1*04~DQB1*03,there was a significantly higher frequency of PfCS responders,and DRB1*16~DQB1*03 haplotype for PvCS and PfCS *** contrast,HLA-DRB1*01 and HLA-DQB1*05 allelic groups were associated with a lack of antibodies to *** and *** CSP repeats,and the haplotype DRB1*01~DQB1*05 was also associated with non-responders,including non-responders to ***:Our results show that in low transmission settings,naturally acquired antibody responses against the CSP repeats of ***,***,and *** in a single cross-sectional study may n

关键词： Malaria Circumsporozoite protein Serological marker Human leucocyte antigen IgG antibody Porto Velho Rondônia Brazil

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Helicobacter pylori infection: Beyond gastric manifestations

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World Journal of Gastroenterology 2020年第28期26卷 4076-4093页

作者： maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva mariana Miranda Sampaio Hanna Santos marques Natalia Oliveira e Silva Dulciene maria de Magalhaes queiroz Fabricio Freire de Melo Instituto Multidisciplinar em Saude Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Universidade Estadual da Bahia Vitória da Conquista 45083-900BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

Helicobacter pylori(***)is a bacterium that infects more than a half of world’s *** it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric *** to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological *** that context,when considered the gastrointestinal tract,*** positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and ***,lower serum levels of iron and vitamin B12 have been found in patients with *** infection,leading to the emergence of anemias in a portion of *** regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barré***,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the *** that,the ***-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected ***,the occurrence of dermatological and ophthalmic disorders have also been related to that *** this sense,this minireview aims to gather the main studies associating *** infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of *** in those diseases.

关键词： Helicobacter pylori Extragastric Neurological Cardiovascular Autoimmune Ophthalmic Diabetes Timeline Treatment

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Triiodothyronine and breast cancer

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World Journal of Clinical Oncology 2014年第3期5卷 503-508页

作者： maria teresa De Sibio Miriane de Oliveira Fernanda Cristina Fontes Moretto Regiane marques Castro Olimpio Sandro José Conde Aline Carbonera Luvizon Célia Regina Nogueira Department of Internal Medicine Botucatu Medical SchoolUniv Estadual PaulistaUNESPBotucatuSP 18618-970Brazil Department of Pathology Botucatu Medical School Univ Estadual Paulista-UNESP Botucatu SP 18618-970Brazil

The thyroid hormones(THs), triiodothyronine(T3) and thyroxine(T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer(BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol(E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the developmentand progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis.

关键词： Thyroid hormone Triiodothyronine Breast cancer Mammary gland and metabolism

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Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital

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World Journal of Clinical Cases 2023年第8期11卷 1761-1770页

作者： Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior maria teresa Araújo de Lorenzo Barcia Renata de Amorim marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene maria de Magalhães queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Hospital Geral de Vitória da Conquista Vitória da Conquista 45030-160BahiaBrazil Departamento de Ciências da Saúde Universidade Estadual do Sudoeste da Bahia(UESB)Vitória da Conquista 45083-900BahiaBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern *** that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and *** To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease *** This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian *** The patients had a median age of 65.60±15.78 *** was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the *** least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with *** and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective *** This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected *** associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features.

关键词： COVID-19 Epidemiology Symptoms Comorbidities Laboratory parameters

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Infections Following Kidney Transplant in Children: A Single-Center Study

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Open Journal of Nephrology 2014年第3期4卷 117-124页

作者： Alexandre Fernandes Liliana Rocha teresa Costa Paula Matos maria Sameiro Faria Laura marques Conceicao Mota Antonio Castro Henriques Pediatric Infectious Diseases and Immunodeficiency Department Centro Hospitalar do PortoOportoPortugal Pediatric Nephrology Department Centro Hospitalar do PortoOportoPortugal Kidney Transplant Department Centro Hospitalar do PortoOportoPortugal

Introduction: Infections are a major cause of morbidity and mortality in pediatric patients undergoing kidney transplantation (KT). Aim and Methods: To determine the patterns of infectious complications during the first 6 months post transplantation, we report our single center experience with data from pediatric kidney recipients transplanted between 2006 and 2011. Results: Thirty-two children (20 males) were submitted to KT. The most common cause of end-stage renal disease (ESRD) was congenital anomalies of the kidney and urinary tract (CAKUT) accounting for 62%. Over the first 6 months post-transplant period, twenty-eight (87.5%) children developed a total of 77 infections, mainly urinary tract infections (UTI) (64.9%). CAKUT etiology of ESRD and UTI before KT increased the risk to develop more than one episode of UTI [71.4% vs. 14.3% and 81.8% vs. 18.2%, respectively;p < 0.05]. Twenty-three (29.9%) viral infections occurred. Cytomegalovirus (CMV) was the most common opportunistic pathogen, occurred in 11 patients and was more frequently in those with a donor (D)+/recipient (R)- CMV sero-status [74.5% vs. 25.5% (p < 0.05)]. A polyomaviruses (BKV) disease with nephropathy and meningitis was registered. The majority of infectious episodes had mild or moderate severity. No deaths occurred. Conclusion: A significant number of patients presented infectious complications during the first 6 months post transplantation. UTI are the most common type of infection, followed by viral infections, particularly CMV. Recognition, prevention and early treatment of infections are of major importance.

关键词： CMV Infection Immunosuppression Kidney Transplantation Urinary Tract Infections

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Effect of Adjunct Culture <i>Lactobacillus helveticus</i>(B02) on the Composition, Proteolysis, Free Amino Acids Release and Sensory Characteristics of Prato Cheese

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Food and Nutrition Sciences 2017年第5期8卷 512-525页

作者： Natália Chinellato de Azambuja Izildinha Moreno Darlila Aparecida Gallina Leila maria Spadoti Eliana maria Pettirossi Motta maria teresa Bertolodo Pacheco Angela Lima Menêses de queiroz Adriane Elisabete Costa Antunes Faculdade de Ciências Aplicadas Universidade Estadual de Campinas (FCA/UNICAMP) Limeira Brazil Centro de Tecnologia de Laticínios Instituto de Tecnologia de Alimentos (TECNOLAT/ITAL) Campinas Brazil Faculdade de Engenharia de Alimentos Universidade Estadual de Campinas (FEA/UNICAMP) Campinas Brazil Centro de Ciência e Qualidade de Alimentos Instituto de Tecnologia de Alimentos (CCQA/ITAL) Campinas Brazil Centro de Tecnologia Universidade Federal da Paraíba Jo&#227o Pessoa Brazil

At semi-industrial scale it was obtained two cheeses, one with aromatic culture (CHN) and the other with also L. helveticus (CHN + LH). Proteolysis during ripening was evaluated using proteolytic indices, electrophoretic profile Urea-PAGE and release of free amino acids. Sensory evaluation was performed by acceptability test. It was observed a 5-fold increase in the fraction corresponding to αs1-I-casein in the CHN cheese and 6.5 times in the CHN + LH cheese and 7.2 and 8.2 increase respectively, for total amino acids. Prato cheese with the adjunct culture showed higher acceptability in terms of overall aroma and flavor.

关键词： Amino Acids Cheese L. helveticus Ripening Sensory Analysis

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Operative Technique for Correction of Gigantomastia,Using the Superior Pedicle,with Special Care for the Nipple-Papillary Grafts:A 13-Year Retrospective Study

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Modern Plastic Surgery 2015年第3期5卷 34-46页

作者： Jose Humberto Cardoso Resende Lucilia Feliciano marques di Carlantonio Luiz Celio Martins Freitas teresa Tonini Nebia maria Almeida de Figueiredo Luiz Carlos Santiago Nursing and Biosciences Federal University of Rio de Janeiro State(UNIRIO)Rio de JaneiroBrazil Member of the Brazilian Society of Plastic Surgery(SBCP) Rio de JaneiroBrazil Brazilian College of Surgeons(CBC) Rio de JaneiroBrazil President of the Catheters committee of the National Cancer Institute(INCa) Rio de JaneiroBrazil Public Health from State of Rio de Janeiro University(UERJ) Rio de JaneiroBrazil Coordinator of the Post-graduate Program in Nursing and Bioscience of UNIRIO Rio de JaneiroBrazil Nursing Federal University of Rio de Janeiro State(UNIRIO)Rio de JaneiroBrazil

This is a retrospective study on gigantomastia correction in obesity facing the technique of nipple-areolar grafts and its complexity. The main question is the technical-surgical care during its execution aiming to achieve reparative results that can return to these women the desire to live with better quality of life and health. Method: We performed a retrospective study of all obese patients with severe gigantomastia who underwent reduction mammaplasty with an operative technique using the superior pedicle, with special care for the nipple-papillary grafts. The study was carried out at a single institution between 2001 and 2013, in a total of 30 cases. This operative technique was presented at first time in 1980, with no changes up to now. We emphasized the perfect decortication of the areola and nipples until they were translucent after the maneuvers of Schwartzman and subsequent grafts operated in both breasts. Results: Results were considered satisfactory, from the reparative and aesthetic point of view, emphasizing the degree of improvement observed in women undergoing technique. Discussion: We can say that during all this time of aesthetic and therapeutic-restorative surgery, due to its realization in a single surgical time, there was big impact on the aesthetics of patients and on their families, even taking into account possible complications in the post-operative. Conclusion: The superior pedicle technique, performed as described here, is a safe and reliable procedure in patients with severe gigantomastia.

关键词： Mammoplasty Gigantomastia Resende’s Technique Surgical Flaps Bariatric Surgery Obesity

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Molecular Study of the Genetic Variability of Pumpkins Landraces from Brazilian Amazon

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Agricultural Sciences 2018年第4期9卷 511-523页

作者： Lúcia Helena Pinheiro Martins maria teresa Gomes Lopes Hiroshi Noda Pedro de queiroz Costa Neto Ayrton Luiz Urizzi Martins Fabíola Viana de Almeida Liane Cristine Reboucas Demosthenes Núcleo de Etnoecologia da Amazonia(NETNO)Universidade Federal do Amazonas ManausBrazil Faculdade de Ciencias Agrarias(FCA) Universidade Federal do AmazonasManausBrazil Instituto Nacional de Pesquisas da Amazonia(INPA) ManausBrazil Instituto Federal de Educacao Tecnologica do Amazonas/Campus Parintins IFAM/ParintinsBrazil Instituto de Ciencias Exatas e Tecnologia(ICET) Universidade Federal do AmazonasItacoatiaraBrazil

The Cucurbita maxima Duchesne is a vegetable crop plant cultivated and maintained by traditional Amazon communities, Brazil. The situation is worsened by the possibility of disappearance of local populations and genetic variability of this specie, taking into account the today changes promoted in family farming. The aim of this study was to estimate the current levels of genetic variability of local cultivars through the use of molecular markers (Amplified Fragment Length Polymorphism—AFLP). We chose to collect in two distinct micro regions in order to identify possible influences of geographic isolation and different levels of market requirements in the conservation of the genetic variability of the C. maxima. For the molecular analysis, bulk samples of fresh leaves of 15 plants/half-sibling family were collected in paper bags. There were 34 samples from the half-sib families. The analysis of the results half-sib obtained by methods of estimation of genetic variation by molecular markers shows that the forms of cultivation and management adopted by family farmers maintain the identities of the local/landraces (native cultivars) and, at the same time, the levels of diversity for the assurance of adaptability macro-environmental.

关键词： Crop Genetic Variability Molecular Marker Amplified Fragment Length Polymorphism Cucurbita maxima Duchesne

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Oral Cancer:Health Promotion and Visual Screening—A Study Report

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Journal of Cancer Therapy 2013年第8期4卷 1313-1320页

作者： Augusta P.Silveira Augusta marques Miguel Pavao Eurico Monteiro Gabriela Pereira Joaquim Goncalves Luís Castro maria Ines Guimaraes Bernardete Carvalho Claudia Ribeiro teresa Sequeira Faculty of Heath Sciences Fernando Pessoa UniversityPortoPortugal Centre of Health Studies and Research Coimbra UniversityCoimbraPortugal Non-Governmental Organization(NGO):Mundo A Sorrir PortoPortugal Portuguese Institute for Oncology PortoPortugal Instituto Politecnico do Cavado e do Ave BarcelosPortugal Porto Portugal Well Medical Spa PortoPortugal Health Sciences Department Portuguese Catholic UniversityViseuPortugal

Background: Oral cancer presents a heterogeneous geographic incidence. Annually, more than 275,000 new cases are diagnosed worldwide. In spite of the easy accessibility of oral cavity during physical examination, most malignancies are not diagnosed until late stages of disease. Methods: Oral health promotion was our main objective, risk factors were identified and oral cavity self-examination was promoted. The population considered (n = 1117) was divided in two main age groups—a youngest (individuals under 25 years old) mostly targeted for oral cancer awareness and oral cavity self examination promotion, and an older group having accumulated potential risk exposure. Results: The results obtained revealed smoking habits and fruits-vegetables consumption deficit as the highest risks factors found. Considering a Risk Factor Exposure Index analysis, individuals with secondary level of instruction and living in sub-urban areas assumed the highest risk exposure. Alcohol consumption had also contributed as a significant risk exposure. Conclusions: Some of these risk factors work as biological reward of quality of life deficit. A wide comprehension of the problem requires a multidisciplinary approach necessarily involving Health and Social Sciences in order to target the core of oral cancer health promotion. An effective epidemiological strategy must thus support three major aspects: population knowledge, sensitization and visual screening.

关键词： Oral Cancer Visual Screening Oral Health Promotion Epidemiological Strategies

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Group Analysis＂ Other Sights of the Conscious and the Unconscious

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Psychology Research 2015年第1期5卷 10-22页

作者： Abreu-Afonso Jose Dinis Cesar Ferreira Guilherme Sara maria Caseiro Ferro marques Paulo Motta Melo Joao Carlos Neto Isaura Porto Manuela Rodrigues teresa Bastos Valente Aucindio Portuguese Group Analytic Society and Group Analytic Psychotherapy (SPG PAG) Lisbon Portugal

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